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EP1100529
European procedure
Extract from the Register of European Patents
EP About this file: EP1100529
| EP1100529 - THYMOSIN BETA 4 PROMOTES WOUND REPAIR [Right-click to bookmark this link] | Status | Patent maintained as amended Status updated on 23.07.2010 Database last updated on 09.04.2026 | Most recent event Tooltip | 23.07.2010 | Patent maintained (B2 publication) | published on 25.08.2010 [2010/34] | Applicant(s) | For all designated states The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health Office of Technology Transfer Suite 325 6011 Executive Boulevard Rockville, MD 20852-3804 / US | [2010/34] |
| Former [2004/46] | For all designated states The Government of the United States of America, as repres. by the Secretary of Health and Human Services, Nat. Inst. of Health Office of Technology Transfer Suite 325 6011 Executive Boulevard Rockville, MD 20852-3804 / US | ||
| Former [2001/21] | For all designated states THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES c/o National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 / US | Inventor(s) | 01 /
KLEINMAN, Hynda, K., Building 30, Room 433 30Convent Drive, MSC-4370 Bethesda, MD 20892 / US | 02 /
GOLDSTEIN, Allan, George Washington University 2300 I Street, N.W. Washington, DC 20037 / US | 03 /
MALINDA, Katherine, M., Building 30, Room 433 30 Convent Drive, MSC-4370 Bethesda, MD 20892 / US | 04 /
SOSNE, Gabriel 25341 Ronald Court Oak Park, MI 48237 / US | [2004/46] |
| Former [2001/21] | 01 /
KLEINMAN, Hynda, K., Building 30, Room 433 30Convent Drive, MSC-4370 Bethesda, MD 20892 / US | ||
| 02 /
GOLDSTEIN, Allan, George Washington University 2300 I Street, N.W. Washingotn, DC 20037 / US | |||
| 03 /
MALINDA, Katherine, M., Building 30, Room 433 300 Convent Drive, MSC-4370 Bethesda, MD 20892 / US | |||
| 04 /
SOSNE, Gabriel 25341 Ronald Court Oak Park, MI 48237 / US | Representative(s) | Klunker, Hans-Friedrich Klunker Schmitt-Nilson Hirsch Patentanwälte Destouchesstrasse 68 80796 München / DE | [N/P] |
| Former [2005/51] | Klunker, Hans-Friedrich Patentanwälte Klunker . Schmitt-Nilson . Hirsch Winzererstrasse 106 80797 München / DE | ||
| Former [2001/21] | Wakerley, Helen Rachael Reddie & Grose, 16 Theobalds Road London WC1X 8PL / GB | Application number, filing date | 99937654.4 | 29.07.1999 | [2001/21] | WO1999US17282 | Priority number, date | US19980094690P | 30.07.1998 Original published format: US 94690 P | [2001/21] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO0006190 | Date: | 10.02.2000 | Language: | EN | [2000/06] | Type: | A1 Application with search report | No.: | EP1100529 | Date: | 23.05.2001 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.02.2000 takes the place of the publication of the European patent application. | [2001/21] | Type: | B1 Patent specification | No.: | EP1100529 | Date: | 06.04.2005 | Language: | EN | [2005/14] | Type: | B2 New European patent specification | No.: | EP1100529 | Date: | 25.08.2010 | Language: | EN | [2010/34] | Search report(s) | International search report - published on: | EP | 10.02.2000 | Classification | IPC: | A61K38/22, A61K39/395, A61P17/02 | [2004/45] | CPC: |
A61K38/2292 (EP,US);
A61K38/08 (EP,US);
A61K38/1841 (EP,US);
A61K45/06 (US);
A61K9/0048 (US);
A61P17/02 (EP);
A61P29/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
Y10S930/18 (EP,US)
(-)
| C-Set: |
A61K38/08, A61K2300/00 (US,EP);
A61K38/1841, A61K2300/00 (US,EP);
A61K38/2292, A61K2300/00 (EP,US)
|
