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Extract from the Register of European Patents

EP About this file: EP0833947

EP0833947 - VARIANT PRESENILIN-2 GENES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  06.02.2004
Database last updated on 22.08.2024
Most recent event   Tooltip06.02.2004Application deemed to be withdrawnpublished on 24.03.2004  [2004/13]
Applicant(s)For all designated states
UNIVERSITY OF SOUTH FLORIDA
4204 East Fowler Avenue
Tampa, FL 33620 / US
For all designated states
Washington University
1 Brookings Drive
St. Louis, MO 63130 / US
For all designated states
THE INSTITUTE FOR GENOMIC RESEARCH
9712 Medical Center Drive Rockville
Maryland 20850 / US
[N/P]
Former [1998/15]For all designated states
University of South Florida
4204 East Fowler Avenue
Tampa, FL 33620 / US
For all designated states
WASHINGTON UNIVERSITY
1 Brookings Drive
St. Louis, MO 63130 / US
For all designated states
THE INSTITUTE FOR GENOMIC RESEARCH
9712 Medical Center Drive
Rockville, Maryland 20850 / US
Inventor(s)01 / HARDY, John
48 Water Street
St. Augustine, FL 32084 / US
02 / GOATE, Alison, M.
1177 Claytonia Terrace
Richmond Heights, MO 63117 / US
03 / FULDNER, Rebecca, A.
21910 Beallsville Road Box 391
Barnesville, MD 20838 / US
[1998/15]
Representative(s)Crump, Julian Richard John
Cleveland
40-43 Chancery Lane
London WC2A 1JQ / GB
[N/P]
Former [1998/35]Crump, Julian Richard John
fJ Cleveland, 40-43 Chancery Lane
London WC2A 1JQ / GB
Former [1998/15]Connell, Anthony Christopher, et al
SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court
Brentford, Middlesex TW8 9EP / GB
Application number, filing date97916930.720.03.1997
[1998/15]
WO1997US04683
Priority number, dateUS1996001486004.04.1996         Original published format: US 14860
[1998/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9738133
Date:16.10.1997
Language:EN
[1997/44]
Type: A1 Application with search report 
No.:EP0833947
Date:08.04.1998
Language:EN
The application published by WIPO in one of the EPO official languages on 16.10.1997 takes the place of the publication of the European patent application.
[1998/15]
Search report(s)International search report - published on:US16.10.1997
(Supplementary) European search report - dispatched on:EP21.05.2003
ClassificationIPC:C12Q1/68, C07H21/04, C07K14/47
[2003/26]
CPC:
C12Q1/6883 (EP); C07K14/4711 (EP); C12Q2600/156 (EP)
Former IPC [1998/15]C12Q1/68, C07H21/04
Designated contracting statesBE,   CH,   DE,   DK,   FR,   GB,   IT,   LI,   NL [1998/15]
TitleGerman:VERSCHIEDENE PRESENILIN-2 GENE[1998/15]
English:VARIANT PRESENILIN-2 GENES[1998/15]
French:VARIANTS DU GENE PRESENILINE 2[1998/15]
Entry into regional phase05.01.1998National basic fee paid 
05.01.1998Search fee paid 
05.01.1998Designation fee(s) paid 
16.04.1998Examination fee paid 
Examination procedure16.04.1998Examination requested  [2000/36]
05.08.2003Application deemed to be withdrawn, date of legal effect  [2004/13]
29.09.2003Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2004/13]
Fees paidRenewal fee
04.03.1999Renewal fee patent year 03
06.03.2000Renewal fee patent year 04
05.03.2001Renewal fee patent year 05
04.03.2002Renewal fee patent year 06
05.03.2003Renewal fee patent year 07
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[PXY]WO9634099  (ROMMENS JOHANNA M ;FRASER PAUL E (CA); HSC RES DEV LP (CA); UNIV T) [PX] 1-4 * page 10, line 18 - page 11, line 12 * * page 13, line 9 - line 14 * * page 14, line 38 - page 15, line 16 * * page 25, line 12 - page 26, line 7 * * page 33, line 8 - page 34, line 6 * * page 39, line 36 - page 40, line 30 * * page 42, line 35 - page 44, line 36 * * page 81, line 13 - page 91, line 25 * * claims 1,5-7,14,18-25,100,101 * [PY] 5;
 [XY]  - ROGAEV E I ET AL, "FAMILIAL ALZHEIMER'S DISEASE IN KINDREDS WITH MISSENSE MUTATIONS INA GENE ON CHROMOSOME 1 RELATED TO THE ALZHEIMER'S DISEASE TYPE 3 GENE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, (19950831), vol. 376, ISSN 0028-0836, pages 775 - 778, XP000196835 [X] 1-4 *whole document, especially page 775, col. 2, last paragraph* [Y] 5

