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EP About this file: EP1127157

EP1127157 - METHYLATED CpG ISLAND AMPLIFICATION (MCA) [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 22.08.2008 Database last updated on 14.09.2024
Most recent event Tooltip	22.08.2008	Application deemed to be withdrawn	published on 24.09.2008 [2008/39]
Applicant(s)	For all designated states THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE 720 Rutland Avenue Baltimore, MD 21205 / US
	[2001/35]
Inventor(s)	01 / Issa, Jean-Pierre 12310 Longworth Lane Houston, TX 77024 / US
	02 / Baylin, Stephen Apt. 419, Harbor Hill Apts., 301 Warren Avenue Baltimore, MD 21230 / US
	03 / Toyota, Minoru, c/o Sapporo University Cancer Res.Inst., Dept.Med.Biol. S-1,W-17, Chuo-ku Sapporo 060-8556 / JP
	[2002/42]
Former [2001/35]	01 / Issa, Jean-Pierre 12310 Longworth Lane Houston, TX 77024 / US
	02 / Baylin, Stephen Apt. 419, Harbor Hill Apts., 301 Warren Avenue Baltimore, MD 21230 / US
	03 / Toyota, Minoru Apt. 102, 6804 Harrowdale Road Baltimore, MD 21209 / US
Representative(s)	Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
	[N/P]
Former [2008/35]	Vossius & Partner Siebertstrasse 3 81675 München / DE
Former [2001/35]	VOSSIUS & PARTNER Siebertstrasse 4 81675 München / DE
Application number, filing date	99971462.9	02.11.1999
	[2001/35]
	WO1999US25251
Priority number, date	US19980106925P	03.11.1998 Original published format: US 106925 P
	US19990309175	10.05.1999 Original published format: US 309175
	[2001/35]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO0026401
	Date:	11.05.2000
	Language:	EN
	[2000/19]
	Type:	A1 Application with search report
	No.:	EP1127157
	Date:	29.08.2001
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 11.05.2000 takes the place of the publication of the European patent application.
	[2001/35]
Search report(s)	International search report - published on:	US	11.05.2000
	(Supplementary) European search report - dispatched on:	EP	18.09.2002
Classification	IPC:	C12Q1/44, C12Q1/48, C12Q1/68, C12P19/34, C12N9/22, C12N15/00, C07H21/02, C07H21/04	[2001/35]
	CPC:	C12Q1/48 (EP,US); C12Q1/6809 (EP,US); C12Q1/6855 (EP,US)
	C-Set:	C12Q1/6809, C12Q2531/113, C12Q2525/191, C12Q2521/331 (EP,US); C12Q1/6855, C12Q2521/331 (US,EP)
Designated contracting states	AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE [2001/35]
Title	German:	AMPLIFIKATION METHYLIERTER CpG-INSELN	[2001/35]
	English:	METHYLATED CpG ISLAND AMPLIFICATION (MCA)	[2001/35]
	French:	AMPLIFICATION D'ILOTS CpG METHYLES (MCA)	[2001/35]
Entry into regional phase	01.06.2001	National basic fee paid
	01.06.2001	Search fee paid
	01.06.2001	Designation fee(s) paid
	01.06.2001	Examination fee paid
Examination procedure	01.06.2000	Request for preliminary examination filed International Preliminary Examining Authority: US
	01.06.2001	Amendment by applicant (claims and/or description)
	01.06.2001	Examination requested [2001/35]
	11.05.2006	Despatch of a communication from the examining division (Time limit: M04)
	06.11.2006	Reply to a communication from the examining division
	17.11.2006	Despatch of a communication from the examining division (Time limit: M04)
	23.03.2007	Reply to a communication from the examining division
	17.04.2007	Despatch of a communication from the examining division (Time limit: M06)
	11.10.2007	Reply to a communication from the examining division
	15.11.2007	Despatch of a communication from the examining division (Time limit: M04)
	26.03.2008	Application deemed to be withdrawn, date of legal effect [2008/39]
	06.05.2008	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2008/39]
Fees paid	Renewal fee
	14.11.2001	Renewal fee patent year 03
	25.11.2002	Renewal fee patent year 04
	21.11.2003	Renewal fee patent year 05
	22.11.2004	Renewal fee patent year 06
	29.11.2005	Renewal fee patent year 07
	27.11.2006	Renewal fee patent year 08
	27.11.2007	Renewal fee patent year 09
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X] - KOHNO TAKASHI ET AL, "identification of CpG islands hypermethylated in human lung cancer the arbitrarily primed-PCR method.", HUMAN GENETICS, (199803), vol. 102, no. 3, ISSN 0340-6717, pages 258 - 264, XP002211910 [X] 7,8 * the whole document * DOI: http://dx.doi.org/10.1007/s004390050689
		[X] - USHIJIMA T ET AL, "ESTABLISHMENT OF METHYLATION-SENSITIVE-REPRESENTATIONAL DIFFERENCE ANALYSIS AND ISOLATION OF HYPO- AND HYPERMETHYLATED GENOMIC FRAGMENTS IN MOUSE LIVER TUMORS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, (199703), vol. 94, no. 6, ISSN 0027-8424, pages 2284 - 2289, XP001037969 [X] 7,8 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.94.6.2284
		[PX] - TOYOTA MINORU ET AL, "Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.", CANCER RESEARCH, (19990515), vol. 59, no. 10, ISSN 0008-5472, pages 2307 - 2312, XP002211911 [PX] 1-49 * the whole document *
	International search	[Y]WO9745560 (NORTH SHORE UNIV HOSPITAL [US]);
		[Y]WO9635704 (UNIV JOHNS HOPKINS MED [US]);
		[A]US5786146 (HERMAN JAMES G [US], et al);
		[AP]US5912147 (STOLER DANIEL [US], et al);
		[A]US5501964 (WIGLER MICHAEL [US], et al);
		[Y] - ZRIHAN-LICHT ET AL., "DNA methylation status of the Mucl gene coding for a breast-cancer-associated protein", INT. J. CANCER,, (199507), vol. 62, no. 3, pages 245-251 - 246-259, XP002927716 DOI: http://dx.doi.org/10.1002/ijc.2910620303
		[Y] - MERLO A, HERMAN J G, "DNA METHYLATION AND INACTIVATION OF TUMOR SUPPRESSOR GENES", HEREDITARY CANCER, XX, XX, XX, (19950901), pages 152 - 160, XP002927717
		[Y] - WEST ET AL., "Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient", J. MOL. NEUROSCIENCE,, (1995), vol. 6, no. 2, pages 141 - 146, XP002927718
		[A] - AHUJA ET AL., "Association between CpG island methylation and microsatellite instability in colorectal cancer", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH,, (199703), vol. 38, pages 360 - 361, XP002927719
		[A] - LISITSYN ET AL., "Cloning the differences between two complex genomes", SCIENCE,, (19930212), vol. 259, pages 946 - 951, XP002927720 DOI: http://dx.doi.org/10.1126/science.8438152

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