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Extract from the Register of European Patents

EP About this file: EP0970198

EP0970198 - MICRO-ORGANISMS WITH INCREASED PRODUCTION OF CLAVULANIC ACID [Right-click to bookmark this link]
Former [2000/02]NOVEL COMPOUNDS
[2005/23]
StatusNo opposition filed within time limit
Status updated on  20.10.2006
Database last updated on 25.09.2024
Most recent event   Tooltip07.03.2008Lapse of the patent in a contracting state
New state(s): IE, LU		published on 09.04.2008  [2008/15]
Applicant(s)For all designated states
SMITHKLINE BEECHAM PLC
980 Great West Road Brentford
Middlesex TW8 9GS / GB
For all designated states
The Governors of the University of Alberta
Industry Liaison Office
222 Campus Towers, 8625 -112 Street
Edmonton
Alberta T6G 2E1 / CA
[N/P]
Former [2005/50]For all designated states
SMITHKLINE BEECHAM PLC
980 Great West Road Brentford
Middlesex TW8 9GS / GB
For all designated states
The Governors of the University of Alberta
Industry Liaison Office, 222 Campus Towers, 8625 -112 Street Edmonton
Alberta T6G 2E1 / CA
Former [2002/36]For all designated states
SmithKline Beecham plc
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
For all designated states
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Industry Liaison Office, 222 Campus Towers, 8625 -112 Street
Edmonton, Alberta T6G 2E1 / CA
Former [2000/02]For all designated states
SMITHKLINE BEECHAM PLC
New Horizons Court
Brentford, Middlesex TW8 9EP / GB
For all designated states
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
Industry Liaison Office, 222 Campus Towers, 8625 -112 Street
Edmonton, Alberta T6G 2E1 / CA
Inventor(s)01 / BARTON, Barry, SmithKline Beecham Pharmaceuticals
Clarendon Road
Worthing West Sussex BN14 8QH / GB
02 / GRIFFIN, John, Patrick, SmithKline Beecham Pharma.
Clarendon Road
Worthing West Sussex BN14 8QH / GB
03 / MOSHER, Roy, Henry, The Governors of Uni. Alberta
222 Campus Tower 8625-112 Street
Edmonton, Alberta T6G 2E1 / CA
04 / PARADKAR, Ashish, Sudhakar, Uni. of Alberta
222 Campus Tower 8625-112 Street
Edmonton, Alberta T6G 2E1 / CA
05 / JENSEN, Susan, The Governors of Uni. Alberta
222 Campus Tower 8625-112 Street
Edmonton, Alberta T6G 2E1 / CA
06 / ANDERS, Cecilia, The University ofAlberta
222 Camfpus Tower 8625-112 Street
Edmonton, Alberta T6G 2E1 / CA
[2000/02]
Representative(s)Connell, Anthony Christopher
GlaxoSmithKline
Global Patents (CN925.1)
980 Great West Road
Brentford, Middlesex TW8 9GS / GB
[N/P]
Former [2000/02]Connell, Anthony Christopher
SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court
Brentford, Middlesex TW8 9EP / GB
Application number, filing date98906924.002.02.1998
[2000/02]
WO1998EP00644
Priority number, dateGB1997000221804.02.1997         Original published format: GB 9702218
[2000/02]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO9833896
Date:06.08.1998
Language:EN
[1998/31]
Type: A2 Application without search report 
No.:EP0970198
Date:12.01.2000
Language:EN
The application published by WIPO in one of the EPO official languages on 06.08.1998 takes the place of the publication of the European patent application.
[2000/02]
Type: B1 Patent specification 
No.:EP0970198
Date:14.12.2005
Language:EN
[2005/50]
Search report(s)International search report - published on:EP19.12.1998
ClassificationIPC:C12N15/52, C12P17/18
[2005/23]
CPC:
C07K14/36 (EP,US); C12N15/52 (EP,KR,US); A61P31/04 (EP);
C12N1/20 (KR); C12N15/76 (EP,US); C12P17/188 (EP,US)
Former IPC [2000/02]C12N15/00
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2000/02]
Extension statesRO03.08.1999
SI03.08.1999
TitleGerman:MIKROORGANISMEN MIT ERHÖHTER HERSTELLUNG VON CLAVULANSÄURE[2000/02]
English:MICRO-ORGANISMS WITH INCREASED PRODUCTION OF CLAVULANIC ACID[2005/23]
French:MICRO-ORGANISMES AVEC UNE PRODUCTION AUGMENTEE D'ACIDE CLAVULANIQUE[2005/23]
Former [2000/02]NOVEL COMPOUNDS
Former [2000/02]NOUVELLES COMPOSITIONS
Entry into regional phase03.08.1999National basic fee paid 
03.08.1999Designation fee(s) paid 
03.08.1999Examination fee paid 
Examination procedure21.08.1998Request for preliminary examination filed
International Preliminary Examining Authority: EP
03.08.1999Examination requested  [2000/02]
04.12.2002Despatch of a communication from the examining division (Time limit: M04)
05.02.2003Reply to a communication from the examining division
12.05.2003Despatch of a communication from the examining division (Time limit: M04)
18.08.2003Reply to a communication from the examining division
05.02.2004Despatch of a communication from the examining division (Time limit: M04)
10.06.2004Reply to a communication from the examining division
21.12.2004Despatch of a communication from the examining division (Time limit: M04)
06.01.2005Reply to a communication from the examining division
28.06.2005Communication of intention to grant the patent
09.09.2005Fee for grant paid
09.09.2005Fee for publishing/printing paid
Divisional application(s)EP03078351.8  / EP1405913
Opposition(s)15.09.2006No opposition filed within time limit [2006/47]
Fees paidRenewal fee
10.02.2000Renewal fee patent year 03
05.02.2001Renewal fee patent year 04
04.02.2002Renewal fee patent year 05
06.02.2003Renewal fee patent year 06
04.02.2004Renewal fee patent year 07
04.02.2005Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
NL14.12.2005
IE02.02.2006
LU28.02.2006
MC28.02.2006
DK14.03.2006
GR14.03.2006
SE14.03.2006
PT15.05.2006
[2007/17]
Former [2007/02]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
NL14.12.2005
MC28.02.2006
DK14.03.2006
GR14.03.2006
SE14.03.2006
PT15.05.2006
Former [2006/49]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
NL14.12.2005
MC28.02.2006
GR14.03.2006
SE14.03.2006
PT15.05.2006
Former [2006/45]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
NL14.12.2005
MC28.02.2006
GR14.03.2006
SE14.03.2006
Former [2006/44]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
MC28.02.2006
GR14.03.2006
SE14.03.2006
Former [2006/38]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
GR14.03.2006
SE14.03.2006
Former [2006/34]AT14.12.2005
CH14.12.2005
FI14.12.2005
LI14.12.2005
SE14.03.2006
Former [2006/33]CH14.12.2005
FI14.12.2005
LI14.12.2005
SE14.03.2006
Former [2006/27]FI14.12.2005
SE14.03.2006
Former [2006/24]FI14.12.2005
Cited inInternational search[Y]CA2108113  (UNIV ALBERTA [CA]) [Y] 1,6,9 * see the whole document and specially example 3 and figure 2 *;
 [XDA]  - E.N. MARSCH ET AL.,, "Two isozymes of clavaminate synthase central to clavulanic acid formation: cloning and sequencing of both genes from Streptomyces clavuligerus", BIOCHEMISTRY, WASHINGTON, DC, US, (1992), vol. 31, pages 12648 - 12657, XP002072686 [XD] 5 * see the whole document and specially figure 3 * [A] 1,2

