| EP1951304 - METHOD FOR TREATING JOINT DAMAGE [Right-click to bookmark this link] | Status | Patent revoked Status updated on 10.12.2021 Database last updated on 14.03.2026 | |
| Former | The patent has been granted Status updated on 15.11.2018 | Most recent event Tooltip | 08.03.2024 | Petition for review: decision | published on 10.04.2024 [2024/15] | Applicant(s) | For all designated states F. Hoffmann-La Roche AG Grenzacherstrasse 124 4002 Basel / CH | For all designated states Biogen Idec Inc. 14 Cambridge Center Cambridge, MA 02142 / US | For all designated states Genentech, Inc. 1 DNA Way South San Francisco, CA 94080-4990 / US | [N/P] |
| Former [2008/38] | For all designated states F. Hoffmann-La Roche AG Grenzacherstrasse 124 4002 Basel / CH | ||
| For all designated states Biogen Idec Inc. 14 Cambridge Center Cambridge, MA 02142 / US | |||
| For all designated states Genentech, Inc. 1 DNA Way South San Francisco CA 94080-4990 / US | |||
| Former [2008/32] | For all designated states F. Hoffmann-La Roche AG Grenzacherstrasse 124 4002 Basel / CH | ||
| For all designated states Biogen Idec Inc. 14 Cambridge Center Cambridge, MA 02142 / US | |||
| For all designated states Genentech, Inc. 1 DNA Way South San Francisco, CA 94080 / US | Inventor(s) | 01 /
TOTORITIS, Mark 15797 Caminito Cantaras Del Mar, CA 92014 / US | 02 /
SHAW, Timothy Mark 3 Brackenhill Berkhamsted Hertfordshire / GB | 03 /
AGARWAL, Sunil 4 Wildflower Court Corte Madera, CA 94925 / US | 04 /
YOCUM, David 1149 Shoreline Drive San Mateo, CA 94404 / US | 05 /
KELMAN, Ariella 1732 Jackson Street, 204 South San Francisco, CA 94109 / US | [2014/43] |
| Former [2008/32] | 01 /
TOTORITIS, Mark 15797 Caminito Cantaras Del Mar, CA 92014 / US | ||
| 02 /
SHAW, Timothy Mark 3 Brackenhill Berkhamsted Hertfordshire / GB | |||
| 03 /
AGARWAL, Sunil 4 Wildflower Court Corte Madera, CA 94925 / US | |||
| 04 /
YOCUM, David 1149 Shoreline Drive San Mateo, CA 94404 / US | |||
| 05 /
KELMAN, Ariella 1732 Jackson Street, 204 South San Francisco, CA 94109 / US | Representative(s) | Mewburn Ellis LLP Aurora Building Counterslip Bristol BS1 6BX / GB | [N/P] |
| Former [2014/43] | Walton, Seán Malcolm, et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS / GB | ||
| Former [2008/32] | Walton, Seán Malcolm, et al Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP / GB | Application number, filing date | 06837634.2 | 14.11.2006 | [2008/32] | WO2006US44290 | Priority number, date | US20050737291P | 15.11.2005 Original published format: US 737291 P | US20060864463P | 06.11.2006 Original published format: US 864463 P | [2008/32] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2007059188 | Date: | 24.05.2007 | Language: | EN | [2007/21] | Type: | A1 Application with search report | No.: | EP1951304 | Date: | 06.08.2008 | Language: | EN | The application published by WIPO in one of the EPO official languages on 24.05.2007 takes the place of the publication of the European patent application. | [2008/32] | Type: | B1 Patent specification | No.: | EP1951304 | Date: | 22.10.2014 | Language: | EN | [2014/43] | Search report(s) | International search report - published on: | EP | 24.05.2007 | Classification | IPC: | A61K39/395, A61P19/02, A61K31/00, C07K16/28 | [2008/32] | CPC: |
C07K16/2896 (EP,US);
A61K39/395 (KR);
C07K16/2887 (US);
A61K31/519 (US);
A61K39/3955 (US);
A61K45/06 (US);
A61K47/6849 (EP,US);
A61K9/0053 (KR);
A61K9/20 (KR);
A61P1/04 (EP);
A61P17/06 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P29/00 (EP);
A61P37/00 (EP);
A61P37/06 (EP);
A61P43/00 (EP);
C07K16/28 (KR);
A61K2039/505 (EP,US);
C07K2317/24 (EP,US);
C07K2317/56 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2008/32] | Extension states | AL | 03.06.2008 | BA | 03.06.2008 | HR | 03.06.2008 | MK | 03.06.2008 | RS | 03.06.2008 | Title | German: | VERFAHREN ZUR BEHANDLUNG VON GELENKSCHÄDEN | [2008/32] | English: | METHOD FOR TREATING JOINT DAMAGE | [2008/32] | French: | PROCEDE DESTINE A TRAITER UNE LESION ARTICULAIRE | [2008/32] | Entry into regional phase | 03.06.2008 | National basic fee paid | 03.06.2008 | Designation fee(s) paid | 03.06.2008 | Examination fee paid | Examination procedure | 04.06.2008 | Amendment by applicant (claims and/or description) | 04.06.2008 | Examination requested [2008/32] | 13.01.2009 | Despatch of a communication from