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Extract from the Register of European Patents

EP About this file: EP0821588

EP0821588 - LEVOBUPIVACAINE AND ITS USE AS AN ANAESTHETIC IN PREGNANT WOMEN [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 23.04.2004 Database last updated on 03.09.2024
Most recent event Tooltip	23.04.2004	No opposition filed within time limit	published on 09.06.2004 [2004/24]
Applicant(s)	For all designated states Darwin Discovery Limited 208 Bath Road Slough Berks SL1 3WE / GB
	[N/P]
Former [2003/04]	For all designated states Darwin Discovery Limited 208 Bath Road Slough Berks SL1 3WE / GB
Former [1999/04]	For all designated states Darwin Discovery Limited Cambridge Science Park, Milton Road Cambridge CB4 4WE / GB
Former [1998/06]	For all designated states Chiroscience Limited Cambridge Science Park, Milton Road Cambridge CB4 4WE / GB
Inventor(s)	01 / BARDSLEY, Hazel, Judith Chiroscience Limited Cambridge Science Park Milton Road Cambridge CB4 4WE / GB
	02 / GRISTWOOD, Robert, William Chiroscience Limited Cambridge Science Park Milton Road Cambridge CB4 4WE / GB
	[1998/06]
Representative(s)	Perry, Robert Edward, et al Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB
	[N/P]
Former [1998/06]	Perry, Robert Edward, et al GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH / GB
Application number, filing date	96910087.4	15.04.1996
	[1998/06]
	WO1996GB00912
Priority number, date	GB19950007677	13.04.1995 Original published format: GB 9507677
	US19950549408	27.10.1995 Original published format: US 549408
	[1998/06]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO9632109
	Date:	17.10.1996
	Language:	EN
	[1996/46]
	Type:	A2 Application without search report
	No.:	EP0821588
	Date:	04.02.1998
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 17.10.1996 takes the place of the publication of the European patent application.
	[1998/06]
	Type:	B1 Patent specification
	No.:	EP0821588
	Date:	18.06.2003
	Language:	EN
	[2003/25]
Search report(s)	International search report - published on:	EP	13.02.1997
Classification	IPC:	A61K31/445, A61P23/02	[2002/20]
	CPC data not yet available
	Former IPC [1998/06]	A61K31/445
Designated contracting states	AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE [1998/06]
Title	German:	LEVOBUPIVACAIN UND DESSEN VERWENDUNG ALS ANÄSTHETIKUM BEI SCHWANGEREN FRAUEN	[1998/06]
	English:	LEVOBUPIVACAINE AND ITS USE AS AN ANAESTHETIC IN PREGNANT WOMEN	[1998/06]
	French:	LEVOBUPIVACAINE ET SON UTILISATION COMME ANESTHESIQUE CHEZ LA FEMME ENCEINTE	[1998/06]
Entry into regional phase	31.10.1997	National basic fee paid
	31.10.1997	Designation fee(s) paid
	31.10.1997	Examination fee paid
Examination procedure	24.10.1996	Request for preliminary examination filed International Preliminary Examining Authority: EP
	31.10.1997	Examination requested [1998/06]
	29.05.2001	Despatch of a communication from the examining division (Time limit: M06)
	07.12.2001	Reply to a communication from the examining division
	31.05.2002	Despatch of communication of intention to grant (Approval: Yes)
	09.12.2002	Communication of intention to grant the patent
	21.02.2003	Fee for grant paid
	21.02.2003	Fee for publishing/printing paid
Opposition(s)	19.03.2004	No opposition filed within time limit [2004/24]
Fees paid	Renewal fee
	14.04.1998	Renewal fee patent year 03
	14.04.1999	Renewal fee patent year 04
	13.04.2000	Renewal fee patent year 05
	12.04.2001	Renewal fee patent year 06
	12.04.2002	Renewal fee patent year 07
	14.04.2003	Renewal fee patent year 08
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[DPX]WO9510276 (CHIROSCIENCE LTD [GB], et al) [DPX] 1-13 * the whole document *;
		[DPX]WO9510277 (CHIROSCIENCE LTD [GB], et al) [DPX] 1-13 * the whole document *;
		[X] - REYNOLDS, F., "In defence of Bupivacaine", INTERNATIONAL JOURNAL OD OBSTETRIC ANALGESIA, (1995), vol. 4, no. 2, pages 93 - 108, XP000613009 [X] 1-3 * the whole document * * especially page 107, line 54, righthand column-page 108, line 13, lefthand column * DOI: http://dx.doi.org/10.1016/0959-289X(95)82999-Q
		[DA] - DENSON, D.D. ET AL, "Enantiomer-specific effects of an intravenously administered arrhythmogenic dose of bupivacaine on neurons of the nucleus tractus solitarius and the cardiovascular system in the anesthetized rat", REGIONAL ANAESTHESIA, (1992), vol. 17, pages 311 - 316, XP000610923 [DA] 1-13 * the whole document *
		[DA] - GRISTWOOD, R. ET AL, "Reduced cardiotoxicity of levobupivacaine compared with racemic bupivacaine (Marcaine): new clinical evidence", EXPERT OPINION ON INVESTIGATIONAL DRUGS, (199411), vol. 3, no. 11, pages 1209 - 1212, XP000610836 [DA] 1-13 * the whole document *
		[DA] - VANHOUTTE, F. ET AL, "Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle", BRITISH JOURNAL OF PHARMACOLOGY, (1991), vol. 103, pages 1275 - 1281, XP000610827 [DA] 1-13 * the whole document *
		[A] - RUTTEN, A.J. ET AL, "Tissue distribution of bupivacaine enantiomers in sheep", CHIRALITY, (1993), vol. 5, no. 7, pages 485 - 491, XP000610881 [A] 1-13 * the whole document * DOI: http://dx.doi.org/10.1002/chir.530050702
		[A] - ABERG, G., "Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds", ACTA PHARMACOLOGICA ET TOXICOLOGICA, (1972), vol. 31, pages 273 - 286, XP000610878 [A] 1-13 * the whole document *
		[A] - KUHNERT, B.R. ET AL, "Bupivacaine disposition in mother, fetus and neonate", FEDERATION PROCEEDINGS, (1981), vol. 40, no. 31, page 684, XP002020663 [A] 1-13 * abstract *

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