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Extract from the Register of European Patents

EP About this file: EP2170930

EP2170930 - AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS [Right-click to bookmark this link]
StatusThe patent has been limited
Status updated on  30.08.2013
Database last updated on 31.03.2026
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
Synergy Pharmaceuticals Inc.
420 Lexington Avenue Suite 1609
New York, NY 10170 / US
[2010/14]
Inventor(s)01 / SHAILUBHAI, Kunwar
2707 Bald Eagle Circle
Audubon, PA 19403 / US
02 / JACOB, Gary, S.
171 East 84th Street, 16J
New York, NY 10028 / US
 [2010/14]
Representative(s)Mintz Levin Cohn Ferris Glovsky and Popeo LLP
Alder Castle
10 Noble Street
London EC2V 7JX / GB
[2013/15]
Former [2012/33]Finnie, Isobel Lara, et al
Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP Alder Castle 10 Noble Street London
EC2V 7JX / GB
Former [2010/14]Finnie, Isobel Lara, et al
Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP Adler Castle 10 Noble Street
London EC2V 7JX / GB
Application number, filing date08770135.504.06.2008
[2010/14]
WO2008US65824
Priority number, dateUS20070933194P04.06.2007         Original published format: US 933194 P
[2010/14]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008151257
Date:11.12.2008
Language:EN
[2008/50]
Type: A2 Application without search report 
No.:EP2170930
Date:07.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 11.12.2008 takes the place of the publication of the European patent application.
[2010/14]
Type: B1 Patent specification 
No.:EP2170930
Date:15.08.2012
Language:EN
[2012/33]
Type: B3 Limited patent 
No.:EP2170930
Date:02.10.2013
Language:EN
[2013/40]
Search report(s)International search report - published on:EP05.03.2009
ClassificationIPC:C07K7/08, A61K38/10, A61K47/48, A61P1/00
[2010/14]
CPC:
C07K7/08 (EP,IL,US); A61K31/192 (EP,IL,US); A61K31/519 (EP,IL,US);
A61K38/10 (EP,IL,US); A61K38/12 (EP,IL,US); A61K45/06 (IL,US);
A61K47/02 (IL,US); A61K47/60 (EP,IL,US); A61K9/0031 (IL,US);
A61K9/02 (IL,US); A61K9/08 (IL,US); A61P1/00 (EP,IL);
A61P1/02 (EP,IL); A61P1/04 (EP,IL); A61P1/10 (EP,IL);
A61P1/14 (EP,IL); A61P1/16 (EP,IL); A61P1/18 (EP,IL);
A61P11/00 (EP,IL); A61P11/06 (EP,IL); A61P11/16 (EP,IL);
A61P13/08 (EP,IL); A61P17/06 (EP,IL); A61P27/04 (EP,IL);
A61P27/06 (EP,IL); A61P29/00 (EP,IL); A61P3/06 (EP,IL);
A61P3/10 (EP,IL); A61P35/00 (EP,IL); A61P35/02 (EP,IL);
A61P35/04 (EP,IL); A61P43/00 (EP,IL); A61P9/04 (EP,IL);
A61P9/12 (EP,IL); C07K7/64 (IL,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/14]
Extension statesALNot yet paid
BANot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:FÜR DIE BEHANDLUNG VON GASTROINTESTINALEN ERKRANKUNGEN, ENTZÜNDUNGEN, KREBS UND ANDEREN ERKRANKUNGEN GEEIGNETE AGONISTEN VON GUANYLATCYCLASE[2010/14]
English:AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS[2010/14]
French:AGONISTES DE GUANYLASE CYCLASE UTILES POUR LE TRAITEMENT DE TROUBLES GASTRO-INTESTINAUX, D'INFLAMMATION, DE CANCER ET D'AUTRES TROUBLES[2010/14]
Entry into regional phase04.01.2010National basic fee paid 
04.01.2010Designation fee(s) paid 
04.01.2010Examination fee paid 
Examination procedure04.01.2010Amendment by applicant (claims and/or description)
04.01.2010Examination requested  [2010/14]
31.03.2010Despatch of a communication from the examining division (Time limit: M06)
06.10.2010Reply to a communication from the examining division
03.03.2011Despatch of a communication from the examining division (Time limit: M04)
30.06.2011Reply to a communication from the examining division
19.03.2012Communication of intention to grant the patent
03.07.2012Fee for grant paid
03.07.2012Fee for publishing/printing paid
Divisional application(s)EP12162903.4  / EP2527360
EP15190713.6  / EP2998314
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  31.03.2010
Opposition(s)16.05.2013No opposition filed within time limit [2013/30]
Limitations:19.10.2012Date of receipt of request for limitation
 admissible
17.05.2013Communication of intention to limit the patent
06.08.2013Fee for printing patent specification after limitation
Fees paidRenewal fee
25.06.2010Renewal fee patent year 03
27.06.2011Renewal fee patent year 04
28.03.2012Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.06.2008
AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
MC15.08.2012
MT15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
TR15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
[2015/34]
Former [2015/32]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
MC15.08.2012
MT15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
TR15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2015/29]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
MC15.08.2012
MT15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2015/13]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
MC15.08.2012
MT15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2014/25]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
MC15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2014/08]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
MC15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2013/34]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
BG15.11.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2013/23]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
RO15.08.2012
SE15.08.2012
SI15.08.2012
SK15.08.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2013/22]AT15.08.2012
BE15.08.2012
CY15.08.2012
CZ15.08.2012
EE15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
SE15.08.2012
SI15.08.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2013/13]AT15.08.2012
BE15.08.2012
CY15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
SE15.08.2012
SI15.08.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
PT17.12.2012
Former [2013/12]AT15.08.2012
BE15.08.2012
CY15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
SE15.08.2012
SI15.08.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
Former [2013/11]AT15.08.2012
CY15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
LV15.08.2012
PL15.08.2012
SI15.08.2012
NO15.11.2012
GR16.11.2012
IS15.12.2012
Former [2013/10]AT15.08.2012
CY15.08.2012
FI15.08.2012
HR15.08.2012
LT15.08.2012
NO15.11.2012
IS15.12.2012
Former [2013/09]AT15.08.2012
FI15.08.2012
LT15.08.2012
NO15.11.2012
Former [2013/08]AT15.08.2012
LT15.08.2012
NO15.11.2012
Former [2013/07]AT15.08.2012
Cited inInternational search[A]   HAMMAN JOSIAS H ET AL: "Oral delivery of peptide drugs - Barriers and developments", BIODRUGS, AUCKLAND, NZ, vol. 19, no. 3, 1 January 2005 (2005-01-01), pages 165 - 177, XP009095961, ISSN: 1173-8804 [A] * page 169, column 2, line 5 - line L *