the examining division (Time limit: M06) | 10.11.2009 | Reply to a communication from the examining division | 04.06.2010 | Despatch of a communication from the examining division (Time limit: M06) | 17.02.2011 | Reply to a communication from the examining division | 19.07.2011 | Despatch of a communication from the examining division (Time limit: M04) | 28.10.2011 | Reply to a communication from the examining division | 19.07.2012 | Observations by third parties | 20.08.2012 | Despatch of a communication from the examining division (Time limit: M02) | 29.10.2012 | Reply to a communication from the examining division | 18.12.2012 | Observations by third parties | 31.05.2013 | Observations by third parties | 15.07.2013 | Despatch of a communication from the examining division (Time limit: M06) | 21.02.2014 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 01.05.2014 | Reply to a communication from the examining division | 15.07.2014 | Observations by third parties | 29.07.2014 | Communication of intention to grant the patent | 31.07.2014 | Fee for grant paid | 31.07.2014 | Fee for publishing/printing paid | 31.07.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | EP13178006.6 Application deemed to be withdrawn : 27.08.2013 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 13.01.2009 | Opposition(s) | Opponent(s) | 01
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21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE | 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 3 Noble Street London EC2V 7BQ / GB | 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park Building Z0 Route de Crassier 1 1262 Eysins / CH | 04
22.07.2015
06.11.2023
WITHDRAWN European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Breuer, Markus Sendlinger Straße 29 80331 München / DE | 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | 08
07.04.2017
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INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE | 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT | [N/P] |
| Former [2023/51] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park Building Z0 Route de Crassier 1 1262 Eysins / CH | |||
| 04
22.07.2015
06.11.2023
WITHDRAWN European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Breuer, Markus Sendlinger Straße 29 80331 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
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12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT | |||
| Former [2023/47] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park Building Z0 Route de Crassier 1 1262 Eysins / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Breuer, Markus Sendlinger Straße 29 80331 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2020/47] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park Building Z0 Route de Crassier 1 1262 Eysins / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
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ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Breuer, Markus Brienner Straße 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2019/41] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park Building Z0 Route de Crassier 1 1262 Eysins / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Breuer, Markus Brienner Straße 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2019/17] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park A2 Route de Crassier 15 1162 Eysins / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
19.03.2019
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Brienner Strasse 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2018/25] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Terre Bonne Business Park A2 Route de Crassier 15 1162 Eysins / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Brienner Strasse 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2017/48] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Brienner Strasse 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2017/47] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Brienner Strasse 1 80333 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP Lacon London 84 Theobalds Road London WC1X 8NL / GB | |||
| Former [2017/30] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
INTERVENTION ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 09
