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Extract from the Register of European Patents

EP About this file: EP2086642

EP2086642 - DNASE FOR THE TREATMENT OF MALE SUB-FERTILITY [Right-click to bookmark this link]
Former [2009/33]METHOD AND PHARMACOLOGICAL COMPOSITION FOR THE DIAGNOSIS AND TREATMENT OF MALE SUB-FERTILITY
[2014/02]
StatusNo opposition filed within time limit
Status updated on  01.05.2015
Database last updated on 01.04.2026
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): MT		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
Periness Ltd.
Ramat Ilan 1 Oranom Street
54052 Givat Shmuel / IL
[2009/33]
Inventor(s)01 / BARTOOV, Benjamin
119 Mevo Hagefen Street
50295 Moshav Hemed / IL
02 / YEHUDA, Ronen
18 Bar Ilan Street
44378 Kfar Saba / IL
03 / DOBROSLAV, Melamed
7/6 Haroe Street
52422 Ramat Gan / IL
 [2009/33]
Representative(s)Duffy, Assumpta Dympna, et al
FRKelly
27 Clyde Road
Dublin D04 F838 / IE
[N/P]
Former [2014/26]Duffy, Assumpta Dympna, et al
FRKelly
27 Clyde Road
Ballsbridge
Dublin 4 / IE
Former [2009/33]Duffy, Assumpta Dympna, et al
FRKelly 27 Clyde Road Ballsbridge
Dublin 4 / IE
Application number, filing date07827224.218.10.2007
[2009/33]
WO2007IL01250
Priority number, dateUS20060852402P18.10.2006         Original published format: US 852402 P
[2009/33]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008047364
Date:24.04.2008
Language:EN
[2008/17]
Type: A2 Application without search report 
No.:EP2086642
Date:12.08.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 24.04.2008 takes the place of the publication of the European patent application.
[2009/33]
Type: B1 Patent specification 
No.:EP2086642
Date:25.06.2014
Language:EN
[2014/26]
Search report(s)International search report - published on:EP28.08.2008
ClassificationIPC:A61K38/48, A61P15/08
[2014/02]
CPC:
A61K31/00 (EP,US); A61K38/465 (EP,CN,US); A61K38/46 (US);
A61K31/194 (EP,US); A61K38/14 (US); A61K38/1709 (EP,US);
A61P15/08 (EP); C12Y301/21001 (CN); G01N33/689 (EP,US);
G01N2333/922 (EP,US); G01N2510/00 (EP,US); Y10T436/143333 (EP,US) (-)
Former IPC [2009/33]A61P15/08, A61K45/06, A61K31/00, A61K45/08, A61K31/194, G01N33/50, A61K38/17
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/33]
TitleGerman:DNASE ZUR BEHANDLUNG VON SUBFERTILITÄT BEIM MANN[2014/02]
English:DNASE FOR THE TREATMENT OF MALE SUB-FERTILITY[2014/02]
French:DNASE DESTINÉE AU TRAITEMENT DE L'HYPOFERTILITÉ MASCULINE[2014/02]
Former [2009/33]VERFAHREN UND PHARMAKOLOGISCHE ZUSAMMENSETZUNG ZUR DIAGNOSE UND BEHANDLUNG VON SUBFERTILITÄT BEIM MANN
Former [2009/33]METHOD AND PHARMACOLOGICAL COMPOSITION FOR THE DIAGNOSIS AND TREATMENT OF MALE SUB-FERTILITY
Former [2009/33]COMPOSITION PHARMACEUTIQUE DESTINÉE AU DIAGNOSTIC ET AU TRAITEMENT DE L'HYPOFERTILITÉ MASCULINE
Entry into regional phase18.05.2009National basic fee paid 
18.05.2009Designation fee(s) paid 
18.05.2009Examination fee paid 
Examination procedure18.05.2009Examination requested  [2009/33]
25.05.2009Amendment by applicant (claims and/or description)
28.09.2009Despatch of a communication from the examining division (Time limit: M04)
08.12.2009Reply to a communication from the examining division
14.11.2012Despatch of a communication from the examining division (Time limit: M06)
09.05.2013Reply to a communication from the examining division
30.01.2014Communication of intention to grant the patent
19.05.2014Fee for grant paid
19.05.2014Fee for publishing/printing paid
19.05.2014Receipt of the translation of the claim(s)
Divisional application(s)EP11183174.9  / EP2416155
EP11183184.8  / EP2416156
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.09.2009
Opposition(s)26.03.2015No opposition filed within time limit [2015/23]
Fees paidRenewal fee
02.11.2009Renewal fee patent year 03
02.11.2010Renewal fee patent year 04
31.10.2011Renewal fee patent year 05
31.10.2012Renewal fee patent year 06
31.10.2013Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipBG25.06.2014
CY25.06.2014
EE25.06.2014
LT25.06.2014
MC25.06.2014
MT25.06.2014
RO25.06.2014
SI25.06.2014
LU18.10.2014
IS25.10.2014
[2016/33]
Former [2016/25]BG25.06.2014
CY25.06.2014
EE25.06.2014
LT25.06.2014
MC25.06.2014
RO25.06.2014
SI25.06.2014
LU18.10.2014
IS25.10.2014
Former [2015/50]CY25.06.2014
EE25.06.2014
LT25.06.2014
MC25.06.2014
RO25.06.2014
SI25.06.2014
LU18.10.2014
IS25.10.2014
Former [2015/27]CY25.06.2014
EE25.06.2014
LT25.06.2014
MC25.06.2014
RO25.06.2014
LU18.10.2014
IS25.10.2014
Former [2015/26]CY25.06.2014
EE25.06.2014
LT25.06.2014
RO25.06.2014
LU18.10.2014
IS25.10.2014
Former [2015/12]CY25.06.2014
EE25.06.2014
LT25.06.2014
RO25.06.2014
IS25.10.2014
Former [2015/11]CY25.06.2014
EE25.06.2014
LT25.06.2014
RO25.06.2014
Former [2015/10]CY25.06.2014
EE25.06.2014
LT25.06.2014
Former [2014/48]CY25.06.2014
LT25.06.2014
Former [2014/47]CY25.06.2014
Cited inInternational search[XY]   ALGHAMDI ABDORRAHMAN S ET AL: "Seminal DNase frees spermatozoa entangled in neutrophil extracellular traps", BIOLOGY OF REPRODUCTION, SOCIETY FOR THE STUDY OF REPRODUCTION, CHAMPAIGN, IL, US, vol. 73, no. 6, December 2005 (2005-12-01), pages 1174 - 1181, XP002448788, ISSN: 0006-3363 [X] 17-20,33 * abstract * * page 1179, column L, paragraph 4 - page 1180, column L, paragraph 2 *[Y] 1-7,21-23

