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Extract from the Register of European Patents

EP About this file: EP2557520

EP2557520 - Determining a nucleic acid sequence imbalance [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.02.2022
Database last updated on 01.04.2026
FormerThe patent has been granted
Status updated on  05.03.2021
FormerGrant of patent is intended
Status updated on  19.10.2020
FormerExamination is in progress
Status updated on  02.11.2018
Most recent event   Tooltip11.02.2022No opposition filed within time limitpublished on 16.03.2022  [2022/11]
Applicant(s)For all designated states
The Chinese University of Hong Kong
Technology Licensing Office
Room 226 Pi Ch'iu Building Shatin
New Territories Hong Kong / CN
[2021/14]
Former [2013/37]For all designated states
The Chinese University of Hong Kong
Technology Licensing Office
Room 226 Pi Ch'iu Building Shatin
New Territories Hong Kong / CN
Former [2013/07]For all designated states
The Chinese University of Hong Kong
Room 226, Pi Ch'iu Building
Shatin
Nt Hong Kong Sar / CN
Inventor(s)01 / Lo, Yuk-Ming Dennis
4th Floor, 7 King Tak Street
Homantin, Kowloon Hong Kong / CN
02 / Chiu, Rossa Wai Kwun
House 31, Double Haven
52 Ma Lok Path
Shatin, New Territories Hong Kong SAR / CN
03 / Chan, Kwan Chee
Flat A, 13/F, Block 34
Broadway Street, Mei Foo Sun Chuen
Kowloon Hong Kong / CN
04 / Zee, Benny Chung Ying
Flat 18E, Tower 2
La Costa, Ma on Shan
New Territories Hong Kong / CN
05 / Chong, Ka Chun
Flat 06, 29/F
Shin King House, Fu Shin Estate, Tai Po
New Territories Hong Kong / CN
 [2013/42]
Former [2013/40]01 / Lo, Yuk-Ming Dennis
4th Floor 7 King Tak Street
Homantin Kowloon Hong Kong / CN
02 / Chiu, Rossa Wai Kwun
House 31, Double Haven, 52 Ma Lok Path, Shatin
New Territories Hong Kong / CN
03 / Chan, Kwan Chee
Flat A, 13/F
Block 34
Broadway Street
Mei Foo Sun Chuen
Kowloon / HK
04 / Zee, Benny Chung Ying
Flat 18E Tower 2 La Costa Ma on Shan
New Territories Hong-Kong / CN
05 / Chong, Ka Chun
Flat 06 29/F Shin King House Fu Shin Estate Tai Po
New Territories, Hong-Kong / CN
Former [2013/36]01 / Lo, Yuk-Ming Dennis
4th Floor 7 King Tak Street
Homantin Kowloon Hong Kong / CN
02 / Chiu, Rossa Wai Kwun
House 31, Double Haven, 52 Ma Lok Path, Shatin
New Territories Hong Kong / CN
03 / Chan, Kwan Chee
Flat A, 13/F Block 34 Broadway Street Mei Foo
Sun Chuen
Kowloon
HK
Kowloon Hong Kong / CN
04 / Zee, Benny Chung Ying
Flat 18E Tower 2 La Costa Ma on Shan
New Territories Hong-Kong / CN
05 / Chong, Ka Chun
Flat 06 29/F Shin King House Fu Shin Estate Tai Po
New Territories, Hong-Kong / CN
Former [2013/07]01 / Lo, Yuk-Ming Dennis
4th Floor 7 King Tak Street
Homantin Kowloon Hong Kong / CN
02 / Chiu, Rossa Wai Kwun
House 31, Double Haven, 52 Ma Lok Path, Shatin
New Territories Hong Kong / CN
03 / Chan, Kwan Chee
Flat A, 13/F Block 34 Broadway Street Mei Foo Sun
Chuen
Kowloon
HK
Kowloon Hong Kong / CN
04 / Zee, Benny Chung Ying
Flat 18E Tower 2 La Costa Ma on Shan
New Territories Hong-Kong / CN
05 / Chong, Ka Chun
Flat 06 29/F Shin King House Fu Shin Estate Tai Po
New Territories, Hong-Kong / CN
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2021/14]J A Kemp LLP
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2014/19]Roques, Sarah Elizabeth
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2013/07]Harrison, Susan Joan, et al
Mewburn Ellis LLP
33 Gutter Lane
London
EC2V 8AS / GB
Application number, filing date12180138.523.07.2008
[2013/07]
Priority number, dateUS20070951438P23.07.2007         Original published format: US 951438 P
[2013/07]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2557520
Date:13.02.2013
Language:EN
[2013/07]
Type: A3 Search report 
No.:EP2557520
Date:29.04.2015
Language:EN
[2015/18]
Type: B1 Patent specification 
No.:EP2557520