DOI:   http://dx.doi.org/10.2165/00063030-200519030-00003
 [A]   MAHATO RAM I ET AL: "Emerging trends in oral delivery of peptide and protein drugs", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 20, no. 2-3, 1 January 2003 (2003-01-01), pages 153 - 214, XP009095998, ISSN: 0743-4863 [A] * page 173, line 8 - page 177, line 5 *

DOI:   http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.v20.i23.30
 [PA]   HARRIS L A ET AL: "Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation", CURRENT OPINION IN MOLECULAR THERAPEUTICS 200708 GB, vol. 9, no. 4, August 2007 (2007-08-01), pages 403 - 410, XP008097427, ISSN: 1464-8431 [PA] 1-4,9-11,17-19 * the whole document *
by applicantUS5489670
 WO2006086653
 WO0125266
 WO02078683
 US2003108885
 US2003082575
 US2006019347
 US6309633
 US4522811
   VAANDRAGER, MOL CELL BIOCHEM, vol. 230, 2002, pages 73 - 83
   JAMESON ET AL., NATURE, vol. 368, 1994, pages 744 - 746
   BRADY ET AL., NATURE, vol. 368, 1994, pages 692 - 693
   HUNT: "The Non-Protein Amino Acids: In Chemistry and Biochemistry of the Amino Acids", 1985, CHAPMAN AND HALL
   SAMSON ET AL., ENDOCRINOLOGY, vol. 137, 1996, pages 5182 - 5185
   DEGRADO, ADV PROTEIN CHEM, vol. 39, 1988, pages 51 - 124
   SOLTERO ET AL., INNOVATIONS IN PHARMACEUTICAL TECHNOLOGY, 2001, pages 106 - 110
   "The Peptides: Analysis, Synthesis, Biology", vol. 1-4, 1979, ACADEMIC PRESS
   BODANSKY, BODANSKY: "The Practice of Peptide Synthesis", 1994, SPRINGER VERLAG
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.