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Extract from the Register of European Patents

EP About this file: EP2558447

EP2558447 - 3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.07.2015
Database last updated on 31.03.2026
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Actelion Pharmaceuticals Ltd.
Gewerbestrasse 16
4123 Allschwil / CH
[2013/08]
Inventor(s)01 / AISSAOUI, Hamed
c/o Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
02 / FRETZ, Heinz
c/o Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
03 / HAZEMANN, Julien
c/o Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
04 / RICHARD-BILDSTEIN, Sylvia
c/o Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
05 / SIEGRIST, Romain
c/o Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
 [2013/08]
Representative(s)Gschwend, Thomas Peter
Actelion Pharmaceuticals Ltd
Gewerbestrasse 16
CH-4123 Allschwil / CH
[N/P]
Former [2013/08]Gschwend, Thomas Peter
Actelion Pharmaceuticals Ltd Gewerbestrasse 16
CH-4123 Allschwil / CH
Application number, filing date11715042.521.03.2011
WO2011IB51165
Priority number, dateWO2010IB5122822.03.2010         Original published format: PCT/IB2010/051228
[2013/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011117798
Date:29.09.2011
Language:EN
[2011/39]
Type: A1 Application with search report 
No.:EP2558447
Date:20.02.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 29.09.2011 takes the place of the publication of the European patent application.
[2013/08]
Type: B1 Patent specification 
No.:EP2558447
Date:17.09.2014
Language:EN
[2014/38]
Search report(s)International search report - published on:EP29.09.2011
ClassificationIPC:C07D209/88, A61K31/403, A61P11/06
[2013/08]
CPC:
C07D209/88 (EP,KR,US); A61K31/403 (KR); A61P1/00 (EP);
A61P1/04 (EP); A61P11/00 (EP); A61P11/02 (EP);
A61P11/06 (EP); A61P13/12 (EP); A61P17/00 (EP);
A61P19/02 (EP); A61P21/00 (EP); A61P27/02 (EP);
A61P27/04 (EP); A61P29/00 (EP); A61P35/02 (EP);
A61P37/00 (EP); A61P37/08 (EP); A61P39/02 (EP);
A61P43/00 (EP); A61P9/00 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/08]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:3-(HETEROARYL-AMINO-)1,2,3,4-TETRAHYDRO-9H-CARBAZOL-DERIVATE UND IHRE VERWENDUNG ALS PROSTAGLANDIN-D2-REZEPTORMODULATOREN[2013/08]
English:3-(HETEROARYL-AMINO)-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS[2013/08]
French:DÉRIVÉS DE 3-(HÉTÉROARYLAMINO)-1,2,3,4-TÉTRAHYDRO-9H-CARBAZOLE ET LEUR UTILISATION COMME MODULATEURS DU RÉCEPTEUR DE LA PROSTAGLANDINE D2[2013/08]
Entry into regional phase22.10.2012National basic fee paid 
22.10.2012Designation fee(s) paid 
22.10.2012Examination fee paid 
Examination procedure22.10.2012Examination requested  [2013/08]
09.07.2013Despatch of a communication from the examining division (Time limit: M06)
20.12.2013Reply to a communication from the examining division
16.04.2014Communication of intention to grant the patent
06.08.2014Fee for grant paid
06.08.2014Fee for publishing/printing paid
06.08.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.07.2013
Opposition(s)18.06.2015No opposition filed within time limit [2015/35]
Fees paidRenewal fee
02.04.2013Renewal fee patent year 03
31.03.2014Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL17.09.2014
MK17.09.2014
MT17.09.2014
RS17.09.2014
SM17.09.2014
[2018/46]
Former [2018/31]MK17.09.2014
MT17.09.2014
RS17.09.2014
SM17.09.2014
Former [2017/38]MT17.09.2014
RS17.09.2014
SM17.09.2014
Former [2017/03]MT17.09.2014
RS17.09.2014
Former [2015/18]RS17.09.2014
Former [2015/12]LV17.09.2014
RS17.09.2014
Cited inby applicant  T. ISHIZUKA ET AL., CARDIOVASCULAR DRUG REV., vol. 22, no. 2, 2004, pages 71 - 90
   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 305, no. 1, 2003, pages 347 - 352
   ULVEN ET AL., J. MED. CHEM., vol. 48, no. 4, 2005, pages 897 - 900
   "Salt selection for basic drugs", INT. J. PHARM., vol. 33, 1986, pages 201 - 217
   REMINGTON: "The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS, article "Pharmaceutical Manufacturing"
   ARIMURA A. ET AL., J. PHARMACOL. EXP. THER., vol. 298, no. 2, 2001, pages 411 - 419
   SAWYER N. ET AL., BR. J. PHARMACOL, vol. 137, 2002, pages 1163 - 1172
   T.W. GREENE, P.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE
   J. D. HA ET AL., BULLETIN OF THE KOREAN SOC. CHEM., vol. 25, 2004, pages 1784 - 1790
   ROSENTRETER U. ET AL., ARZNEIM.-FORSCH., vol. 39, no. 12, 1989, pages 1519 - 1521
   ULVEN, T., KOSTENIS, E., J. MED. CHEM., vol. 48, 2005, pages 897 - 900
   SHIMIZU T, YAMASHITA A, HAYAISHI 0.: "Specific binding of prostaglandin D2 to rat brain synaptic membranes", J. BIOL. CHEM., vol. 257, 1982, pages 13570 - 13575
   FORTINI A, MODESTI PA, ABBATE R, GENSINI GF, NERI SERNERI GG: "Heparin does not interfere with prostacyclin and prostaglandin D2 binding to platelets", THROMB. RES., vol. 40, 1985, pages 319 - 328, XP022880602, DOI: doi:10.1016/0049-3848(85)90267-1

DOI:   http://dx.doi.org/10.1016/0049-3848(85)90267-1
   SAWYER N, CAUCHON E, CHATEAUNEUF A, CRUZ RP, NICHOLSON DW, METTERS KM, O'NEILL GP, GERVAIS FG: "Molecular pharmacology of the human PGD2 receptor CRTH2", BR. J. OF PHARMACOL., vol. 137, 2002, pages 1163 - 1172
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.