DOI:   http://dx.doi.org/10.1095/biolreprod.105.045666
 [XY]   MCCAULEY T C ET AL: "PURIFICATION AND CHARATERIZATION OF FERTILITY-ASSOCIATED ANTIGEN (FAA) IN BOVINE SEMINAL FLUID", MOLECULAR REPRODUCTION AND DEVELOPMENT, LISSS, NEW YORK, NY, US, vol. 54, 1999, pages 145 - 153, XP002946841, ISSN: 1040-452X [X] 17,33 * abstract * * page 151, column R, paragraph 4 * [Y] 1-7,18-23

DOI:   http://dx.doi.org/10.1002/(SICI)1098-2795(199910)54:2<145::AID-MRD6>3.0.CO;2-6
 [Y]   TAKESHITA H ET AL: "Detection of deoxyribonucleases I and II (DNases I and II) activities in reproductive organs of male rabbits", INTERNATIONAL JOURNAL OF BIOCHEMISTRY, PERGAMON, vol. 26, no. 8, August 1994 (1994-08-01), pages 1025 - 1031, XP009098102, ISSN: 0020-711X [Y] 17-23,33 * abstract *
 [A]   YASUDA T ET AL: "HUMAN SEMINAL DEOXYRIBONUCLEASE I (DNASE I): PURIFICATON, ENZYMOLOGICAL AND IMMUNOLOGICAL CHARACTERIZATION AND ORIGIN", CLINICA CHIMICA ACTA, AMSTERDAM, NL, vol. 218, no. 1, 17 September 1993 (1993-09-17), pages 5 - 16, XP001107219, ISSN: 0009-8981 [A] 1-7,17-23,33 * the whole document *

