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EP0786998
European procedure
Extract from the Register of European Patents
EP About this file: EP0786998
| EP0786998 - USE OF R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO 2.2.2] OCT-3-YL) ACETONITRILE TO REDUCE AMYLOID BETA A4 FORMATION IN ALZHEIMER'S DISEASE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 31.01.2003 Database last updated on 13.07.2024 | Most recent event Tooltip | 31.01.2003 | No opposition filed within time limit | published on 19.03.2003 [2003/12] | Applicant(s) | For all designated states SMITHKLINE BEECHAM PLC 980 Great West Road Brentford Middlesex TW8 9GS / GB | [N/P] |
| Former [2002/34] | For all designated states SmithKline Beecham plc 980 Great West Road Brentford, Middlesex TW8 9GS / GB | ||
| Former [2002/13] | For all designated states SMITHKLINE BEECHAM PLC New Horizons Court Brentford, Middlesex TW8 9EP / GB | ||
| Former [1997/32] | For all designated states SMITHKLINE BEECHAM PLC New Horizons Court Brentford, Middlesex TW8 9EP / GB | Inventor(s) | 01 /
MARKWELL, Roger, E. SmithKline Beecham Pharma. Coldharbour Road The Pinnacles Harlow Essex CM19 5AD / GB | 02 /
HAWKINS, Julie SmithKline Beecham Pharmaceuticals Coldharbour Road The Pinnacles Harlow Essex CM19 5AD / GB | 03 /
GRAY, Carol, W. SmithKline Beecham Pharmaceuticals Coldharbour Road The Pinnacles Harlow Essex CM19 5AD / GB | [2002/11] |
| Former [1997/32] | 01 /
MARKWELL, Roger, E. SmithKline Beecham Pharma. Coldharbour Road The Pinnacles Harlow Essex CM19 5ADs / GB | ||
| 02 /
HAWKINS, Julie SmithKline Beecham Pharmaceuticals Coldharbour Road The Pinnacles Harlow Essex CM19 5AD / GB | |||
| 03 /
GRAY, Carol, W. SmithKline Beecham Pharmaceuticals Coldharbour Road The Pinnacles Harlow Essex CM19 5AD / GB | Representative(s) | Valentine, Jill Barbara GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB | [N/P] |
| Former [1997/32] | Valentine, Jill Barbara SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP / GB | Application number, filing date | 95936515.6 | 17.10.1995 | [1997/32] | WO1995EP04082 | Priority number, date | GB19940021472 | 25.10.1994 Original published format: GB 9421472 | [1997/32] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO9612486 | Date: | 02.05.1996 | Language: | EN | [1996/20] | Type: | A1 Application with search report | No.: | EP0786998 | Date: | 06.08.1997 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.05.1996 takes the place of the publication of the European patent application. | [1997/32] | Type: | B1 Patent specification | No.: | EP0786998 | Date: | 27.03.2002 | Language: | EN | [2002/13] | Search report(s) | International search report - published on: | EP | 02.05.1996 | Classification | IPC: | A61K31/435 | [1997/32] | CPC: |
A61K31/439 (EP,US);
A61K31/435 (KR);
A61P25/28 (EP)
| Designated contracting states | AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1997/32] | Extension states | SI | 02.04.1997 | Title | German: | VERWENDUNG VON [R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO [2.2.2.] OCT-3-YL) ACETONITRIL ZUR HEMMUNG DER AMYLOID-BETA-A4-BILDUNG BEI DER ALZHEIMERSCHEN KRANKHEIT | [2002/11] | English: | USE OF R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO 2.2.2] OCT-3-YL) ACETONITRILE TO REDUCE AMYLOID BETA A4 FORMATION IN ALZHEIMER'S DISEASE | [1997/32] | French: | UTILISATION DE [R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO [2.2.2] OCT-3-YL) ACETONITRILE POUR REDUIRE LA FORMATION BETA A4 AMYLOIDE DANS LA MALADIE D'ALZHEIMER | [2002/11] |
| Former [1997/32] | Verwendung von [R-(Z)]-aplha-(methoxyimino)-alpha-(1-Azabicyclo[z.z.z.]oct-3-yl)Acetonitril zur Hemmung der Amyloid Beta A4 Bildung in Alzheimerschen Krankheit. | ||
| Former [1997/32] | UTILISATION DE R-(Z)]-ALPHA-(METHOXYIMINO)-ALPHA-(1-AZABICYCLO 2.2.2] OCT-3-YL) ACETONITRILE POUR REDUIRE LA FORMATION BETA A4 AMYLOIDE DANS LA MALADIE D'ALZHEIMER | Entry into regional phase | 02.04.1997 | National basic fee paid | 02.04.1997 | Designation fee(s) paid | 02.04.1997 | Examination fee paid | Examination procedure | 30.04.1996 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 02.04.1997 | Examination requested [1997/32] | 29.06.2000 | Despatch of a communication from the examining division (Time limit: M04) | 18.10.2000 | Reply to a communication from the examining division | 06.02.2001 | Despatch of communication of intention to grant (Approval: Yes) | 24.08.2001 | Communication of intention to grant the patent | 19.11.2001 | Fee for grant paid | 19.11.2001 | Fee for publishing/printing paid | Opposition(s) | 30.12.2002 | No opposition filed within time limit [2003/12] | Fees paid | Renewal fee | 13.10.1997 | Renewal fee patent year 03 | 08.10.1998 | Renewal fee patent year 04 | 15.10.1999 | Renewal fee patent year 05 | 09.10.2000 | Renewal fee patent year 06 | 08.10.2001 | Renewal fee patent year 07 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [DX]EP0392803 (BEECHAM GROUP PLC [GB]) [DX] 5,6 * claims 1,5,6 *; | [DA]WO9409370 (MASSACHUSETTS INST TECHNOLOGY [US]); | [DA] - R.M. NITSCH ET AL., "Release of alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.", SCIENCE, vol. 258, no. 5080, pages 304 - 307, XP000562717 DOI: http://dx.doi.org/10.1126/science.1411529 | [DA] - R. HARING ET AL., "Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B.", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 203, no. 1, pages 652 - 658, XP000562718 DOI: http://dx.doi.org/10.1006/bbrc.1994.2232 | [A] - C.C. FELDER ET AL., "Muscarinic acetylcholine receptor subtypes associated with release of alzheimer amyloid precursor derivatives activate multiple signal transduction pathways.", ANN. N. Y. ACAD. SCI., vol. 695, pages 15 - 18, XP000563390 DOI: http://dx.doi.org/10.1111/j.1749-6632.1993.tb23020.x | [A] - R.M. NITSCH ET AL., "Receptor-coupled amyloid precursor protein processing.", ANN. N. Y. ACAD. SCI., vol. 695, pages 122 - 127, XP000563389 DOI: http://dx.doi.org/10.1111/j.1749-6632.1993.tb23039.x | [A] - A.Y. HUNG ET AL., "Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.", J. BIOL. CHEM., vol. 268, no. 31, pages 22959 - 22962, XP000562715 |