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EP About this file: EP1001764

EP1001764 - HETEROCYCLIC AMIDE COMPOUNDS AS CELL ADHESION INHIBITORS [Right-click to bookmark this link]
Status	The application has been refused Status updated on 09.01.2009 Database last updated on 05.10.2024
Most recent event Tooltip	09.01.2009	Refusal of application	published on 11.02.2009 [2009/07]
Applicant(s)	For all designated states Merck & Co., Inc. (a New Jersey corp.) 126 East Lincoln Avenue Rahway, N.J. 07065 / US
	[2000/21]
Inventor(s)	01 / DURETTE, Philippe, L. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	02 / HAGMANN, William, K. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	03 / MacCOSS, Malcolm 126 East Lincoln Avenue Rahway, NJ 07065 / US
	04 / MILLS, Sander, G. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	05 / MUMFORD, Richard, A. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	06 / VAN RIPER, Gail, M. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	07 / SCHMIDT, Jack, A. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	08 / KEVIN, Nancy, J. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	[2000/21]
Representative(s)	Horgan, James Michael Frederic, et al Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB
	[N/P]
Former [2006/49]	Horgan, James Michael Frederic, et al Merck & Co., Inc. European Patent Department Merck Sharp & Dohme Limited, Hertford Road, Hoddesdon Hertfordshire, EN11 9BU / GB
Former [2004/27]	Horgan, James Michael Frederic, et al Merck & Co., Inc. European Patent Department Terlings Park Eastwick Road Harlow, Essex CM20 2QR / GB
Former [2000/21]	Hiscock, Ian James, et al European Patent Department, Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR / GB
Application number, filing date	98926122.7	29.05.1998
	[2000/21]
	WO1998US10940
Priority number, date	US19970048017P	29.05.1997 Original published format: US 48017 P
	GB19970014314	07.07.1997 Original published format: GB 9714314
	US19970066525P	25.11.1997 Original published format: US 66525 P
	GB19980000686	14.01.1998 Original published format: GB 9800686
	[2000/21]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9853814
	Date:	03.12.1998
	Language:	EN
	[1998/48]
	Type:	A1 Application with search report
	No.:	EP1001764
	Date:	24.05.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 03.12.1998 takes the place of the publication of the European patent application.
	[2000/21]
Search report(s)	International search report - published on:	US	03.12.1998
	(Supplementary) European search report - dispatched on:	EP	11.07.2005
Classification	IPC:	C07F9/02, A61K31/405, A61K31/395, A61K31/41, A61K31/415, A61K31/425, A61K31/435, A61K31/445	[2005/32]
	CPC:	A61K31/472 (EP); A61K31/401 (EP); A61K31/445 (EP); A61K31/4725 (EP); A61P1/04 (EP); A61P11/06 (EP); (+) A61P25/00 (EP); A61P37/08 (EP); A61P43/00 (EP); A61P9/10 (EP); C07K5/06139 (EP); C07K5/06165 (EP); C07K5/06191 (EP); A61K38/00 (EP) (-)
	Former IPC [2004/40]	C07F9/02, A61K31/404, A61P43/00
	Former IPC [2000/21]	A61K31/395, A61K31/40, A61K31/41, A61K31/415, A61K31/425, A61K31/435, A61K31/44, A61K31/445, A61K31/47, A61K31/495, A61K31/535, C07D205/02, C07D209/04, C07D209/14, C07D209/30, C07D217/12, C07D235/02, C07D233/64, C07D241/02, C07D257/04, C07D265/30, C07D275/02, C07D277/02, C07D277/08, C07D295/08
Designated contracting states	AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE [2000/21]
Title	German:	HETEROZYKLISCHE AMIDE ALS ZELLADHÄSIONSHEMMERN	[2000/21]
	English:	HETEROCYCLIC AMIDE COMPOUNDS AS CELL ADHESION INHIBITORS	[2000/21]
	French:	COMPOSES D'AMIDE HETEROCYCLIQUES UTILISES EN TANT QU'INHIBITEURS DE L'ADHESION CELLULAIRE	[2000/21]
Entry into regional phase	29.12.1999	National basic fee paid
	29.12.1999	Search fee paid
	29.12.1999	Designation fee(s) paid
	29.12.1999	Examination fee paid
Examination procedure	23.12.1998	Request for preliminary examination filed International Preliminary Examining Authority: US
	29.12.1999	Examination requested [2000/21]
	07.10.2005	Despatch of a communication from the examining division (Time limit: M04)
	09.02.2006	Reply to a communication from the examining division
	05.05.2006	Despatch of a communication from the examining division (Time limit: M02)
	04.07.2006	Reply to a communication from the examining division
