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Extract from the Register of European Patents

EP About this file: EP0733103

EP0733103 - GENERATION OF HIGH TITERS OF RECOMBINANT AAV VECTORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.01.2005
Database last updated on 18.11.2024
Most recent event   Tooltip07.01.2005No opposition filed within time limitpublished on 23.02.2005  [2005/08]
Applicant(s)For all designated states
TARGETED GENETICS CORPORATION
Suite 100, 1100 Olive Way
Seattle, WA 98101 / US
For all designated states
JOHNS HOPKINS UNIVERSITY
720 Rutland Avenue
Baltimore, MD 21205-2109 / US
[N/P]
Former [2004/10]For all designated states
TARGETED GENETICS CORPORATION
Suite 100, 1100 Olive Way
Seattle, WA 98101 / US
For all designated states
THE JOHNS HOPKINS UNIVERSITY
720 Rutland Avenue
Baltimore, MD 21205-2109 / US
Former [1996/39]For all designated states
TARGETED GENETICS CORPORATION
Suite 100, 1100 Olive Way
Seattle, WA 98101 / US
For all designated states
THE JOHNS HOPKINS UNIVERSITY
720 Rutland Avenue
Baltimore, MD 21205 / US
Inventor(s)01 / FLOTTE, Terence R.
Apartment T3, 7853 American Circle
Glen Burnie, MD 21060 / US
02 / CARTER, Barrie J.
1218 Third Avenue North
Seattle, WA 98109 / US
03 / GUGGINO, William B.
1005 Poplar Hill Road
Baltimore, MD 21210 / US
04 / SOLOW, Rikki
10267 Ridge Line Drive
Gaithersburg, MD 20879 / US
[1996/39]
Representative(s)Goldin, Douglas Michael, et al
J.A. KEMP & CO. 14 South Square Gray's Inn
London WC1R 5JJ / GB
[N/P]
Former [1996/39]Goldin, Douglas Michael, et al
J.A. KEMP & CO. 14, South Square Gray's Inn
London WC1R 5LX / GB
Application number, filing date95902421.703.11.1994
[1996/39]
WO1994US12587
Priority number, dateUS1993014933209.11.1993         Original published format: US 149332
[1996/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9513365
Date:18.05.1995
Language:EN
[1995/21]
Type: A1 Application with search report 
No.:EP0733103
Date:25.09.1996
Language:EN
The application published by WIPO in one of the EPO official languages on 18.05.1995 takes the place of the publication of the European patent application.
[1996/39]
Type: B1 Patent specification 
No.:EP0733103
Date:03.03.2004
Language:EN
[2004/10]
Search report(s)International search report - published on:US18.05.1995
(Supplementary) European search report - dispatched on:EP30.10.1997
ClassificationIPC:C12N15/86, C12N7/00, C12N7/01, C12N15/10, C12N15/48, A61K35/76, C07K14/015, C12N5/10, C07K14/47
[1997/49]
CPC:
C12N15/86 (EP,US); A61P1/18 (EP); A61P11/00 (EP);
A61P3/12 (EP); A61P43/00 (EP); A61P7/06 (EP);
C12N2750/14143 (EP,US) (-)
Former IPC [1996/39]C12N7/00, C12N7/01, C12N15/10, C12N15/48, C12N15/86, A61K35/76
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1996/39]
TitleGerman:DIE ERZIELUNG HOHER TITER DES REKOMBINANTEN AAV-VEKTORS[1996/39]
English:GENERATION OF HIGH TITERS OF RECOMBINANT AAV VECTORS[1996/39]
French:PRODUCTION DE TITRES ELEVES DE VECTEURS D'AAV RECOMBINANTS[1996/39]
Entry into regional phase03.06.1996National basic fee paid 
03.06.1996Search fee paid 
03.06.1996Designation fee(s) paid 
03.06.1996Examination fee paid 
Examination procedure25.04.1995Request for preliminary examination filed
International Preliminary Examining Authority: US
03.06.1996Examination requested  [1996/39]
25.06.2001Despatch of a communication from the examining division (Time limit: M06)
15.02.2002Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
19.04.2002Reply to a communication from the examining division
03.09.2002Despatch of a communication from the examining division (Time limit: M06)
13.03.2003Reply to a communication from the examining division
20.05.2003Communication of intention to grant the patent
15.09.2003Fee for grant paid
15.09.2003Fee for publishing/printing paid
Opposition(s)06.12.2004No opposition filed within time limit [2005/08]
Request for further processing for:19.04.2002Request for further processing filed
19.04.2002Full payment received (date of receipt of payment)
Request granted
30.05.2002Decision despatched
Fees paidRenewal fee
11.11.1996Renewal fee patent year 03
10.11.1997Renewal fee patent year 04
26.10.1998Renewal fee patent year 05
08.11.1999Renewal fee patent year 06
10.11.2000Renewal fee patent year 07
07.11.2001Renewal fee patent year 08
07.11.2002Renewal fee patent year 09
26.11.2003Renewal fee patent year 10
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Documents cited:Search[XY]WO9210574  (US HEALTH [US]) [X] 7,8 * page 16, line 15 - page 21, line 11; claims 1-10 * [Y] 1-10;
 [E]WO9513392  (OHIO MED COLLEGE [US], et al) [E] 1,2,7 * the whole document *;
 [Y]  - TRATSCHIN J D ET AL, "NEGATIVE AND POSITIVE REGULATION IN TRANS OF GENE EXPRESSION FROM ADENO-ASSOCIATED VIRUS VECTORS IN MAMMALIAN CELLS BY A VIRAL REP GENE PRODUCT", MOLECULAR AND CELLULAR BIOLOGY, (198608), vol. 6, no. 8, pages 2884 - 2894, XP000618965 [Y] 1-10 * the whole document *
 [Y]  - BEATON A ET AL, "EXPRESSION FROM THE ADENO-ASSOCIATED VIRUS P5 AND P19 PROMOTERS IS NEGATIVELY REGULATED IN TRANS BY THE REP PROTEIN", JOURNAL OF VIROLOGY, (198910), vol. 63, no. 10, pages 4450 - 4454, XP000609489 [Y] 1-10 * the whole document *
 [T]  - FLOTTE, T.R. ET AL., "An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction", GENE THERAPY, (199501), vol. 2, no. 1, pages 29 - 37, XP002043509 [T] 1-10 * the whole document *
International search[A]  - THE JOURNAL OF BIOLOGICAL CHEMISTRY, Volume 268, issued 15 February 1993, FLOTTE et al., "Expression of the Cystic Fibrosis Transmembrane Conductance Regulator from a Novel Adeno-Associated Virus Promoter", pages 3781-3790.
 [A]  - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Volume 90, issued November 1993, FLOTTE et al., "Stable In Vivo Expression of the Cystic Fibrosis Transmembrane Conductance Regulator with an Adeno-Associated Virus Vector", pages 10613-10617.
 [A]  - JOURNAL OF VIROLOGY, Volume 63, Number 9, issued September 1989, SAMULSKI et al., "Helper-Free Stocks of Recombinant Adeno-Associated Viruses: Normal Integration does not Require Viral Gene Expression", pages 3822-3828.
 [A]  - NATURE, Volume 358, issued 13 August 1992, EGAN et al., "Defective Regulation of Outwardly Rectifying Cl-Channels by Protein Kinase A Corrected by Insertion of CFTR", pages 581-584.
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.