| EP2785359 - MESENCHYMAL STROMAL CELLS AND USES RELATED THERETO [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 05.07.2019 Database last updated on 01.04.2026 | |
| Former | The patent has been granted Status updated on 27.07.2018 | ||
| Former | Grant of patent is intended Status updated on 07.03.2018 | ||
| Former | Examination is in progress Status updated on 01.11.2016 | Most recent event Tooltip | 05.07.2019 | No opposition filed within time limit | published on 07.08.2019 [2019/32] | Applicant(s) | For all designated states Astellas Institute for Regenerative Medicine 33 Locke Drive Marlborough, MA 01752 / US | [2016/36] |
| Former [2014/41] | For all designated states Advanced Cell Technology, Inc. 33 Locke Drive Marlborough, MA 01752 / US | Inventor(s) | 01 /
LANZA, Robert 35 South Meadow Road Clinton, Massachusetts 01510 / US | 02 /
KIMBREL, Erin, Anne 72 Austin Road Sudbury, Massachusetts 01776 / US | 03 /
CHU, Jianlin 27 LibertyRoad Bedford, Massachusetts 01730 / US | 04 /
KOURIS, Nicholas, Arthur 35 School St. Unit A Hudson, Massachusetts 01749 / US | [2014/41] | Representative(s) | Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB | [N/P] |
| Former [2018/35] | Boult Wade Tennant LLP Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB | ||
| Former [2014/41] | Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB | Application number, filing date | 12854438.4 | 30.11.2012 | [2018/35] | WO2012US67464 | Priority number, date | US201161565358P | 30.11.2011 Original published format: US 201161565358 P | [2014/41] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013082543 | Date: | 06.06.2013 | Language: | EN | [2013/23] | Type: | A1 Application with search report | No.: | EP2785359 | Date: | 08.10.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.06.2013 takes the place of the publication of the European patent application. | [2014/41] | Type: | B1 Patent specification | No.: | EP2785359 | Date: | 29.08.2018 | Language: | EN | [2018/35] | Search report(s) | International search report - published on: | KR | 06.06.2013 | (Supplementary) European search report - dispatched on: | EP | 13.10.2015 | Classification | IPC: | A61K35/28, A61K35/30, A61K35/34, A61K35/36, A61K35/407, C12N5/0789, C12N5/077, C12N5/071, A61K35/39, C12N5/0775 | [2018/10] | CPC: |
A61K35/28 (EP,KR,US);
A61F2/141 (US);
A61F9/08 (US);
A61K35/30 (EP,US);
A61K35/34 (EP,US);
A61K35/36 (EP,US);
A61K35/39 (EP,US);
A61K35/407 (EP,US);
A61P1/02 (EP);
A61P1/04 (EP);
A61P1/16 (EP);
A61P11/00 (EP);
A61P11/02 (EP);
A61P11/06 (EP);
A61P13/12 (EP);
A61P17/00 (EP);
A61P17/02 (EP);
A61P17/06 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P21/00 (EP);
A61P25/00 (EP);
A61P25/16 (EP);
A61P25/28 (KR);
A61P27/02 (EP);
A61P27/16 (EP);
A61P29/00 (EP);
A61P3/00 (EP);
A61P3/06 (EP);
A61P3/10 (EP);
A61P31/04 (EP);
A61P31/12 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/00 (EP,KR);
A61P37/02 (EP);
A61P37/06 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
A61P7/00 (EP);
A61P9/00 (EP);
