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EP About this file: EP0989855

EP0989855 - OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS [Right-click to bookmark this link]
Status	The application has been refused Status updated on 14.08.2009 Database last updated on 01.01.2025
Most recent event Tooltip	14.08.2009	Refusal of application	published on 16.09.2009 [2009/38]
Applicant(s)	For all designated states Osiris Therapeutics, Inc. 2001 Aliceanna Street Baltimore, MD 21231-2001 / US
	For all designated states CASE WESTERN RESERVE UNIVERSITY 10900 Euclid Avenue Cleveland, OH 44106-7080 / US
	[2000/14]
Inventor(s)	01 / GOLDBERG, Victor, M. 1710 Country Line Road Gates Mills, OH 44040 / US
	02 / CAPLAN, Arnold, I. 1300 Oakridge Drive Cleveland Heights, OH 44121 / US
	03 / BARRY, Francis, P. 2510 Pickwick Road Baltimore, MD 21207 / US
	04 / FINK, David, J. 2891 Warrington Road Shaker Heights, OH 44120 / US
	05 / MARSHAK, Daniel, R. 11639 St. David's Lane Lutherville, MD 21093 / US
	06 / BURNS, James, S. 3301 Hidden River View Annapolis, MD 21403 / US
	[2000/14]
Representative(s)	Schnappauf, Georg, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
	[N/P]
Former [2008/35]	Schnappauf, Georg, et al Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6 81679 München / DE
Former [2008/10]	Schnappauf, Georg, et al Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6 81679 München / DE
Former [2000/14]	LOUIS, PÖHLAU, LOHRENTZ & SEGETH Postfach 3055 90014 Nürnberg / DE
Application number, filing date	98922211.2	13.05.1998
	[2000/14]
	WO1998US09614
Priority number, date	US19970047002	13.05.1997 Original published format: US 47002
	[2000/14]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9851317
	Date:	19.11.1998
	Language:	EN
	[1998/46]
	Type:	A1 Application with search report
	No.:	EP0989855
	Date:	05.04.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 19.11.1998 takes the place of the publication of the European patent application.
	[2000/14]
Search report(s)	International search report - published on:	US	19.11.1998
	(Supplementary) European search report - dispatched on:	EP	03.05.2002
Classification	IPC:	C12N5/06, A61K38/39, A61K38/18, // (C12N5/06, A61K38:39, 38:18)	[2002/24]
	CPC:	A61L27/3886 (EP); A61L27/3817 (EP); A61L27/3834 (EP); A61L27/3852 (EP); C12N5/0655 (EP); C12N5/0663 (EP); (+) A61K2035/124 (EP); A61K38/00 (EP); A61L2430/06 (EP); C12N2500/38 (EP); C12N2501/15 (EP); C12N2501/23 (EP); C12N2501/39 (EP); C12N2501/70 (EP); C12N2533/54 (EP) (-)
	Former IPC [2000/14]	A61K35/28, C12N5/02, C12N5/08
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/14]
Title	German:	REGENERATION VON KNORPEL BEI OSTEOARTHRITIS MITTELS MENSCHLICHER MESENCHYMALER STAMMZELLEN	[2000/14]
	English:	OSTEOARTHRITIS CARTILAGE REGENERATION USING HUMAN MESENCHYMAL STEM CELLS	[2000/14]
	French:	REGENERATION DE CARTILAGE DANS L'ARTHROSE A L'AIDE DE CELLULES SOUCHES MESENCHYMATEUSES HUMAINES	[2000/14]
Entry into regional phase	29.11.1999	National basic fee paid
	29.11.1999	Search fee paid
	29.11.1999	Designation fee(s) paid
	29.11.1999	Examination fee paid
Examination procedure	10.12.1998	Request for preliminary examination filed International Preliminary Examining Authority: US
	29.11.1999	Examination requested [2000/14]
	11.08.2003	Despatch of a communication from the examining division (Time limit: M04)
	22.12.2003	Reply to a communication from the examining division
	05.10.2004	Despatch of a communication from the examining division (Time limit: M04)
	21.01.2005	Reply to a communication from the examining division
	20.02.2007	Date of oral proceedings
	20.04.2007	Despatch of communication that the application is refused, reason: substantive examination [2009/38]
