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EP About this file: EP2800811

EP2800811 - METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION [Right-click to bookmark this link]
Status	The patent has been granted Status updated on 07.04.2017 Database last updated on 24.04.2024
Former	Grant of patent is intended Status updated on 17.03.2017
Former	Examination is in progress Status updated on 12.12.2016
Most recent event Tooltip	04.07.2023	Change: Date of oral proceedings
	04.07.2023	Deletion: Despatch of minutes of oral proceedings
Applicant(s)	For all designated states The Regents of the University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607 / US
	For all designated states University of Vienna Universitätsring 1 1010 Vienna / AT
	For all designated states Charpentier, Emmanuelle Department Of Regulation in Infection Biology Max Planck Institute for Infection Biology Charitéplatz 1 10117 Berlin / DE
	[2017/18]
Former [2014/46]	For all designated states The Regents of the University of California 1111 Franklin Street, 12th Floor Oakland, CA 94607 / US
	For all designated states University of Vienna Universitätsring 1 1010 Vienna / AT
	For all designated states Charpentier, Emmanuelle Department "Regulation in Infection Biology" Helmholtz Centre for Infection Research Inhoffenstrasse 7 38124 Braunschweig / DE
Inventor(s)	01 / JINEK, Martin 1846 Spruce Street Berkeley, California 94709 / US
	02 / DOUDNA CATE, James Harrison 164 Vicente Road Berkeley, California / US
	03 / LIM, Wendell 149 Collins Street San Francisco, California 94118 / US
	04 / QI, Lei 730 Kinkead Way 302 Albany, California 94706 / US
	05 / CHARPENTIER, Emmanuelle Department "Regulation in Infection Biology" Helmholtz Centre for Infection Research Inhoffenstrasse 7 38124 Braunschweig / DE
	06 / CHYLINSKI, Krzysztof Simmeringer Hauptstrasse 45/8 1110 Vienna / AT
	07 / DOUDNA, Jennifer A. 164 Vicente Road Berkeley, California 94705 / US
	[2017/19]
Former [2014/46]	01 / JINEK, Martin 1846 Spruce Street Berkeley, California 94709 / US
	02 / DOUDNA CATE, James Harrison 164 Vicente Road Berkeley, California / US
	03 / LIM, Wendell 149 Collins Street San Francisco, California 94118 / US
	04 / QI, Lei 730 Kinkead Way 302 Albany, California 94706 / US
	05 / CHARPENTIER, Emmanuelle Department "Regulation in Infection Biology" Helmholtz Centre for Infection Research Inhoffenstrasse 7 38124 Braunschweig / DE
	06 / CHYLINSKI, Krysztof Simmeringer Hauptstrasse 45/8 1110 Vienna / AT
	07 / DOUDNA, Jennifer A. 164 Vicente Road Berkeley, California 94705 / US
Representative(s)	Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE
	[N/P]
Former [2017/19]	Green, Katherine, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB
Former [2014/46]	Brasnett, Adrian Hugh Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS / GB
Application number, filing date	13793997.1	15.03.2013
	[2017/19]
	WO2013US32589
Priority number, date	US201261652086P	25.05.2012 Original published format: US 201261652086 P
	US201261716256P	19.10.2012 Original published format: US 201261716256 P
	US201361757640P	28.01.2013 Original published format: US 201361757640 P
	US201361765576P	15.02.2013 Original published format: US 201361765576 P
	[2014/46]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2013176772
	Date:	28.11.2013
	Language:	EN
	[2013/48]
	Type:	A1 Application with search report
	No.:	EP2800811
	Date:	12.11.2014
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 28.11.2013 takes the place of the publication of the European patent application.
