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Extract from the Register of European Patents

EP About this file: EP0910628

EP0910628 - INACTIVATION RESISTANT FACTOR VIII [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.01.2007
Database last updated on 28.06.2024
Most recent event   Tooltip01.08.2008Lapse of the patent in a contracting state
New state(s): LU		published on 03.09.2008  [2008/36]
Applicant(s)For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Technology Management Wolverine Tower Office Room 2071, 3003 South State Street
Ann Arbor, Michigan 48109-1280 / US
[2006/10]
Former [1999/17]For all designated states
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Technology Management Office, Wolverine Towers, Room 2071, 3003 South State Street
Ann Arbor, Michigan 48109-1280 / US
Inventor(s)01 / KAUFMAN, Randal, J.
5065 Red Fox Run
Ann Arbor, MI 48105 / US
02 / PIPE, Steven, W.
8261 Lake Crest Drive
Ypsilanti, MI 48197-6754 / US
03 / AMANO, Kagehiro
Apartment No. 105, 1115 Maiden Lane Court
Ann Arbor, MI 48105 / US
[1999/17]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [1999/17]VOSSIUS & PARTNER
Postfach 86 07 67
81634 München / DE
Application number, filing date97927596.324.04.1997
[1999/17]
WO1997US06563
Priority number, dateUS19960016117P24.04.1996         Original published format: US 16117 P
US19960017785P15.05.1996         Original published format: US 17785 P
[1999/17]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9740145
Date:30.10.1997
Language:EN
[1997/46]
Type: A1 Application with search report 
No.:EP0910628
Date:28.04.1999
Language:EN
The application published by WIPO in one of the EPO official languages on 30.10.1997 takes the place of the publication of the European patent application.
[1999/17]
Type: B1 Patent specification 
No.:EP0910628
Date:08.03.2006
Language:EN
[2006/10]
Search report(s)International search report - published on:US30.10.1997
(Supplementary) European search report - dispatched on:EP13.03.2001
ClassificationIPC:C12N9/48, C12N15/63, C12N1/21, C07H21/04, A61K38/48, A61K39/395
[1999/17]
CPC:
C07K14/755 (EP,US); A61P7/00 (EP); A61P7/04 (EP);
A61K38/00 (EP,US)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1999/17]
Extension statesAL19.11.1998
LT19.11.1998
LV19.11.1998
RO19.11.1998
SI19.11.1998
TitleGerman:GEGEN INAKTIVIERUNG RESISTENTER FAKTOR VIII[1999/17]
English:INACTIVATION RESISTANT FACTOR VIII[1999/17]
French:FACTEUR VIII RESISTANT A L'INACTIVATION[1999/17]
Entry into regional phase19.11.1998National basic fee paid 
19.11.1998Search fee paid 
19.11.1998Designation fee(s) paid 
19.11.1998Examination fee paid 
Examination procedure28.10.1997Request for preliminary examination filed
International Preliminary Examining Authority: US
19.11.1998Examination requested  [1999/17]
19.10.2001Despatch of a communication from the examining division (Time limit: M06)
25.04.2002Reply to a communication from the examining division
16.04.2003Despatch of a communication from the examining division (Time limit: M06)
27.10.2003Reply to a communication from the examining division
10.12.2004Despatch of a communication from the examining division (Time limit: M04)
07.04.2005Reply to a communication from the examining division
26.07.2005Communication of intention to grant the patent
05.12.2005Fee for grant paid
05.12.2005Fee for publishing/printing paid
Divisional application(s)EP06004484.9  / EP1754718
EP10157809.4  / EP2202242
Opposition(s)11.12.2006No opposition filed within time limit [2007/07]
Fees paidRenewal fee
06.04.1999Renewal fee patent year 03
03.04.2000Renewal fee patent year 04
02.04.2001Renewal fee patent year 05
22.04.2002Renewal fee patent year 06
22.04.2003Renewal fee patent year 07
26.04.2004Renewal fee patent year 08
20.04.2005Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.03.2006
BE08.03.2006
CH08.03.2006
FI08.03.2006
IT08.03.2006
LI08.03.2006
NL08.03.2006
IE24.04.2006
LU24.04.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
GR09.06.2006
ES19.06.2006
PT08.08.2006
[2008/36]
Former [2008/21]AT08.03.2006
BE08.03.2006
CH08.03.2006
FI08.03.2006
IT08.03.2006
LI08.03.2006
NL08.03.2006
IE24.04.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
GR09.06.2006
ES19.06.2006
PT08.08.2006
Former [2008/07]AT08.03.2006
BE08.03.2006
CH08.03.2006
FI08.03.2006
IT08.03.2006
LI08.03.2006
NL08.03.2006
IE24.04.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
ES19.06.2006
PT08.08.2006
Former [2007/29]AT08.03.2006
BE08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
NL08.03.2006
IE24.04.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
ES19.06.2006
PT08.08.2006
Former [2007/17]AT08.03.2006
BE08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
NL08.03.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
ES19.06.2006
PT08.08.2006
Former [2007/07]AT08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
NL08.03.2006
MC30.04.2006
DK08.06.2006
SE08.06.2006
ES19.06.2006
Former [2006/50]AT08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
NL08.03.2006
SE08.06.2006
ES19.06.2006
Former [2006/45]AT08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
NL08.03.2006
SE08.06.2006
Former [2006/43]AT08.03.2006
CH08.03.2006
FI08.03.2006
LI08.03.2006
Former [2006/42]CH08.03.2006
FI08.03.2006
LI08.03.2006
Former [2006/36]FI08.03.2006
Documents cited:Search[DXY]  - KIMBERLY A. MARQUETTE ET AL., "A 110-amino acid region within the A1-domain of coagulation factor VIII inhibits secretion from mammalian cells", JOURNAL OF BIOLOGICAL CHEMISTRY, MD US, (19950428), vol. 270, no. 17, pages 10297 - 10303, XP002157395 [DX] 1,2,12-17 * page 10299, column R, paragraph 4 - page 10300, column R, paragraph 1 * * page 10301, column R, paragraph 2 * * page 1032, column R, paragraph 1 - page 1033, column L, paragraph 2 * [Y] 7