DOI:   http://dx.doi.org/10.1021/bi00165a015
 [DY]  - A.S. PARADKAR AND S.E. JENSEN, "Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, (1995), vol. 177, no. 5, pages 1307 - 1314, XP002072687 [DY] 1,6,9 * the whole document *
 [YD]  - K.A. AIDOO ET AL.,, "Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis", GENE, AMSTERDAM, NL, (1994), vol. 147, pages 41 - 46, XP002072688 [YD] 1,6,9 * the whole document *

DOI:   http://dx.doi.org/10.1016/0378-1119(94)90036-1
 [YA]  - J.E. HODGSON ET AL.,, "Clavulanic acid biosynthesis in Streptomyces clavuligerus: gene cloning and characterization", GENE, AMSTERDAM, NL, (1995), vol. 166, pages 49 - 55, XP002072689 [Y] 1 * see the whole document and specially figure 2 * [A] 2-4
 [A]  - J.M. WARD AND J.E. HODGSON, "The biosynthetic genes for clavulanic acid and cephamycin production occur as a 'super-cluster' in three Streptomyces", FEMS MICROBIOLOGICAL LETTERS, AMSTERDAM, NL, (1993), vol. 110, pages 239 - 242, XP000601357 [A] 1 * see the whole document and specially figure 1 *

DOI:   http://dx.doi.org/10.1016/0378-1097(93)90472-E
Examination   - J BIOL CHEM, vol. 270, pages 5399 - 5404
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.