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Extract from the Register of European Patents

EP About this file: EP2247297

EP2247297 - THERAPEUTIC TREATMENT FOR LUNG CONDITIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.11.2019
Database last updated on 24.04.2024
FormerThe patent has been granted
Status updated on  07.12.2018
FormerGrant of patent is intended
Status updated on  01.08.2018
FormerExamination is in progress
Status updated on  25.06.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Vanderbilt University
1207 17th Avenue South, Suite 105
Nashville, TN 37212 / US
[2010/45]
Inventor(s)01 / SUMMAR, Marshall, L.
513 Bel Air Place
Brentwood TN 37027 / US
02 / BARR, Frederick, E.
2507 Natchez Trace
Nashville TN 37212 / US
03 / FIKE, Candice, D.
1125 Mrb IV
Vanderbilt University Medical Center
Nashville TN 37232-0656 / US
04 / ASCHNER, Judy, L.
654 Lysander Court
Brentwood TN 37027 / US
 [2019/02]
Former [2010/45]01 / SUMMAR, Marshall, L.
513 Bel Air Place
Brentwood TN 37027 / US
02 / BARR, Frederick, E.
2507 Natchez Trace
Nashville TN 37212 / US
03 / FIKE, Candice, D.
1125 Mrb IV Vanderbilt University Medical Center
Nashville TN 37232-0656 / US
04 / ASCHNER, Judy, L.
654 Lysander Court
Brentwood TN 37027 / US
Representative(s)Isarpatent
Patent- und Rechtsanwälte Barth
Charles Hassa Peckmann & Partner mbB
Postfach 44 01 51
80750 München / DE
[N/P]
Former [2019/02]Isarpatent
Patent- und Rechtsanwälte Behnisch Barth Charles
Hassa Peckmann & Partner mbB
Postfach 44 01 51
80750 München / DE
Former [2012/18]Isarpatent
Patent- und Rechtsanwälte
Postfach 44 01 51
80750 München / DE
Former [2010/45]Behnisch, Werner
Reinhard, Skuhra, Weise & Partner GbR Patent- und Rechtsanwälte Friedrichstrasse 31
80801 München / DE
Application number, filing date09707788.702.02.2009
[2010/45]
WO2009US32824
Priority number, dateUS2008002515731.01.2008         Original published format: US 25157
[2010/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009099998
Date:13.08.2009
Language:EN
[2009/33]
Type: A2 Application without search report 
No.:EP2247297
Date:10.11.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 13.08.2009 takes the place of the publication of the European patent application.
[2010/45]
Type: B1 Patent specification 
No.:EP2247297
Date:09.01.2019
Language:EN
[2019/02]
Search report(s)International search report - published on:US30.12.2009
(Supplementary) European search report - dispatched on:EP28.04.2011
ClassificationIPC:A61K31/198, A61K38/00, A61P11/00, A61P9/12
[2018/28]
CPC:
A61K31/198 (EP,KR,US); A61K9/0019 (KR); A61K9/08 (KR);
A61K9/10 (KR); A61P11/00 (EP); A61P9/12 (EP)
Former IPC [2011/21]A61K38/00, A61P11/00, A61P9/12
Former IPC [2010/45]A61K38/00, A61P11/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2019/02]
Former [2010/45]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL05.08.2010
BA05.08.2010
RS05.08.2010
TitleGerman:THERAPEUTISCHE BEHANDLUNG VON LUNGENERKRANKUNGEN[2010/45]
English:THERAPEUTIC TREATMENT FOR LUNG CONDITIONS[2010/45]
French:TRAITEMENT THÉRAPEUTIQUE DE CONDITIONS PULMONAIRES[2010/45]
Entry into regional phase05.08.2010National basic fee paid 
05.08.2010Search fee paid 
05.08.2010Designation fee(s) paid 
05.08.2010Examination fee paid 
Examination procedure05.08.2010Examination requested  [2010/45]
28.11.2011Amendment by applicant (claims and/or description)
