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Extract from the Register of European Patents

EP About this file: EP2401375

EP2401375 - IMPROVED DESIGN OF SMALL-INTERFERING RNA [Right-click to bookmark this link]
StatusOpposition rejected
Status updated on  21.02.2020
Database last updated on 27.05.2026
FormerThe patent has been granted
Status updated on  21.07.2017
FormerGrant of patent is intended
Status updated on  28.03.2017
FormerExamination is in progress
Status updated on  22.11.2016
Most recent event   Tooltip26.06.2020Lapse of the patent in a contracting state
New state(s): CY, MK		published on 29.07.2020  [2020/31]
Applicant(s)For all designated states
RiboxX GmbH
Meissner Strasse 191
01445 Radebeul / DE
[2012/01]
Inventor(s)01 / ROHAYEM, Jacques
Draesekestrasse 4
01277 Dresden / DE
 [2012/01]
Representative(s)Habermann, Hruschka & Schnabel
Patentanwälte
Montgelasstraße 2
81679 München / DE
[N/P]
Former [2012/01]Habermann, Hruschka & Schnabel
Montgelasstrasse 2
81679 Munich / DE
Application number, filing date10704945.424.02.2010
[2017/34]
WO2010EP52348
Priority number, dateEP2009015348724.02.2009         Original published format: EP 09153487
[2012/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010097414
Date:02.09.2010
Language:EN
[2010/35]
Type: A1 Application with search report 
No.:EP2401375
Date:04.01.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 02.09.2010 takes the place of the publication of the European patent application.
[2012/01]
Type: B1 Patent specification 
No.:EP2401375
Date:23.08.2017
Language:EN
[2017/34]
Search report(s)International search report - published on:EP02.09.2010
ClassificationIPC:C12N15/11, C12N15/113
[2016/32]
CPC:
C12N15/111 (EP,US); A61P31/04 (EP); A61P31/10 (EP);
A61P31/12 (EP); A61P35/00 (EP); C12N15/1131 (EP,US);
C12N2310/14 (EP,US); C12N2320/51 (EP,US) (-)
Former IPC [2012/01]C12N15/113, C12N15/79, C12N5/10, A61K31/7088
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/01]
Extension statesALNot yet paid
BANot yet paid
RSNot yet paid
TitleGerman:VERBESSERTE KONSTRUKTION VON SMALL-INTERFERING-RNA[2012/01]
English:IMPROVED DESIGN OF SMALL-INTERFERING RNA[2012/01]
French:CONCEPTION AMÉLIORÉE DE PETITS ARN INTERFÉRANTS[2012/01]
Entry into regional phase05.08.2011National basic fee paid 
05.08.2011Designation fee(s) paid 
05.08.2011Examination fee paid 
Examination procedure05.08.2011Amendment by applicant (claims and/or description)
05.08.2011Examination requested  [2012/01]
02.09.2014Despatch of a communication from the examining division (Time limit: M04)
02.01.2015Reply to a communication from the examining division
13.03.2015Despatch of a communication from the examining division (Time limit: M04)
20.08.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
20.10.2015Reply to a communication from the examining division
27.06.2016Date of oral proceedings
09.08.2016Minutes of oral proceedings despatched
12.08.2016Communication of intention to grant the patent
07.11.2016Observations by third parties
22.11.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
25.11.2016Despatch of a communication from the examining division (Time limit: M04)
04.12.2016Reply to a communication from the examining division
19.12.2016Observations by third parties
29.03.2017Communication of intention to grant the patent
11.07.2017Fee for grant paid
11.07.2017Fee for publishing/printing paid
11.07.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.09.2014
Opposition(s)Opponent(s)01  23.05.2018    ADMISSIBLE
Rigontec GmbH
Am Klopferspitz 19
82152 Planegg / Martinsried / DE
Opponent's representative
Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte und Rechtsanwalt PartG mbB
Schweigerstraße 2
81541 München / DE
 [N/P]
Former [2018/26]
Opponent(s)01  23.05.2018    ADMISSIBLE
Rigontec GmbH
Am Klopferspitz 19
82152 Planegg / Martinsried / DE
Opponent's representative
Wichmann, Hendrik
Wuesthoff & Wuesthoff
Patentanwälte PartG mbB
Schweigerstraße 2
81541 München / DE
06.06.2018Invitation to proprietor to file observations on the notice of opposition
14.02.2019Reply of patent proprietor to notice(s) of opposition
09.10.2019Legal effect of rejection of opposition [2020/13]
09.10.2019Date of oral proceedings
08.11.2019Despatch of minutes of oral proceedings
08.11.2019Date of despatch of rejection of opposition
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
20.10.2015Request for further processing filed
20.10.2015Full payment received (date of receipt of payment)
Request granted
04.11.2015Decision despatched
Fees paidRenewal fee
08.12.2011Renewal fee patent year 03
08.02.2013Renewal fee patent year 04
17.02.2014Renewal fee patent year 05
09.02.2015Renewal fee patent year 06
09.02.2016Renewal fee patent year 07
21.02.2017Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU24.02.2010