	[2014/46]
	Type:	B1 Patent specification
	No.:	EP2800811
	Date:	10.05.2017
	Language:	EN
	[2017/19]
Search report(s)	International search report - published on:	KR	28.11.2013
	(Supplementary) European search report - dispatched on:	EP	26.08.2015
Classification	IPC:	C12N15/11, C12N15/63, C07K19/00, C12N15/10, C12N15/90	[2015/39]
	CPC:	A61K38/465 (EP,IL,US); C12N15/907 (GB,IL,KR,US); C12N15/111 (EP,GB,IL,KR,US); C12N15/102 (EP,GB,IL,KR,US); A01H6/4684 (IL,US); A01K67/027 (IL,US); (+) A61K48/00 (IL,US); A61P31/00 (EP,IL); A61P31/04 (EP,IL); A61P31/12 (EP,IL); A61P35/00 (EP,IL); A61P43/00 (EP,IL); C12N15/113 (EP,GB,IL,KR,US); C12N15/63 (EP,GB,IL,KR,US); C12N15/70 (IL,US); C12N15/746 (IL,US); C12N15/90 (GB,IL,KR,US); C12N15/902 (IL,US); C12N5/10 (IL,KR); C12N9/22 (EP,GB,IL,KR,US); C12Q1/686 (IL,US); C12Y301/04 (EP,GB,IL,US); H01L21/02312 (US); H01L21/02365 (US); H01L33/0075 (US); C07K2319/71 (GB,IL); C07K2319/85 (GB,IL); C12N2310/11 (GB,IL,KR,US); C12N2310/13 (GB,IL,KR,US); C12N2310/14 (IL,US); C12N2310/20 (EP,IL,US); C12N2310/31 (IL,US); C12N2310/32 (IL,US); C12N2310/33 (IL,US); C12N2310/3519 (EP,GB,IL,KR,US); C12N2310/531 (EP,GB,IL,US); C12N2800/80 (IL,US); Y02A50/30 (EP) (-)
	Former IPC [2014/46]	C12N15/11, C12N15/63, C07K19/00, C12N5/10
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/18]
Former [2014/46]	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Extension states	BA	14.10.2014
	ME	14.10.2014
Title	German:	VERFAHREN UND ZUSAMMENSETZUNGEN ZUR RNA-GERICHTETEN ZIEL-DNA-MODIFIKATION UND ZUR RNA-GERICHTETEN TRANSKRIPTIONSMODULATION	[2014/46]
	English:	METHODS AND COMPOSITIONS FOR RNA-DIRECTED TARGET DNA MODIFICATION AND FOR RNA-DIRECTED MODULATION OF TRANSCRIPTION	[2014/46]
	French:	PROCÉDÉS ET COMPOSITIONS PERMETTANT LA MODIFICATION DE L'ADN CIBLE DIRIGÉE PAR L'ARN ET LA MODULATION DE LA TRANSCRIPTION DIRIGÉE PAR L'ARN	[2014/46]
Entry into regional phase	08.08.2014	National basic fee paid
	08.08.2014	Search fee paid
	08.08.2014	Designation fee(s) paid
	08.08.2014	Examination fee paid
Examination procedure	08.08.2014	Examination requested [2014/46]
	05.12.2014	Observations by third parties
	06.01.2015	Observations by third parties
	03.02.2015	Observations by third parties
	05.02.2015	Observations by third parties
	24.07.2015	Observations by third parties
	04.09.2015	Observations by third parties
	14.03.2016	Amendment by applicant (claims and/or description)
	20.04.2016	Observations by third parties
	12.05.2016	Despatch of a communication from the examining division (Time limit: M04)
	22.09.2016	Reply to a communication from the examining division
	08.12.2016	Despatch of a communication from the examining division (Time limit: M04)
	12.12.2016	Reply to a communication from the examining division
	15.12.2016	Observations by third parties
	24.03.2017	Communication of intention to grant the patent
	27.03.2017	Fee for grant paid
	27.03.2017	Fee for publishing/printing paid
	27.03.2017	Receipt of the translation of the claim(s)
Divisional application(s)	EP17163434.8 / EP3241902
	EP18152360.6 / EP3401400
	EP19157590.1 / EP3597749
	EP21207127.8 / EP4043564
	EP23187511.3
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.05.2016
Opposition(s)	Opponent(s)	01 10.05.2017 05.03.2018 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Fünf Höfe Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 05.03.2018 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 05.03.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 05.03.2018 ADMISSIBLE HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF HGF Limited 1 City Walk Leeds LS11 9DX / GB
		05 09.02.2018 05.03.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 05.03.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 05.03.2018 ADMISSIBLE Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Greaves Brewster LLP Copa House Station Road Cheddar, Somerset BS27 3AH / GB
		[N/P]
	Former [2020/30]