13.01.2014Despatch of a communication from the examining division (Time limit: M06)
03.07.2014Reply to a communication from the examining division
05.02.2016Despatch of a communication from the examining division (Time limit: M06)
16.08.2016Reply to a communication from the examining division
08.05.2018Date of oral proceedings
15.06.2018Despatch of a communication from the examining division (Time limit: M02)
15.06.2018Minutes of oral proceedings despatched
25.06.2018Reply to a communication from the examining division
02.08.2018Communication of intention to grant the patent
30.11.2018Fee for grant paid
30.11.2018Fee for publishing/printing paid
30.11.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  13.01.2014
Opposition(s)10.10.2019No opposition filed within time limit [2019/51]
Fees paidRenewal fee
28.02.2011Renewal fee patent year 03
29.02.2012Renewal fee patent year 04
27.02.2013Renewal fee patent year 05
27.02.2014Renewal fee patent year 06
26.02.2015Renewal fee patent year 07
26.02.2016Renewal fee patent year 08
27.02.2017Renewal fee patent year 09
27.02.2018Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY09.01.2019
EE09.01.2019
HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
MK09.01.2019
RO09.01.2019
SI09.01.2019
SK09.01.2019
MT02.02.2019
BG09.04.2019
IS09.05.2019
[2022/31]
Former [2021/26]CY09.01.2019
EE09.01.2019
HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
RO09.01.2019
SI09.01.2019
SK09.01.2019
MT02.02.2019
BG09.04.2019
IS09.05.2019
Former [2020/29]EE09.01.2019
HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
RO09.01.2019
SI09.01.2019
SK09.01.2019
MT02.02.2019
BG09.04.2019
IS09.05.2019
Former [2020/13]EE09.01.2019
HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
RO09.01.2019
SI09.01.2019
SK09.01.2019
BG09.04.2019
IS09.05.2019
Former [2019/49]EE09.01.2019
HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
RO09.01.2019
SK09.01.2019
BG09.04.2019
IS09.05.2019
Former [2019/46]HR09.01.2019
LT09.01.2019
LV09.01.2019
MC09.01.2019
BG09.04.2019
IS09.05.2019
Former [2019/39]HR09.01.2019
LT09.01.2019
LV09.01.2019
BG09.04.2019
IS09.05.2019
Former [2019/38]LT09.01.2019
BG09.04.2019
Former [2019/33]LT09.01.2019
Documents cited:Search[XY]  - NELIN LEIF D ET AL, "L-arginine, but not D-arginine, increases nitric oxide production and vasodilates hypoxic neonatal pig lungs", FASEB JOURNAL, & FASEB MEETING ON EXPERIMENTAL BIOLOGY: TRANSLATING THE GENOME; WASHINGTON, DISTRICT OF COLUMBIA, USA; APRIL 17-21, 2004, (2004), vol. 18, no. 4-5, ISSN 0892-6638, page A327, XP009147240 [X] 1-10 * abstract * [Y] 1-10
 [XY]  - FIKE CANDICE D ET AL, "L-arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs", JOURNAL OF APPLIED PHYSIOLOGY, (200005), vol. 88, no. 5, ISSN 8750-7587, pages 1797 - 1803, XP002633028 [X] 1-10 * abstract * * figure 2 * [Y] 1-10
 [XY]  - MITANI YOSHIHIDE ET AL, "PROLONGED ADMINISTRATION OF L-ARGININE AMELIORATES CHRONIC PULMONARY HYPERTENSION AND PULMONARY VASCULAR REMODELING IN RATS", CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, US, (19970715), vol. 96, no. 2, ISSN 0009-7322, pages 689 - 697, XP009083116 [X] 1-10 * figures 2,4,5 * * page 689, column 2 * [Y] 1-10
 [XY]  - FAGAN JULIE M ET AL, "L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (19990108), vol. 254, no. 1, ISSN 0006-291X, pages 100 - 103, XP002633029 [X] 1-10 * abstract * * table 3 * [Y] 1-10