AT23.08.2017
CY23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
MK23.08.2017
NL23.08.2017
PL23.08.2017
PT23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
TR23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
MT24.02.2018
BE28.02.2018
[2020/31]
Former [2020/27]HU24.02.2010
AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
PT23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
TR23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
MT24.02.2018
BE28.02.2018
Former [2020/16]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
TR23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
MT24.02.2018
BE28.02.2018
Former [2020/08]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
MT24.02.2018
BE28.02.2018
Former [2019/12]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
BE28.02.2018
Former [2019/09]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
IE24.02.2018
LU24.02.2018
Former [2018/52]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
LU24.02.2018
Former [2018/44]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
MC23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/39]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SI23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/24]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
IT23.08.2017
LT23.08.2017
LV23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SK23.08.2017
SM23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/23]AT23.08.2017
CZ23.08.2017
DK23.08.2017
EE23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
LT23.08.2017
LV23.08.2017
NL23.08.2017
PL23.08.2017
RO23.08.2017
SE23.08.2017
SK23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/21]AT23.08.2017
CZ23.08.2017
DK23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
LT23.08.2017
LV23.08.2017
NL23.08.2017
PL23.08.2017
SE23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/12]AT23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
LT23.08.2017
LV23.08.2017
NL23.08.2017
PL23.08.2017
SE23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/11]AT23.08.2017
ES23.08.2017
FI23.08.2017
HR23.08.2017
LT23.08.2017
NL23.08.2017
PL23.08.2017
SE23.08.2017
BG23.11.2017
NO23.11.2017
GR24.11.2017
IS23.12.2017
Former [2018/10]AT23.08.2017
FI23.08.2017
HR23.08.2017
LT23.08.2017
NL23.08.2017
SE23.08.2017
NO23.11.2017
Former [2018/09]FI23.08.2017
LT23.08.2017
NL23.08.2017
SE23.08.2017
NO23.11.2017
Former [2018/08]FI23.08.2017
LT23.08.2017
NL23.08.2017
NO23.11.2017
Former [2018/07]LT23.08.2017
NO23.11.2017
Cited inInternational search[X] US2005096284  (MCSWIGGEN JAMES et al.)
 [IY] WO2005014782  (ALNYLAM PHARMACEUTICALS et al.)
 [YD] WO2007012329  (UNIV DRESDEN TECH et al.)
by applicantEP1407044
 EP1486564
 US4458066
 WO2007012329
 WO2009150156
   KIM ET AL., NATURE REVIEWS GENETICS, vol. 8, 2007, pages 173 - 184
   NARANG ET AL., METHODS IN ENZYMOLOGY, vol. 68, 1979, pages 90
   BRAUN ET AL., METHODS IN ENZYMOLOGY, vol. 68, 1979, pages 109
   BEAUCAGE ET AL., TETRAHYDRON LETTERS, vol. 22, 1981, pages 1859
   MILLIGAN ET AL., METHODS ENZYMOL., vol. 180, 1989, pages 51 - 62
   "Current Protocols in Molecular Biology", JOHN WILEY & SONS
   "Remington's Pharmaceutical Sciences", MACK PUBLISHING CO.
OppositionWO2010097414
 US2005096284
   "Collins English Dictionary", 1992, HARPER COLLINS PUBLISHERS, article "Entry for ''transfect'' and ''transfection", pages: 1634, XP055497199
   "Rmpp Lexikon Biotechnologie", 1992, article "Transfektion", pages: 775, XP055497205
   "RICHTLINIEN Amtsblatt der Europaischen Union", EU DIRECTIVE 2010/63/EU, 20 October 2010 (2010-10-20), pages L 276/33 - L 276/79, XP055497209
   JENS KURRECK: "siRNA Efficiency: Structure or Sequence-That Is the Question", JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, vol. 2006, 2006, pages 1 - 7, XP055497216

DOI:   http://dx.doi.org/10.1155/JBB/2006/83757
   ROSE ET AL.: "Functional polarity is introduced by Dicer processing of short substrate RNAs", NUCLEIC ACIDS RESEARCH, vol. 33, no. 13, 2005, pages 4140 - 4156, XP002399886

DOI:   http://dx.doi.org/10.1093/nar/gki732
   MARQUES ET AL.: "A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells", NATURE BIOTECHNOLOGY, vol. 24, no. 5, 2006, pages 559 - 565, XP002447307

DOI:   http://dx.doi.org/10.1038/nbt1205
   "Methods in Molecular Biology", vol. 442, 2008, HUMANA PRESS, article SAILEN BARIK: "RNAi Design and Application", XP055497225
   SANO ET AL.: "Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection", NUCLEIC ACIDS RESEARCH, vol. 36, no. 18, 2008, pages 5812 - 5821, XP055001292

DOI:   http://dx.doi.org/10.1093/nar/gkn584
   UI-TEI ET AL.: "Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference", NUCLEIC ACIDS RESEARCH, vol. 32, no. 3, 2004, pages 936 - 948, XP002449895
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.