	Opponent(s)	01 10.05.2017 05.03.2018 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 05.03.2018 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 05.03.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 05.03.2018 ADMISSIBLE HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF 1 City Walk Leeds LS11 9DX / GB
		05 09.02.2018 05.03.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 05.03.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 05.03.2018 ADMISSIBLE Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Greaves Brewster LLP Copa House Station Road Cheddar, Somerset BS27 3AH / GB
	Former [2020/28]
	Opponent(s)	01 10.05.2017 05.03.2018 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 05.03.2018 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 05.03.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 05.03.2018 ADMISSIBLE HGF 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF 1 City Walk Leeds LS11 9DX / GB
		05 09.02.2018 05.03.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 05.03.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 05.03.2018 ADMISSIBLE Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Greaves Brewster LLP Copa House Station Road Cheddar, Somerset BS27 3AH / GB
	Former [2020/02]
	Opponent(s)	01 10.05.2017 05.03.2018 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 05.03.2018 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 05.03.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 05.03.2018 ADMISSIBLE HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF Limited 1 City Walk Leeds West Yorkshire LS11 9DX / GB
		05 09.02.2018 05.03.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 05.03.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 05.03.2018 ADMISSIBLE Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Greaves Brewster LLP Copa House Station Road Cheddar, Somerset BS27 3AH / GB
	Former [2018/52]
	Opponent(s)	01 10.05.2017 05.03.2018 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 05.03.2018 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 05.03.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 05.03.2018 ADMISSIBLE HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF Limited 1 City Walk Leeds West Yorkshire LS11 9DX / GB
		05 09.02.2018 05.03.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 05.03.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 05.03.2018 ADMISSIBLE Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Elkington & Fife LLP Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR / GB
	Former [2018/12]
	Opponent(s)	01 10.05.2017 ADMISSIBLE Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 ADMISSIBLE Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
		03 08.02.2018 ADMISSIBLE TL Brand & Co Ltd 17 Hannover Square London W1S 1BN / GB Opponent's representative Sharp, Christopher William Pinsent Masons LLP 30 Crown Place Earl Street London EC2A 4ES / GB
		04 09.02.2018 HGF Limited 1 City Walk Leeds Yorkshire LS11 9DX / GB Opponent's representative HGF Limited 1 City Walk Leeds West Yorkshire LS11 9DX / GB
		05 09.02.2018 ADMISSIBLE Jones Day 901 Lakeside Avenue Cleveland, OH 44114 / US Opponent's representative Jones Day Rechtsanwälte, Attorneys-at-Law, Patentanwälte Prinzregentenstrasse 11 80538 München / DE
		06 11.02.2018 ADMISSIBLE Allergan Pharmaceuticals International Limited Clonshaugh Industrial Estate Coolock Dublin 17 / IE Opponent's representative Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
		07 12.02.2018 Truscott, Glyn, John Elkington & Fife LLP Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA / GB Opponent's representative Truscott, Glyn John Elkington and Fife LLP Thavies Inn House 3-4 Holborn Circus London EC1N 2HA / GB
	Former [2017/25]
	Opponent(s)	01 10.05.2017 Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
		02 12.05.2017 Griebling, Onno Sportweg 10 5037 AC Tilburg / NL Opponent's representative Griebling, Onno Octrooibureau Griebling BV Sportweg 10 5037 AC Tilburg / NL
