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Extract from the Register of European Patents

EP About this file: EP0852494

EP0852494 - PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  09.12.2005
Database last updated on 03.10.2024
Most recent event   Tooltip09.12.2005Application deemed to be withdrawnpublished on 25.01.2006  [2006/04]
Applicant(s)For all designated states
The Regents of the University of California
9500 Gilman Drive
Mail Code 0093
La Jolla, CA 92093-0093 / US
For all designated states
Adolor Corporation
395 Phoenixville Pike
Malvern, PA 19355 / US
[N/P]
Former [1998/29]For all designated states
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
9500 Gilman Drive
La Jolla, CA 92093-0093 / US
For all designated states
Adolor Corporation
395 Phoenixville Pike
Malvern, PA 19355 / US
Inventor(s)01 / YAKSH, Tony, L.
4219 St. James Place
San Diego, CA 92103 / US
02 / FARRAR, John, J.
1066 Bodine Road
Chester Springs, PA 19425 / US
03 / MAYCOCK, Alan, L.
1908 Standiford Drive
Malvern, PA 19355 / US
04 / LEWIS, Michael, E.
1007 Saber Road
West Chester, PA 19382 / US
05 / DOW, Gordon, J.
4189 Chaparral Court
Santa Rosa, CA 95409 / US
[1998/29]
Representative(s)Campbell, Patrick John Henry, et al
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[N/P]
Former [2003/47]Campbell, Patrick John Henry, et al
J.A. Kemp & Co., 14 South Square, Gray's Inn
London WC1R 5JJ / GB
Former [1998/29]Goldin, Douglas Michael
J.A. KEMP & CO. 14 South Square Gray's Inn
London WC1R 5LX / GB
Application number, filing date96931567.012.09.1996
[1998/29]
WO1996US14727
Priority number, dateUS1995052851012.09.1995         Original published format: US 528510
[1998/29]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO9709973
Date:20.03.1997
Language:EN
[1997/13]
Type: A2 Application without search report 
No.:EP0852494
Date:15.07.1998
Language:EN
The application published by WIPO in one of the EPO official languages on 20.03.1997 takes the place of the publication of the European patent application.
[1998/29]
Search report(s)International search report - published on:EP05.06.1997
ClassificationIPC:A61K31/00, A61K31/17, A61K31/41, A61K31/435, A61K31/445, A61K31/415, A61K31/535, A61P29/00
[2005/03]
CPC:
A61K31/17 (EP,US); A61K31/00 (EP,KR,US); A61K31/439 (EP,US);
A61K31/445 (EP,US); A61K31/451 (EP,US); A61K31/454 (EP,US);
A61K31/4545 (EP,US); A61K31/485 (EP,US); A61K9/0048 (EP,US);
A61K9/06 (EP,US); A61P1/12 (EP); A61P25/00 (EP);
A61P25/02 (EP); A61P29/00 (EP); A61P43/00 (EP) (-)
Former IPC [2004/14]A61K31/00, A61K31/445, A61K31/17, A61K31/41, A61K31/435, A61K31/415, A61K31/535
Former IPC [1998/29]A61K31/00, A61K31/17, A61K31/41, A61K31/435, A61K31/445, A61K31/415, A61K31/535
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1998/29]
Extension statesAL14.04.1998
LT14.04.1998
LV14.04.1998
SI14.04.1998
TitleGerman:PERIPHERAL WIRKSAME ANTI-HYPERALGESISCHE OPIATE[1998/29]
English:PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES[1998/29]
French:OPIACES ANTI-HYPERALGESIQUES A ACTION PERIPHERIQUE[1998/29]
Entry into regional phase09.04.1998National basic fee paid 
09.04.1998Designation fee(s) paid 
09.04.1998Examination fee paid 
Examination procedure30.01.1997Request for preliminary examination filed
International Preliminary Examining Authority: EP
14.04.1998Examination requested  [1998/29]
26.02.2001Despatch of a communication from the examining division (Time limit: M06)
05.09.2001Reply to a communication from the examining division
30.01.2002Despatch of a communication from the examining division (Time limit: M06)
27.06.2002Reply to a communication from the examining division
22.06.2004Despatch of a communication from the examining division (Time limit: M06)
27.10.2004Reply to a communication from the examining division
10.01.2005Communication of intention to grant the patent
21.07.2005Application deemed to be withdrawn, date of legal effect  [2006/04]
24.08.2005Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2006/04]
Fees paidRenewal fee
28.09.1998Renewal fee patent year 03
13.09.1999Renewal fee patent year 04
13.09.2000Renewal fee patent year 05
12.09.2001Renewal fee patent year 06
12.09.2002Renewal fee patent year 07
12.09.2003Renewal fee patent year 08
14.09.2004Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
30.09.200510   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]FR2100711  (JANSSEN PHARMACEUTICA NV [BE]) [X] 1-460 * the whole document *;
 [X]US4277605  (BUYNISKI JOSEPH P, et al) [X] 1-4,7,8 * the whole document *;
 [X]EP0127154  (WELLCOME FOUND [GB]) [X] 1-3 * the whole document *;
 [X]EP0582727  (LINTEC CORP [JP]) [X] 1,2 * the whole document *;
 [A]US5354863  (DAPPEN MICHAEL S [US], et al) [A] 1,2;
 [X]  - SMITH, T.W. ET AL., "Peripheral antinociceptive effects of N-Methyl Morphine", LIFE SCIENCES, (1982), vol. 31, pages 1205 - 1208, XP000611242 [X] 1,2 * the whole document *

