EP2509942 - BIS-ACYLATED HYDROXYLAMINE DERIVATIVES [Right-click to bookmark this link] | Status | The application has been refused Status updated on 01.03.2019 Database last updated on 15.05.2024 | |
Former | Examination is in progress Status updated on 14.11.2016 | Most recent event Tooltip | 01.03.2019 | Refusal of application | published on 03.04.2019 [2019/14] | Applicant(s) | For all designated states Johns Hopkins University 3400 North Charles Street Baltimore, MD 21218 / US | For all designated states Cardioxyl Pharmaceuticals Inc. Exchange East, Suite 212 1450 Raleigh Road Chapel Hill, NC 27571 / US | [2012/42] | Inventor(s) | 01 /
TOSCANO, John P. 18 Tree Farm Court Glen Arm Maryland 21057 / US | 02 /
SUTTON, Art 627 West 34th Street Apt. A4 Baltimore Maryland 21218 / US | 03 /
KALISH, Vincent J. 344 Dubois Road Annapolis Maryland 21401 / US | 04 /
BROOKFIELD, Frederick Arthur 114 Milton Park Abingdon Oxfordshire OX14 4SA / GB | 05 /
COURTNEY, Stephen Martin 114 Milton Park Abingdon Oxfordshire OX14 4SA / GB | 06 /
FROST, Lisa Marie 114 Milton Park Abingdon Oxfordshire OX14 4SA / GB | [2012/42] | Representative(s) | J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | [N/P] |
Former [2012/42] | Wright, Simon Mark J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB | Application number, filing date | 10795136.0 | 07.12.2010 | WO2010US59331 | Priority number, date | US20090267399P | 07.12.2009 Original published format: US 267399 P | US20090291224P | 30.12.2009 Original published format: US 291224 P | [2012/42] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2011071947 | Date: | 16.06.2011 | Language: | EN | [2011/24] | Type: | A2 Application without search report | No.: | EP2509942 | Date: | 17.10.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 16.06.2011 takes the place of the publication of the European patent application. | [2012/42] | Search report(s) | International search report - published on: | EP | 29.03.2012 | Classification | IPC: | C07C311/48, C07C233/92, C07C233/66, A61K31/67, A61K31/18, A61P9/04 | [2012/42] | CPC: |
C07D333/34 (EP,US);
A61P35/00 (EP);
A61P9/00 (EP);
A61P9/04 (EP);
A61P9/10 (EP);
A61P9/12 (EP);
C07C233/01 (US);
C07C233/64 (US);
C07C259/06 (EP,US);
C07C259/10 (EP,US);
C07C271/08 (EP,US);
C07C311/51 (EP,US);
C07C311/53 (EP,US);
C07C317/14 (EP,US);
C07C317/28 (US);
C07C317/32 (US);
C07D207/16 (EP,US);
C07D213/40 (EP,US);
C07D213/71 (EP,US);
C07D295/205 (EP,US);
C07D295/215 (EP,US);
C07D307/82 (EP,US);
C07D309/12 (EP,US);
C07C2601/08 (EP,US);
C07C2601/14 (EP,US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/42] | Title | German: | BIS-ACYLIERTE HYDROXYLAMINDERIVATE | [2012/42] | English: | BIS-ACYLATED HYDROXYLAMINE DERIVATIVES | [2012/42] | French: | DÉRIVÉS D'HYDROXYLAMINE BIS-ACYLÉE | [2012/42] | Entry into regional phase | 15.06.2012 | National basic fee paid | 15.06.2012 | Designation fee(s) paid | 15.06.2012 | Examination fee paid | Examination procedure | 15.06.2012 | Examination requested [2012/42] | 04.02.2013 | Amendment by applicant (claims and/or description) | 07.11.2013 | Despatch of a communication from the examining division (Time limit: M06) | 19.05.2014 | Reply to a communication from the examining division | 07.04.2016 | Despatch of a communication from the examining division (Time limit: M06) | 