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Extract from the Register of European Patents

EP About this file: EP0977560

EP0977560 - IBUPROFEN THIOESTERS AS INHIBITORS OF Nf-kappaB-DEPENDENT PAIN AND INFLAMMATION MEDIATOR FORMATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.05.2005
Database last updated on 01.01.2025
Most recent event   Tooltip06.05.2005No opposition filed within time limitpublished on 22.06.2005  [2005/25]
Applicant(s)For all designated states
PAZ Arzneimittel- Entwicklungsgesellschaft mbH
In der Schildwacht 13
65933 Frankfurt am Main / DE
[2004/27]
Former [2000/06]For all designated states
PAZ ARZNEIMITTEL- ENTWICKLUNGSGESELLSCHAFT MBH
In der Schildwacht 13
65933 Frankfurt / DE
Inventor(s)01 / BANG, Holger
Fischerring 19
06120 Halle / DE
02 / BRUNE, Kay, Prof.Dr.Dr.
Weiherackerweg 17
D-91080 Rathsberg / DE
03 / GEISSLINGER, Gerd
Geiwitzenweg 29
D-91085 Weisendorf / DE
04 / PAHL, Andreas
Ritzer Strasse 13
D-91054 Erlangen / DE
05 / SCHEUREN, Nicole
Drausnickstrasse 30
D-91052 Erlangen / DE
06 / NEUPERT, Werner
Reuthlehenstrasse 38
D-91056 Erlangen / DE
[2000/06]
Representative(s)Böhm, Brigitte, et al
Weickmann & Weickmann
Patentanwälte
Richard-Strauss-Strasse 80
81679 Munich / DE
[N/P]
Former [2000/06]Böhm, Brigitte, Dipl.-Chem. Dr., et al
Kopernikusstrasse 9
81679 Munich / DE
Application number, filing date98921471.320.04.1998
[2000/06]
WO1998EP02318
Priority number, dateDE199711671321.04.1997         Original published format: DE 19716713
[2000/06]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO9847502
Date:29.10.1998
Language:DE
[1998/43]
Type: A1 Application with search report 
No.:EP0977560
Date:09.02.2000
Language:DE
The application published by WIPO in one of the EPO official languages on 29.10.1998 takes the place of the publication of the European patent application.
[2000/06]
Type: B1 Patent specification 
No.:EP0977560
Date:30.06.2004
Language:DE
[2004/27]
Search report(s)International search report - published on:EP29.10.1998
ClassificationIPC:A61K31/19, A61K31/70, A61P29/00
[2003/49]
CPC:
A61K31/7076 (EP); A61K31/192 (EP); A61P25/04 (EP);
A61P29/00 (EP); A61P43/00 (EP)
Former IPC [2000/06]A61K31/19, A61K31/70
Designated contracting statesAT,   BE,   CH,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   NL,   PT,   SE [2000/06]
TitleGerman:IBUPROFENTHIOESTER ALS HEMMER DER Nf-kappa B ABHÄNGIGEN BILDUNG VON MEDIATOREN VON ENTZÜNDUNG UND SCHMERZ[2000/06]
English:IBUPROFEN THIOESTERS AS INHIBITORS OF Nf-kappaB-DEPENDENT PAIN AND INFLAMMATION MEDIATOR FORMATION[2000/06]
French:THIOESTERS D'IBUPROFENE UTILISES COMME INHIBITEURS DE LA FORMATION DE MEDIATEURS D'INFLAMMATION ET DE DOULEUR Nf-kappa-B-DEPENDANTE[2000/06]
Entry into regional phase21.10.1999National basic fee paid 
21.10.1999Designation fee(s) paid 
21.10.1999Examination fee paid 
Examination procedure02.11.1998Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.10.1999Examination requested  [2000/06]
04.02.2002Despatch of a communication from the examining division (Time limit: M06)
14.08.2002Reply to a communication from the examining division
28.10.2002Despatch of a communication from the examining division (Time limit: M06)
07.05.2003Reply to a communication from the examining division
12.01.2004Communication of intention to grant the patent
22.04.2004Fee for grant paid
22.04.2004Fee for publishing/printing paid
Opposition(s)31.03.2005No opposition filed within time limit [2005/25]
Fees paidRenewal fee
29.02.2000Renewal fee patent year 03
31.01.2001Renewal fee patent year 04
31.01.2002Renewal fee patent year 05
31.01.2003Renewal fee patent year 06
31.03.2004Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]EP0255164  (ZAMBON SPA [IT]) [X] 1-4* page 3, line 30 - line 31 *;
 [X]EP0299558  (GIST BROCADES NV [NL], et al) [X] 1-4 * page 2, line 15 - line 17 *;
 [X]WO9310762  (ALFATEC PHARMA GMBH [DE], et al) [X] 1-4 * page 8, line 4 - line 9; claims 18-22 *;
 [XP]WO9748391  (ADVANCED RES & TECH INST [US], et al) [XP] 1-4 * page 3, line 12 - line 30 * * page 11, line 9 - line 28 * * page 14, line 26 - page 16, line 4 *;
 [X]  - W. NEUPERT ET AL., "STEREOSELECTIVE INHIBITION OF CYCLOOXYGENASE-1 (COX-1) AND COX-2 BY IBOPROFENOYL-CoA-THIOESTERS AND IBUPROFEN ENANTIOMERS", NAUNYN SCHMIEDEBERG'S ARCH. PHARMACOL., (19970311), vol. 335, no. sUPPL., page R127, XP002077651 [X] 1-4 * abstract *
 [XP]  - W.NEUPERT ET AL., "Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases", BR.J.PHARMACOL., (199710), vol. 122, no. 3, pages 487 - 492, XP002077652 [XP] 1-4 * the whole document * * page 488, column L, line 7 - line 11 * * page 491, paragraph L *