DOI:   http://dx.doi.org/10.1016/0024-3205(82)90343-5
 [X]  - GOTTSCHLICH, R. ET AL., "The Peripherally acting kappa-opiate agonist EMD 61753 and analogues: Opioid activity versus peripheral selectivity.", DRUGS EXPTL. CLIN. RES., (1995), vol. 21, no. 5, pages 171 - 174, XP000609171 [X] 1,2 * the whole document *
 [A]  - MOLINA, N. ET. AL, "The peripheral analgesic effects of Morphine, Codeine, Pentazocine and D-Propoxyphene.", BRAZILIAN J. MED. BIOL. RES., (1983), vol. 16, pages 345 - 352, XP000609164 [A] 1,2 * the whole document *
 [X]  - LEVINE, J.D.; TAIWO, Y.O., "Involvement of the mu-Opiate receptor in peripheral analgesia.", NEUROSCIENCE, (1989), vol. 32, no. 3, pages 571 - 576, XP000609169 [X] 1 * the whole document *

DOI:   http://dx.doi.org/10.1016/0306-4522(89)90279-0
 [X]  - MACKERER ET AL., "Loperamide binding to opiate receptor sites of brain and myenteric plexus.", J. PHARMACOL. EXP. THER., (1976), vol. 199, pages 131 - 140, XP000670263 [X] 1-460 * the whole document *
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 [X]  - NIEMEGEERS ET AL., "Dissociation between Opiate-Like and Antidiarrheal Activities of Antidiarrheal Drugs", J. PHARMACOL. EXP. THER., (1979), vol. 210, no. 3, pages 327 - 333, XP000670158 [X] 1-460 * the whole document *
 [X]  - MACKERER ET AL., "Antidiarrheal and central nervous system activities of SC-27166 (2-[3-5-methyl-1,3,4-oxadiazol-2-yl)-3,3-diphenylpropyl]-2-azabicyclo[2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus", J. PHARMACOL. EXP. THER., (1977), vol. 203, no. 3, pages 527 - 538, XP000670177 [X] 1-460 * the whole document *
 [X]  - MEGENS ET AL., "Normalization of small intestinal propulsion with loperamide-like antidiarrheals in rats.", EUR. J. PHARMACOL., (1990), vol. 178, no. 3, pages 357 - 364, XP000670152 [X] 1-7,9-460 * the whole document *

DOI:   http://dx.doi.org/10.1016/0014-2999(90)90115-M
 [X]  - ADELSTEIN ET AL., "3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a Novel Series of Antidiarrheal Agents.", J. MED. CHEM., (1976), vol. 19, no. 10, pages 1221 - 1225, XP002029507 [X] 1-460 * the whole document *
 [XY]  - VAN DER KOOY, D., "Hyperalgesic Functions of Peripheral Opiate Receptors", ANN. N. Y. ACAD. SCI., (1986), vol. 467, pages 154 - 168, XP000609166 [X] 1-7 * the whole document * [Y] 1-460

DOI:   http://dx.doi.org/10.1111/j.1749-6632.1986.tb14626.x
 [Y]  - GOODMAN ET AL., The pharmacological basis of Therapeutics, NEW YORK, MACMILLAN, (1985), 131620, XP002029508 [Y] 1-460 * page 512, column 2, paragraph 3 - page 514, column 1, paragraph 2 *
 [X]  - STOKBROEKX ET AL., "Synthetic Antidiarrheal Agents. 2,2-diphenyl-4-(4'-aryl-4'hydroxypiperidino)butyramides", J. MED. CHEM., P0C038, (1973), vol. 16, no. 7, pages 782 - 786, XP000567748 [X] 1-460 * the whole document *

DOI:   http://dx.doi.org/10.1021/jm00265a009
 [X]  - MEGENS ET AL., "Is In Vivo Dissociation Between the Antipropulsive and Antidiarrheal Porperties of Opioids in Rats Related to Gut Selectivity?", ARCH. INT. PHARMACODYN. THER., (1989), vol. 298, pages 220 - 229, XP000670160 [X] 1-460 * the whole document *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.