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Extract from the Register of European Patents

EP About this file: EP0975345

EP0975345 - (-)-MEFLOQUINE TO BLOCK PURINERGIC RECEPTORS AND TO TREAT MOVEMENT OR NEURODEGENERATIVE DISORDERS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 11.06.2004 Database last updated on 10.05.2025
Most recent event Tooltip	11.06.2004	Application deemed to be withdrawn	published on 28.07.2004 [2004/31]
Applicant(s)	For all designated states VERNALIS RESEARCH LIMITED Oakdene Court, 613 Reading Road Winnersh Wokingham RG41 5UA / GB
	[N/P]
Former [2000/36]	For all designated states VERNALIS RESEARCH LIMITED Oakdene Court, 613 Reading Road Winnersh, Wokingham RG41 5UA / GB
Former [2000/05]	For all designated states Cerebrus Pharmaceuticals Limited Oakdene Court, 613 Reading Road Winnersh, Wokingham RG41 5UA / GB
Inventor(s)	01 / SHEPHERD, Robin deceased / GB
	02 / FLETCHER, Allan 59 The Granary Wynyard Village, Cleveland TS22 5QG / GB
	03 / KNUTSEN, Lars Jacob Stray 6 Waylands Close, Bradfield Reading, Berkshire RG7 6AG / GB
	04 / PORTER, Richard H. P. 17 Sycamore Road Chalfont St.Giles, Bucks HP8 4LE / GB
	05 / WEISS, Scott Murray 9 Lindsey Close Wokingham, Berkshire RG41 3AW / GB
	[2000/05]
Representative(s)	Howard, Paul Nicholas, et al Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	[N/P]
Former [2000/05]	Howard, Paul Nicholas, et al Carpmaels & Ransford 43 Bloomsbury Square London WC1A 2RA / GB
Application number, filing date	98955789.7	26.11.1998
	[2000/05]
	WO1998GB03536
Priority number, date	GB19970025049	26.11.1997 Original published format: GB 9725049
	GB19980019385	04.09.1998 Original published format: GB 9819385
	[2000/05]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9926627
	Date:	03.06.1999
	Language:	EN
	[1999/22]
	Type:	A1 Application with search report
	No.:	EP0975345
	Date:	02.02.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 03.06.1999 takes the place of the publication of the European patent application.
	[2000/05]
Search report(s)	International search report - published on:	EP	03.06.1999
Classification	IPC:	A61K31/47, A61P25/16, A61P25/28, A61P25/14	[2003/33]
	CPC:	A61K31/4709 (EP,US)
	Former IPC [2000/05]	A61K31/47
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2000/05]
Title	German:	(-)-MEFLOQUINE ZUR BLOCKIERUNG DER PURINREZEPTOREN UND ZUR BEHANDLUNG VON BEWEGUNG- ODER NEURODEGENERATIVEN ERKRANKUNGEN	[2000/05]
	English:	(-)-MEFLOQUINE TO BLOCK PURINERGIC RECEPTORS AND TO TREAT MOVEMENT OR NEURODEGENERATIVE DISORDERS	[2000/05]
	French:	(-)-MEFLOQUINE UTILISEE POUR LE BLOCAGE DE RECEPTEURS PURINERGIQUES ET POUR LE TRAITEMENT DE DESORDRES NEURODEGENERATIF ET DES MOUVEMENTS	[2003/36]
	Former [2000/05]	(-)-MEFLOQUINE UTILISEE POUR LE BLOCAGE DE RECEPTEURS PURINERGIQUES ET POUR LE TRAITEMENT DE PERTURBATIONS NEURODEGENERATIVES ET DES MOUVEMENTS
Entry into regional phase	28.07.1999	National basic fee paid
	28.07.1999	Designation fee(s) paid
	28.07.1999	Examination fee paid
Examination procedure	28.07.1999	Examination requested [2000/05]
	28.09.2001	Despatch of a communication from the examining division (Time limit: M06)
	02.04.2002	Reply to a communication from the examining division
	22.07.2002	Despatch of a communication from the examining division (Time limit: M04)
	21.11.2002	Reply to a communication from the examining division
	04.09.2003	Communication of intention to grant the patent
	15.01.2004	Application deemed to be withdrawn, date of legal effect [2004/31]
	23.02.2004	Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2004/31]
Fees paid	Renewal fee
	25.01.2001	Renewal fee patent year 03
	14.11.2001	Renewal fee patent year 04
	13.11.2002	Renewal fee patent year 05
	12.11.2003	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	30.11.2000	03 M06 Fee paid on 25.01.2001
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[PX]WO9839003 (CEREBRUS LTD [GB], et al) [PX] 1-8,12,15 * page 2 * * page 4, line 1 - line 11 * * page 7, line 9 - line 15 * * page 8, line 12 - line 15 * * page 9, line 16 - line 37 * * page 18 - page 23 *;
		[A] - EMERY ET AL., "Arylmethanol and thiosemicarbazone influence on Plasmodial macromolecular synthesis and cell stability", LIFE SCI., (1983), vol. 33, no. 13, pages 1285 - 1294, XP002054347 [A] 1-5 * page 1292 * DOI: http://dx.doi.org/10.1016/0024-3205(83)90010-3
		[A] - LITMAN ET AL., "Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity", BIOCHIM. BIOPHYS. ACTA, (1997), vol. 1361, no. 2, pages 159 - 163, XP002054348 [A] 1-4 * page 162; figure 5 * * page 164; table 1 * * page 165; figure 9 * DOI: http://dx.doi.org/10.1016/S0925-4439(97)00026-4
		[A] - BESSER ET AL., "Verdacht auf anfallfördernde Wirkung von Mefloquine (Lariam(R))", NERVENARZT, (1991), vol. 62, no. 12, pages 760 - 761, XP002054349 [A] 5-7,11,12 * the whole document *
		[Y] - NGIAM ET AL., "Stereospecific inhibition of cholinesterases by mefloquine", CHEM. PHARM. BULL., (1987), vol. 35, no. 1, pages 409 - 412, XP002093900 [Y] 6,7,11,16-20 * the whole document *
		[Y] - GOODMAN-GILMAN ET AL., The pharmacological basis of therapeutics, NEW YORK, USA, MACMILLAN PUBLISHING COMPANY, (1987), XP002093901 [Y] 6,7,11,16-20 * page 125 - page 127 *

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