10.04.2017
18.04.2017
INTERVENTION Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| Former [2017/20] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| 08
07.04.2017
12.04.2017
ADMISSIBLE Mundipharma GmbH Mundipharma Strasse 2 65549 Limburg / DE Opponent's representative Cornish, Kristina Victoria Joy, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 09
10.04.2017
INTERVENTION ADMISSIBLE Mundipharma Pharmaceutical s.r.l Via Serbelloni, n. 4 Milan / IT Opponent's representative Briscoe, Paul Brian, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| Former [2015/47] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Limited 20 Red Lion Street London WC1R 4PJ / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| Former [2015/41] | |||
| Opponent(s) | 01
21.07.2015
21.08.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
21.08.2015
ADMISSIBLE Boehringer Ingelheim Pharma GmbH & Co. KG/ Boehringer Ingelheim International GmbH Binger Straße 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
21.08.2015
ADMISSIBLE Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
21.08.2015
ADMISSIBLE European Oppositions Ltd 12 New Fetter Lane London EC4A 1AG / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
21.08.2015
ADMISSIBLE Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
21.08.2015
ADMISSIBLE Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| 07
22.07.2015
21.08.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| Former [2015/37] | |||
| Opponent(s) | 01
21.07.2015
ADMISSIBLE Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Binger Strasse 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
European Oppositions Ltd 12 New Fetter Lane London EC4A 1AG / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
WITHDRAWN Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| 07
22.07.2015
ADMISSIBLE Celltrion, Inc. 23 Academy-ro Yeonsu-gu Incheon 406-840 / KR Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | |||
| Former [2015/36] | |||
| Opponent(s) | 01
21.07.2015
Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Binger Strasse 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
European Oppositions Ltd 12 New Fetter Lane London EC4A 1AG / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | |||
| 06
22.07.2015
Hexal AG Industriestrasse 25 83607 Holzkirchen / DE Opponent's representative Henkel, Breuer & Partner Patentanwälte Erika-Mann Strasse 23 80636 München / DE | |||
| Former [2015/35] | |||
| Opponent(s) | 01
21.07.2015
Richter Gedeon Nyrt. Gyömröi út 19-21 1103 Budapest / HU Opponent's representative Neuefeind, Regina Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
| 02
21.07.2015
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Binger Strasse 173 55216 Ingelheim am Rhein / DE Opponent's representative D Young & Co LLP 120 Holborn London EC1N 2DY / GB | |||
| 03
21.07.2015
Merck Serono S.A. Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH Opponent's representative Merck Serono S.A. Intellectual Property Zone Industrielle de l'Ouriettaz 1170 Aubonne / CH | |||
| 04
22.07.2015
European Oppositions Ltd 12 New Fetter Lane London EC4A 1AG / GB Opponent's representative Care, Alison, et al, et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ / GB | |||
| 05
22.07.2015
Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB Opponent's representative Royle, Matthew Charles James Taylor Wessing LLP 5 New Street Square London EC4A 3TW / GB | 01.09.2015 | Invitation to proprietor to file observations on the notice of opposition | 11.05.2016 | Reply of patent proprietor to notice(s) of opposition | 22.06.2017 | No. 09: Notification indicating deficiencies in the notice of opposition | 04.09.2017 | No. 09: Reply to notification indicating deficiencies in the notice of opposition | 27.06.2018 | Date of oral proceedings | 16.11.2018 | Despatch of minutes of oral proceedings | 16.11.2018 | Despatch of communication that the patent will be revoked | 01.10.2020 | Legal effect of revocation of patent [2022/02] | Appeal following opposition | 05.12.2018 | Appeal received No. T2842/18 | 26.03.2019 | Statement of grounds filed | 01.10.2020 | Result of appeal procedure: appeal of the proprietor was rejected | 19.03.2021 | Despatch of the decision of the Board of Appeal | 01.10.2020 | Date of oral proceedings | Petition(s) for review: | Petition for review received | Number: R0007/21 | for appeal No. T2842/18-3304 | Petitioner: APPR | 24.11.2023 | Decision: Rejection of petition for review. | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 17.02.2011 | Request for further processing filed | 17.02.2011 | Full payment received (date of receipt of payment) Request granted | 02.03.2011 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the examination report | 01.05.2014 | Request for further processing filed | 01.05.2014 | Full payment received (date of receipt of payment) Request granted | 15.05.2014 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the examination report | 10.11.2009 | Request for further processing filed | 10.11.2009 | Full payment received (date of receipt of payment) Request granted | 25.11.2009 | Decision despatched | Fees paid | Renewal fee | 03.06.2008 | Renewal fee patent year 03 | 12.11.2009 | Renewal fee patent year 04 | 12.11.2010 | Renewal fee patent year 05 | 14.11.2011 | Renewal fee patent year 06 | 13.11.2012 | Renewal fee patent year 07 | 07.11.2013 | Renewal fee patent year 08 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | IS | 22.02.2015 | GB | 19.02.2016 | [2016/23] |
| Former [2015/23] | IS | 22.02.2015 | Cited in | International search | [X] WO0222212 (IDEC PHARMA CORP et al.) [X] 1-61,65-98,101-112 * example 1; claim 34 * | [X] WO2005060999 (GENENTECH INC et al.) [X] 1-112 * page 12, line 19 - page 14, column 1, line 14; claims 1-7 * * example 1 * | [X] US2004202658 (BENYUNES MARK C et al.) [X] 1-112 * example 1; claim 12 * | [X] WO0067796 (GENENTECH INC et al.) [X] 1-61,65-98,101-112 * example 1 * | [X] WO2004056312 (GENENTECH INC et al.) [X] 1-61,65-98,101-112 * examples 3,6,16; sequences 21, 22 * | [X] WO2004091657 (GENENTECH INC et al.) [X] 1-112 * example 1; sequences 1-4 * | [X] PROTHEREO A ET AL: "REMISSION OF INFLAMMATORY ARTHROPATHY IN ASSOCIATION WITH ANTI-CD20THERAPY FOR NON-HODGKIN'S LYMPHOMA", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, vol. 38, no. 11, November 1999 (1999-11-01), pages 1150 - 1152, XP000942661, ISSN: 1462-0324 [X] 1-61,65-98,101-112 * the whole document * DOI: http://dx.doi.org/10.1093/rheumatology/38.11.1150 | [X] EDWARDS J C W ET AL: "Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, vol. 40, no. 2, February 2001 (2001-02-01), pages 205 - 211, XP002348931, ISSN: 1462-0324 [X] 1-61,65-98,101-112 * page 206, column RIGHT, paragraph 2; tables 1,2 * * page 207, column LEFT, paragraphs 2-4 * DOI: http://dx.doi.org/10.1093/rheumatology/40.2.205 | [X] KNEITZ C ET AL: "Improvement of refractory rheumatoid arthritis after depletion of B cells.", SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 2004, vol. 33, no. 2, 2004, pages 82 - 86, XP008076371, ISSN: 0300-9742 [X] 1-61,65-98,101-112 * page 82, column RIGHT, paragraph LAST - page 83, column LEFT, line 1; table 1 * * page 83, column LEFT, paragraph 2 * * page 85, column RIGHT, paragraph LAST * DOI: http://dx.doi.org/10.1080/03009740310004379 | [X] GENENTECH: "Phase III Study Shows Rituxan Significantly Improves Symptoms in Patients with Rheumatoid Arthritis Who Inadequately Responded to Anti-TNF Therapies", GENENTECH PRESS RELEASE, 5 April 2005 (2005-04-05), Internet, pages 1 - 2, XP002425321, Retrieved from the Internet | [X] EDWARDS: "Efficacy and Safety of Rituximab, a B-Cell Targeted Chimeric Monoclonal Antibody: A Randomized, Placebo-Controlled Trial in Patients with Rheumatoid Arthritis", ARTHRITIS & RHEUMATISM, vol. 46, no. 9suppl, 25 October 2002 (2002-10-25) - 29 October 2002 (2002-10-29), USA, XP002425322, Retrieved from the Internet | [X] EMERY: "PRIMARY ANALYSIS OF A DOUBLE-BLIND, PLACEBO-CONTROLLED, DOSE-RANGING TRIAL OF RITUXIMAB, AN ANTI-CD20 MONOCLONAL ANTIBODY, IN PATIENTS WITH RHEUMATOID ARTHRITIS RECEIVING METHOTREXATE (DANCER TRIAL", ANNALS OF THE RHEUMATIC DISEASES, vol. 64, no. suppl3, June 2005 (2005-06-01), pages 1 - 2, XP002425323, Retrieved from the Internet DOI: http://dx.doi.org/10.1136/ard.2004.025072 | [X] LEANDRO M J ET AL: "Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 61, no. 10, October 2002 (2002-10-01), pages 883 - 888, XP002348932, ISSN: 0003-4967 [X] 1-61,65-98,101-112 * page 884; tables 1,2 * DOI: http://dx.doi.org/10.1136/ard.61.10.883 | [X] DE VITA SALVATORE ET AL: "Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells", ARTHRITIS