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Extract from the Register of European Patents

EP About this file: EP0856049

EP0856049 - OVEREXPRESSION OF RECOMBINANT BACTERIOPHAGE T4 ENDONUCLEASE VII AND USES THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.06.2006
Database last updated on 11.04.2026
Most recent event   Tooltip04.07.2008Change - representativepublished on 06.08.2008  [2008/32]
Applicant(s)For all designated states
Variagenics, Inc.
Building 700, One Kendall Square
Cambridge MA 02139 / US
[1998/32]
Inventor(s)01 / KEMPER, Borries
Universitätsstrasse 69
D-50931 Köln / DE
02 / GOLZ, Stefan
Im Osterbruch 14
D-45329 Essen / DE
03 / BIRKENBIHL, Rainer, P.
Severinstrasse 41
D-50678 Köln / DE
[1999/48]
Former [1998/32]01 / KEMPER, Borries
Universitaetsstrasse 69
D-50931 Köln / DE
02 / GOLZ, Stefan
Im Osterbruch 14
D-45329 Essen / DE
03 / BIRKENBIHL, Rainer, P.
Severinstrasse 41
D-50678 Köln / DE
Representative(s)Rollins, Anthony John
GE Healthcare Limited
Amersham Place
Little Chalfont
Buckinghamshire HP7 9NA / GB
[N/P]
Former [2008/32]Rollins, Anthony John
GE Healthcare Limited Amersham Place Little Chalfont
Buckinghamshire HP7 9NA / GB
Former [1998/32]Rollins, Anthony John
Group Patents, Nycomed Amersham plc, White Lion Road
Amersham, Buckinghamshire HP7 9LL / GB
Application number, filing date96929795.130.08.1996
[1998/32]
WO1996US13917
Priority number, dateUS19950003104P01.09.1995         Original published format: US 3104 P
US1996062170828.03.1996         Original published format: US 621708
[1999/48]
Former [1998/32]US1995000031001.09.1995
US1996062170828.03.1996
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9709422
Date:13.03.1997
Language:EN
[1997/12]
Type: A1 Application with search report 
No.:EP0856049
Date:05.08.1998
Language:EN
The application published by WIPO in one of the EPO official languages on 13.03.1997 takes the place of the publication of the European patent application.
[1998/32]
Search report(s)International search report - published on:US13.03.1997
(Supplementary) European search report - dispatched on:EP22.02.2001
ClassificationIPC:C12N9/22
[1998/32]
CPC:
C12N9/22 (EP,US)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   FI,   FR,   GB,   IE,   IT,   LI,   LU,   NL,   SE [1998/32]
TitleGerman:ÜBEREXPRESSION VON REKOMBINANTER ENDONUCLEASE VII DES BAKTERIOPHAGEN T4 UND DEREN ANWENDUNGEN[1998/32]
English:OVEREXPRESSION OF RECOMBINANT BACTERIOPHAGE T4 ENDONUCLEASE VII AND USES THEREOF[1998/32]
French:SUREXPRESSION DE L'ENDONUCLEASE VII DU BACTERIOPHAGE T4 RECOMBINANTE ET SON UTILISATION[1998/32]
Entry into regional phase25.02.1998National basic fee paid 
25.02.1998Search fee paid 
25.02.1998Designation fee(s) paid 
25.02.1998Examination fee paid 
Examination procedure25.03.1997Request for preliminary examination filed
International Preliminary Examining Authority: US
25.02.1998Examination requested  [1998/32]
01.12.2003Despatch of a communication from the examining division (Time limit: M04)
08.03.2004Reply to a communication from the examining division
04.02.2005Despatch of a communication from the examining division (Time limit: M06)
01.08.2005Reply to a communication from the examining division
11.10.2005Despatch of a communication from the examining division (Time limit: M03)
24.01.2006Application deemed to be withdrawn, date of legal effect  [2006/28]
27.02.2006Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2006/28]
Fees paidRenewal fee
10.08.1998Renewal fee patent year 03
04.08.1999Renewal fee patent year 04
03.08.2000Renewal fee patent year 05
14.08.2001Renewal fee patent year 06
14.08.2002Renewal fee patent year 07
13.08.2003Renewal fee patent year 08
23.08.2004Renewal fee patent year 09
19.08.2005Renewal fee patent year 10
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]   BARTH K A ET AL: "REGULATION OF TWO NESTED PROTEINS FROM GENE 49 RECOMBINATION ENDONUCLEASE VII AND OF A LAMBDA REXA-LIKE PROTEIN OF BACTERIOPHAGE T4", GENETICS, vol. 120, no. 2, 1988, pages 329 - 344, XP000972865, ISSN: 0016-6731 [Y] 1-10 * abstract *
 [Y]   DUBENDORFF JW ET AL.: "Controlling basal expression in an inducible T7 expression system by blocking the target T7 promoter with lac repressor", J. MOL. BIOL., vol. 219, no. 1, 5 May 1991 (1991-05-05), pages 45 - 59, XP000605448 [Y] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1016/0022-2836(91)90856-2
 [Y]   KALBACH CATHY E ET AL: "Stable expression plasmid for high-level production of GroE molecular chaperones in large-scale cultures.", ENZYME AND MICROBIAL TECHNOLOGY, vol. 15, no. 9, 1993, pages 730 - 735, XP000972849, ISSN: 0141-0229 [Y] 1-10 * page 731, paragraph 2 - page 733, paragraph 1; figure 2 *

DOI:   http://dx.doi.org/10.1016/0141-0229(93)90002-J
 [PX]   GOLZ STEFAN ET AL.: "Improved Large-Scale Preparation of Phage T4 Endonuclease VII Overexpressed in E.coli", DNA RESEARCH, vol. 2, 1995, pages 277 - 284, XP000945224 [PX] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1093/dnares/2.6.277
International search[YP]   GIRAUD-PANIS M.-J.E., DUCKETT D.R., LILLEY D.M.J.: "THE MODULAR CHARACTER OF A DNA JUNCTION-RESOLVING ENZYME: A ZINC-BINDING MOTIF IN BACTERIOPHAGE T4 ENDONUCLEASE VII.", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 252., no. 05., 1 January 1995 (1995-01-01), United Kingdom, pages 596 - 610., XP000612466, ISSN: 0022-2836, DOI: 10.1006/jmbi.1995.0523 [YP]

DOI:   http://dx.doi.org/10.1006/jmbi.1995.0523
 [YP]   GOLZ S., BIRKENBIHL R. P., KEMPER B.: "IMPROVED LARGE-SCALE PREPARATION OF PHAGE T4 ENDONUCLEASE VII OVEREXPRESSED IN E. COLI.", DNA RESEARCH., UNIVERSAL ACADEMY PRESS., JP, vol. 02., no. 06., 31 December 1995 (1995-12-31), JP, pages 277 - 284., XP000945224, ISSN: 1340-2838, DOI: 10.1093/dnares/2.6.277 [YP]

DOI:   http://dx.doi.org/10.1093/dnares/2.6.277
 [A]   KOSAK H.G., KEMPER B.W.: "LARGE-SCALE PREPARATION OF T4 ENDONUCLEASE VII FROM OVER-EXPRESSING BACTERIA.", EUROPEAN JOURNAL OF BIOCHEMISTRY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 194., no. 03., 1 December 1990 (1990-12-01), GB, pages 779 - 784., XP000615294, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1990.tb19469.x [A]

DOI:   http://dx.doi.org/10.1111/j.1432-1033.1990.tb19469.x
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.