	Former [2017/24]
	Opponent(s)	01 10.05.2017 Pohlman, Sandra M. df-mp Dörries Frank-Molina & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE Opponent's representative Pohlman, Sandra M. df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
	16.02.2018	No. 03: Notification indicating deficiencies in the notice of opposition
	20.02.2018	No. 03: Reply to notification indicating deficiencies in the notice of opposition
	16.03.2018	Invitation to proprietor to file observations on the notice of opposition
	25.10.2018	Reply of patent proprietor to notice(s) of opposition
	06.05.2020	Despatch of interlocutory decision in opposition
Appeal following opposition	23.06.2020	Appeal received No. T1087/20
	16.09.2020	Statement of grounds filed
	30.03.2020	Appeal received No. T1087/20
	16.09.2020	Statement of grounds filed
	18.02.2020	Appeal received No. T1087/20
	16.09.2020	Statement of grounds filed
	15.07.2020	Appeal received No. T1087/20
	15.09.2020	Statement of grounds filed
	05.02.2020	Date of oral proceedings
	06.05.2020	Minutes of the oral proceedings despatched
	07.10.2024	Date of oral proceedings
Fees paid	Renewal fee
	27.03.2015	Renewal fee patent year 03
	31.03.2016	Renewal fee patent year 04
	27.03.2017	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	SM	10.05.2017
	[2018/13]
Documents cited:	Search	[E]WO2014065596 (TOOLGEN INC [KR]) [E] 1-21 * the whole document *;
		[T]WO2014089290 (SIGMA ALDRICH CO LLC [US], et al) [T] * figure 4; examples 2-4; table 4 *;
		[E]WO2014093661 (BROAD INST INC [US], et al) [E] 1-21 * the whole document *;
		[E]WO2014093712 (BROAD INST INC [US], et al) [E] 1-21 * the whole document *;
		[E]WO2014099744 (HARVARD COLLEGE [US]) [E] 1-21 * the whole document *;
		[XPI] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, page 821, XP055067747 [XP] 1,2,9,13,18 * the whole document * [I] 1-21 DOI: http://dx.doi.org/10.1126/science.1225829
		[XPI] - L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067741 [XP] 1-20 * the whole document * [I] 1-21 DOI: http://dx.doi.org/10.1126/science.1231143
		[XPI] - L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [XP] 1-20 * the whole document * [I] 1-21 DOI: http://dx.doi.org/10.1126/science.1231143
		[XPI] - P. MALI ET AL, "RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055111247 [XP] 1-20 * the whole document * [I] 1-21 DOI: http://dx.doi.org/10.1126/science.1232033
		[XPI] - MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", E-LIFE, SAM LTD, GB, vol. 2, doi:10.7554/ELIFE.00471, ISSN 2050-084X, (20130129), pages e00471 - 1, (20130628), XP002699851 [XP] 1-20 * the whole document * [I] 1-21 DOI: http://dx.doi.org/10.7554/eLife.00471
		[IP] - PHILIPPE HORVATH ET AL, "RNA-guided genome editing à la carte", CELL RESEARCH, (20130312), vol. 23, no. 6, doi:10.1038/cr.2013.39, ISSN 1001-0602, pages 733 - 734, XP055184973 [IP] 1-21 * the whole document * DOI: http://dx.doi.org/10.1038/cr.2013.39
	International search	[A]US2010076057 (SONTHEIMER ERIK J [US], et al);
		[A]US2011189776 (TERNS REBECCA [US], et al);
		[X] - SASHITAL, DIPALI G. ET AL., "Mechanism of foreign DNA selection in a bacterial adaptive immune system", MOLECULAR CELL, (20120419), vol. 46, no. 5, pages 606 - 615, XP028522142 DOI: http://dx.doi.org/10.1016/j.molcel.2012.03.020
		[A] - WIEDENHEFT, BLAKE ET AL., "RNA-guided genetic silencing systems in bacteria and archaea", NATURE, (20120215), vol. 482, no. 7385, pages 331 - 338, XP055116249 DOI: http://dx.doi.org/10.1038/nature10886
		[A] - HALE, CARYN R. ET AL., "RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex", CELL, (20091125), vol. 139, no. 5, pages 945 - 956, XP055038712 DOI: http://dx.doi.org/10.1016/j.cell.2009.07.040
		[XP] - JINEK, MARTIN ET AL., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", SCIENCE, (20120817), vol. 337, no. 6096, pages 816 - 821, XP055067747 DOI: http://dx.doi.org/10.1126/science.1225829
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