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EP About this file: EP0973390

EP0973390 - RETINOID RELATED MOLECULES FOR THE INHIBITION OF ENDOTHELIN-1 OVERPRODUCTION IN DISEASE [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 03.10.2003 Database last updated on 20.09.2024
Most recent event Tooltip	03.10.2003	Application deemed to be withdrawn	published on 19.11.2003 [2003/47]
Applicant(s)	For all designated states SIDNEY KIMMEL CANCER CENTER 10835 Altman Row San Diego, CA 92121 / US
	[2000/04]
Inventor(s)	01 / PFAHL, Magnus 605 North Rios Avenue Solano Beach, CA 92075 / US
	02 / HSU, Ju-YU 3520 Lebanon Drive 5123 San Diego, CA 92122 / US
	[2000/04]
Representative(s)	Leißler-Gerstl, Gabriele Eisenführ, Speiser & Partner Arnulfstrasse 27 80335 München / DE
	[N/P]
Former [2000/04]	Leissler-Gerstl, Gabriele Eisenführ, Speiser & Partner, Patentanwälte, Arnulfstrasse 25 80335 München / DE
Application number, filing date	98914647.7	10.04.1998
	[2000/04]
	WO1998US07125
Priority number, date	US19970043293P	11.04.1997 Original published format: US 43293 P
	[2000/04]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9846076
	Date:	22.10.1998
	Language:	EN
	[1998/42]
	Type:	A1 Application with search report
	No.:	EP0973390
	Date:	26.01.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 22.10.1998 takes the place of the publication of the European patent application.
	[2000/04]
Search report(s)	International search report - published on:	US	22.10.1998
	(Supplementary) European search report - dispatched on:	EP	30.01.2003
Classification	IPC:	A01N37/10, A61K31/19, A61K31/335, A61K31/385, A61K31/38, A61K31/34	[2002/50]
	CPC:	A61K31/203 (EP); A61P1/16 (EP); A61P13/08 (EP); A61P13/12 (EP); A61P17/00 (EP); A61P25/04 (EP); (+) A61P35/00 (EP); A61P43/00 (EP); A61P9/02 (EP); A61P9/04 (EP); A61P9/10 (EP); A61P9/12 (EP) (-)
	Former IPC [2000/04]	A01N37/10, A61K31/19
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/04]
Title	German:	MIT RETINOIDEN VERWANDTE VERBINDUNGEN ZUR HEMMUNG KRANKHAFTER ENDOTHELIN-1-ÜBERPRODUKTION	[2000/04]
	English:	RETINOID RELATED MOLECULES FOR THE INHIBITION OF ENDOTHELIN-1 OVERPRODUCTION IN DISEASE	[2000/04]
	French:	MOLECULES LIEES AUX RETINOIDES ET PERMETTANT D'ENRAYER LA SURPRODUCTION D'ENDOTHELINE 1 DANS L'AFFECTION	[2000/04]
Entry into regional phase	11.11.1999	National basic fee paid
	11.11.1999	Search fee paid
	11.11.1999	Designation fee(s) paid
	11.11.1999	Examination fee paid
Examination procedure	28.10.1998	Request for preliminary examination filed International Preliminary Examining Authority: US
	11.11.1999	Examination requested [2000/04]
	24.04.2003	Application deemed to be withdrawn, date of legal effect [2003/47]
	12.06.2003	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2003/47]
Fees paid	Renewal fee
	07.04.2000	Renewal fee patent year 03
	09.04.2001	Renewal fee patent year 04
	02.05.2002	Renewal fee patent year 05
	07.04.2003	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]WO9321146 (LIGAND PHARM INC [US]) [X] 1-15,17,18,20,21,25,27 * abstract * * page 2, lines 3-16 * * page 10, line 34 - page 11, line 2 * * page 13, lines 25-28; example 2 * * page 59, line 3 - page 60, line 21; claims 1-41 *;
		[X]EP0749752 (CIRD GALDERMA [FR]) [X] 1,2,5-13,25,27 * abstract * * page 3, lines 23-46 * * page 4, line 32 - page 5, line 34; examples 1,2; claims 1,2,6,7 *;
		[X]US5324840 (CHANDRARATNA ROSHANTHA A S [US]) [X] 1 * abstract * * column 3, line 61 - column 6, line 46; claims 1-9 *;
		[X]EP0747347 (SQUIBB BRISTOL MYERS CO [US]) [X] 1 * abstract * * page 5, line 8 - page 6, line 11 * * page 7, line 53 - page 8, line 30; claims 1-22 *;
		[X]US5455265 (CHANDRARATNA ROSHANTHA A S [US]) [X] 1 * abstract * * column 4, lines 32-64 * * column 18, line 62 - column 22, line 25; claims 1-11 *;
		[X]EP0694301 (CIRD GALDERMA [FR]) [X] 1,2,5-13,25,27 * abstract * * column 6, lines 8-21; claims 1-12 *;
		[X] - NAKAJIMA, MOTOWO ET AL, "Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells", CANCER RES. ( 1989 ), 49(7), 1698-706, XP008008736 [X] 1 * abstract * * page 1703, column 1, paragraph 2 - page 1705, column 1, paragraph 2; figure 6; table 5 *
		[X] - GOTTARDIS, MARCO M. ET AL, "Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand", CANCER RESEARCH ( 1996 ), 56(24), 5566-5570, XP001108852 [X] 1 * the whole document *
		[X] - DAWSON ET AL, "Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (1995), vol. 38, no. 17, ISSN 0022-2623, pages 3368 - 3383, XP002148373 [X] 1,2,5-13,25,27 * abstract * * page 3368, column 1, paragraph 1 - page 3369, column 1, paragraph 1; table 1 * DOI: http://dx.doi.org/10.1021/jm00017a021
		[X] - LOPEZ-BOADO, YOLANDA S. ET AL, "Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RAR.alpha.-dependent signaling pathway", JOURNAL OF BIOLOGICAL CHEMISTRY ( 1996 ), 271(50), 32105-32111, XP001115034 [X] 1,2,5-13,20,21,25,27 * abstract * * page 32105, column 1, paragraph 1 - page 32106, column 1, paragraph 2 * * page 32107, column 1, paragraph 2 * * page 32108, column 1, paragraph 1 * DOI: http://dx.doi.org/10.1074/jbc.271.50.32105
		[X] - BOEHM M F ET AL, "SYNTHESIS AND STRUCTURE - ACTIVITY RELATIONSHIPS OF NOVEL RETINOID X RECEPTOR-SELECTIVE RETINOIDS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (19940902), vol. 37, no. 18, ISSN 0022-2623, pages 2930 - 2941, XP000615432 [X] 1,2,5-13,25,27 * abstract * * page 2930, column 1, paragraph 1; table 1 * DOI: http://dx.doi.org/10.1021/jm00044a014
		[X] - BOEHM M F ET AL, "DESIGN AND SYNTHESIS OF POTENT RETINOID X RECEPTOR SELECTIVE LIGANDS THAT INDUCE APOPTOSIS IN LEUKEMIA CELLS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (19950804), vol. 38, no. 16, ISSN 0022-2623, pages 3146 - 3155, XP000615461 [X] 1,2,5-13,25,27 * abstract * * page 3146, column 1, paragraph 1 - page 3147, column 2, paragraph 2; figure 2; table 1 * DOI: http://dx.doi.org/10.1021/jm00016a018
	International search	[XP]WO97
		[XP] - STN WPIDS, (19000101), Database accession no. 97-145349, XP002910025 & WO97 A 00000000

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