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EP2718293
European procedure
Extract from the Register of European Patents
EP About this file: EP2718293
| EP2718293 - SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 31.08.2018 Database last updated on 01.04.2026 | |
| Former | The patent has been granted Status updated on 22.09.2017 | ||
| Former | Grant of patent is intended Status updated on 10.05.2017 | ||
| Former | Examination is in progress Status updated on 14.04.2017 | ||
| Former | Grant of patent is intended Status updated on 20.03.2017 | ||
| Former | Examination is in progress Status updated on 24.02.2017 | Most recent event Tooltip | 31.08.2018 | No opposition filed within time limit | published on 03.10.2018 [2018/40] | Applicant(s) | For all designated states Hutchison Medipharma Limited Building 4, 720 Cailun Road, ZJ. Hi-tech Park Shanghai 201203 / CN | [2016/45] |
| Former [2014/16] | For all designated states Hutchison Medipharma Limited Building 4, 720 Cailun Road Hi-tech Park Shanghai 201203 / CN | Inventor(s) | 01 /
SU, Wei-Guo Building 4 720 Cailun Road ZJ. Hi-Tech Park Shanghai 201203 / CN | 02 /
DENG, Wei Building 4 720 CailunRoad ZJ. Hi-Tech Park Shanghai 201203 / CN | 03 /
JI, Jianguo Building 4 720 Cailun Road ZJ. Hi-Tech Park Shanghai 201203 / CN | [2014/16] | Representative(s) | Altmann Stößel Dick Patentanwälte PartG mbB Theodor-Heuss-Anlage 2 68165 Mannheim / DE | [N/P] |
| Former [2017/43] | Herzog, Fiesser & Partner Patentanwälte PartG mbB Dudenstrasse 46 68167 Mannheim / DE | ||
| Former [2014/16] | Dick, Alexander Herzog Fiesser & Partner Patentanwälte Dudenstraße 46 68167 Mannheim / DE | Application number, filing date | 12797167.9 | 07.06.2012 | [2017/43] | WO2012CN76576 | Priority number, date | WO2011CN75431 | 08.06.2011 Original published format: PCT/CN2011/075431 | [2014/16] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2012167733 | Date: | 13.12.2012 | Language: | EN | [2012/50] | Type: | A1 Application with search report | No.: | EP2718293 | Date: | 16.04.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 13.12.2012 takes the place of the publication of the European patent application. | [2014/16] | Type: | B1 Patent specification | No.: | EP2718293 | Date: | 25.10.2017 | Language: | EN | [2017/43] | Search report(s) | International search report - published on: | CN | 13.12.2012 | (Supplementary) European search report - dispatched on: | EP | 04.11.2014 | Classification | IPC: | C07D471/04, A61K31/4985, A61K31/5375, A61K31/553, A61P43/00, A61P29/00, A61P37/08, A61P37/00, A61P35/00, A61P35/02, A61P7/00 | [2014/16] | CPC: |
A61K31/5377 (EP,US);
C07D471/04 (EP,CN,KR,US);
A61K31/4985 (EP,KR,US);
A61K31/506 (EP,US);
A61K31/541 (EP,US);
A61K31/551 (EP,US);
A61K31/553 (EP,US);
A61P11/00 (EP);
A61P11/02 (EP);
A61P11/06 (EP);
A61P19/02 (EP);
A61P25/00 (EP);
A61P29/00 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/00 (EP);
A61P37/02 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
A61P7/00 (EP);
A61P7/06 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/16] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | SUBSTITUIERTE PYRIDOPYRAZINE ALS NEUE SYK-HEMMER | [2014/16] | English: | SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | [2014/16] | French: | PYRIDOPYRAZINES SUBSTITUÉES EN TANT QUE NOUVEAUX INHIBITEURS DE SYK | [2014/16] | Entry into regional phase | 08.01.2014 | National basic fee paid | 08.01.2014 | Search fee paid | 08.01.2014 | Designation fee(s) paid | 08.01.2014 | Examination fee paid | Examination procedure | 08.01.2014 | Examination requested [2014/16] | 22.05.2015 | Amendment by applicant (claims and/or description) | 29.09.2015 | Despatch of a communication from the examining division (Time limit: M04) | 04.02.2016 | Reply to a communication from the examining division | 02.03.2016 | Despatch of a communication from the examining division (Time limit: M04) | 11.07.2016 | Reply to a communication from the examining division | 12.10.2016 | Communication of intention to grant the patent | 20.02.2017 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 21.03.2017 | Communication of intention to grant the patent | 10.04.2017 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 11.05.2017 | Communication of intention to grant the patent | 18.09.2017 | Fee for grant paid | 18.09.2017 | Fee for publishing/printing paid | 18.09.