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Extract from the Register of European Patents

EP About this file: EP0960106

EP0960106 - 1-PHENYL-4-BENZYLPIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS (D4) [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.03.2005
Database last updated on 16.11.2024
Most recent event   Tooltip07.03.2008Lapse of the patent in a contracting state
New state(s): PT		published on 09.04.2008  [2008/15]
Applicant(s)For all designated states
NEUROGEN CORPORATION
35 N.E. Industrial Road
Branford, CT 06405 / US
[1999/48]
Inventor(s)01 / THURKAUF, Andrew
16 Fox Den Road
Danbury, CT 06811 / US
02 / CHEN, Xi
17 Blueberry Hill Reserve Road
Killingworth, Connecticut 06719 / US
[1999/48]
Representative(s)Vossius, Volker, et al
ZSP Patentanwälte PartG mbB
Radlkoferstrasse 2
81373 München / DE
[N/P]
Former [1999/48]Vossius, Volker, Dr., et al
Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5
81679 München / DE
Application number, filing date98903796.529.01.1998
[1999/48]
WO1998US01628
Priority number, dateUS1997079167330.01.1997         Original published format: US 791673
[1999/48]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO9833784
Date:06.08.1998
Language:EN
[1998/31]
Type: A1 Application with search report 
No.:EP0960106
Date:01.12.1999
Language:EN
The application published by WIPO in one of the EPO official languages on 06.08.1998 takes the place of the publication of the European patent application.
[1999/48]
Type: B1 Patent specification 
No.:EP0960106
Date:06.05.2004
Language:EN
[2004/19]
Search report(s)International search report - published on:EP06.08.1998
ClassificationIPC:C07D295/06, A61K31/495, C07D405/10
[1999/48]
CPC:
C07D295/073 (EP,KR,US); A61K31/495 (EP,KR,US); A61P25/00 (EP);
A61P25/18 (EP); A61P43/00 (EP); C07D295/096 (EP,KR,US);
C07D295/112 (EP,KR,US); C07D295/135 (EP,US); C07D317/58 (KR);
C07D319/18 (KR); C07C2603/08 (EP,KR,US) (-)
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [1999/48]
Extension statesAL06.08.1999
LT06.08.1999
LV06.08.1999
MK06.08.1999
RO06.08.1999
SI06.08.1999
TitleGerman:1-PHENYL-4-BENZYLPIPERAZINE: SPEZIFISCHE LIGANDEN FÜR DEN DOPAMIN REZEPTOR (D4)[1999/48]
English:1-PHENYL-4-BENZYLPIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS (D4)[1999/48]
French:LIGANDS DE 1-PHENYLE-4-BENZYLPIPERAZINES SPECIFIQUES POUR LE SOUS-TYPE DU RECEPTEUR DE DOPAMINE (D4)[1999/48]
Entry into regional phase06.08.1999National basic fee paid 
06.08.1999Designation fee(s) paid 
06.08.1999Examination fee paid 
Examination procedure06.07.1998Request for preliminary examination filed
International Preliminary Examining Authority: EP
06.08.1999Examination requested  [1999/48]
27.08.2002Despatch of a communication from the examining division (Time limit: M06)
06.03.2003Reply to a communication from the examining division
25.09.2003Date of oral proceedings
27.10.2003Minutes of oral proceedings despatched
07.11.2003Communication of intention to grant the patent
05.03.2004Fee for grant paid
05.03.2004Fee for publishing/printing paid
Opposition(s)08.02.2005No opposition filed within time limit [2005/17]
Fees paidRenewal fee
27.12.1999Renewal fee patent year 03
05.01.2001Renewal fee patent year 04
21.01.2002Renewal fee patent year 05
20.01.2003Renewal fee patent year 06
26.01.2004Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
NL06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
PT06.10.2004
LU29.01.2005
IE31.01.2005
MC31.01.2005
[2008/15]
Former [2007/17]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
NL06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
LU29.01.2005
IE31.01.2005
MC31.01.2005
Former [2006/24]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
NL06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
IE31.01.2005
MC31.01.2005
Former [2006/14]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
NL06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
MC31.01.2005
Former [2006/13]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
NL06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
Former [2005/18]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
DK06.08.2004
GR06.08.2004
SE06.08.2004
Former [2005/14]AT06.05.2004
BE06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
GR06.08.2004
SE06.08.2004
Former [2005/11]AT06.05.2004
CH06.05.2004
FI06.05.2004
LI06.05.2004
GR06.08.2004
SE06.08.2004
Former [2005/06]CH06.05.2004
FI06.05.2004
LI06.05.2004
GR06.08.2004
SE06.08.2004
Former [2005/02]CH06.05.2004
FI06.05.2004
LI06.05.2004
SE06.08.2004
Former [2004/52]CH06.05.2004
LI06.05.2004
SE06.08.2004
Former [2004/51]CH06.05.2004
LI06.05.2004
Cited inInternational search[Y]US3299067  (GILBERT REGNIER, et al) [Y] 1-33,35-55 * column W *;
 [Y]US4260610  (REGNIER GILBERT, et al) [Y] 1-33,35-55 * column W *;
 [YD]WO9304684  (MCNEILAB INC [US]) [YD] 1-33,35-55 * column W *;
 [Y]WO9304682  (MCNEILAB INC [US]) [Y] 1-33,35-55 * column W *;
 [Y]EP0574271  (MCNEILAB INC [US]) [Y] 1-33,35-55 * column W *;
 [Y]WO9406768  (MCNEILAB INC [US]) [Y] 1-33,35-55 * column W *;
 [Y]WO9420471  (MERCK SHARP & DOHME [GB], et al) [Y] 1-33,35-55 * column W *;
 [PX]WO9741108  (WARNER LAMBERT CO [US], et al) [PX] 1-33,35-55* column W *;
 [Y]  - SARATI,S. ET AL., "Kinetics of PIREBEDIL and effects on dopamine metabolsim: hepatic biotransformation is not a determinat of its dopaminergic action in rats", PSYCHOPHARMACOLOGY, BERLIN, (1991), vol. 105, pages 541 - 545, XP002065935 [Y] 1-33,35-55 * column W *

