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Extract from the Register of European Patents

EP About this file: EP2771468

EP2771468 - ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION [Right-click to bookmark this link]
Status	Patent revoked Status updated on 27.11.2020 Database last updated on 24.04.2024
Former	The patent has been granted Status updated on 25.03.2018
Most recent event Tooltip	27.11.2020	Revocation of patent	published on 30.12.2020 [2020/53]
Applicant(s)	For all designated states The Broad Institute, Inc. 415 Main Street Cambridge, MA 02142 / US
	For all designated states Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge, MA 02139 / US
	For all designated states President and Fellows of Harvard College 17 Quincy Street Cambridge, MA 02138 / US
	[2018/16]
Former [2015/40]	For all designated states The Broad Institute, Inc. 415 Main Street Cambridge, MA 02142 / US
	For all designated states Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02142 / US
	For all designated states President and Fellows of Harvard College 17 Quincy Street Cambridge, MA 02138 / US
Former [2014/36]	For all designated states The Broad Institute, Inc. 7 Cambridge Center Cambridge, MA 02142 / US
	For all designated states Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02142 / US
	For all designated states President and Fellows of Harvard College 17 Quincy Street Cambridge, MA 02138 / US
Inventor(s)	01 / ZHANG, Feng 100 Pacific Street Apt. 11 Cambridge, MA 02139 / US
	02 / CONG, Le 100 Memorial Dr Apt 8-21B Cambridge, MA 02142 / US
	03 / HSU, Patrick 37 Kirkland St., Apt. B1 Cambridge, MA 02138 / US
	04 / RAN, Fei 30 Clarendon Street Boston, MA 02116 / US
	[2015/39]
Former [2014/36]	01 / ZHANG, Feng 100 Pacific Street Apt. 11 Cambridge, MA 02139 / US
	02 / CONG, Le 1200 Massachusetts Ave., Apt. 33E Cambridge, MA 02138 / US
	03 / HSU, Patrick 37 Kirkland St., Apt. B1 Cambridge, MA 02138 / US
	04 / RAN, Fei 129 St. Botolph St., Apt. 2 Boston, MA 02115 / US
Representative(s)	De Clercq, Ann G. Y., et al De Clercq & Partners Edgard Gevaertdreef 10a 9830 Sint-Martens-Latem / BE
	[N/P]
Former [2014/36]	Williams, Gareth Owen Marks & Clerk LLP 62-68 Hills Road Cambridge CB2 1LA / GB
Application number, filing date	13818570.7	12.12.2013
	WO2013US74819
Priority number, date	US201261736527P	12.12.2012 Original published format: US 201261736527 P
	US201361748427P	02.01.2013 Original published format: US 201361748427 P
	US201361758468P	30.01.2013 Original published format: US 201361758468 P
	US201361769046P	25.02.2013 Original published format: US 201361769046 P
	US201361791409P	15.03.2013 Original published format: US 201361791409 P
	US201361802174P	15.03.2013 Original published format: US 201361802174 P
	US201361806375P	28.03.2013 Original published format: US 201361806375 P
	US201361814263P	20.04.2013 Original published format: US 201361814263 P
	US201361819803P	06.05.2013 Original published format: US 201361819803 P
	US201361828130P	28.05.2013 Original published format: US 201361828130 P
	US201361835931P	17.06.2013 Original published format: US 201361835931 P
	US201361836127P	17.06.2013 Original published format: US 201361836127 P
	[2014/36]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2014093712
	Date:	19.06.2014
	Language:	EN
	[2014/25]
	Type:	A1 Application with search report
	No.:	EP2771468
	Date:	03.09.2014
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 19.06.2014 takes the place of the publication of the European patent application.
