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EP About this file: EP2586788

EP2586788 - Prevention of disulfide bond reduction during recombinant production of polypeptides [Right-click to bookmark this link]
Status	Patent revoked Status updated on 16.12.2022 Database last updated on 24.04.2024
Former	The patent has been granted Status updated on 27.10.2017
Former	Grant of patent is intended Status updated on 15.06.2017
Former	Examination is in progress Status updated on 14.12.2016
Most recent event Tooltip	16.12.2022	Revocation of patent	published on 18.01.2023 [2023/03]
Applicant(s)	For all designated states Genentech, Inc. 1 DNA Way South San Francisco, CA 94080 / US
	[2013/18]
Inventor(s)	01 / Kao, Yung-hsiang 760 Pico Avenue San Mateo, CA 94403 / US
	02 / Schmidt, Melody Trexher 30 Northview Court Danville, CA 94506 / US
	03 / Laird, Michael W. 244 Silk Hill Ct. San Ramon, CA 94582 / US
	04 / Wong, Rita L. 15 West Summit Drive Redwood City, CA 94062 / US
	05 / Hewitt, Daniel P. 715 Conrado Terrace, Unit 1 Sunnyvale, CA 94085 / US
	[2013/18]
Representative(s)	Mewburn Ellis LLP Aurora Building Counterslip Bristol BS1 6BX / GB
	[N/P]
Former [2017/48]	Woolley, Lindsey Claire, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB
Former [2013/18]	Woolley, Lindsey Claire, et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS / GB
Application number, filing date	12178200.7	08.07.2008
	[2013/18]
Priority number, date	US20070948677P	09.07.2007 Original published format: US 948677 P
	[2013/18]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP2586788
	Date:	01.05.2013
	Language:	EN
	[2013/18]
	Type:	B1 Patent specification
	No.:	EP2586788
	Date:	29.11.2017
	Language:	EN
	[2017/48]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	05.04.2013
Classification	IPC:	C07K1/00, C07K14/00	[2013/18]
	CPC:	C07K16/2887 (EP,KR,US); C12N1/38 (KR); C07K14/00 (CN); A61K39/39591 (EP,US); A61P37/02 (EP); A61P5/00 (EP); (+) C07K1/14 (EP,KR,US); C07K1/22 (KR); C07K16/28 (KR); C07K16/2863 (KR); C07K16/32 (KR); C12N5/0018 (KR); C07K2317/14 (KR); C07K2317/24 (EP,KR,US); C07K2317/31 (KR) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2017/48]
Former [2013/18]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
Title	German:	Verhindern der Disulfid-Bindungsreduktion während der rekombinanten Herstellung von Polypeptiden	[2013/18]
	English:	Prevention of disulfide bond reduction during recombinant production of polypeptides	[2013/18]
	French:	Prévention de la réduction des liaisons de disulfure pendant la production recombinante de polypeptides	[2013/18]
Examination procedure	31.10.2013	Examination requested [2013/50]
	20.02.2014	Amendment by applicant (claims and/or description)
	12.02.2015	Despatch of a communication from the examining division (Time limit: M06)
	25.11.2015	Reply to a communication from the examining division
	24.02.2016	Despatch of a communication from the examining division (Time limit: M06)
	10.10.2016	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	14.12.2016	Reply to a communication from the examining division
	14.06.2017	Communication of intention to grant the patent
	13.10.2017	Receipt of the translation of the claim(s)
	19.10.2017	Fee for grant paid
	19.10.2017	Fee for publishing/printing paid
Parent application(s) Tooltip	EP08781481.0 / EP2188302
Divisional application(s)	EP17196350.7 / EP3327026
	EP19181777.4 / EP3597659
	EP23153140.1 / EP4219522
	EP23172637.3 / EP4245766
	EP23214759.5 / EP4335863
	EP24160370.3
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20080781481) is 19.07.2010
Opposition(s)	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 03.09.2018 ADMISSIBLE UCB Biopharma SRL Allée de la Recherche 60 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 03.09.2018 ADMISSIBLE Maiwald GmbH Elisenhof, Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 03.09.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Hamborner Straße 53 40472 Düsseldorf / DE
		07 29.08.2018 03.09.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		08 29.08.2018 03.09.2018 ADMISSIBLE Oetke, Cornelia Wallinger Ricker Schlotter Tostmann Zweibrückenstraße 5-7 80331 München / DE Opponent's representative Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte mbB Zweibrückenstraße 5-7 80331 München / DE
		09 29.08.2018 03.09.2018 ADMISSIBLE Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US Opponent's representative Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
		[N/P]
	Former [2021/37]