AND RHEUMATISM, LIPPINCOTT, PHILADELPHIA, US, vol. 46, no. 8, August 2002 (2002-08-01), pages 2029 - 2033, XP002306249, ISSN: 0004-3591 [X] 1-112 * page 2032, column LEFT, paragraph LAST; tables 1,2 * | [X] MOORE J ET AL: "A phase II study of Rituximab in rheumatoid arthritis patients with recurrent disease following haematopoietic stem cell transplantation.", BONE MARROW TRANSPLANTATION AUG 2004, vol. 34, no. 3, August 2004 (2004-08-01), pages 241 - 247, XP002425324, ISSN: 0268-3369 [X] 1-61,65-98,101-112 * page 242, column LEFT, paragraph 2 * * page 245, column RIGHT, paragraph 2 - page 246, column LEFT, paragraph LAST * DOI: http://dx.doi.org/10.1038/sj.bmt.1704570 | [X] GOTTENBERG J-E ET AL: "Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases.", ANNALS OF THE RHEUMATIC DISEASES JUN 2005, vol. 64, no. 6, June 2005 (2005-06-01), pages 913 - 920, XP002425325, ISSN: 0003-4967 [X] 1-61,65-98,101-112 * page 916, column LEFT, paragraph 5; table 1 * DOI: http://dx.doi.org/10.1136/ard.2004.029694 | [X] ANONYMOUS: "MabThera highly effective in treating rheumatoid arthritis", NEWS-MEDICAL.NET, 9 June 2005 (2005-06-09), pages 1 - 2, XP002425326, Retrieved from the Internet | [X] HIGASHIDA: "Safety and Efficacy of Rituximab in the Treatment of Refractory Rheumatoid Arthritis. Session Type: Poster Session 139-I", BLOOD, vol. 102, no. 11, 16 November 2003 (2003-11-16), USA, pages 1, XP002425327 [X] 1-61,65-98,101-112 * abstract * DOI: http://dx.doi.org/10.1182/blood-2003-05-1447 | [X] ANONYMOUS, NCT00077870: "A Safety Study of Escalating Doses of PRO70769 for Subjects With Moderate to Severe Rheumatoid Arthritis Receiving Stable Doses of Concomitant Methotrexate", CLINICALTRIALS.GOV, 12 February 2004 (2004-02-12) - 12 August 2005 (2005-08-12), internet, pages 1 - 3, XP002425328, Retrieved from the Internet | [A] EDWARDS J C W ET AL: "B LYMPHOCYTE DEPLETION THERAPY WITH RITUXIMAB IN RHEUMATOID ARTHRITIS", RHEUMATIC DISEASES CLINICS OF NORTH AMERICA, W.B. SAUNDERS, PHILADELPHIA, PA, US, vol. 30, no. 2, 2004, pages 393 - 403, XP008076293, ISSN: 0889-857X [A] 1-112 * page 398, paragraph 3 * * page 396, paragraph 4 - page 397, paragraph 4 * DOI: http://dx.doi.org/10.1016/j.rdc.2004.01.006 | [X] GENENTECH: "Biogen Idec and Genentech Announce FDA Acceptance of Supplemental Biologics License Application and Priority Review Designation for Rituxan in Rheumatoid Arthritis", INTERNET ARTICLE, 31 October 2005 (2005-10-31), USA, pages 1 - 2, XP002425329, Retrieved from the Internet | [PX] HIBBLE: "Rehaumatoid arthritis - MabThera provides lasting benefits", MEDICAL NEWS TODAY, 21 November 2005 (2005-11-21), pages 1 - 2, XP002425335, Retrieved from the Internet | [A] EDWARDS J C W ET AL: "B-lymphocyte depletion therapy in rheumatoid arthritis and other autoimmune disorders", BIOCHEMICAL SOCIETY TRANSACTIONS, COLCHESTER, ESSEX, GB, vol. 30, no. 4, August 2002 (2002-08-01), pages 824 - 828, XP002306250, ISSN: 0300-5127 [A] * page 826, column RIGHT, paragraph 4 - page 827, paragraph 3; table 1 * DOI: http://dx.doi.org/10.1042/BST0300824 | [A] FIELDS: "Rituximab in the treatment of rheumatoid arthritis, systemic lupus, and other autoimmune diseases: past, present, and future Special Report", HOSPITAL OF SPECIAL SURGERY, 25 October 2002 (2002-10-25), pages 1 - 9, XP002425336, Retrieved from the Internet | [PX] BATHON: "Rheumatoid arthritis treatments", THE JOHN HOPKINS ARTHRITIS CENTER, 2005 AMERICAN COLEGE OF RHEUMATOLOGY, - 17 November 2005 (2005-11-17), USA, pages 1 - 12, XP002425337, Retrieved from the Internet | Examination | MEASE PHILIP J ET AL: "Efficacy and safety of retreatment in patients with rheumatoid arthritis with previous inadequate response to tumor necrosis factor inhibitors: results from the SUNRISE trial.", THE JOURNAL OF RHEUMATOLOGY MAY 2010 LNKD- PUBMED:20194448, vol. 37, no. 5, May 2010 (2010-05-01), pages 917 - 927, ISSN: 0315-162X | EUROPEAN MEDICINES AGENCY: "Summary of product characteristics", 30 October 2009 (2009-10-30), pages 1 - 91, Retrieved from the Internet | FDA: "Rituxan: prescribing information", 1997, USA, pages 1 - 38 | PAVELKA K ET AL: "Efficacy and safety following repeated courses of rituximab in patients with active rheumatoid arthritis", ANNALS OF THE RHEUMATIC DISEASES, vol. 64, no. 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