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Extract from the Register of European Patents

EP About this file: EP1097134

EP1097134 - ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  29.06.2007
Database last updated on 28.06.2024
Most recent event   Tooltip29.06.2007Application deemed to be withdrawnpublished on 01.08.2007  [2007/31]
Applicant(s)For all designated states
Ranbaxy Laboratories Limited
19, Nehru Place
New Delhi 110 019 / IN
[N/P]
Former [2001/19]For all designated states
RANBAXY LABORATORIES, LTD.
19, Nehru Place
New Delhi 110 019 / IN
Inventor(s)01 / ANAND, Nitya
B-62, Nirala Nagar, Lucknow 226 007
Uttar Pradesh / IN
02 / SINHA, Neelima
K-94, Sector-25, Noida 201 301
Uttar Pradesh / IN
03 / JAIN, Sanjay
K-55, Sector-25, Noida 201 301
Uttar Pradesh / IN
04 / MEHTA, Anita
L-19/3, Phase II-DLF, Qutab Enclave
Gurgaon, 122 001, Haryana / IN
05 / SAXENA, Anil Kumar
D-1051, Indira Nagar
Lucknow 266 01, Uttar Pradesh / IN
06 / GUPTA, Jang, Bahadur
C-41-B, Gangotri Enclave
Alaknanda, New Delhi 110 019 / IN
 [2001/19]
Representative(s)Cronin, Brian Harold John
CRONIN Intellectual Property Chemin de Précossy 31
1260 Nyon / CH
[N/P]
Former [2006/31]Cronin, Brian Harold John
Cronin Intellectual Property Route de Clémenty 62
1260 Nyon / CH
Former [2005/04]Gilholm, Stephen Philip
Ranbaxy Laboratories Ltd, 95 Park Lane
Mayfair, London W1K 7TE / GB
Former [2001/19]Cronin, Brian Harold John
Moinas Savoye & Cronin 42 rue Plantamour
1201 Genève / CH
Application number, filing date99929633.816.07.1999
[2001/19]
WO1999IB01296
Priority number, dateUS1998012026521.07.1998         Original published format: US 120265
WO1999IB0014026.01.1999         Original published format: PCT/IB99/00140
[2001/19]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO0005205
Date:03.02.2000
Language:EN
[2000/05]
Type: A1 Application with search report 
No.:EP1097134
Date:09.05.2001
Language:EN
The application published by WIPO in one of the EPO official languages on 03.02.2000 takes the place of the publication of the European patent application.
[2001/19]
Search report(s)International search report - published on:EP03.02.2000
ClassificationIPC:C07D207/40, C07D211/88, C07D401/06, A61K31/495
[2001/19]
CPC:
C07D207/404 (EP); C07D207/408 (EP); C07D211/88 (EP);
C07D401/06 (EP)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2001/19]
Extension statesAL21.02.2001
LT21.02.2001
LV21.02.2001
MK21.02.2001
RO21.02.2001
SI21.02.2001
TitleGerman:ARYLPIPERAZIN DERIVATE VERWENDBAR ALS URO-SELECTIEVE ALPHA-1-ADRENOZEPTORENBLOCKERN[2001/19]
English:ARYLPIPERAZINE DERIVATIVES USEFUL AS UROSELECTIVE ALPHA1-ADRENOCEPTOR BLOCKERS[2001/19]
French:DERIVES D'ARYLPIPERAZINE UTILISES COMME AGENTS BLOQUANTS LES RECEPTEURS ALPHA1-ADRENERGIQUES UROSELECTIFS[2001/19]
Entry into regional phase21.02.2001National basic fee paid 
21.02.2001Designation fee(s) paid 
21.02.2001Examination fee paid 
Examination procedure16.02.2000Request for preliminary examination filed
International Preliminary Examining Authority: EP
21.02.2001Examination requested  [2001/19]
17.06.2003Despatch of a communication from the examining division (Time limit: M06)
10.12.2003Reply to a communication from the examining division
06.08.2004Despatch of a communication from the examining division (Time limit: M06)
15.02.2005Reply to a communication from the examining division
01.02.2007Application deemed to be withdrawn, date of legal effect  [2007/31]
13.03.2007Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2007/31]
13.06.2007Cancellation of oral proceeding that was planned for 18.06.2007
13.06.2007Minutes of oral proceedings despatched
18.06.2007Date of oral proceedings (cancelled)
Fees paidRenewal fee
31.07.2001Renewal fee patent year 03
31.07.2002Renewal fee patent year 04
31.07.2003Renewal fee patent year 05
02.08.2004Renewal fee patent year 06
01.08.2005Renewal fee patent year 07
Penalty fee
Additional fee for renewal fee
31.07.200608   M06   Not yet paid
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Cited inInternational search[X]DE2242382  (PFIZER) [X] 1,2,26 * example -; claim 1 *;
 [X]EP0000220  (HOECHST AG [DE]) [X] 1,26 * see Table IV, 32,33;; example 7; claim 1 *;
 [X]EP0103357  (WARNER LAMBERT CO [US]) [X] 1,26 * page 13; claim 1 *;
 [X]US4479954  (HIROSE NORIYASU [JP], et al) [X] 1,2,26 * column 7, line 1 - line 2; claim 1 *;
 [X]US4675403  (ABOU-GHARBIA MAGID A [US], et al) [X] 1,26 * example 3; claim 1 *;
 [X]EP0748800  (HOFFMANN LA ROCHE [CH]) [X] 1,26,27,32,37,42 * page 40, line 1 - line 3; claims 1,21 *;
 [A]ES2094690  (UNIV MADRID COMPLUTENSE [ES]) [A] 1,26* abstract *;
 [X]  - MOKROSZ, MARIA J. ET AL, "Structure-activity relationship studies of CNS agents. Part 32. Effect o structural modifications in 1-arylpiperazine derivatives on.alpha.1-adrenoreceptor affinity", CHEMICAL ABSTRACTS, (19980105), vol. 128, no. 1, Database accession no. 128, XP002103455 [X] 1,26,27 * abstract *
    [ ] - CHEMICAL ABSTRACTS, Chemical Abstracts Service, XP002103462 [ ] * see compound with RN=159311-94-1 *
    [ ] - ARCH. PHARM. (WEINHEIM, GER.) (1997), 330(6), 177-180 ;ISSN: 0365-6233
 [X]  - KHADILKAR, B. M. ET AL, "Synthesis and hypotensive activity of some succinimide derivatives", CHEMICAL ABSTRACTS, (19930719), vol. 119, no. 3, Database accession no. 27951, XP002103456 [X] 1,2,26 * abstract *
    [ ] - CHEMICAL ABSTRACTS, Chemical Abstracts Service, XP002103463 [ ] * see compounds with RN=148304-50-1; 148304-49-8; 148304-48-7 *
    [ ] - INDIAN J. CHEM., SECT. B (1993), 32B(3), 338-42 ;ISSN: 0376-4699
 [X]  - WU, YAO-HUA ET AL, "Psychosedative agents. N-(4-phenyl-1-piperazinylalkyl)-substituted cycli imides", J. MED. CHEM. (1969), 12, 876-81, (1969), XP002103451 [X] 1,2,26 * table I *