DOI:   http://dx.doi.org/10.1006/bbrc.1998.9887
 [XY]  - MCCAFFREY MARTIN J ET AL, "Effect of L-arginine infusion on infants with persistent pulmonary hypertension of the newborn", BIOLOGY OF THE NEONATE, (1995), vol. 67, no. 4, ISSN 0006-3126, pages 240 - 243, XP009147215 [X] 1-10 * abstract * [Y] 1-10
 [XY]  - ASCHNER JUDY L, "New therapies for pulmonary hypertension in neonates and children.", PEDIATRIC PULMONOLOGY. SUPPLEMENT 2004 LNKD- PUBMED:15029628, (2004), vol. 26, ISSN 1054-187X, pages 132 - 135, XP002633030 [X] 1-13 * page 132, column 1, paragraph 2 * * page 133, column 1, paragraph l - column 2, paragraph 1 * [Y] 1-10

DOI:   http://dx.doi.org/10.1002/ppul.70082
 [XY]  - SMITH ET AL, "Nitric oxide precursors and congenital heart surgery: A randomized controlled trial of oral citrulline", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, (20060701), vol. 132, no. 1, doi:10.1016/J.JTCVS.2006.02.012, ISSN 0022-5223, pages 58 - 65, XP005693517 [X] 11-13 * abstract * * page 64, column 2, paragraph l * [Y] 1-10

DOI:   http://dx.doi.org/10.1016/j.jtcvs.2006.02.012
 [XY]  - ROMERO M J ET AL, "Therapeutic use of citrulline in cardiovascular disease", CARDIOVASCULAR DRUG REVIEWS 200609 GB LNKD- DOI:10.1111/J.1527-3466.2006.00275.X, (200609), vol. 24, no. 3-4, ISSN 0897-5957, pages 275 - 290, XP002633031 [X] 11-13 * abstract * * page 283, paragraph l - page 284, paragraph l * * page 286, paragraph 1 * [Y] 1-10

DOI:   http://dx.doi.org/10.1111/j.1527-3466.2006.00275.x
 [T]  - "Persistierende fetale Zirkulation (PFC-Syndrom)", Ania Carolina Muntau, Intensivkurs Pädiatrie, München, Elsevier Urban & Fischer, (2009), pages 17 - 18, ISBN 978-3-437-43392-4, XP002633032 [T] * page 18, paragraph 1 *
 [A]  - KINSELLA J P ET AL, "Bronchopulmonary dysplasia", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 367, no. 9520, doi:10.1016/S0140-6736(06)68615-7, ISSN 0140-6736, (20060429), pages 1421 - 1431, (20060429), XP025094032 [A] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0140-6736(06)68615-7
 [T]  - ANANTHAKRISHNAN MADHUMITA ET AL, "L-Citrulline ameliorates chronic hypoxia-induced pulmonary hypertension in newborn piglets", AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, (200909), vol. 297, no. 3, ISSN 1040-0605, pages L506 - L511, XP002633033 [T] * the whole document *

DOI:   http://dx.doi.org/10.1152/ajplung.00017.2009
International search[Y]US2004235953  (SUMMAR MARSHALL L [US], et al);
 [A]US2007026448  (RAMANATHAN CHANDRA S [US], et al)
 [Y]  - SCHREIBER ET AL., "Inhaled nitric oxide in premature infants with the respiratory distress syndrome.", N ENGL. J. MED., (2003), vol. 349, doi:doi:10.1056/NEJMoa031154, pages 2099 - 2107, XP002744286

DOI:   http://dx.doi.org/10.1056/NEJMoa031154
 [Y]  - BERKENBOSCH ET AL., "Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia induced pulmonary hypertension.", AM. J. PHYSIOL. JUNG CELL. MOL. PHYSIOL., (2000), vol. 278, pages L276 - L283
Examination   - ESCOBEDO M B ET AL, "A baboon model of bronchopulmonary dysplasia - I. Clinical features", EXPERIMENTAL AND MOLECULAR PATHOLOGY, ACADEMIC PRESS, US, vol. 37, no. 3, doi:10.1016/0014-4800(82)90045-4, ISSN 0014-4800, (19821201), pages 323 - 334, (19821201), XP022973006

DOI:   http://dx.doi.org/10.1016/0014-4800(82)90045-4
    - ROBERTA A. BALLARD ET AL, "Inhaled Nitric Oxide in Preterm Infants Undergoing Mechanical Ventilation", NEW ENGLAND JOURNAL OF MEDICINE, (20060727), vol. 355, no. 4, doi:10.1056/NEJMoa061088, ISSN 0028-4793, pages 343 - 353, XP055212287

DOI:   http://dx.doi.org/10.1056/NEJMoa061088
    - ARUL VADIVEL ET AL, "L-Citrulline Attenuates Arrested Alveolar Growth and Pulmonary Hypertension in Oxygen-Induced Lung Injury in Newborn Rats", PEDIATRIC RESEARCH, US, (20101201), vol. 68, no. 6, doi:10.1203/PDR.0b013e3181f90278, ISSN 0031-3998, pages 519 - 525, XP055473629

DOI:   http://dx.doi.org/10.1203/PDR.0b013e3181f90278
by applicantUS2004235953
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 US6343382
 US6743823
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.