A61P9/04 (EP);
A61P9/10 (EP);
C12N5/0647 (EP,KR,US);
C12N5/0662 (US);
C12N5/0668 (EP,KR,US);
C12N5/0692 (EP,KR,US);
G06F9/542 (US);
A61K2300/00 (KR);
C12N2501/115 (EP,KR,US);
C12N2501/125 (EP,KR,US);
C12N2501/145 (EP,KR,US);
C12N2501/155 (EP,KR,US);
C12N2501/165 (EP,KR,US);
C12N2501/26 (EP,KR,US);
C12N2502/1171 (EP,KR,US);
C12N2506/02 (EP,KR,US);
C12N2506/11 (EP,KR,US);
C12N2506/28 (EP,KR,US);
| C-Set: |
A61K35/28, A61K2300/00 (EP,US);
A61K35/30, A61K2300/00 (EP,US);
A61K35/34, A61K2300/00 (US,EP);
A61K35/36, A61K2300/00 (US,EP); |
| Former IPC [2015/30] | A61K35/12, A61K48/00, A61K38/30, A61K38/19, A61P19/02, A61P9/00, C12N5/0775 | ||
| Former IPC [2014/41] | A61K35/12, A61K48/00, A61K38/30, A61K38/19, A61P19/02, A61P9/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/41] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | MESENCHYMALE STROMAZELLEN UND IHRE VERWENDUNGEN | [2014/41] | English: | MESENCHYMAL STROMAL CELLS AND USES RELATED THERETO | [2014/41] | French: | CELLULES STROMALES MÉSENCHYMATEUSES ET UTILISATION S'Y RAPPORTANT | [2014/41] | Entry into regional phase | 26.06.2014 | National basic fee paid | 26.06.2014 | Search fee paid | 26.06.2014 | Designation fee(s) paid | 26.06.2014 | Examination fee paid | Examination procedure | 26.06.2014 | Examination requested [2014/41] | 06.05.2016 | Amendment by applicant (claims and/or description) | 20.10.2016 | Despatch of a communication from the examining division (Time limit: M06) | 10.04.2017 | Reply to a communication from the examining division | 08.03.2018 | Communication of intention to grant the patent | 16.07.2018 | Fee for grant paid | 16.07.2018 | Fee for publishing/printing paid | 16.07.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | EP18186151.9 / EP3449929 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 20.10.2016 | Opposition(s) | 31.05.2019 | No opposition filed within time limit [2019/32] | Fees paid | Renewal fee | 26.11.2014 | Renewal fee patent year 03 | 30.11.2015 | Renewal fee patent year 04 | 28.11.2016 | Renewal fee patent year 05 | 27.11.2017 | Renewal fee patent year 06 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | SM | 29.08.2018 | [2019/27] | Documents cited: | Search | [A] WO2007120811 (ADVANCED CELL TECH INC et al.) [A] 1-14 * the whole document * | [A] WO2009137629 (ADVANCED CELL TECH INC et al.) [A] 1-22 * the whole document * | [A] WO2009104825 (KOREA ADVANCED INST SCI & TECH et al.) [A] 15-19,22 * the whole document * | [I] PASCALE V. GUILLOT ET AL: "Human First-Trimester Fetal MSC Express Pluripotency Markers and Grow Faster and Have Longer Telomeres Than Adult MSC", STEM CELLS, vol. 25, no. 3, 22 March 2007 (2007-03-22), pages 646 - 654, XP055192288, ISSN: 1066-5099, DOI: 10.1634/stemcells.2006-0208 [I] 1-14,20-22 * figures 2, 3 * DOI: http://dx.doi.org/10.1634/stemcells.2006-0208 | [I] KERN SUSANNE ET AL: "Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 24, no. 5, 1 May 2006 (2006-05-01), pages 1294 - 1301, XP002432657, ISSN: 1066-5099 [I] 1-14,20-22 * table 