| Former IPC [2001/21] | A61K38/22, A61K39/395 | Designated contracting states | AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2001/21] | Extension states | AL | Not yet paid | LT | Not yet paid | LV | Not yet paid | MK | Not yet paid | RO | Not yet paid | SI | Not yet paid | Title | German: | THYMOSIN BETA 4 STIMULIERT WUNDHEILUNG | [2001/21] | English: | THYMOSIN BETA 4 PROMOTES WOUND REPAIR | [2001/21] | French: | AMELIORATION DE LA GUERISON DES BLESSURES PAR LA THYMOSINE BETA 4 | [2001/21] | Entry into regional phase | 28.02.2001 | National basic fee paid | 28.02.2001 | Designation fee(s) paid | 28.02.2001 | Examination fee paid | Examination procedure | 10.02.2000 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 28.02.2001 | Examination requested [2001/21] | 01.05.2001 | Amendment by applicant (claims and/or description) | 28.06.2001 | Despatch of a communication from the examining division (Time limit: M06) | 31.12.2001 | Reply to a communication from the examining division | 18.01.2002 | Despatch of a communication from the examining division (Time limit: M04) | 24.05.2002 | Reply to a communication from the examining division | 28.06.2002 | Despatch of a communication from the examining division (Time limit: M06) | 23.12.2002 | Reply to a communication from the examining division | 17.03.2003 | Despatch of a communication from the examining division (Time limit: M06) | 01.08.2003 | Reply to a communication from the examining division | 12.11.2003 | Despatch of a communication from the examining division (Time limit: M01) | 12.12.2003 | Reply to a communication from the examining division | 27.04.2004 | Despatch of a communication from the examining division (Time limit: M04) | 27.08.2004 | Reply to a communication from the examining division | 29.09.2004 | Communication of intention to grant the patent | 28.01.2005 | Fee for grant paid | 28.01.2005 | Fee for publishing/printing paid | Divisional application(s) | EP04077891.2 Application deemed to be withdrawn : 23.10.2004 | EP04078459.7 / EP1591128 | EP10186120.1 / EP2311485 | Opposition(s) | Opponent(s) | 01
06.01.2006
19.01.2006
ADMISSIBLE Grannus Biosciences Limited 191 West George Street Glasgow G2 2LD / GB Opponent's representative Smaggasgale, Gillian Helen, et al, et al WP Thompson 138 Fetter Lane London EC4A 1BT / GB | [N/P] |
| Former [2006/10] | |||
| Opponent(s) | 01
06.01.2006
19.01.2006
ADMISSIBLE Grannus Biosciences Limited 191 West George Street Glasgow G2 2LD / GB Opponent's representative Smaggasgale, Gillian Helen, et al, et al W.P. Thompson & Co, 55 Drury Lane London WC2B 5SQ / GB | 14.02.2006 | Invitation to proprietor to file observations on the notice of opposition | 21.08.2006 | Reply of patent proprietor to notice(s) of opposition | 10.12.2009 | Legal effect of interlocutory decision in opposition | 10.12.2009 | Date of oral proceedings | 21.12.2009 | Despatch of interlocutory decision in opposition | 21.12.2009 | Despatch of minutes of oral proceedings | 08.04.2010 | Despatch of communication that the patent will be maintained as amended | 07.07.2010 | Fee for printing new specification paid | Fees paid | Renewal fee | 25.07.2001 | Renewal fee patent year 03 | 12.07.2002 | Renewal fee patent year 04 | 23.07.2003 | Renewal fee patent year 05 | 22.07.2004 | Renewal fee patent year 06 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | BE | 06.04.2005 | GR | 06.07.2005 | CY | 29.07.2005 | [2007/23] |
| Former [2006/14] | BE | 06.04.2005 | |
| GR | 06.07.2005 | ||
| Former [2006/13] | BE | 06.04.2005 | Cited in | International search | [XY] MALINDA K M ET AL: "Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.", FASEB JOURNAL, vol. 11, no. 6, May 1997 (1997-05-01), pages 474 - 481, XP002125695 [X] 1,2,5-8,13,16-19,23-28,31-35,38,53,57-64 * the whole document *[Y] 3,4,11,12,14,15,22,29,30,36,37 | [XY] SUN H -Q ET AL: "BETA-THYMOSINS ARE NOT SIMPLE ACTIN MONOMER BUFFERING PROTEINS. INSIGHTS FROM OVEREXPRESSION STUDIES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 16, April 1996 (1996-04-01), pages 9223 - 9230, XP002041936, ISSN: 0021-9258 [X] 1,2,8-10,13,19-21,23,24,26,53,60,62,63,45,46 * page 9223, column 1, line 15 - line 18 * * page 9229; figure 3 * * page 9224, section "Quantitative Immunoblotting" * * page 9227, column 1, line 5 - page 9228, column 1, line 3 * [Y] 11,22,36 DOI: http://dx.doi.org/10.1074/jbc.271.16.9223 | [YA] NIMNI M E: "Polypeptide growth factors: targeted delivery