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 29.09.2015 | Opposition(s) | 26.07.2018 | No opposition filed within time limit [2018/40] | Fees paid | Renewal fee | 30.06.2014 | Renewal fee patent year 03 | 29.06.2015 | Renewal fee patent year 04 | 27.06.2016 | Renewal fee patent year 05 | 27.06.2017 | Renewal fee patent year 06 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [E] WO2012123312 (GLAXO GROUP LTD et al.) [E] 1-14,18-26 * Intermediates 6, 8, 16-19, 21, 23 Examples 1-5, 11, 12, 15, 17-24; page 1, paragraph 1; claims 1-21 * | [A] WO2009099801 (IRM LLC et al.) [A] 1-26 * the whole document * | [A] WO2011014795 (IRM LLC et al.) [A] 1-26 * the whole document * | [A] WO03057695 (BOEHRINGER INGELHEIM PHARMA et al.) [A] 1-26 * the whole document * | International search | [X] CARROLL TEMPLE, JR. ET AL.: "1,2-Dihydropyrido[3,4-b] pyrazines: Structure-Activity Relationships.", J. MED. CHEM., vol. 26, no. 1, 1983, pages 91 - 95, XP002112043 DOI: http://dx.doi.org/10.1021/jm00355a018 | [X] JEFFREY W. WILLIAMS ET AL.: "The inhibition of dihydrofolate reductase by folate analogues: structural requirements for slow- and tight-binding inhibition.", BIOCHEMICAL PHARMACOLOGY, vol. 29, no. 4, 1980, pages 589 - 595, XP023730157 DOI: http://dx.doi.org/10.1016/0006-2952(80)90381-0 | [X] BRITTA NISIUS ET AL.: "Development of a Fingerprint Reduction Approach for Bayesian Similarity Searching Based on Kullback-Leibler Divergence Analysis.", J. CHEM. INF. MODEL., vol. 49, no. 6, 2009, pages 1347 - 1358, XP055139297 DOI: http://dx.doi.org/10.1021/ci900087y | [X] ROBERT D. ELLIOTT ET AL.: "Potential Folic Acid Antagonists. VI. The Syntheses of 1- and 3-Deazamethotrexate.", J. ORG. CHEM., vol. 36, no. 19, 1971, pages 2818 - 2823, XP055139301 DOI: http://dx.doi.org/10.1021/jo00818a019 | [X] C. CHOO HOFFMANN ET AL.: "Comparative effects of selected antifolates on transforming human lymphocytes and on established human lymphoblastic cell lines.", BIOCHEMICAL PHARMACOLOGY, vol. 25, no. 17, 1976, pages 1947 - 1954, XP023718954 DOI: http://dx.doi.org/10.1016/0006-2952(76)90048-4 | [X] DELIANG CHEN ET AL.: "Computational Selection of Inhibitors of A-beta Aggregation and Neuronal Toxicity.", BIOORG MED CHEM., vol. 17, no. 14, 15 July 2009 (2009-07-15), pages 5189 - 5197, XP026302987 DOI: http://dx.doi.org/10.1016/j.bmc.2009.05.047 | [X] ROBERT D . ELLIOTT ET AL.: "The Isomeric Pyridopyrazines from the Reaction of Some Tetraaminopyridines with Pyruvaldehyde and Benzil.", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 33, no. 6, June 1968 (1968-06-01), pages 2393 - 2397, XP055139316 DOI: http://dx.doi.org/10.1021/jo01270a048 | [X] DATABASE REGISTRY [online] 21 December 2007 (2007-12-21), XP003032810, Database accession no. 959372-94-2 | [XP] DATABASE REGISTRY [online] 2 December 2011 (2011-12-02), XP003032812, Database accession no. 1347587-04-5 | [X] DATABASE REGISTRY [online] 21 December 2007 (2007-12-21), XP003032814, Database accession no. 959323-27-4 | [X] DATABASE REGISTRY [online] 21 December 2007 (2007-12-21), XP003032819, Database accession no. 959318-76-4 | [X] DATABASE REGISTRY [online] 5 December 2011 (2011-12-05), XP003032818, Database accession no. 1349080-70-1 [X] | [X] DATABASE REGISTRY [online] 4 December 2011 (2011-12-04), XP003032817, Database accession no. 1348540-80-6 [X] | [X] DATABASE REGISTRY [online] 21 December 2007 (2007-12-21), XP003032821, Database accession no. 959318-74-2 [X] | by applicant | G. C. PIMENTEL; A. L. MCCLELLAN: "The Hydrogen Bond", 1960, FREEMAN | R. TAYLOR; O. KENNARD: "Hydrogen Bond Geometry in Organic Crystals", ACCOUNTS OF CHEMICAL RESEARCH, vol. 17, 1984, pages 320 - 326 | R. LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS | T.W. GREENE; P.G.M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS | L. FIESER; M. FIESER: "Fieser and Fieser's Reagents for Organic Synthesis", 1994, JOHN WILEY AND SONS | "Encyclopedia of Reagents for Organic Synthesis", 1995, JOHN WILEY AND SONS |