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EP0815102
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EP About this file: EP0815102
| EP0815102 - REDUCTIVE ALKYLATION PROCESS FOR THE PREPARATION N-(2-(R)-HYDROXY-1-(S)-INDANYL)-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-(1-(4-(3-PYRIDYLMETHYL)-2(S)-N'-(t-BUTYLCARBOXAMIDO)-PIPERAZINYL))-PENTANEAMIDE (=COMPOUND J OR L-735,524) [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 18.02.2005 Database last updated on 14.03.2026 | Most recent event Tooltip | 18.02.2005 | Application deemed to be withdrawn | published on 06.04.2005 [2005/14] | Applicant(s) | For all designated states Merck & Co., Inc. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US | [N/P] |
| Former [1998/02] | For all designated states MERCK & CO., INC. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US | Inventor(s) | 01 /
ASKIN, David 126 East Lincoln Avenue Rahway, NJ 07065 / US | 02 /
CIANCIOSI, Steven, J. 126 East Lincoln Avenue Rahway, NJ 07065 / US | 03 /
HOERRNER, Robert, S. 126 East Lincoln Avenue Rahway, NJ 07065 / US | [1998/02] | Representative(s) | Horgan, James Michael Frederic, et al Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road, Harlow Essex CM20 2QR / GB | [N/P] |
| Former [2004/27] | Horgan, James Michael Frederic, et al Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR / GB | ||
| Former [1998/02] | Cole, William Gwyn, et al European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR / GB | Application number, filing date | 96908541.4 | 11.03.1996 | [1998/02] | WO1996US02646 | Priority number, date | US19950404776 | 15.03.1995 Original published format: US 404776 | [1998/02] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO9628440 | Date: | 19.09.1996 | Language: | EN | [1996/42] | Type: | A1 Application with search report | No.: | EP0815102 | Date: | 07.01.1998 | Language: | EN | The application published by WIPO in one of the EPO official languages on 19.09.1996 takes the place of the publication of the European patent application. | [1998/02] | Search report(s) | International search report - published on: | EP | 19.09.1996 | Classification | IPC: | C07D401/06 | [1998/02] | CPC: |
C07D401/06 (EP,US)
| Designated contracting states | AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE [1998/02] | Title | German: | REDUKTIVES ALKYLIERUNGVERFAHREN ZUR HERSTELLUNG VON N-(2(R)-HYDROXY-1(S)-INDANYL)-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-(1-(4-(3-PYRIDYLMETHYL)-2(S)-N'-(t-BUTYLCARBOXAMIDO)-PIPERAZINYL)-PENTANEAMID(=VERBINDUNG J ODER L-735,524) | [1998/02] | English: | REDUCTIVE ALKYLATION PROCESS FOR THE PREPARATION N-(2-(R)-HYDROXY-1-(S)-INDANYL)-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-(1-(4-(3-PYRIDYLMETHYL)-2(S)-N'-(t-BUTYLCARBOXAMIDO)-PIPERAZINYL))-PENTANEAMIDE (=COMPOUND J OR L-735,524) | [1998/02] | French: | PROCEDE D'AMINATION REDUCTRICE POUR LA PREPARATION DE N-(-2-(R)-HYDROXY-1-(S)-INDANYL)-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-(1-(4-(3-PHYRIDYLMETHYL)-2(S)-N'-(t-BUTYLCARBOXAMIDO)-PIPERAZINYL))-PENTANEAMIDE (=COMPOSE J OU L-735,524) | [1998/02] | Entry into regional phase | 15.10.1997 | National basic fee paid | 15.10.1997 | Designation fee(s) paid | 15.10.1997 | Examination fee paid | Examination procedure | 04.10.1996 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 15.10.1997 | Examination requested [1998/02] | 28.10.2002 | Despatch of a communication from the examining division (Time limit: M04) | 04.03.2003 | Reply to a communication from the examining division | 01.10.2004 | Application deemed to be withdrawn, date of legal effect [2005/14] | 05.11.2004 | Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2005/14] | Fees paid | Renewal fee | 31.03.1998 | Renewal fee patent year 03 | 31.03.1999 | Renewal fee patent year 04 | 31.03.2000 | Renewal fee patent year 05 | 02.04.2001 | Renewal fee patent year 06 | 02.04.2002 | Renewal fee patent year 07 | 05.03.2003 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 31.03.2004 | 09 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [DY] BORCH R.F. ET AL.: "The cyanohydridoborate anion as a selective reducing agent", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 93, no. 12, 16 June 1971 (1971-06-16), pages 2897 - 2904, XP002007204 [DY] 1-13 * the whole document * DOI: http://dx.doi.org/10.1021/ja00741a013 | [DY] ABDEL-MAGID A.F. ET AL.: "Reductive amination of aldehydes and ketones by using sodium triacetoxyborohydride", TETRAHEDRON LETTERS, vol. 31, no. 39, 17 September 1990 (1990-09-17), pages 5595 - 5598, XP002007205 [DY] 1-13 * the whole document * DOI: http://dx.doi.org/10.1016/S0040-4039(00)97905-X | [A] DORSEY B.D. ET AL.: "L-735,524: The design of a potent and orally bioavailable HIV protease inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 21, 14 October 1994 (1994-10-14), pages 3443 - 3451, XP002007206 [A] 1-13 * column W * DOI: http://dx.doi.org/10.1021/jm00047a001 |