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EP About this file: EP2513135

EP2513135 - METHOD OF PURIFYING POLYPEPTIDES [Right-click to bookmark this link]
Status	The patent has been granted Status updated on 20.03.2020 Database last updated on 11.05.2024
Former	Grant of patent is intended Status updated on 02.01.2020
Former	Examination is in progress Status updated on 23.01.2017
Most recent event Tooltip	20.09.2023	Change: Date of oral proceedings
	20.09.2023	Deletion: Despatch of minutes of oral proceedings
Applicant(s)	For all designated states CSL Limited 655 Elizabeth Street Melbourne VIC 3000 / AU
	[2023/39]
Former [2012/43]	For all designated states CSL Limited 45 Poplar Road Parkville VIC 3052 / AU
Inventor(s)	01 / CHARLTON, Adam 73 Harvex Street Collinswood, South Australia 5081 / AU
	02 / NAPOLI, Mark 20 Vernon Court Hoppers Crossing Victoria 3029 / AU
	03 / SMRDELJ, Paul 2 Barlby Court Greenvale Victoria 3059 / AU
	04 / STOWERS, Anthony 2 Martin Street Preston Victoria 3072 / AU
	05 / PIRZAS, Vicky Am Lorch 5 35041 Marburg / DE
	06 / SCHRÖDER, Magnus 12 Gedye Street Doncaster East, Victoria 3109 / AU
	07 / WALKER, Ian 43 Millewa Avenue Victoria, 3145 / AU
	[2020/16]
Former [2012/43]	01 / CHARLTON, Adam 73 Harvex Street Collinswood, South Australia 5081 / AU
	02 / NAPOLI, Mark 20 Vernon Court Hoppers Crossing Victoria 3029 / AU
	03 / SMRDELJ, Paul 2 Barlby Court Greenvale Victoria 3059 / AU
	04 / STOWERS, Anthony 2 Martin Street Preston Victoria 3072 / AU
	05 / PIRZAS, Vicky 13 Gay Street Blackburn North Victoria 3130 / AU
	06 / SCHRÖDER, Magnus 12 Gedye Street Doncaster East, Victoria 3109 / AU
	07 / WALKER, Ian 43 Millewa Avenue Victoria, 3145 / AU
Representative(s)	Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	[N/P]
Former [2012/43]	Hauser, Hans-Peter, et al CSL Behring GmbH Patents & Licenses Emil-von-Behring-Strasse 76 35041 Marburg / DE
Application number, filing date	10798291.0	15.12.2010
	[2020/17]
	WO2010EP69713
Priority number, date	EP20090015707	18.12.2009 Original published format: EP 09015707
	[2012/43]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2011073235
	Date:	23.06.2011
	Language:	EN
	[2011/25]
	Type:	A1 Application with search report
	No.:	EP2513135
	Date:	24.10.2012
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 23.06.2011 takes the place of the publication of the European patent application.
	[2012/43]
	Type:	B1 Patent specification
	No.:	EP2513135
	Date:	22.04.2020
	Language:	EN
	[2020/17]
Search report(s)	International search report - published on:	EP	23.06.2011
Classification	IPC:	C07K1/22, C12N9/64	[2012/43]
	CPC:	C07K1/22 (EP,US); C07K1/18 (KR,US); C07K14/435 (KR); C07K16/00 (US); C12N9/64 (KR); C12N9/6437 (EP,US); (+) C12N9/644 (EP,US); C12Y304/21022 (EP,US); C12Y304/21021 (EP,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/43]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	Verfahren zur Reinigung von Polypeptiden	[2020/02]
	English:	METHOD OF PURIFYING POLYPEPTIDES	[2012/43]
	French:	Procédé de purification de polypeptides	[2020/02]
	Former [2012/43]	VERFAHREN ZUR AUFREINIGUNG VON POLYPEPTIDEN
	Former [2012/43]	PROCÉDÉ DE PURIFICATION DE POLYPEPTIDES
Entry into regional phase	18.07.2012	National basic fee paid
	18.07.2012	Designation fee(s) paid
	18.07.2012	Examination fee paid
Examination procedure	18.07.2012	Examination requested [2012/43]
	28.05.2013	Amendment by applicant (claims and/or description)
	15.06.2016	Despatch of a communication from the examining division (Time limit: M06)
	24.01.2017	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	16.03.2017	Reply to a communication from the examining division
	03.01.2020	Communication of intention to grant the patent
	10.03.2020	Fee for grant paid
	10.03.2020	Fee for publishing/printing paid
	10.03.2020	Receipt of the translation of the claim(s)
Divisional application(s)	EP20162007.7 / EP3715356
	EP23202384.6
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 15.06.2016
Opposition(s)	Opponent(s)	01 21.01.2021 27.01.2021 ADMISSIBLE Maiwald GmbH Elisenhof Elisenstr. 3 80335 München / DE Opponent's representative Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE
		[N/P]
	Former [2021/09]
	Opponent(s)	01 21.01.2021 27.01.2021 ADMISSIBLE MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH Elisenhof Elisenstr. 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
	08.02.2021	Invitation to proprietor to file observations on the notice of opposition
	18.06.2021	Reply of patent proprietor to notice(s) of opposition
	16.06.2022	Date of oral proceedings
	13.07.2022	Despatch of interlocutory decision in opposition
	13.07.2022	Despatch of minutes of oral proceedings
Appeal following opposition	23.09.2022	Appeal received No. T2192/22
	23.09.2022	Payment of appeal fee
	23.11.2022	Statement of grounds filed
	28.11.2024	Date of oral proceedings
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	16.03.2017	Request for further processing filed
	16.03.2017	Full payment received (date of receipt of payment) Request granted
	19.05.2017	Decision despatched
	28.05.2013	Request for further processing filed
	28.05.2013	Full payment received (date of receipt of payment) Request granted
	14.06.2013	Decision despatched
Fees paid	Renewal fee
	02.01.2013	Renewal fee patent year 03
	02.01.2014	Renewal fee patent year 04
	05.01.2015	Renewal fee patent year 05
	04.01.2016	Renewal fee patent year 06
	02.01.2017	Renewal fee patent year 07
	02.01.2018	Renewal fee patent year 08
	02.01.2019	Renewal fee patent year 09
	02.01.2020	Renewal fee patent year 10