	20.04.2007	Minutes of oral proceedings despatched
	01.08.2009	Application refused, date of legal effect [2009/38]
Appeal following examination	24.05.2007	Appeal received No. T1767/07
	14.08.2007	Statement of grounds filed
	09.07.2009	Result of appeal procedure: appeal of the applicant was rejected
	09.07.2009	Date of oral proceedings
	14.07.2009	Minutes of oral proceedings despatched
	09.07.2009	Date of oral proceedings
Divisional application(s)	EP09008942.6 / EP2110431
Fees paid	Renewal fee
	25.04.2000	Renewal fee patent year 03
	04.05.2001	Renewal fee patent year 04
	21.05.2002	Renewal fee patent year 05
	26.05.2003	Renewal fee patent year 06
	24.05.2004	Renewal fee patent year 07
	19.05.2005	Renewal fee patent year 08
	30.05.2006	Renewal fee patent year 09
	30.05.2007	Renewal fee patent year 10
	14.05.2008	Renewal fee patent year 11
	25.05.2009	Renewal fee patent year 12
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[XY]WO9628539 (MORPHOGEN PHARMACEUTICALS INC [US], et al) [X] 1-3,7-9,11,12,14-19,22,24,26,31,32 * see claims 1-9, pages 9,11-12,15 and example 1 * [Y] 1-5,7-20,22-36;
		[XY]US5197985 (CAPLAN ARNOLD I [US], et al) [X] 1-3,7-9,11,14,15,17,22,25,26,31-33,35 * see claim 11, col. 16 lines 40-59 * [Y] 1-5,7-20,22-36
		[XY] - WAKITANI S ET AL, "MESENCHYMAL CELL-BASED REPAIR OF LARGE, FULL-THICKNESS DEFECTS OF ARTICULAR CARTILAGE", JOURNAL OF BONE AND JOINT SURGERY, JOURNAL OF BONE AND JOINT SURGERY. BOSTON, US, (199404), vol. 76-A, no. 4, ISSN 0021-9355, pages 579 - 592, XP000940573 [X] 1-4,7-9,11,14-19,22,24,26,31,32 * see abstract and page 581 * [Y] 1-5,7-20,22-36
	International search	[Y]US4642120 (NEVO ZVI [IL], et al);
		[Y]US5053050 (ITAY SAMUEL [IL]);
		[Y]US5226914 (CAPLAN ARNOLD I [US], et al);
		[Y]US5486359 (CAPLAN ARNOLD I [US], et al);
		[Y]US5206023 (HUNZIKER ERNST B [CH]);
		[Y]US5326357 (KANDEL RITA A [CA]);
		[YP]US5716616 (PROCKOP DARWIN J [US], et al);
		[YP]US5736396 (BRUDER SCOTT P [US], et al);
		[Y]US5399493 (EMERSON STEPHEN G [US], et al)
		[Y] - SOLURSHI M, ET AL., "EXTRACELLULAR MATRIX MEDIATES EPITHELIAL EFFECTS ON CHONDROGENESIS IN VITRO", Developmental Biology, Academic Press, AMSTERDAM, NL, AMSTERDAM, NL, (19840101), vol. 105, doi:10.1016/0012-1606(84)90302-6, ISSN 0012-1606, pages 451 - 457, XP002913931 DOI: http://dx.doi.org/10.1016/0012-1606(84)90302-6
		[Y] - HUNZIKER E B, ET AL., "REPAIR OF PARTIAL-THICKNESS DEFECTS IN ARTICULAR CARTILAGE: CELL RECRUITMENT FROM THE SYNOVIAL MEMBRANE", JOURNAL OF BONE AND JOINT SURGERY. AMERICAN VOLUME, Journal of Bone and Joint Surgery, US, US, (19960501), vol. 78-A, no. 05, ISSN 0021-9355, pages 721 - 733, XP002913932
		[Y] - BRADHAM D M, PASSANITI A, HORTON W E, "MESENCHYMAL CELL CHONDROGENESIS IS STIMULATED BY BASEMENT MEMBRANE MATRIX AND INHIBITED BY AGE-ASSOCIATED FACTORS", MATRIX BIOLOGY., XX, XX, XX, (19940101), vol. 14, doi:10.1016/S0945-053X(05)80005-8, pages 561 - 571, XP002913933 DOI: http://dx.doi.org/10.1016/S0945-053X(05)80005-8
		[Y] - JOYCE M E, ET AL., "TRANSFORMING GROWTH FACTOR-BETA AND THE INITIATION OF CHONDROGENESIS AND OSTEOGENESIS IN THE RAT FEMUR", The journal of cell biology : JCB, The Rockefeller University Press, US, US, (19900601), vol. 110, doi:10.1083/jcb.110.6.2195, ISSN 0021-9525, pages 2195 - 2207, XP002913934 DOI: http://dx.doi.org/10.1083/jcb.110.6.2195
		[Y] - BRUDER S P, FINK D J, CAPLAN A I, "MESENCHYMAL STEM CELLS IN BONE DEVELOPMENT, BONE REPAIR, AND SKELETAL REGENERATION THERAPY", Journal of Cellular Biochemistry, WILEY-LISS INC, US, US, (19940101), vol. 56, doi:10.1002/jcb.240560303, ISSN 0730-2312, pages 283 - 294, XP002913935 DOI: http://dx.doi.org/10.1002/jcb.240560303

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