1 * | [XI] BARBERI T ET AL: "Derivation of multipotent mesenchymal precursors from human embryonic stem cells", PLOS MEDICINE, PUBLIC LIBRARY OF SCIENCE, US, vol. 2, 28 June 2005 (2005-06-28), pages 554 - 560, XP002404210, ISSN: 1549-1676, DOI: 10.1371/JOURNAL.PMED.0020161 [X] 18 * figure 1 * [I] 1-14,19-22 DOI: http://dx.doi.org/10.1371/journal.pmed.0020161 | [I] WOLFGANG WAGNER ET AL: "Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 3, no. 5, 21 May 2008 (2008-05-21), pages E2213 - 1, XP002686801, ISSN: 1932-6203, DOI: 10.1371/JOURNAL.PONE.0002213 [I] 1-14,20-22 * figure 1 * DOI: http://dx.doi.org/10.1371/journal.pone.0002213 | [A] LU S-J ET AL: "Generation of functional hemangioblasts from human embryonic stem cells", NATURE METHODS, NATURE PUBLISHING GROUP, GB, vol. 4, no. 6, 1 June 2007 (2007-06-01), pages 501 - 509, XP008133153, ISSN: 1548-7091, [retrieved on 20070507], DOI: 10.1038/NMETH1041 [A] 1-22 * the whole document * DOI: http://dx.doi.org/10.1038/nmeth1041 | [A] HEMATTI PEIMAN: "Human embryonic stem cell-derived mesenchymal progenitors: an overview", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS, INC, US, vol. 690, 1 January 2011 (2011-01-01), pages 163 - 174, XP009161182, ISSN: 1940-6029 [A] 1-14 * the whole document * | [AP] XIN FU ET AL: "Comparison of Immunological Characteristics of Mesenchymal Stem Cells Derived from Human Embryonic Stem Cells and Bone Marrow", TISSUE ENGINEERING PART A, vol. 21, no. 3-4, 1 February 2015 (2015-02-01), pages 616 - 626, XP055191852, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2013.0651 [AP] 1-14 * the whole document * DOI: http://dx.doi.org/10.1089/ten.tea.2013.0651 | [T] ERIN A. KIMBREL ET AL: "Mesenchymal Stem Cell Population Derived from Human Pluripotent Stem Cells Displays Potent Immunomodulatory and Therapeutic Properties", STEM CELLS AND DEVELOPMENT, vol. 23, no. 14, 15 July 2014 (2014-07-15), pages 1611 - 1624, XP055191836, ISSN: 1547-3287, DOI: 10.1089/scd.2013.0554 [T] * the whole document * DOI: http://dx.doi.org/10.1089/scd.2013.0554 | [XI] MAXIM A VODYANIK ET AL: "A mesoderm-derived precursor for mesenchymal stem and endothelial cells", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, vol. 7, no. 6, 3 December 2010 (2010-12-03), pages 718 - 729, XP028211788, ISSN: 1934-5909, [retrieved on 20101202], DOI: 10.1016/J.STEM.2010.11.011 [X] 18 * material and methods;; figure 6 *[I] 19,22 DOI: http://dx.doi.org/10.1016/j.stem.2010.11.011 | [XI] TAN ZHOU ET AL: "Immunomodulative effects of mesenchymal stem cells derived from human embryonic stem cells in vivo and in vitro", JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B, vol. 12, no. 1, January 2011 (2011-01-01), pages 18 - 27, XP002744077, ISSN: 1673-1581 [X] 18 * figures 1-3, 5 *[I] 15-17,19,22 DOI: http://dx.doi.org/10.1631/jzus.B1000074 | [A] MERVIN C YODER: "A Bipotent Mesoderm Subset Identified via Colony-Forming Assay", CELL STEM CELL, vol. 7, no. 6, 3 December 2010 (2010-12-03), pages 643 - 644, XP028211779, ISSN: 1934-5909, [retrieved