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Extract from the Register of European Patents

EP About this file: EP0953633

EP0953633 - Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.12.2000
Database last updated on 20.07.2024
Most recent event   Tooltip01.12.2000Application deemed to be withdrawnpublished on 17.01.2001 [2001/03]
Applicant(s)For all designated states
Livercell L.L.C.
HC 75, Box 234A East Sebago
Maine 04029 / US
[N/P]
Former [1999/44]For all designated states
Livercell L.L.C.
HC 75, Box 234A
East Sebago, Maine 04029 / US
Inventor(s)01 / Curcio, Francesco
Via Dei Castagni 35/1
33010 Pagnacco / IT
02 / Coon, Hayden G.
HC 75, Box 234A
East Sebago, Maine 04029 / US
03 / Ambesi-Impiombato, Francesco Saverio
via Divisione Julia, 30
33100 Udine / IT
[1999/44]
Representative(s)Knott, Stephen Gilbert, et al
Mathisen & Macara LLP
Communications House
South Street
Staines-upon-Thames
Middlesex, TW18 4PR / GB
[N/P]
Former [1999/44]Knott, Stephen Gilbert, et al
MATHISEN, MACARA & CO. The Coach House 6-8 Swakeleys Road
Ickenham Uxbridge UB10 8BZ / GB
Application number, filing date99303337.228.04.1999
[1999/44]
Priority number, dateUS1998006689728.04.1998         Original published format: US 66897
[1999/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP0953633
Date:03.11.1999
Language:EN
[1999/44]
Search report(s)(Supplementary) European search report - dispatched on:EP04.08.1999
ClassificationIPC:C12N5/06, C12N5/02, C12N5/10, A61K39/12, A61K39/002, A61K47/38, A61K47/42
[1999/44]
CPC:
C12N5/0671 (EP); C12N7/00 (EP); A61K2035/128 (EP);
C12N2503/02 (EP); C12N2510/00 (EP)
Designated contracting states(deleted) [2000/28]
Former [1999/44]AT,  BE,  CH,  CY,  DE,  DK,  ES,  FI,  FR,  GB,  GR,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  SE 
TitleGerman:Zellkulturverfahren und Medium zur Herstellung von vermehrungsfähige, normale, differenzierte Humane Leberzellen[1999/44]
English:Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells[1999/44]
French:Procédé de culture cellulaire et milieu pour la production des cellules de foie normales, aptes à proliferer et differencieés[1999/44]
Examination procedure04.05.2000Application deemed to be withdrawn, date of legal effect  [2001/03]
28.08.2000Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2001/03]
Fees paidPenalty fee
Penalty fee Rule 85a EPC 1973
15.06.2000AT   M01   Not yet paid
15.06.2000BE   M01   Not yet paid
15.06.2000CH   M01   Not yet paid
15.06.2000CY   M01   Not yet paid
15.06.2000DE   M01   Not yet paid
15.06.2000DK   M01   Not yet paid
15.06.2000ES   M01   Not yet paid
15.06.2000FI   M01   Not yet paid
15.06.2000FR   M01   Not yet paid
15.06.2000GB   M01   Not yet paid
15.06.2000GR   M01   Not yet paid
15.06.2000IE   M01   Not yet paid
15.06.2000IT   M01   Not yet paid
15.06.2000LU   M01   Not yet paid
15.06.2000MC   M01   Not yet paid
15.06.2000NL   M01   Not yet paid
15.06.2000PT   M01   Not yet paid
15.06.2000SE   M01   Not yet paid
Penalty fee Rule 85b EPC 1973
15.06.2000M01   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO9423572  (HUMAN CELL CULTURES INC) [Y] 1-11,13-15,17-20,26-30 * page 13, line 36 - page 24, line 12 * * see table from example 1 *;
 [A]WO9630492  (UNIV MINNESOTA) [A] 1 * page 18, lines 25-35; examples I-VII *;
 [A]WO9734999  (UNIV PITTSBURGH) [A] 1-11,13-15,17-20,26-30 * page 7, line 10 - page 8, line 30 * * page 13, line 20 - page 41, line 21 *;
 [A]WO9007007  (US GOVERNMENT) [A] 1-11 * page 1, lines 5-8; example 3 *;
 [A]WO9513697  (EINSTEIN COLL MED) [A] 1,18,21,30 * page 1, lines 7-18 * * page 11, line 21 - page 13, line 34 *;
 [A]WO9303142  (EINSTEIN COLL MED) [A] 1,11,18,22 * page 1, paragraph 1 - page 7, paragraph 1 * * page 8, paragraph 2 - page 10, paragraph 2 * * page 15, paragraph 2 - page 16, paragraph L *;
 [A]US4914032  (KURI-HARCUCH WALID ET AL) [A] 1,11,18,25,31 * column 4, line 10 - column 6, line 58 *;
 [PX]WO9821312  (RPMS TECHNOLOGY LTD ;SELDON CLARE (GB); HODGSON HUMPHREY (GB)) [PX] 1-11,13-15,17-20,26-30 * the whole document *
 [Y]  - SELDEN C ET AL, "HUMAN LIVER CELL LINES PROLIFERATE FREELY AND MAINTAIN THEIR DIFFERENTIATED PHENOTYPE SECRETING HIGH LEVELS OF LIVER SPECIFIC PROTEINS WHEN GROWN IN 3-DIMENSIONAL CULTURE FOR OVER 20 DAYS", HEPATOLOGY, (19961001), vol. 24, no. 4, PART 02, ISSN 0270-9139, page 134A, XP002056141 [Y] 1-11,13-15,17-20,26-30 * the whole document *
 [Y]  - SMALLEY M, "BEHAVIOUR OF A CELL LINE DERIVED FROM NORMAL HUMAN HEPATOCYTES ON NON-PHYSIOLOGICAL AND PHYSIOLOGICAL-TYPE SUBSTRATES", HEPATOLOGY, (19961001), vol. 24, no. 4, PART 02, ISSN 0270-9139, page 135A, XP000199197 [Y] 1-11,13-15,17-20,26-30 * the whole document *
 [A]  - H. HOSHI AND W.L. MCKEEHAN, "Brain- and liver cell-derived factors are required for growth of human endothelial cells in serum-free culture", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (1984), vol. 81, pages 6413 - 6417, XP002109854 [A] 1,9 * abstract * * page 6415 *

DOI:   http://dx.doi.org/10.1073/pnas.81.20.6413
 [A]  - MOONEY D ET AL, "SWITCHING FROM DIFFERENTIATION TO GROWTH IN HEPATOCYTES: CONTROL BYEXTRACELLULAR MATRIX", JOURNAL OF CELLULAR PHYSIOLOGY, (19920101), vol. 151, ISSN 0021-9541, pages 497 - 505, XP002040998 [A] 1,6,7

DOI:   http://dx.doi.org/10.1002/jcp.1041510308
 [A]  - B.A. NAUGHTON ET AL.,, "A stereotypic, transplatable liver tissue-culture system", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, (199509), vol. 54, no. 1-3, pages 65 - 91, XP002109855 [A] 1-6 * abstract * * pages 68-69 * * page 71, paragraph 2; table 1 * * pages 75-79 *
 [A]  - A.A. DEMETRIOU ET AL.,, "Hepatocyte transplantation. A potential treatment for liver disease", DIGESTIVE DISEASES AND SCIENCES, (199109), vol. 36, no. 9, pages 1320 - 1326, XP002109856 [A] 1-6,26-30 * the whole document *

DOI:   http://dx.doi.org/10.1007/BF01307530
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.