15.11.2016 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 20.01.2017 | Reply to a communication from the examining division | 17.09.2018 | Cancellation of oral proceeding that was planned for 18.09.2018 | 18.09.2018 | Date of oral proceedings (cancelled) | 13.11.2018 | Despatch of communication that the application is refused, reason: substantive examination [2019/14] | 23.11.2018 | Application refused, date of legal effect [2019/14] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 07.11.2013 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 20.01.2017 | Request for further processing filed | 20.01.2017 | Full payment received (date of receipt of payment) Request granted | 03.02.2017 | Decision despatched | Fees paid | Renewal fee | 11.12.2012 | Renewal fee patent year 03 | 12.12.2013 | Renewal fee patent year 04 | 11.12.2014 | Renewal fee patent year 05 | 10.12.2015 | Renewal fee patent year 06 | 13.12.2016 | Renewal fee patent year 07 | 12.12.2017 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 31.12.2018 | 09   M06   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [X]DE1768511 (BASF AG) [X] 1,3-5,8,9,12,13 * page 9, lines 3-4 *; | [X]US3948967 (KRENZER JOHN, et al) [X] 1,3 * example 5 *; | [X]US4405357 (CHANG JUN HSIN [US]) [X] 1,7-11,16,17 * examples 13-15,37-39,41-43,45-47,51-53,56,62-65 *; | [X]US5977146 (MUELLER BERND [DE], et al) [X] 1,6,8-10,16 * column 124, lines 36-45 *; | [Y] - LEE M J C ET AL, "PRODRUGS OF NITROXYL AS INHIBITORS OF ALDEHYDE DEHYDROGENASE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (19920101), vol. 35, doi:10.1021/JM00098A008, ISSN 0022-2623, pages 3648 - 3652, XP002056135 [Y] 1,3-13,16,17,19-32 * the whole document * DOI: http://dx.doi.org/10.1021/jm00098a008 | [Y] - KLAUS REHSE AND CO, "Hydroxylamine Derivatives", ARCHIV DER PHARMAZIE, (19980424), vol. 331, pages 365 - 367, XP002660162 [Y] 1,3-13,16,17,19-32 * compounds 4,8,12 * * the whole document * | [X] - LEE JEEWOO ET AL, "Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N'-(4-(methylsulfonylamino)benzyl)thiou rea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, (20040503), vol. 14, no. 9, doi:10.1016/J.BMCL.2004.02.002, ISSN 0960-894X, pages 2291 - 2297, XP002445723 [X] 1,7-10,16 * compounds 20,21 * DOI: http://dx.doi.org/10.1016/j.bmcl.2004.02.002 | [X] - OTTO NEUNHOEFFER AND CO, JUSTUS LIEBIGS ANNALEN DER CHEMIE, (19700129), vol. 736, pages 100 - 109, XP002660163 [X] 1,3-5,7-10 * compound 5 * | [X] - BYEONG HYO KIM ET AL, "INDIUM MEDIATED REDUCTIVE ACYLATIONS OF NITROARENES TOWARDS N,O-DIACYLATED N-ARYLHYDROXYLAMINES", SYNTHETIC COMMUNICATIONS, TAYLOR & FRANCIS GROUP, PHILADELPHIA, PA, (20010101), vol. 31, no. 23, ISSN 0039-7911, pages 3577 - 3586, XP009152508 [X] 1,3-6,8-11,16,17 * entries 5-10;; table 3; compound 5 * | [X] - TOMAZIC A ET AL, "SYNTHESES OF SOME AZINYLHYDROXYLAMINES (1)", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, (19790701), vol. 16, no. 5, doi:10.1002/JHET.5570160507, ISSN 0022-152X, pages 861 - 864, XP002021611 [X] 1,6,8-11,16,17 * compound 7 * DOI: http://dx.doi.org/10.1002/jhet.5570160507 | [X] - YAGODINA O V AND CO, CHEMISTRY OF HETEROCYCLIC COMPOUNDS, (19880609), vol. 25, pages 908 - 913, XP002660164 [X] 1,6,8-11,16,17 * compounds IVa, Va * | [X] - LOUIS F. 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