Date:07.04.2021
Language:EN
[2021/14]
Search report(s)(Supplementary) European search report - dispatched on:EP30.03.2015
ClassificationIPC:C12Q1/6827, C12Q1/6883, G16B20/10
[2020/40]
CPC:
C12Q1/6883 (EP,CN,KR,US); G16B20/20 (EP,CN,KR,US); C12Q1/6809 (CN);
C12Q1/68 (EA); C12Q1/6827 (EP,CN,KR,US); C12Q1/6869 (CN);
C12Q1/6888 (US); G16B20/00 (CN,US); G16B20/10 (EP,CN,US);
G16B30/00 (EP,CN,KR,US); C12Q2600/112 (KR,US); C12Q2600/154 (CN,US);
C12Q2600/156 (KR,US); G01N2800/387 (KR,US); Y02A90/10 (EP,US) (-)
C-Set:
C12Q1/6827, C12Q2521/331, C12Q2537/16 (CN,US);
C12Q1/6827, C12Q2535/122, C12Q2537/159, C12Q2537/16, C12Q2565/501 (EP);
C12Q1/6827, C12Q2537/16 (CN);
C12Q1/6869, C12Q2535/122 (CN)
Former IPC [2015/02]G06F19/18, C12Q1/68, // G06F19/22
Former IPC [2013/07]G06F19/18, C12Q1/68
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/47]
Former [2013/07]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Bestimmung eines Nukleinsäuresequenzungleichgewichts[2013/07]
English:Determining a nucleic acid sequence imbalance[2013/07]
French:Détermination d'un déséquilibre de séquences d'acide nucléique[2013/07]
Examination procedure13.10.2015Amendment by applicant (claims and/or description)
13.10.2015Examination requested  [2015/47]
02.11.2018Despatch of a communication from the examining division (Time limit: M06)
01.05.2019Reply to a communication from the examining division
25.08.2020Cancellation of oral proceeding that was planned for 04.09.2020
04.09.2020Date of oral proceedings (cancelled)
20.10.2020Communication of intention to grant the patent
26.02.2021Fee for grant paid
26.02.2021Fee for publishing/printing paid
26.02.2021Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP08776038.5  / EP2183692
Divisional application(s)EP21165151.8  / EP3892736
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20080776038) is  03.08.2010
Opposition(s)10.01.2022No opposition filed within time limit [2022/11]
Fees paidRenewal fee
07.09.2012Renewal fee patent year 03
07.09.2012Renewal fee patent year 04
07.09.2012Renewal fee patent year 05
10.07.2013Renewal fee patent year 06
14.07.2014Renewal fee patent year 07
10.07.2015Renewal fee patent year 08
11.07.2016Renewal fee patent year 09
12.07.2017Renewal fee patent year 10
11.07.2018Renewal fee patent year 11
15.07.2019Renewal fee patent year 12
14.07.2020Renewal fee patent year 13
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Documents cited:Search[X] WO2007075836  (RAVGEN INC et al.)
 [X]   RAVINDER DHALLAN ET AL: "A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study", THE LANCET, LANCET LIMITED. LONDON, GB, vol. 369, 1 February 2007 (2007-02-01), pages 474 - 481, XP008144740, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(07)60115-9

DOI:   http://dx.doi.org/10.1016/S0140-6736(07)60115-9
 [XP]   LO YMD ET AL: "Digital PCR for the molecular detection of fetal chromosomal aneuploidy.", PNAS, vol. 104, no. 32, 7 August 2007 (2007-08-07), pages 13116 - 13121, XP007905909

DOI:   http://dx.doi.org/10.1073/pnas.0705765104
 [AD]   TONG YU K ET AL: "Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: Theoretical and empirical considerations", CLINICAL CHEMISTRY, AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY, WASHINGTON, DC, vol. 52, no. 12, 13 October 2006 (2006-10-13), pages 2194 - 2202, XP002470084, ISSN: 0009-9147

DOI:   http://dx.doi.org/10.1373/clinchem.2006.076851
 [AD]   LO YMD ET AL: "Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection", NATURE MEDICINE, vol. 13, no. 2, February 2007 (2007-02-01), pages 218 - 223, XP007905910

DOI:   http://dx.doi.org/10.1038/nm1530
 [A]   H. CHRISTINA FAN ET AL: "Detection of Aneuploidy with Digital PCR", 8 May 2007 (2007-05-08), XP055143116, Retrieved from the Internet
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