on 20101122], DOI: 10.1016/J.STEM.2010.11.022 [A] 1-22 * the whole document * DOI: http://dx.doi.org/10.1016/j.stem.2010.11.022 | [A] LU SHI-JIANG ET AL: "Robust generation of hemangioblastic progenitors from human embryonic stem cells", REGENERATIVE MEDICINE, vol. 3, no. 5, September 2008 (2008-09-01), pages 693 - 704, XP002744078, ISSN: 1746-0751 [A] 1-22 * the whole document * DOI: http://dx.doi.org/10.2217/17460751.3.5.693 | [A] KSIAZEK KRZYSZTOF: "A comprehensive review on mesenchymal stem cell growth and senescence.", REJUVENATION RESEARCH APR 2009, vol. 12, no. 2, April 2009 (2009-04-01), pages 105 - 116, XP002744079, ISSN: 1557-8577 [A] 15-18,22 * the whole document * DOI: http://dx.doi.org/10.1089/rej.2009.0830 | International search | [X] US2011129918 (HUNG SHIH-CHIEH et al.) | [Y] US2009232777 (LUNDGREN-AKERLUND EVY et al.) | [A] WO2011097242 (UNIV ROCHESTER et al.) | [A] US2009010896 (CENTENO CHRISTOPHER J et al.) | [A] US2011195054 (COHEN MICHAEL et al.) | [A] US2011123498 (WESTENFELDER CHRISTOF et al.) | [A] KR20070114449 (IND ACADEMIC COOP et al.) | [XP] US2012087933 (TOM SAMSON et al.) | by applicant | US8017393 | US2002103542 | EP1454641 | US8198085 | WO2004098285 | US2012077181 | THU ET AL., NAT MED., vol. 18, no. 3, 26 February 2012 (2012-02-26), pages 463 - 7 | GO ET AL., BIOCHEM., vol. 142, 2007, pages 741 - 748 | SHI ET AL., HAEMATOLOGICA, vol. 92, no. 7, July 2007 (2007-07-01), pages 897 - 904 | SASPORTAS ET AL., PROC NATL ACAD SCI USA., vol. 106, no. 12, 24 March 2009 (2009-03-24), pages 4822 - 7 | GO ET AL., J. BIOCHEM., vol. 142, 2007, pages 741 - 748 | SUH; BLELLOCH, DEVELOPMENT, vol. 138, 2011, pages 1653 - 1661 | MIYOSH ET AL., CELL STEM CELL, 2011 | SANCHO-MARTINEZ ET AL., JOURNAL OF MOLECULAR CELL BIOLOGY, 2011, pages 1 - 3 | ANOKYE-DANSO ET AL., CELL STEM CELL, vol. 8, 8 April 2011 (2011-04-08), pages 376 - 388 | ORKIN; HOCHEDLINGER, CELL, vol. 145, 10 June 2011 (2011-06-10), pages 835 - 850 | YU ET AL., SCIENCE, vol. 324, no. 5928, 8 May 2009 (2009-05-08), pages 797 - 801 | CHOI ET AL., DEVELOPMENT, vol. 125, no. 4, 1998, pages 725 - 732 | MIKKOLA ET AL., J. HEMATOTHER. STEM CELL RES, vol. 11, no. 1, 2002, pages 9 - 17 | KENNEDY ET AL., NATURE, 1997, pages 488 - 493 | PERLINGEIRO ET AL., STEM CELLS, 2003, pages 272 - 280 | YU ET AL., BLOOD, vol. 116, 2010, pages 4786 - 4794 | BORDONI ET AL., HEPATOLOGY, vol. 45, no. 5, pages 1218 - 1228 | CIRACI ET AL., BLOOD, vol. 118, pages 2105 - 2115 | SUN ET AL., BLOOD, vol. 116, no. 16, 2010, pages 2932 - 2941 | ITSKOVITZ-ELDOR ET AL., MOL MED., vol. 6, no. 2, February 2000 (2000-02-01), pages 88 - 95 | ZHOU ET AL., CELL STEM CELL, 2009, pages 1 - 4 | MIYOSHI ET AL., CELL STEM CELL, 2011, pages 1 - 6 | DANSO ET AL., CELL STEM CELL, 2011, pages 376 - 388 | KARLSSON ET AL., STEM CELL RESEARCH, vol. 3, 2009, pages 39 - 50 | GONG ET AL., J. CELL. PHYSIOL., vol. 224, 2010, pages 664 - 671 | DOMINICI ET AL., CYTOTHERAPY, vol. 8, no. 4, 2006, pages 315 - 317 | WAGNER W ET AL.: "Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process", PLOS ONE, vol. 3, no. 5, 2008, pages E2213, XP002686801, DOI: doi:10.1371/journal.pone.0002213 DOI: http://dx.doi.org/10.1371/journal.pone.0002213 | MUSINA, R ET AL.: "Comparison of Mesenchymal Stem Cells Obtained from Different Human Tissues", CELL TECHNOLOGIES IN BIOLOGY AND MEDICINE, vol. 1, no. 2, April 2005 (2005-04-01), pages 504 - 509 | MEISEL R: "Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation", BLOOD, vol. 103, no. 12, 15 June 2004 (2004-06-15), pages 4619 - 21, XP002437352, DOI: doi:10.1182/blood-2003-11-3909 DOI: http://dx.doi.org/10.1182/blood-2003-11-3909 | BRAUN, D: "A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation", BLOOD, vol. 106, no. 7, 1 October 2005 (2005-10-01), pages 2375 - 81, XP002367564, DOI: doi:10.1182/blood-2005-03-0979 DOI: http://dx.doi.org/10.1182/blood-2005-03-0979 | PAREKKADAN ET AL., MOLECULAR THERAPY, vol. 20, no. 1, 2011, pages 178 - 186 | MOHANTY ET AL., STEM CELLS, vol. 30, 2012, pages 1134 - 1143 | ZAPPIA, E. ET AL.: "Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy", BLOOD, vol. 106, no. 5, 2005, pages 1755 - 61, XP002587343 | GERDONI, E. ET AL.: "Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis", ANN NEUROL, vol. 61, no. 3, 2007, pages 219 - 27, XP002603337 | LANZA, C. ET AL.: "Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in viva", J NEUROCHEM, vol. 110, no. 5, 2009, pages 1674 - 84 | RAFEI, M. ET AL.: "Allogeneic mesenchymal stem cells for treatment of experimental autoimmune encephalomyelitis", MOL THER, vol. 17, no. 10, 2009, pages 1799 - 803 | RAFEI, M. ET AL.: "Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th 17 T cells in a CC chemokine ligand 2-dependent manner", J IMMUNOL, vol. 182, no. 10, 2009, pages 5994 - 6002 | CONSTANTIN, G. ET AL.: "Adipose-derived mesenchymal stem cells ameliorate chronic experimental autoimmune encephalomyelitis", STEM CELLS, vol. 27, no. 10, 2009, pages 2624 - 35, XP055034543, DOI: doi:10.1002/stem.194 DOI: http://dx.doi.org/10.1002/stem.194 | UCCELLI, A; D.J. PROCKOP: "Why should mesenchymal stem cells (MSCs) cure autoimmune diseases?", CURR OPIN IMMUNOL, vol. 22, no. 6, 2010, pages 768 - 74, XP027544864 | OHTAKI, H. ET AL.: "Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses", PROC NATL ACAD SCI USA, vol. 105, no. 38, 2008, pages 14638 - 43, XP055036993, DOI: doi:10.1073/pnas.0803670105 DOI: http://dx.doi.org/10.1073/pnas.0803670105 | BARBERI, T. ET AL.: "Derivation of multipotent mesenchymal precursors from human embryonic stem cells", PLOS MED, vol. 2, no. 6, 2005, pages E161 | HWANG, N.S. ET AL.: "In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells", PROC NATL ACAD SCI USA, vol. 105, no. 52, 2008, pages 20641 - 6, XP055266736, DOI: doi:10.1073/pnas.0809680106 DOI: http://dx.doi.org/10.1073/pnas.0809680106 | OLIVIER, E.N.; A.C. RYBICKI; E.E. BOUHASSIRA: "Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells", STEM CELLS, vol. 24, no. 8, 2006, pages 1914 - 22, XP002475361, DOI: doi:10.1634/stemcells.2005-0648 