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EP About this file: EP0934269

EP0934269 - ANALOGS OF CC-1065 AND THE DUOCARMYCINS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 09.08.2002 Database last updated on 01.01.2025
Most recent event Tooltip	09.08.2002	Application deemed to be withdrawn	published on 25.09.2002 [2002/39]
Applicant(s)	For all designated states THE SCRIPPS RESEARCH INSTITUTE 10550 North Torrey Pines Road La Jolla, CA 92037 / US
	[N/P]
Former [1999/32]	For all designated states The Scripps Research Institute 10550 North Torrey Pines Road La Jolla, CA 92037 / US
Inventor(s)	01 / BOGER, Dale, L. 2819 Via Posada La Jolla, CA 92037 / US
	[1999/32]
Representative(s)	Hedley, Nicholas James Matthew, et al Kilburn & Strode LLP Lancon London 84 Theobalds Road London WC1X 8NL / GB
	[N/P]
Former [2000/06]	Hedley, Nicholas James Matthew, et al Stephenson Harwood One, St. Paul's Churchyard London EC4M 8SH / GB
Former [1999/32]	Gold, Tibor Z., et al Stephenson Harwood One, St. Paul's Churchyard London EC4M 8SH / GB
Application number, filing date	97927807.4	30.05.1997
	[1999/32]
	WO1997US09076
Priority number, date	US19960018860P	31.05.1996 Original published format: US 18860 P
	US19960023346P	12.09.1996 Original published format: US 23346 P
	[1999/32]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9745411
	Date:	04.12.1997
	Language:	EN
	[1997/52]
	Type:	A1 Application with search report
	No.:	EP0934269
	Date:	11.08.1999
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 04.12.1997 takes the place of the publication of the European patent application.
	[1999/32]
Search report(s)	International search report - published on:	US	04.12.1997
	(Supplementary) European search report - dispatched on:	EP	30.11.1999
Classification	IPC:	C07D403/06, A61K31/40, C07D487/04, C07D417/12, A61K31/425, C07D209/90	[2000/02]
	CPC:	C07D403/06 (EP,US); C07D209/94 (EP,US); C07D209/96 (EP,US); C07D417/14 (EP,US); C07D487/10 (EP,US)
	Former IPC [1999/32]	C07D209/90, C07D403/02, C07D403/14, C07D403/06, C07D417/14, A61K31/40, C07D473/04, C07D417/12, A61K31/425
Designated contracting states	AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [1999/32]
Extension states	AL	20.11.1998
	LT	20.11.1998
	LV	20.11.1998
	RO	20.11.1998
	SI	20.11.1998
Title	German:	ANALOGE VON CC-1065 UND DUOCARMYCINE	[1999/32]
	English:	ANALOGS OF CC-1065 AND THE DUOCARMYCINS	[1999/32]
	French:	ANALOGUES DE CC-1065 ET DUOCARMYCINES	[1999/32]
Entry into regional phase	20.11.1998	National basic fee paid
	20.11.1998	Search fee paid
	20.11.1998	Designation fee(s) paid
	20.11.1998	Examination fee paid
Examination procedure	16.12.1997	Request for preliminary examination filed International Preliminary Examining Authority: US
	20.11.1998	Examination requested [1999/32]
	12.11.2001	Despatch of a communication from the examining division (Time limit: M04)
	23.03.2002	Application deemed to be withdrawn, date of legal effect [2002/39]
	26.04.2002	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2002/39]
Fees paid	Renewal fee
	12.05.1999	Renewal fee patent year 03
	15.05.2000	Renewal fee patent year 04
	31.05.2001	Renewal fee patent year 05
	31.05.2002	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[E]WO9732850 (SCRIPPS RESEARCH INST [US], et al) [E] 1,2 * claim 1 *;
		[A]EP0680964 (UNIV SANTIAGO COMPOSTELA [ES]) [A] 3 * claim 1 *;
		[PX] - BOGER D L ET AL, "Examination Of The Role Of The Duocarmycin SA Methoxy Substituents: Identification Of The Minimum, Fully Potent DNA Binding Subunit", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 6, no. 18, ISSN 0960-894X, page 2207-2210, XP004135686 [PX] 3 * page 2207 * DOI: http://dx.doi.org/10.1016/0960-894X(96)00401-5
		[PX] - BOGER ET AL, "Duocarmycin SA Shortened, Simplified, and Extended Agents: A Systematic Examination of the Role of the DNA Binding Subunit", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 119, no. 21, ISSN 0002-7863, page 4977-4986-4986, XP002106676 [PX] 3 * examples 23-25 * DOI: http://dx.doi.org/10.1021/ja9637208
		[PX] - BOGER D L ET AL, "pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 7, no. 2, ISSN 0960-894X, page 233-238, XP004135999 [PX] 1 * example 3 * DOI: http://dx.doi.org/10.1016/S0960-894X(96)00605-1
		[PX] - BOGER ET AL, "Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) Alkylation Subunit", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 118, no. 37, ISSN 0002-7863, page 8860-8870-8870, XP002106677 [PX] 7 * See Fig 1 where X is F. * DOI: http://dx.doi.org/10.1021/ja961888n
		[X] - BOGER D L ET AL, "CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit", BIOORGANIC & MEDICINAL CHEMISTRY,GB,ELSEVIER SCIENCE LTD, vol. 3, no. 6, ISSN 0968-0896, page 761-775, XP002086065 [X] 1,2 * page 766; example 40 * DOI: http://dx.doi.org/10.1016/0968-0896(95)00066-P
		[X] - BOGER D L ET AL, "1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation", BIOORGANIC & MEDICINAL CHEMISTRY,GB,ELSEVIER SCIENCE LTD, vol. 3, no. 11, ISSN 0968-0896, page 1429-1453, XP002086069 [X] 3 * the whole document * DOI: http://dx.doi.org/10.1016/0968-0896(95)00130-9
		[X] - BOGER D L ET AL, "A Hammett correlation for CC-1065 and duocarmycin analogs: magnitude of substituent electronic effects on functional reactivity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, (199602), vol. 6, no. 6, ISSN 0960-894X, page 659-664, XP004135001 [X] 1 * page 661; example 15 * DOI: http://dx.doi.org/10.1016/0960-894X(96)00093-5
		[A] - BOGER D L ET AL, "CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions", BIOORGANIC & MEDICINAL CHEMISTRY,GB,ELSEVIER SCIENCE LTD, vol. 3, no. 6, ISSN 0968-0896, page 611-621, XP002086064 [A] 3 DOI: http://dx.doi.org/10.1016/0968-0896(95)00048-L
	International search	[YP]WO9712862
		[YP] - DATABASE WPIDS ON STN, Week 9721, Columbus, Ohio, USA, DERWENT INFORMATION LTD., AN 97-235552; & WO,A,97 12862 (SCRIPPS RESEARCH INSTITUTE), April 1997., & WO9712862 A 00000000

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