DOI:   http://dx.doi.org/10.1007/BF02244377
 [Y]  - BOYFIELD,I. ET AL., "N-(Substituted-phenyl)-piperazines: Antagonists with high Binding and Functional Selectivity for Dopamine D4 Receptors", BIOORG.&MED.CHEM.LETT., OXFORD, (1996), vol. 6, no. 11, pages 1227 - 1232, XP002065936 [Y] 1-33,35-55 * column W *

DOI:   http://dx.doi.org/10.1016/0960-894X(96)00198-9
 [Y]  - REITZ,A.B. ET AL., "N-Aryl-N'-Benzylpiperazines as Potential Antipsychotic Agents", J.MED.CHEM., WASHINGTON, (1995), vol. 38, no. 21, pages 4211 - 4222, XP002065378 [Y] 1-33,35-55 * see page 4215, table 3 *; column W *

DOI:   http://dx.doi.org/10.1021/jm00021a010
 [Y]  - HADLEY M S, "D4 RECEPTORS AND THEIR ANTAGONISTS", MEDICINAL RESEARCH REVIEWS, (1996), vol. 16, no. 6, pages 507 - 526, XP000654693 [Y] 1-33,35-55 * see page 521, fig. 4 *; column W *

DOI:   http://dx.doi.org/10.1002/(SICI)1098-1128(199611)16:6<507::AID-MED1>3.0.CO;2-6
 [YD]  - MACH,R.H. ET AL., "The use of [18F]4-Fluorobenzyl Iodide (FBI) in PET Radiotracer Synthesis : Model Alkylation Studies and Its Application in the Design of Dopamine D1 and D2 Receptor-based Imaging Agents", NUCL.MED.BIOL., OXFORD, (1993), vol. 20, no. 6, pages 777 - 794, XP002065565 [YD] 1-33,35-55 * column W *

DOI:   http://dx.doi.org/10.1016/0969-8051(93)90165-Q
 [AD]  - PRASAD R N ET AL, "POTENTIAL ANTIHYPERTENSIVE AGENTS. II. UNSYMMETRICALLY 1,4-DISUBSTITUTED PIPERAZINES. I", JOURNAL OF MEDICINAL CHEMISTRY, (196811), vol. 11, no. 6, pages 1144 - 1150, XP002036253 [AD] 1-33,35-55 * column W *

DOI:   http://dx.doi.org/10.1021/jm00312a009
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.