DOI: http://dx.doi.org/10.1634/stemcells.2005-0648 | BROWN, S.E.; W. TONG; P.H. KREBSBACH: "The derivation of mesenchymal stem cells from human embryonic stem cells", CELLS TISSUES ORGANS, vol. 189, no. 1-4, 2009, pages 256 - 60, XP055100750, DOI: doi:10.1159/000151746 DOI: http://dx.doi.org/10.1159/000151746 | KARLSSON, C.; EMANUELSSON, K.; WESSBERG, F.; KAJIC, K.; AXELL, M. Z.; ERIKSSON, P. S.; LINDAHL, A.; HYLLNER, J.; STREHL, R.: "Human embryonic stem cell-derived mesenchymal progenitors-Potential in regenerative medicine", STEM CELL RES., vol. 3, no. 1, 2009, pages 39 - 50 | LU, S. J.; FENG, Q.; CABALLERO, S.; CHEN, Y.; MOORE, M. A.; GRANT, M. B.; LANZA, R.: "Generation offunctional hemangioblasts from human embryonic stem cells", NAT. METHODS, vol. 4, 2007, pages 501 - 509 | LU, S. J.; LUO, C.; HOLTON, K.; FENG, Q.; IVANOVA, Y.; LANZA, R.: "Robust generation of hemangioblastic progenitors from human embryonic stem cells", REGEN. MED., vol. 3, 2008, pages 693 - 704, XP002744078, DOI: doi:10.2217/17460751.3.5.693 DOI: http://dx.doi.org/10.2217/17460751.3.5.693 | KLIMANSKAYA, I.; CHUNG, Y.; BECKER, S.; LU, S.-J.; LANZA, R.: "Human embryonic stem-cell lines derived from single blastomeres", NATURE, vol. 444, 2006, pages 481 - 485, XP009076989, DOI: doi:10.1038/nature05142 DOI: http://dx.doi.org/10.1038/nature05142 | MADSEN, L.S. ET AL.: "A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor", NAT GENET, vol. 23, no. 3, 1999, pages 343 - 7, XP002283438, DOI: doi:10.1038/15525 DOI: http://dx.doi.org/10.1038/15525 | STROMNES, I.M.; J.M. GOVERMAN: "Passive induction of experimental allergic encephalomyelitis", NAT PROTOC, vol. 1, no. 4, 2006, pages 1952 - 60 | LIANG, J. ET AL.: "Allogeneic mesenchymal stem cells transplantation in treatment of multiple sclerosis", MULT SCLER, vol. 15, no. 5, 2009, pages 644 - 6 | COSTA, M. ET AL.: "The ESC line Envy expresses high levels of GFP in all differentiated progeny", NAT METHODS, vol. 2, no. 4, 2005, pages 259 - 60, XP008120057, DOI: doi:10.1038/NMETH748 DOI: http://dx.doi.org/10.1038/NMETH748 | POMPER, M.G. ET AL.: "Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models", CELL RES, vol. 19, no. 3, 2009, pages 370 - 9 | PHINNEY, D.G; D.J. PROCKOP: "Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views", STEM CELLS, vol. 25, no. 11, 2007, pages 2896 - 902, XP002612819, DOI: doi:10.1634/stemcells.2007-0637 DOI: http://dx.doi.org/10.1634/stemcells.2007-0637 | RYAN, J.M. ET AL.: "Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells", CLIN EXP IMMUNOL, vol. 149, no. 2, 2007, pages 353 - 63, XP008146500, DOI: doi:10.1111/j.1365-2249.2007.03422.x DOI: http://dx.doi.org/10.1111/j.1365-2249.2007.03422.x | DELAROSA, 0.; E. LOMBARDO: "Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential", MEDIATORS INFLAMM, 2010, pages 865601 | ENGLISH, K. ET AL.: "IFN-gamma and TNF-alpha differentially regulate immunomodulation by murine mesenchymal stem cells.", IMMUNOL LETT, vol. 110, no. 2, 2007, pages 91 - 100 | BARRY, F. ET AL.: "The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells", BIOCHEM BIOPHYS RES COMMUN, vol. 289, no. 2, 2001, pages 519 - 24, XP055218830, DOI: doi:10.1006/bbrc.2001.6013 DOI: http://dx.doi.org/10.1006/bbrc.2001.6013 | ALHADLAQ, A.; J.J. MAO: "Mesenchymal stem cells: isolation and therapeutics", STEM CELLS DEV, no. 4, 2004, pages 436 - 48, XP008118326 | MIKAMI, Y. ET AL.: "CD271/p75NTR inhibites the differentiation of mesenchymal stem cells into osteogenic, adipogenic, chondrogenic, and myogenic lineages", STEM CELLS DEV, 2010 | DI NICOLA, M. ET AL.: "Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli", BLOOD, vol. 99, no. 10, 2002, pages 3838 - 43, XP002982803, DOI: doi:10.1182/blood.V99.10.3838 DOI: http://dx.doi.org/10.1182/blood.V99.10.3838 | JOHNSON, T.A.; F.R. JIRIK; S. FOUNDER: "Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination", SEMIN IMMUNOPATHOL, vol. 32, no. 2, 2010, pages 197 - 209, XP019843417 | HUSEBY, E.S.; C. OHLEN; J. GOVERMAN: "Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice", J IMMUNOL, vol. 163, no. 3, pages 1115 - 8 | TANG, Q.; J.A. BLUESTONE: "Regulatory T-cellphysiology and application to treat autoimmunity", IMMUNOL REV, vol. 212, 2006, pages 217 - 37, XP002464882, DOI: doi:10.1111/j.0105-2896.2006.00421.x DOI: http://dx.doi.org/10.1111/j.0105-2896.2006.00421.x | BOUMAZA, I. ET AL.: "Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia", J AUTOIMMUN, vol. 32, no. 1, 2009, pages 33 - 4, XP025926169, DOI: doi:10.1016/j.jaut.2008.10.004 DOI: http://dx.doi.org/10.1016/j.jaut.2008.10.004 | MACCARIO, R. ET AL.: "Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype", HAEMATOLOGICA, vol. 90, no. 4, 2005, pages 516 - 25, XP009111749 | LOCATELLI, F.; R. MACCARIO; F. FRASSONI: "Mesenchymal stromal cells, from indifferent spectators to principal actors. Are we going to witness a revolution in the scenario of allograft and immune-mediated disorders?", HAEMATOLOGICA, vol. 92, no. 7, 2007, pages 872 - 7 | WAN, Y.Y.; R.A. FLAVELL: "Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter", PROC NATL ACAD SCI U S A, vol. 102, no. 14, 2005, pages 5126 - 31 | DUIJVESTEIN ET AL., STEM CELLS, vol. 29, no. 10, 2011, pages 1549 - 1558 | LIANG ET AL., CELL TRANSPLANT, vol. 20, no. 9, 2011, pages 1395 - 1408 | PIZARRO ET AL., TRENDS MOL MED, vol. 9, no. 5, 2003, pages 218 - 222 | COPLAND ET AL., IOVS, vol. 49, no. 12, 2008, pages 5458 - 5465 | WAKITANI ET AL., OSTEOARTHRITIS AND CARTILAGE, vol. 10, 2002, pages 199 - 206 | MOBASHERI ET AL., HISTOL. HISTOPATHOL, vol. 24, no. 3, 2009, pages 347 - 366 | NOTH ET AL., NAT CLIN PRACT RHEUMATO, vol. 4, no. 7, 2008, pages 371 - 380 | GOTHERSTROM ET AL., AM J OBSTET GYNECOL, vol. 190, no. 1, 2004, pages 239 - 45 | RASMUSSON ET AL., EXP. CELL RESEARCH, vol. 312, no. 12, 2006, pages 2169 - 79 | NEWMAN ET AL., INFLAMM ALLERGY DRUG TARGETS, vol. 8, no. 2, 2009, pages 110 - 123 | LE BLANC ET AL., EXP. HEMATOL., vol. 31, 2003, pages 890 - 896 | LIU ET AL., J. OF IMMUNOL., vol. 176, 2006, pages 2864 - 2871 |