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EP About this file: EP1040351

EP1040351 - C-TERMINAL REGION OF AGOUTI-RELATED TRANSCRIPT (ART) PROTEIN [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 23.05.2008 Database last updated on 01.01.2025
Most recent event Tooltip	08.01.2010	Lapse of the patent in a contracting state New state(s): LU	published on 10.02.2010 [2010/06]
Applicant(s)	For all designated states Merck & Co., Inc. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US
	[2007/29]
Former [2000/40]	For all designated states MERCK & CO., INC. 126 East Lincoln Avenue Rahway, New Jersey 07065 / US
Inventor(s)	01 / FONG, Tung, Ming 126 East Lincoln Avenue Rahway, NJ 07065 / US
	02 / VAN DER PLOEG, Leonardus, H., T. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	03 / TOTA, Michael, R. 126 East Lincoln Avenue Rahway, NJ 07065 / US
	[2000/40]
Representative(s)	Horgan, James Michael Frederic, et al Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB
	[N/P]
Former [2006/49]	Horgan, James Michael Frederic, et al Merck & Co., Inc. European Patent Department Merck Sharp & Dohme Limited, Hertford Road, Hoddesdon Hertfordshire, EN11 9BU / GB
Former [2000/40]	Horgan, James Michael Frederic Merck & Co., Inc., Terlings Park, Eastwick Road Harlow, Essex CM20 2QR / GB
Application number, filing date	98963882.0	11.12.1998
	[2000/40]
	WO1998US26457
Priority number, date	US19970069747P	16.12.1997 Original published format: US 69747 P
	[2000/40]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO9931508
	Date:	24.06.1999
	Language:	EN
	[1999/25]
	Type:	A1 Application with search report
	No.:	EP1040351
	Date:	04.10.2000
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 24.06.1999 takes the place of the publication of the European patent application.
	[2000/40]
	Type:	B1 Patent specification
	No.:	EP1040351
	Date:	18.07.2007
	Language:	EN
	[2007/29]
Search report(s)	International search report - published on:	US	24.06.1999
	(Supplementary) European search report - dispatched on:	EP	11.03.2003
Classification	IPC:	G01N33/53, G01N33/566, C07K14/435, C07K19/00	[2006/50]
	CPC:	C07K14/47 (EP); C07K2319/00 (EP)
	Former IPC [2000/40]	G01N33/53, G01N33/566, C07K14/435, C07K19/00, C12N15/12
Designated contracting states	AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE [2000/40]
Title	German:	C-TERMINALE REGION DES "AGOUTI-RELATED-TRANSCRIPT"-PROTEINS (ART)	[2000/40]
	English:	C-TERMINAL REGION OF AGOUTI-RELATED TRANSCRIPT (ART) PROTEIN	[2000/40]
	French:	REGION C-TERMINALE DE PROTEINE DE TRANSCRIPT LIE A L'AGOUTI (ART)	[2000/40]
Entry into regional phase	17.07.2000	National basic fee paid
	17.07.2000	Search fee paid
	17.07.2000	Designation fee(s) paid
	17.07.2000	Examination fee paid
Examination procedure	13.07.1999	Request for preliminary examination filed International Preliminary Examining Authority: US
	17.07.2000	Examination requested [2000/40]
	07.08.2003	Despatch of a communication from the examining division (Time limit: M06)
	19.02.2004	Reply to a communication from the examining division
	21.03.2005	Despatch of a communication from the examining division (Time limit: M06)
	14.09.2005	Reply to a communication from the examining division
	22.01.2007	Communication of intention to grant the patent
	01.06.2007	Fee for grant paid
	01.06.2007	Fee for publishing/printing paid
Opposition(s)	21.04.2008	No opposition filed within time limit [2008/26]
Request for further processing for:	19.02.2004	Request for further processing filed
	19.02.2004	Full payment received (date of receipt of payment) Request granted
	08.03.2004	Decision despatched
Fees paid	Renewal fee
	02.01.2001	Renewal fee patent year 03
	02.01.2002	Renewal fee patent year 04
	04.12.2002	Renewal fee patent year 05