	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 03.09.2018 ADMISSIBLE UCB Biopharma SRL Allée de la Recherche 60 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 03.09.2018 ADMISSIBLE Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof, Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 03.09.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Hamborner Straße 53 40472 Düsseldorf / DE
		07 29.08.2018 03.09.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		08 29.08.2018 03.09.2018 ADMISSIBLE Oetke, Cornelia Wallinger Ricker Schlotter Tostmann Zweibrückenstraße 5-7 80331 München / DE Opponent's representative Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte mbB Zweibrückenstraße 5-7 80331 München / DE
		09 29.08.2018 03.09.2018 ADMISSIBLE Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US Opponent's representative Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2021/16]
	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 03.09.2018 ADMISSIBLE UCB Biopharma SRL Allée de la Recherche 60 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 03.09.2018 ADMISSIBLE Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof, Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 03.09.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Hamborner Straße 53 40472 Düsseldorf / DE
		07 29.08.2018 03.09.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		08 29.08.2018 03.09.2018 ADMISSIBLE Oetke, Cornelia Wallinger Ricker Schlotter Tostmann Zweibrückenstraße 5-7 80331 München / DE Opponent's representative Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte mbB Zweibrückenstraße 5-7 80331 München / DE
		09 29.08.2018 03.09.2018 ADMISSIBLE Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US Opponent's representative Oates, Edward Christopher Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2020/03]
	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 03.09.2018 ADMISSIBLE UCB Biopharma SRL Allée de la Recherche 60 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 03.09.2018 ADMISSIBLE Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 03.09.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Kennedydamm 55 / Roßstrasse 40476 Düsseldorf / DE
		07 29.08.2018 03.09.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		08 29.08.2018 03.09.2018 ADMISSIBLE Oetke, Cornelia Wallinger Ricker Schlotter Tostmann Zweibrückenstraße 5-7 80331 München / DE Opponent's representative Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte mbB Zweibrückenstraße 5-7 80331 München / DE
		09 29.08.2018 03.09.2018 ADMISSIBLE Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US Opponent's representative Oates, Edward Christopher Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2018/41]
	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 DE-40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 03.09.2018 ADMISSIBLE UCB Biopharma SPRL IP Department 60, Allée de la Recherche 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SPRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 03.09.2018 ADMISSIBLE Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 03.09.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Kennedydamm 55 / Roßstrasse 40476 Düsseldorf / DE
		07 29.08.2018 03.09.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		08 29.08.2018 03.09.2018 ADMISSIBLE Oetke, Cornelia Wallinger Ricker Schlotter Tostmann Zweibrückenstraße 5-7 80331 München / DE Opponent's representative Wallinger Ricker Schlotter Tostmann Patent- und Rechtsanwälte mbB Zweibrückenstraße 5-7 80331 München / DE
		09 29.08.2018 03.09.2018 ADMISSIBLE Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US Opponent's representative Oates, Edward Christopher Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2018/40]
	Opponent(s)	01 24.08.2018 29.08.2018 ADMISSIBLE Michalski Hüttermann & Partner Patentanwälte mbB Speditionstraße 21 DE-40221 Düsseldorf / DE
		02 27.08.2018 30.08.2018 ADMISSIBLE Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstrasse 4 80802 München / DE Opponent's representative Grünecker Patent- und Rechtsanwälte PartG mbB, et al, et al Leopoldstraße 4 80802 München / DE
		03 27.08.2018 30.08.2018 ADMISSIBLE Glaxo Group Limited 980 Great West Road Brentford Middlesex TW8 9GS / GB Opponent's representative Bhogal, Jasber Kaur GlaxoSmithKline Global Patents (CN925.1) 980 Great West Road Brentford, Middlesex TW8 9GS / GB
		04 29.08.2018 UCB Biopharma SPRL IP Department 60, Allée de la Recherche 1070 Brussels / BE Opponent's representative UCB Intellectual Property c/o UCB Biopharma SPRL Intellectual Property Department Allée de la Recherche 60 1070 Brussels / BE
