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Extract from the Register of European Patents

EP About this file: EP0729459

EP0729459 - PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  19.01.2004
Database last updated on 06.07.2024
Most recent event   Tooltip03.12.2004Lapse of the patent in a contracting state
New state(s): IE		published on 19.01.2005  [2005/03]
Applicant(s)For all designated states
Schering Corporation
2000 Galloping Hill Road
Kenilworth, NJ 07033 / US
[N/P]
Former [1996/36]For all designated states
SCHERING CORPORATION
2000 Galloping Hill Road
Kenilworth New Jersey 07033 / US
Inventor(s)01 / ASLANIAN, Robert, G.
144 Philip Drive
Rockaway, NJ 07866 / US
02 / GREEN, Michael, J.
43 Meadow Run Drive
Skillman, NJ 08558 / US
03 / SHIH, Neng-Yang
1 Maple Drive
North Caldwell, NJ 07006 / US
[1996/36]
Representative(s)Ritter, Stephen David, et al
Mathys & Squire LLP 120 Holborn London
EC1N 2SQ / GB
[N/P]
Former [1996/36]Ritter, Stephen David, et al
Mathys & Squire 100 Grays Inn Road
London WC1X 8AL / GB
Application number, filing date95902442.310.11.1994
[1996/36]
WO1994US12717
Priority number, dateUS1993015323115.11.1993         Original published format: US 153231
[1996/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9514007
Date:26.05.1995
Language:EN
[1995/22]
Type: A1 Application with search report 
No.:EP0729459
Date:04.09.1996
Language:EN
The application published by WIPO in one of the EPO official languages on 26.05.1995 takes the place of the publication of the European patent application.
[1996/36]
Type: B1 Patent specification 
No.:EP0729459
Date:12.03.2003
Language:EN
[2003/11]
Search report(s)International search report - published on:EP26.05.1995
ClassificationIPC:C07D233/54, A61K31/415, C07D401/12
[1996/36]
CPC:
C07D233/64 (EP,US); A61P25/00 (EP); A61P29/00 (EP);
A61P37/08 (EP); A61P43/00 (EP); A61P9/00 (EP);
C07D401/12 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   NL,   PT,   SE [1996/36]
TitleGerman:PHENYLALKYL-IMIDAZOLE ALS H3-REZEPTOR-ANTAGONISTEN[1996/36]
English:PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS[1996/36]
French:PHENYL-ALKYL-IMIDAZOLES SERVANT D'ANTAGONISTES DU RECEPTEUR DE H3[1996/36]
Entry into regional phase16.05.1996National basic fee paid 
16.05.1996Designation fee(s) paid 
16.05.1996Examination fee paid 
Examination procedure02.06.1995Request for preliminary examination filed
International Preliminary Examining Authority: EP
16.05.1996Examination requested  [1996/36]
09.09.1997Despatch of a communication from the examining division (Time limit: M06)
02.03.1998Reply to a communication from the examining division
05.10.1998Despatch of a communication from the examining division (Time limit: M06)
01.04.1999Reply to a communication from the examining division
23.06.2000Despatch of a communication from the examining division (Time limit: M06)
08.11.2000Reply to a communication from the examining division
03.06.2002Despatch of communication of intention to grant (Approval: Yes)
24.09.2002Communication of intention to grant the patent
09.12.2002Fee for grant paid
09.12.2002Fee for publishing/printing paid
Opposition(s)15.12.2003No opposition filed within time limit [2004/10]
Fees paidRenewal fee
21.10.1996Renewal fee patent year 03
20.10.1997Renewal fee patent year 04
27.10.1998Renewal fee patent year 05
22.10.1999Renewal fee patent year 06
10.11.2000Renewal fee patent year 07
07.11.2001Renewal fee patent year 08
07.11.2002Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT12.03.2003
BE12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
DK12.06.2003