	03.04.2007	Despatch of a communication from the examining division (Time limit: M04)
	01.08.2007	Reply to a communication from the examining division
	09.07.2008	Cancellation of oral proceeding that was planned for 23.09.2008
	09.07.2008	Minutes of oral proceedings despatched
	23.09.2008	Date of oral proceedings
	23.09.2008	Date of oral proceedings (cancelled)
	24.09.2008	Despatch of communication that the application is refused, reason: substantive examination [2009/07]
	04.10.2008	Application refused, date of legal effect [2009/07]
Fees paid	Renewal fee
	31.05.2000	Renewal fee patent year 03
	31.05.2001	Renewal fee patent year 04
	31.05.2002	Renewal fee patent year 05
	07.05.2003	Renewal fee patent year 06
	05.05.2004	Renewal fee patent year 07
	13.05.2005	Renewal fee patent year 08
	27.03.2006	Renewal fee patent year 09
	07.05.2007	Renewal fee patent year 10
	18.03.2008	Renewal fee patent year 11
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[PX]WO9721690 (CEPHALON INC [US]) [PX] 1-20 * pages 1-3 * * examples 81,84-86,94-96,102,103,111 *;
		[X]EP0443132 (FUJISAWA PHARMACEUTICAL CO [JP]) [X] 1-20 * page 3 *;
		[A]EP0696593 (SQUIBB BRISTOL MYERS CO [US]) [A] 1-14,17-20 * examples 1-3,6,9-11,28 *;
		[A]US4350698 (GLEASON JOHN G, et al) [A] 1-14,17-20 * abstract * * claim 1 *;
		[A]WO9640641 (TANABE SEIYAKU CO [JP], et al) [A] 1-14,17-20 * the whole document *;
		[X] - CALCAGNI A ET AL, "Peptides containing the sulfonamide junction: Synthesis, structure, and conformation of Z-Tau-Pro-Phe-NHiPr", BIOPOLYMERS 1997 UNITED STATES, (1997), vol. 41, no. 5, ISSN 0006-3525, pages 555 - 567, XP002332346 [X] 5-17,20 * scheme 1 * DOI: http://dx.doi.org/10.1002/(SICI)1097-0282(19970415)41:5<555::AID-BIP7>3.0.CO;2-L
		[A] - BYK G ET AL, "Local constrained shifty pseudopeptides inhibitors of ras-farnesyl transferase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (19951116), vol. 5, no. 22, ISSN 0960-894X, pages 2677 - 2682, XP004135213 [A] 1-14,17-20 * the whole document * DOI: http://dx.doi.org/10.1016/0960-894X(95)00482-9
		[PA] - LIN L S ET AL, "Specific and dual antagonists of [alpha]4[beta]1 and [alpha]4[beta]7 integrins", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 21 JAN 2002 UNITED KINGDOM, (20020121), vol. 12, no. 2, ISSN 0960-894X, pages 133 - 136, XP002332347 [PA] 1-20 * table 1 * DOI: http://dx.doi.org/10.1016/S0960-894X(01)00705-3
		[PA] - LIN L S ET AL, "The discovery of acylated [beta]-amino acids as potent and orally bioavailable VLA-4 antagonists", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 25 FEB 2002 UNITED KINGDOM, (20020225), vol. 12, no. 4, ISSN 0960-894X, pages 611 - 614, XP002332348 [PA] 1-20 * scheme 1 * DOI: http://dx.doi.org/10.1016/S0960-894X(01)00818-6
		[PA] - HAGMANN W K ET AL, "The discovery of sulfonylated dipeptides as Potent VLA-4 antagonists", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS 22 OCT 2001 UNITED KINGDOM, (20011022), vol. 11, no. 20, ISSN 0960-894X, pages 2709 - 2713, XP002332349 [PA] 1-20 * tables 1-4 * DOI: http://dx.doi.org/10.1016/S0960-894X(01)00544-3
	International search	[A]US5424329 (BOSCHELLI DIANE H [US], et al);
		[Y]EP0618221 (SQUIBB BRISTOL MYERS CO [US]);
		[Y]US5602099 (SCHILLER PETER [CA]);
		[Y]US5229381 (DOHERTY JAMES B [US], et al);
		[Y]EP0190852 ;
		[Y]WO9204369 (DEPHA TEAM SRL [IT]);
		[Y]WO9204369
		[A] - BOSCHELLI D. H., ET AL., "INHIBITION OF E-SELECTIN-, ICAM-1-, AND VCAM-1-MEDIATED CELL ADHESION BY BENZOÚB3⁄4THIOPHENE-, BENZOFURAN-, INDOLE-, AND NAPHTHALENE-2-CARBOXAMIDES: IDENTIFICATION OF PD 144795 AS AN ANTIINFLAMMATORY AGENT.", Journal of Medicinal Chemistry, American Chemical Society, US, US, (19950101), vol. 38., doi:10.1021/jm00022a026, ISSN 0022-2623, pages 4597 - 4614., XP002913225 DOI: http://dx.doi.org/10.1021/jm00022a026
		[Y] - Chemical Abstracts Service (C A S), (19000101), Database accession no. 107-97096, XP002913226
		[Y] - Chemical Abstracts Service (C A S), (19000101), Database accession no. 105-227343, XP002913227 & EP0190852 A 00000000
		[Y] - Chemical Abstracts Service (C A S), (19000101), Database accession no. 120-107719, XP002913228
		[Y] - Chemical Abstracts Service (C A S), (19000101), Database accession no. 117-131564, XP002913229 & WO9204369 A 00000000

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