DOI:   http://dx.doi.org/10.1021/jm00305a037
 [X]  - ISHIZUMI, KIKUO ET AL, "Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (tandospirone) and related compounds", CHEM. PHARM. BULL. (1991), 39(9), 2288-300 ;ISSN: 0009-2363, (1991), XP002103452 [X] 1,2,26 * the whole document *
 [X]  - KHADILKAR, B. M. ET AL, "Synthesis and pharmacology of some 2-[3-(4-aryl-1-piperazinyl)propyl]-1H- benz[de]isoquinolin-1,3(2H)-diones and -2,5-pyrrolidinediones", CHEMICAL ABSTRACTS, (19871123), vol. 107, no. 21, Database accession no. 198046, XP002103457 [X] 1,2,26 * abstract *
 [X]  - DIMOGLO, A. S. ET AL, "Study of structure-activity relations in a series of buspirone analogs using an electron-topological approach", CHEMICAL ABSTRACTS, (19980720), vol. 129, no. 3, Database accession no. 22916, XP002103458 [X] 1,26 * abstract *
    [ ] - CHEMICAL ABSTRACTS, Chemical Abstracts Service, XP002103464 [ ] * see compound with RN=25024-93-5 *
    [ ] - KHIM.-FARM. ZH. (1998), 32(1), 36-40 ;ISSN: 0023-1134
 [X]  - RYAN, M. J. ET AL, "CI-926 (3-[4-[4-(3-methylphenyl)-1-piperazinyl]butyl]-2,4- imidazolinedione): antihypertensive profile and pharmacology", CHEMICAL ABSTRACTS, (19861110), vol. 105, no. 19, Database accession no. 164679, XP002103459 [X] 1,26 * abstract *
 [X]  - CHILMONCZYK, ZDZISLAW ET AL, "Conformational flexibility of serotonin1A receptor ligands from crystallographic data. Updated model of the receptor pharmacophore", CHEMICAL ABSTRACTS, (19971027), vol. 127, no. 17, Database accession no. 234308, XP002103460 [X] 1,26 * abstract *
    [ ] - CHEMICAL ABSTRACTS, Chemical Abstracts Service, XP002103465 [ ] * see compound with RN=140245-72-3 *
 [X]  - HAYS, SHERYL J., "Synthesis of carbon-14 labeled CI-926 and CI-927, new antihypertensives", CHEMICAL ABSTRACTS, (19880118), vol. 108, no. 3, Database accession no. 21844, XP002103461 [X] 1,26 * abstract *
 [AD]  - B. KENNY ET AL, "Pharmacological Options in the Treatment of Benign Prostatic Hyperplasia", JOURNAL OF MEDICINAL CHEMISTRY., WASHINGTON US, (1997), vol. 40, no. 9, pages 1292 - 1315, XP002103453 [AD] 1,26,27,32

DOI:   http://dx.doi.org/10.1021/jm960697s
 [AD]  - P.E. CROSS ET AL, "Substituted trifluoromethyl phenyl piperazines as anorectic agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY.CHIMICA THERAPEUTICA., PARIS FR, (1977), vol. 12, no. 2, pages 173 - 176, XP002103454 [AD] 1,26,46
 [A]  - JERZY L MOKROSZ ET AL, "8-[4-[2-(1,2,3,4-tetrahydroisoquinolyl)butyl]-8-azaspiro[4,5]decane-7,9-dione: A new 5-HT1a receptor ligand with the same activity profile as buspirone", JOURNAL OF MEDICINAL CHEMISTRY, (19960101), vol. 5, no. 39, page 1125 1129, XP002074949 [A] 1,26 * see Chart 1 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.