DOI:   http://dx.doi.org/10.1074/jbc.270.17.10297
 [XY]  - PITTMAN D D ET AL, "PROTEOLYTIC REQUIREMENTS FOR THROMBIN ACTIVATION OF ANTI-HEMOPHILIC FACTOR (FACTOR VIII)", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, (19880401), vol. 85, ISSN 0027-8424, pages 2429 - 2433, XP002019693 [X] 5,8,9,11-17 * page 2430, column L, paragraph L - column R, paragraph 1; figure 1 * * page 2431, column R, paragraph 2 * * page 2433, column L, paragraph 2 * [Y] 7

DOI:   http://dx.doi.org/10.1073/pnas.85.8.2429
 [A]  - DORNER A J ET AL, "The relationship of N-linked glycosylation and heavy chain-binding protei association with the secretion of glycoproteins.", JOURNAL OF CELL BIOLOGY, (1987 DEC) 105 (6 PT 1) 2665-74., XP000971862 [A] 1-4,12-17 * abstract * * page 2666, column L, paragraph 2 - paragraph 3 * * page 2667, column R, paragraph 3 - page 2668, column L, paragraph 3 * * page 2671, column R, paragraph 3 - page 2672, column L, paragraph L *

DOI:   http://dx.doi.org/10.1083/jcb.105.6.2665
 [A]  - TOOLE J J ET AL, "Exploration of structure-function relationships in human factor VIII by site-directed mutagenesis.", COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, (1986) 51 PT 1 543-9, XP000971857 [A] 1-4,12-17 * page 546, column L, paragraph 2 - page 548, column R, paragraph 3 *
 [PX]  - MANJU SWAROOP ET AL., "Mutation of Phe309Ser, a putative BIP binding site, enhances secretion of coagulation factor VIII", BLOOD, (19961115), vol. 88, no. 10, page 441a, XP000971878 [PX] 1-3,12-17 * abstract no. 1753 *
 [PX]  - STEVEN W. PIPE ET AL., "Construction and characterization of inactivation resistant factor VIII (R366I/R562K/R740A/DEL795-1688)", BLOOD, (19961115), vol. 88, no. 10, page 441a, XP000982682 [PX] 5,6,8,12-15 * abstract no. 1752 *
International search[X]US5004803  (KAUFMAN RANDAL J [US], et al);
 [X]US5451521  (KAUFMAN RANDAL J [US], et al);
 [Y]  - CASTAMAN G, TOSETTO A, RODEGHIERO F, "EFFECTIVENESS OF HIGH-DOSE INTRAVENOUS IMMUNOGLOBULIN IN A CASE OF ACQUIRED VON WILLEBRAND SYNDROME WITH CHRONIC MELENA NOT RESPONSIVETO DESMOPRESSIN AND FACTOR VIII CONCENTRATE", AMERICAN JOURNAL OF HEMATOLOGY, NEW YORK, NY, US, US, (19920101), vol. 41, no. 02, ISSN 0361-8609, page 132/133 + 136, XP002940621
 [Y]  - SCANDELA D., ET AL., "SOME FACTOR VIII INHIBITOR ANTIBODIES RECOGNIZE A COMMON EPITOPE CORRESPONDING TO C2 DOMAIN AMINO ACIDS 2248 THROUGH 2312, WHICH OVERLAP A PHOSPHOLIPID-BINDING SITE.", Blood, American Society of Hematology, US, US, (19950901), vol. 86., no. 05., ISSN 0006-4971, pages 1811 - 1819., XP002919521
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.