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	15.12.2010
	AL	22.04.2020
	AT	22.04.2020
	CY	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	MK	22.04.2020
	MT	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	TR	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
	BE	31.12.2020
	SE	16.12.2021
	[2022/48]
Former [2022/33]	HU	15.12.2010
	AL	22.04.2020
	AT	22.04.2020
	CY	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	MK	22.04.2020
	MT	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	TR	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
	BE	31.12.2020
Former [2022/32]	HU	15.12.2010
	AL	22.04.2020
	AT	22.04.2020
	CY	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	MK	22.04.2020
	MT	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	TR	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
Former [2022/27]	HU	15.12.2010
	AL	22.04.2020
	AT	22.04.2020
	CY	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	MT	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	TR	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
Former [2022/26]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	TR	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
Former [2021/47]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
	LU	15.12.2020
Former [2021/46]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
	IE	15.12.2020
Former [2021/40]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	MC	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2021/24]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SI	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2021/10]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	PL	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SK	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2021/09]	AL	22.04.2020
	AT	22.04.2020
	CZ	22.04.2020
	EE	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	RO	22.04.2020
	RS	22.04.2020
	SM	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2021/04]	AL	22.04.2020
	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	RS	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2021/01]	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	RS	22.04.2020
	BG	22.07.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2020/51]	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	RS	22.04.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2020/50]	FI	22.04.2020
	HR	22.04.2020
	LT	22.04.2020
	LV	22.04.2020
	NO	22.07.2020
	GR	23.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2020/48]	FI	22.04.2020
	LT	22.04.2020
	NO	22.07.2020
	IS	22.08.2020
	PT	24.08.2020
Former [2020/47]	LT	22.04.2020
	NO	22.07.2020
	IS	22.08.2020
Former [2020/46]	IS	22.08.2020
Cited in	International search	[XI]WO0055203 (NOVO NORDISK AS [DK]) [X] 1-6,8,9,13-16,18-26 * page 36, line 17 - page 37, line 15; example - * [I] 7,10-12,17,27-29;
		[XI] - TAUC P ET AL, "Ion-exchange chromatography of proteins: modulation of selectivity by addition of organic solvents to mobile phase - Application to single-step purification of a proteinase inhibitor from corn and study of the mechanism of selectivity modulation", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL LNKD- DOI:10.1016/S0021-9673(98)00688-8, (19981030), vol. 825, no. 1, ISSN 0021-9673, pages 17 - 27, XP004141938 [X] 1,2,6,13,14,19,20,24,25 * the whole document * [I] 3-5,7-12,15-18,21-23,26-29 DOI: http://dx.doi.org/10.1016/S0021-9673(98)00688-8
		[XI] - GAGNON P ET AL, "Method for obtaining unique selectivities in ion-exchange chromatography by addition of organic polymers to the mobile phase", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL LNKD- DOI:10.1016/0021-9673(96)00125-2, (19960830), vol. 743, no. 1, ISSN 0021-9673, pages 51 - 55, XP004020270 [X] 1,2,6,13,14,19,20,24,25 * the whole document * [I] 3-5,7-12,15-18,21-23,26-29 DOI: http://dx.doi.org/10.1016/0021-9673(96)00125-2
	Examination	EP0829537
		WO0137861
		WO2004006962
		GB2440273
	by applicant	US499437
		EP0107278
		EP0183070
		EP0244234
		US4784950
		EP0402226
		WO03102132
		WO2006067230
		WO2006110277
		WO2007071768
		WO2007108955
		WO2007117490
		WO2007144173
		WO2008031020
		WO2008091740
		WO2008122089
		WO2009082443
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		- CHEN ET AL., PROTEIN EXPRESSION AND PURIFICATION, (2009), pages 76 - 81
		- YINGST ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, (1994), vol. 1189, pages 113 - 118
		- "Affinity Chromatography: Methods and Protocols", CHARLTON A, Methods in Molecular Biology, HUMANA PRESS, vol. 241, pages 211 - 227
		- LEDUNG ET AL., J.BIOTECHNOLOGY, (2009), vol. 141, pages 64 - 72
		- ZHU ET AL., PROCESS BIOCHEMISTRY, (2009), vol. 44, pages 875 - 879
		- CHEN ET AL., J.CHROMATORGR. A, (2009), vol. 1216, pages 4877 - 4886
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		- WHITE GC ET AL., "Recombinant factor IX", THROMB HAEMOST., (1997), vol. 78, pages 261 - 265
		- EWENSTEIN BM ET AL., "Pharmacokinetic analysis of plasma-derived and recombinant F IX concentrates in previously treated patients with moderate or severe hemophilia B", TRANSFUSION, (2002), vol. 42, pages 190 - 197
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	Opposition	US4828990
		WO9821234
		WO9931120
		WO0172844
		WO03042344
		WO2006127284
		WO2009099829
		WO2009149067
		WO2011073235
		- ARAKAWA et al., "The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography", Protein Expression and Purification, (20070000), vol. 54, doi:10.1016/j.pep.2007.02.010, pages 110 - 116, XP022056642 DOI: http://dx.doi.org/10.1016/j.pep.2007.02.010

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