PT12.06.2003
SE12.06.2003
IE10.11.2003
LU10.11.2003
[2005/03]
Former [2004/39]AT12.03.2003
BE12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
DK12.06.2003
PT12.06.2003
SE12.06.2003
LU10.11.2003
Former [2004/23]AT12.03.2003
BE12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
DK12.06.2003
PT12.06.2003
SE12.06.2003
Former [2004/10]AT12.03.2003
BE12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
PT12.06.2003
SE12.06.2003
Former [2003/50]AT12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
PT12.06.2003
SE12.06.2003
Former [2003/47]AT12.03.2003
CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
PT12.06.2003
Former [2003/46]CH12.03.2003
GR12.03.2003
LI12.03.2003
NL12.03.2003
PT12.06.2003
Former [2003/43]CH12.03.2003
LI12.03.2003
NL12.03.2003
PT12.06.2003
Former [2003/41]CH12.03.2003
LI12.03.2003
NL12.03.2003
Former [2003/40]CH12.03.2003
LI12.03.2003
Cited inInternational search[X]EP0024829  (FARMOS OY [FI]) [X] 1,9,10 * page 41 - page 42; examples 27,28 *;
 EP0269599  [ ] (UCB SA [BE]);
 JPH01242571  [ ] (MITSUI PETROCHEMICAL IND);
 [X]EP0341231  (UCB SA [BE]) [X] 1,9 * page 15 - page 20; examples 1-2 * * page 22, line 27; examples 3-6 *;
 [A]WO9314070  (INST NAT SANTE RECH MED [FR], et al) [A] 1-23 * page 104 - page 107; claim 1 ** page 1, line 15 - line 22 *
 [X]  - C.J. CARDIN ET AL., "Synthesis of 3-[4(5)-imidazolylmethyl]-2-methylbenzoic acid, a metabolite of the drug detomidine.", CHEMICAL ABSTRACTS, (19930329), vol. 118, no. 13, Database accession no. 124448b, page 800, column 2 [X] 1,9 * see abstract and Chemical Abstracts, CHEMICAL SUBSTANCE INDEX, vol 118, 1993, pages1406CS and 1688CS: RN [115664-37-4], 115664-39-6] and [146197-56-0] *
    [ ] - J. CHEM. RES., SYNOP., (1992), no. 12, page 389
 [X]  - N. KIHARA ET AL., "Preparation of imidazole derivatives as drugs.", CHEMICAL ABSTRACTS, (19900409), vol. 112, no. 15, Database accession no. 139033, page 721, column 2 [X] 1,9,10 * see abstract and Chemical Abstracts, CHEMICAL SUBSTANCES, 12th Collective Index, vol. 106-115, 1987-1991, pages 7972CS and 45772CS: RN [125883-66-1] and [78892-56-5] *
 [X]  - E. COSSEMENT ET AL., "Preparation of 4-(substituted benzyl)imidazoles as antiischemic agents.", CHEMICAL ABSTRACTS, (19881219), vol. 109, no. 25, Database accession no. 231016v, page 862, column 2 [X] 1,9 * see abstract and Chemical Abstracts, CHEMICAL SUBSTANCES, 12th Collective Index, vol. 106-115, 1987-1991, page12424CS: RN [116796-03-3] *
 [X]  - J. HORA, "The synthesis of bis-endo-2-(hydroxymethyl)-5-(4-imidazolymethyl)-bicyclo[2.2.2]octane and the corresponding cyclohexane analogue", RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS, DEN HAAG NL, (197602), vol. 95, no. 2, pages 45 - 49 [X] 1,9,10 * see page 46, column 1, compound no. 16 *
 [X]  - W. SCHUNACK, "Structure-activity relations of histamine analogs. 9. Aminobenzyl- and aminocyclohexylmethylimidazoles.", CHEMICAL ABSTRACTS, (19760202), vol. 84, no. 5, Database accession no. 30961r, page 454, column 1 [X] 1,9 * see abstract and Chemical Abstracts, CHEMICAL SUBSTANCES, 9th Collective Index, vol. 76-85, 1972-1976, page 3264CS: RN [57662-33-6] and [57662-34-7] *
    [ ] - ARCH. PHARM., WEINHEIM, DE, (1975), vol. 308, no. 10, pages 755 - 759
 [PX]  - I. STOILOV ET AL., "Synthesis of Detomidine and Medetomidine Metabolites: 1,2,3-Trisubstituted Arenes with 4'(5')-Imidazolylmethyl Groups", JOURNAL OF HETEROCYCLIC CHEMISTRY, PROVO US, (199312), vol. 30, no. 6, pages 1645 - 1651 [PX] 1,9-11 * see page 1646, figure 3, compound no. 15 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.