	03.12.2003	Renewal fee patent year 06
	03.12.2004	Renewal fee patent year 07
	05.12.2005	Renewal fee patent year 08
	05.12.2006	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	AT	18.07.2007
	BE	18.07.2007
	DK	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	SE	18.10.2007
	GR	19.10.2007
	IE	11.12.2007
	LU	11.12.2007
	PT	18.12.2007
	[2010/06]
Former [2008/48]	AT	18.07.2007
	BE	18.07.2007
	DK	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	SE	18.10.2007
	GR	19.10.2007
	IE	11.12.2007
	PT	18.12.2007
Former [2008/28]	AT	18.07.2007
	BE	18.07.2007
	DK	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	SE	18.10.2007
	GR	19.10.2007
	PT	18.12.2007
Former [2008/23]	AT	18.07.2007
	BE	18.07.2007
	DK	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	GR	19.10.2007
	PT	18.12.2007
Former [2008/21]	AT	18.07.2007
	BE	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	GR	19.10.2007
	PT	18.12.2007
Former [2008/16]	AT	18.07.2007
	FI	18.07.2007
	NL	18.07.2007
	PT	18.12.2007
Documents cited:	Search	[Y]WO9743412 (AMGEN INC [US]) [Y] 1,4-16 * see p. 2, 10-11 *;
		[PY]WO9747316 (MILLENNIUM PHARM INC [US]) [PY] 6-16* see claims *;
		[Y] - OLLMANN M M ET AL, "ANTAGONISM OF CENTRAL MELANOCORTIN RECEPTORS IN VITRO AND IN VIVO BY AGOUTI-RELATED PROTEIN", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, (19971003), vol. 278, ISSN 0036-8075, pages 135 - 138, XP002923098 [Y] 1,4-16 * the whole document * DOI: http://dx.doi.org/10.1126/science.278.5335.135
		[Y] - WILLARD DERRIL H ET AL, "Agouti structure and function: Characterization of a potent alpha-melanocyte stimulating hormone receptor antagonist.", BIOCHEMISTRY, (1995), vol. 34, no. 38, ISSN 0006-2960, pages 12341 - 12346, XP002216829 [Y] 1,4-16 * see p. 12341-2, 12345 * DOI: http://dx.doi.org/10.1021/bi00038a030
		[Y] - BODI J ET AL, "New Strategy for the Synthesis of Large Peptides as Applied to the C-terminal Cysteine-Rich 41 Amino Acid Fragment of the Mouse Agouti Protein", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (19970505), vol. 38, no. 18, ISSN 0040-4039, pages 3293 - 3296, XP004059834 [Y] 1,4 * see p. 3293 and figure 1 * DOI: http://dx.doi.org/10.1016/S0040-4039(97)00589-3
		[Y] - HASKELL-LUEVANO C ET AL, "Discovery of Prototype Peptidomimetic Agonists at the Human Melanocortin Receptors MC1R and MC4R", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (19970704), vol. 40, no. 14, ISSN 0022-2623, pages 2133 - 2139, XP002084110 [Y] 6-16 * the whole document * DOI: http://dx.doi.org/10.1021/jm960840h
		[Y] - PERRY W L ET AL, "A transgenic mouse assay for agouti protein activity.", GENETICS. UNITED STATES MAY 1995, (199505), vol. 140, no. 1, ISSN 0016-6731, pages 267 - 274, XP001118193 [Y] 1,4-16 * see abstract, p.273 *
	International search	[YP]US5766877 (STARK KEVIN LEE [US], et al);
		[A] - KWON H Y, ET AL., "MOLECULAR STRUCTURE AND CHROMOSOMAL MAPPING OF THE HUMAN HOMOLOG OFTHE AGOUTI GENE", Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US, (19941001), vol. 91, doi:10.1073/pnas.91.21.9760, ISSN 0027-8424, pages 9760 - 9764, XP002918707 DOI: http://dx.doi.org/10.1073/pnas.91.21.9760
		[A] - STARK M J R, ET AL., "THE KILLER TOXIN OF KLUYVEROMYCES LACTIS: CHARACTERIZATION OF THE TOXIN SUBUNITS AND IDENTIFICATION OF THE GENES WHICH ENCODE THEM", EMBO JOURNAL., OXFORD UNIVERSITY PRESS, SURREY., GB, GB, (19860101), vol. 05, no. 08, ISSN 0261-4189, pages 1995 - 2002, XP002918708
		[A] - SHUTTER J R, ET AL., "HYPOTHALAMIC EXPRESSION OF ART, A NOVEL GENE RELATED TO AGOUTI, IS UP-REGULATED IN OBESE AND DIABETIC MUTANT MICE", GENES AND DEVELOPMENT., COLD SPRING HARBOR LABORATORY PRESS, PLAINVIEW, NY., US, US, (19970101), vol. 11, ISSN 0890-9369, pages 593 - 602, XP002918709

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