		05 29.08.2018 ADMISSIBLE Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstrasse 3 80335 München / DE Opponent's representative Maiwald Patent- und Rechtsanwaltsgesellschaft mbH Elisenhof Elisenstraße 3 80335 München / DE
		06 29.08.2018 ADMISSIBLE Bayer Intellectual Property GmbH Alfred-Nobel-Strasse 10 40789 Monheim / DE Opponent's representative Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte Kennedydamm 55 / Roßstrasse 40476 Düsseldorf / DE
		07 29.08.2018 ADMISSIBLE df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte ParG mbB Fünf Höfe Theatinerstrasse 16 80333 München / DE Opponent's representative Eder, Michael df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
	11.09.2018	Invitation to proprietor to file observations on the notice of opposition
	23.04.2019	Reply of patent proprietor to notice(s) of opposition
	13.05.2020	Cancellation of oral proceeding that was planned for 15.06.2020
	15.06.2020	Date of oral proceedings
	25.08.2022	Cancellation of oral proceeding that was planned for 14.11.2022
	31.08.2022	Despatch of communication that the patent will be revoked
	12.09.2022	Legal effect of revocation of patent [2023/03]
	14.11.2022	Date of oral proceedings
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	14.12.2016	Request for further processing filed
	14.12.2016	Full payment received (date of receipt of payment) Request granted
	22.12.2016	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the examination report
	25.11.2015	Request for further processing filed
	25.11.2015	Full payment received (date of receipt of payment) Request granted
	04.12.2015	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
	20.02.2014	Request for further processing filed
	20.02.2014	Full payment received (date of receipt of payment) Request granted
	28.02.2014	Decision despatched
Fees paid	Renewal fee
	15.08.2012	Renewal fee patent year 03
	15.08.2012	Renewal fee patent year 04
	15.08.2012	Renewal fee patent year 05
	08.07.2013	Renewal fee patent year 06
	08.07.2014	Renewal fee patent year 07
	09.07.2015	Renewal fee patent year 08
	11.07.2016	Renewal fee patent year 09
	10.07.2017	Renewal fee patent year 10
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	CY	29.11.2017
	DK	29.11.2017
	EE	29.11.2017
	FI	29.11.2017
	LT	29.11.2017
	LV	29.11.2017
	PT	29.11.2017
	BG	28.02.2018
	NO	28.02.2018
	IS	29.03.2018
	[2020/33]
Former [2020/27]	CY	29.11.2017
	DK	29.11.2017
	EE	29.11.2017
	FI	29.11.2017
	LT	29.11.2017
	LV	29.11.2017
	PT	29.11.2017
	BG	28.02.2018
	NO	28.02.2018
Former [2019/11]	CY	29.11.2017
	DK	29.11.2017
	EE	29.11.2017
	FI	29.11.2017
	LT	29.11.2017
	LV	29.11.2017
	BG	28.02.2018
	NO	28.02.2018
Former [2018/35]	CY	29.11.2017
	DK	29.11.2017
	EE	29.11.2017
	FI	29.11.2017
	HR	29.11.2017
	LT	29.11.2017
	LV	29.11.2017
	BG	28.02.2018
	NO	28.02.2018
Former [2018/25]	FI	29.11.2017
	HR	29.11.2017
	LT	29.11.2017
	LV	29.11.2017
	BG	28.02.2018
	NO	28.02.2018
Former [2018/22]	FI	29.11.2017
	LT	29.11.2017
	NO	28.02.2018
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		[A] - BOBOVNIKOVA Y ET AL, "Characterization of soluble, disulfide bond-stabilized, prokaryotically depressed human thyrotropin receptor ectodomain", ENDOCRINOLOGY, (1997), vol. 138, no. 2, ISSN 0013-7227, pages 588 - 593, XP002519385 [A] 1-20 * abstract * * page 588, column R, paragraphs 1-6 * DOI: http://dx.doi.org/10.1210/en.138.2.588
		[A] - TEILUM K ET AL, "Disulfide Bond Formation and Folding of Plant Peroxidases Expressed as Inclusion Body Protein inEscherichia coliThioredoxin Reductase Negative Strains", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, (19990201), vol. 15, no. 1, ISSN 1046-5928, pages 77 - 82, XP004441744 [A] 1-20 * abstract * * page 77, right-hand column, last sentence of last full paragraph. * DOI: http://dx.doi.org/10.1006/prep.1998.0985
		[A] - POWIS G ET AL, "Thioredoxin redox control of cell growth and death and the effects of inhibitors", CHEMICO-BIOLOGICAL INTERACTIONS 19980424 IE, (19980424), vol. 111-112, ISSN 0009-2797, pages 23 - 34, XP002519386 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1016/S0009-2797(97)00148-8
		[A] - POWIS G ET AL, "Properties and biological activities of thioredoxins", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY 2001 US, (2001), vol. 41, ISSN 0362-1642, pages 261 - 295, XP002519387 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1146/annurev.pharmtox.41.1.261
		[A] - NORDBERG J ET AL, "Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.", FREE RADICAL BIOLOGY & MEDICINE 1 DEC 2001, (20011201), vol. 31, no. 11, ISSN 0891-5849, pages 1287 - 1312, XP002519388 [A] 1-20 * the whole document * DOI: http://dx.doi.org/10.1016/S0891-5849(01)00724-9
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