DOI:   http://dx.doi.org/10.1038/sj.bjp.0701415
 [X]  - G.KLEIN, "Isomerischer Ballast: Pharmakologische Spitzfindigkeit oder medizinischer Fortschritt?", THERAPIEWOCHE, ÖSTERREICH, (199312), vol. 8, no. 12, pages 652 - 657, XP002077653 [X] 1-4 * the whole document *
 [Y]  - C.-S. CHEN ET AL., "Metabolic stereoisomeric inversion of ibuprofen in mammals", BIOCHIM. BIOPHYS. ACTA, (1991), vol. 1078, no. 3, pages 411 - 417, XP002077654 [Y] 1-4 * abstract *
 [Y]  - R.D.KNIHINICKI ET AL., "CHIRAL INVERSION OF 2-ARYLPROPIONIC ACID NON-STEROIDAL ANTI-INFLAMMATORY DRUGS--1. IN VITRO STUDIES OF IBUPROFEN AND FLURBIPROFEN", BIOCHEM.PHARMACOL., (1989), vol. 38, no. 24, pages 4389 - 4395, XP002077655 [Y] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0006-2952(89)90647-3
 [Y]  - T.S.TRACY ET AL., "METABOLIC INVERSION OF (R)-IBUPROFEN", DRUG METAB. DISPOS., (199301), vol. 21, no. 1, pages 114 - 120, XP002077656 [Y] 1-4 * abstract *
 [Y]  - T.S.TRACY ET AL., "METABOLIC INVERSION OF (R)-IBUPROFEN", DRUG.METAB.DISPOS., (199203), vol. 20, no. 2, pages 322 - 327, XP002077657 [Y] 1-4 * abstract *
 [Y]  - R.D.KNIHINICKI ET AL., "CHIRAL INVERSION OF 2-ARYLPROPIONIC ACID NON-STEROIDAL ANTI-INFLAMMATORY DRUGS--II. RACEMIZATION AND HYDROLYSIS OF (R)- AND (S)-IBUPROFEN-CoA THIOESTERS", BIOCHEM.PHARMACOL., (19911024), vol. 42, no. 10, pages 1905 - 1911, XP002077658 [Y] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0006-2952(91)90588-V
 [Y]  - S.D.HALL ET AL., "The role of coenzyme A in the biotransformation of 2-arylpropionic acids", CHEM. BIOL. INTERACT., (199403), vol. 90, no. 3, pages 235 - 251, XP002077659 [Y] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0009-2797(94)90013-2
 [Y]  - S.MENZEL ET AL., "Is the formation of R-ibuprofenyl-adenylate the first stereoselective step of chiral inversion?", BIOCHEM.PHARMACOL., (19940830), vol. 48, no. 5, pages 1056 - 1058, XP002077660 [Y] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0006-2952(94)90380-8
 [Y]  - C.KEMAL ET AL., "COENZYME A ESTERS OF 2-ARYLOXYPHENOXYPROPIONATE HERBICIDES AND 2-ARYLPROPIONATE ANTIINFLAMMATORY DRUGS ARE POTENT AND STEREOSELECTIVE INHIBITORS OF RAT LIVER ACETYL-CoA CARBOXYLASE", LIFE SCI., (1992), vol. 50, no. 7, pages 533 - 540, XP002077661 [Y] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0024-3205(92)90393-4
 [A]  - A.M.EVANS, "Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs", EUR.J.CLIN.PHARMACOL., (199203), vol. 42, no. 3, pages 237 - 256, XP002077662 [A] 1-4 * the whole document *
 [A]  - K.WILLIAMS ET AL., "The stereoselective uptake of ibuprofen enantiomers into adipose tissue", BIOCHEM. PHARMACOL., (1986), vol. 35, no. 19, pages 3403 - 3405, XP002077663 [A] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1016/0006-2952(86)90443-0
 [A]  - K.M.KNIGHTS ET AL., "Enhanced chiral inversion of R-ibuprofen in liver from rats treated with clofibric acid", BIOCHEM. PHARMACOL., (1991), vol. 41, no. 11, pages 1775 - 1777, XP002077664 [A] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1016/0006-2952(91)90184-7
 [A]  - R.BRUGGER ET AL., "Isolation and Characterization of Rat Liver Microsomal R-Ibuprofenyl-CoA Synthetase", BIOCHEM.PHARMACOL., (1996), vol. 52, no. 7, pages 1007 - 1013, XP002077665 [A] 1-4 * abstract *

DOI:   http://dx.doi.org/10.1016/0006-2952(96)00415-7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.