DOI:   http://dx.doi.org/10.1038/376775a0
 [X]  - LEVY-LAHAD E ET AL, "CANDIDATE GENE FOR THE CHROMOSOME 1 FAMILIAL ALZHEIMER'S DISEASE LOCUS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (19950818), vol. 269, ISSN 0036-8075, pages 973 - 977, XP000616667 [X] 1,4 * page 975, column 1, paragraph 2 - column 3, paragraph 1 * * figure 3 * * page 976, column 3, paragraph 13 - page 977, column 1, paragraph 16 *

DOI:   http://dx.doi.org/10.1126/science.7638622
 [Y]  - PEREZ-TUR J ET AL, "A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene", NEUROREPORT, RAPID COMMUNICATIONS OF OXFORD, OXFORD, GB, (19951229), vol. 7, no. 1, ISSN 0959-4965, pages 297 - 301, XP002114867 [Y] 5 * abstract * * page 298, column 1, paragraph 3 - page 299, column 1, paragraph 1 * * figures 2,3 *
 [A]  - LEVY-LAHAD E ET AL, "A FAMILIAL ALZHEIMER'S DISEASE LOCUS ON CHROMOSOME I", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (19950818), vol. 269, no. 5226, ISSN 0036-8075, pages 970 - 973, XP001093899 [A] 1-3 * the whole document *

DOI:   http://dx.doi.org/10.1126/science.7638621
 [A]  - ANWAR R ET AL, "MOLECULAR ANALYSIS OF THE PRESINILIN 1 (S182) GENE IN SPORADIC CASES OF ALZHEIMER'S DISEASE: IDENTIFICATION AND CHARACTERISATION OF UNUSUAL SPLICE VARIANTS", JOURNAL OF NEUROCHEMISTRY, NEW YORK, NY, US, (199604), vol. 66, no. 4, ISSN 0022-3042, pages 1774 - 1777, XP000891244 [A] 5 * the whole document *
 [PXA]  - LEVY-LAHAD E ET AL, "GENOMIC STRUCTURE AND EXPRESSION OF STM2, THE CHROMOSOME 1 FAMILIAL ALZHEIMER DISEASE GENE", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, (19960601), vol. 34, no. 2, ISSN 0888-7543, pages 198 - 204, XP002072677 [PX] 1 * abstract * * figure 1 * * table 2 * * page 200, column 1, paragraph L - column 2, paragraph 1 * * page 201, column 1, paragraph L * [PA] 2-5

DOI:   http://dx.doi.org/10.1006/geno.1996.0266
    [ ] - GENBANK, (19960708), Database accession no. U50871, URL: GENBANK, XP002236889 [ ] * the whole document *
 [PX]  - PRIHAR G ET AL, "STRUCTURE AND ALTERNATIVE SPLICING OF THE PRESENILIN-2 GENE", NEUROREPORT, RAPID COMMUNICATIONS OF OXFORD, OXFORD, GB, (199607), vol. 7, no. 10, ISSN 0959-4965, pages 1680 - 1684, XP002921818 [PX] 1-5 * the whole document *
 [PX]  - CRUTS M ET AL, "THE PRESENILIN GENES: A NEW GENE FAMILY INVOLVED IN ALZHEIMER DISEASE PATHOLOGY", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, (199609), vol. 5, ISSN 0964-6906, pages 1449 - 1455, XP001094396 [PX] 1-3 * abstract * * page 1451, column 1, paragraph 1 - column 2, paragraph 1 *
International search[T]US5525714
 [T]  - AMERICAN J. PATHOLOGY, December 1996, Vol. 149, No. 6, MURPHY G.M. et al., "Antibodies to Presenilin Proteins Detect Neurofibrillary Tangles in Alzheimer's Disease", pages 1839-1845.
 [Y]  - NATURE MEDICINE, February 1996, Vol. 2, No. 2, KOVACS et al., "Alzheimer-Associated Presenilins 1 and 2: Neuronal Expression in Brain and Localization to Intracellular Membranes in Mammalian Cells", pages 224-229.
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