systems", BIOMATERIALS, vol. 18, no. 18, 1997, pages 1201 - 1225, XP004086390, ISSN: 0142-9612 [Y] 3,4,11,12,14,15,22,29,30,36,37 * page 1210, column 1, line 15 - line 53 * * page 1203 - page 1211 * * page 1205, section "Keloid and hypertrophic scars" * * pages 1215-1216, sections "Delivery of growth factors in wound healing" and "Some novel and potentially useful approaches for local delivery of growth factors" *[A] 38-40,54-61,64,41-44 DOI: http://dx.doi.org/10.1016/S0142-9612(97)00050-1 | [Y] FRANK, S ET AL: "Regulation of vascular endothelial growth factor expression in cultured keratinocytes and implications for normal and impaired wound healing", J. BIOL. CHEM., vol. 270, no. 21, May 1995 (1995-05-01), pages 12607 - 12613, XP002125696 [Y] 11,12,22,36,37 * page 12607, column 2, line 13 - line 26 * * page 12609, column 2, line 7 - line 12 * DOI: http://dx.doi.org/10.1074/jbc.270.21.12607 | [A] SABOLINSKI M L ET AL: "Cultured skin as a 'smart material' for healing wounds: experience in venous ulcers", BIOMATERIALS, vol. 17, no. 3, 1996, pages 311 - 320, XP004032797, ISSN: 0142-9612 [A] 26 * Introduction * DOI: http://dx.doi.org/10.1016/0142-9612(96)85569-4 | [A] HANNAPPEL E & WARTENBERG F: "Actin-sequestring ability of thymosin beta 4, thymosin beta 4 fragments and thymosin beta 4-like peptides as assessed by the DNAse I inhibition assay", BIOL. CHEM., vol. 374, February 1993 (1993-02-01), pages 117 - 122, XP002118663 [A] 1,2,9,10,20,21,23,24,62,63 * page 121, column 1, line 8 - column 2, line 17 * | Examination | WO9423739 | WO9509646 | JPH04234325 | EP0450240 | DATABASE WPI Week 199240, Derwent World Patents Index; Class B04, AN 1992-327505 [A] | by applicant | NODA ET AL., ENDOCRINOLOGY, vol. 124, 1989, pages 2991 - 2995 [X] 1,2,5-8,13,16-19,23-28,31-35,38,53,57-64 * the whole document * [Y] 3,4,11,12,14,15,22,29,30,36,37 | GOEY ET AL., J. LMMUNOL., vol. 143, 1989, pages 877 - 880 [X] 1,2,8-10,13,19-21,23,24,26,53,60,62,63,45,46 * page 9223, column 1, line 15 - line 18 * * page 9229; figure 3 * * page 9224, section "Quantitative Immunoblotting" * * page 9227, column 1, line 5 - page 9228, column 1, line 3 *[Y] 11,22,36 | PIETENPOL ET AL., PROC. NAT'L. ACAD SCI. USA, vol. 87, 1990, pages 3758 - 3762 [Y] 3,4,11,12,14,15,22,29,30,36,37 * page 1210, column 1, line 15 - line 53 * * page 1203 - page 1211 * * page 1205, section "Keloid and hypertrophic scars" * * pages 1215-1216, sections "Delivery of growth factors in wound healing" and "Some novel and potentially useful approaches for local delivery of growth factors" *[A] 38-40,54-61,64,41-44 | IGNOTZ ET AL., J. BIOL CHEM., vol. 261, 1986, pages 4337 - 4345 [A] 6,7,17,18,33,34,58,61,64 | MUSTOE ET AL., SCIENCE, vol. 237, 1987, pages 1333 - 1335 [Y] 11,12,22,36,37 * page 12607, column 2, line 13 - line 26 * * page 12609, column 2, line 7 - line 12 * | ROSS R. ET AL., PROC NAT' ACAD SCI USA, vol. 71, no. 4, pages 1207 - 1210 [A] 41-44,47-49 | KOHLER N. ET AL., EXP. CELL RES., vol. 87, 1974, pages 297 - 301 | PIERCE, GF ET AL., J. EXP. MED., vol. 167, 1988, pages 974 - 987 | GROTENDORST, GR ET AL., J. CLIN. INVEST., vol. 76, 1985, pages 2323 - 2329 [A] 26 * Introduction * | SPORN, MB ET AL., SCIENCE, vol. 219, 1983, pages 1329 [A] 1,2,9,10,20,21,23,24,62,63 * page 121, column 1, line 8 - column 2, line 17 * | CECH, J.AMER.MED. ASSN., vol. 260, 1988, pages 3030 | HASSELHOFF, NATURE, vol. 334, 1988, pages 585 | DE MESMAEKER ET AL.: "Backbone modifications in oligonucleotides and peptide nucleic acid systems", CURR. OPIN. STRUCT. BIOL, vol. 5, 1995, pages 343 - 355 | GEWIRTZ, A.M. ET AL.: "Facilitating delivery of antisense oligodeoxynucleotides: Helping antisense deliver on its promise", PROC. NATL. ACAD SCI. U.S.A., vol. 93, 1996, pages 3161 - 3163 | STEIN, C.A.: "A discussion of G-tetrads 1996. Exploiting the potential of antisense: beyond phosphorothioate oligodeoxynucleotides", CHEM. AND BIOL., vol. 3, pages 319 - 323 | MANNINO ET AL., BIOTECHNIQUES, vol. 6, 1988, pages 682 |