DOI:   http://dx.doi.org/10.1016/0009-8981(93)90217-R
by applicant  ISIDORI A; LATINI M; ROMANELLI F; ISIDORI A; LATINI M; ROMANELLI F: "Treatment of male infertility", CONTRACEPTION, vol. 72, no. 4, October 2005 (2005-10-01), pages 314 - 8 [Y] 5-7,17-23,33
   KERIN JFP; PEEK J; WARMS GM; KIRBY C; JEFFREY R; MATTHEWS CD; COX LW: "Improved conception rate after intrauterine insemination of washed spermatozoa from men with poor quality semen", LANCET, vol. 1, 1984, pages 533 - 534 [Y] 5,7,17-23,33
   OMBELET W; PUTTEMANS P; BOSMANS E: "Intrauterine insemination: a first step procedure in the algorithm of male subfertility treatment", HUM REPROD, vol. 10, 1995, pages 90 - 102 [X] 17-20,33 * abstract * * page 1179, column L, paragraph 4 - page 1180, column L, paragraph 2 * [Y] 1-7,21-23
   HINTING A; COMHAIRE F; VERMEULEN L; DHONT M; VERMEULEN A; VANDEKERCKHOVE D: "Possibilities and limitations of techniques of assisted reproduction for the treatment of male infertility", HUM REPROD, vol. 5, 1990, pages 544 - 548 [Y] 1-7,18-23
   COMHAIRE F; MILINGOS S; LIAPI A; GORDTS S; CAMPO R; DEPYPERE H; DHONT M; SCHOONJANS F: "The effective cumulative pregnancy rate of different modes of treatment of male infertility", ANDROLOGIA, vol. 27, 1995, pages 217 - 221 [X] 17,33 * abstract * * page 151, column R, paragraph 4 *[Y] 1-7,18-23
   PALERMO GD; COHEN J; ALIKANI M; ADLER A; ROZENWAKS Z: "Intracytoplasmic sperm injection: a novel treatment for all forms of male factor infertility", FERTIL STERIL, vol. 63, 1995, pages 1231 - 1240 [Y] 17-23,33 * abstract *
   BARTOOV B; BERKOVITZ A; ELTES F: "Selection of spermatozoa with normal nuclei to improve the pregnancy rate with intracytoplasmic sperm injection", N ENGL J MED., vol. 345, no. 14, 4 October 2001 (2001-10-04), pages 1067 - 8 [A] 1-7,17-23,33 * the whole document *
   BARTOOV B; BERKOVITZ A; ELTES F; KOGOSOVSKY A; YAGODA A; LEDERMAN H; ARTZI S; GROSS M; BARAK Y: "Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection", FERTIL STERIL, vol. 80, no. 6, December 2003 (2003-12-01), pages 1413 - 9
   BERKOVITZ A; ELTES F; LEDERMAN H; PEER S; ELLENBOGEN A; FELDBERG B; BARTOOV B: "How to improve IVF-ICSI outcome by sperm selection", REPROD BIOMED ONLINE, vol. 12, no. 5, May 2006 (2006-05-01), pages 634 - 8
   "WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction", 1999, CAMBRIDGE UNIVERSITY PRESS
   AITKEN RJ: "Sperm function tests and fertility", INT J ANDROL, vol. 29, no. 1, February 2006 (2006-02-01), pages 69 - 75
   BARTOOV B; BERKOVITZ A; ELTES F; KOGOSOWSKI A; MENEZO Y; BARAK Y: "Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome", J ANDROL, vol. 23, no. 1, January 2002 (2002-01-01), pages 1 - 8
   SPADAFORA C: "Sperm cells and foreign DNA: a controversial relation", BIOESSAYS, vol. 20, no. 11, November 1998 (1998-11-01), pages 955 - 64
   SHAK S; CAPON DJ; HELLMISS R; MARSTERS SA; BAKER CL: "Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum", PROC NATL ACAD SCI USA, vol. 87, 1990, pages 9188 - 92
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.