	[2014/36]
	Type:	B1 Patent specification
	No.:	EP2771468
	Date:	11.02.2015
	Language:	EN
	[2015/07]
Search report(s)	International search report - published on:	EP	19.06.2014
Classification	IPC:	C12N15/63	[2014/36]
	CPC:	C12N9/22 (EP,IL,RU,US); A61K48/00 (IL); C12N9/16 (EP,IL,RU,US); A61K48/005 (EP,IL); C12N15/01 (EP,IL,RU,US); C12N15/102 (EP,IL); (+) C12N15/1082 (EP,IL,RU,US); C12N15/113 (EP,IL); C12N15/52 (EP,IL,RU,US); C12N15/63 (EP,IL,RU,US); C12N15/79 (EP,IL,RU,US); C12N15/85 (IL,RU,US); C12N15/86 (IL,RU,US); C12N15/902 (IL,RU,US); C12N15/907 (EP,IL,US); C12Q1/6806 (IL,RU,US); C12Y301/00 (EP,IL,RU,US); G16B20/00 (EP,IL); G16B20/20 (EP,IL); G16B20/30 (EP,IL); G16B20/50 (EP,IL); G16B30/00 (EP,IL); G16B30/10 (EP,IL); C12N2310/10 (EP,IL); C12N2310/20 (EP,IL,US); C12N2320/11 (EP,IL); C12N2320/30 (EP,IL); C12N2750/14143 (EP,IL); C12N2800/10 (IL,US); C12N2810/50 (IL,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/36]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	HERSTELLUNG VON SYSTEMEN, VERFAHREN UND OPTIMIERTEN FÜHRUNGSZUSAMMENSETZUNGEN ZUR SEQUENZMANIPULATION	[2014/36]
	English:	ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION	[2014/36]
	French:	FABRICATION DE SYSTÈMES, PROCÉDÉS ET COMPOSITIONS DE GUIDE OPTIMISÉES POUR LA MANIPULATION DE SÉQUENCES	[2014/36]
Entry into regional phase	27.05.2014	National basic fee paid
	27.05.2014	Designation fee(s) paid
	27.05.2014	Examination fee paid
Examination procedure	27.05.2014	Examination requested [2014/36]
	11.09.2014	Amendment by applicant (claims and/or description)
	01.10.2014	Observations by third parties
	07.11.2014	Despatch of a communication from the examining division (Time limit: M04)
	14.11.2014	Reply to a communication from the examining division
	12.12.2014	Communication of intention to grant the patent
	19.12.2014	Fee for grant paid
	19.12.2014	Fee for publishing/printing paid
	19.12.2014	Receipt of the translation of the claim(s)
	20.11.2019	Observations by third parties
Divisional application(s)	EP14170383.5 / EP2784162
	EP15154539.9 / EP2896697
	EP15154565.4 / EP2940140
	EP15154566.2 / EP2921557
	EP16194919.3 / EP3144390
	EP20158349.9 / EP3702463
	EP23193042.1
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 07.11.2014
Opposition(s)	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2 80538 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 WITHDRAWN Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 29.08.2019 WITHDRAWN Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson Chapel Quarter Mount Street Nottingham NG1 6HQ / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP 10A Printing House Yard Hackney Road London E2 7PR / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Marlow International Parkway Marlow SL7 1YL / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire The Shard 32 London Bridge Street London SE1 9SG / GB
		[N/P]
	Former [2019/40]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Nikolaistrasse 15 80802 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 WITHDRAWN Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 29.08.2019 WITHDRAWN Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP 10A Printing House Yard Hackney Road London E2 7PR / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Marlow International Parkway Marlow SL7 1YL / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2018/43]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Nikolaistrasse 15 80802 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 WITHDRAWN Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP 10A Printing House Yard Hackney Road London E2 7PR / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2018/35]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 WITHDRAWN Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP 10A Printing House Yard Hackney Road London E2 7PR / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2018/16]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Baarerstrasse 14 6300 Zug / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP 10A Printing House Yard Hackney Road London E2 7PR / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2017/12]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Aeschenvorstadt 36 4051 Basel / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Patent Boutique LLP Aldgate Tower 2 Leman Street London E1 8FA / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2017/06]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Patentanwalt und Solicitor PartG mbB Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Aeschenvorstadt 36 4051 Basel / CH Opponent's representative Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Boxall, Sarah Jane Boxall IPM Ltd 9 King Street Sandwich Kent CT13 9BT / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2016/24]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative Bezzubova, Olga Jones Day Prinzregentenstraße 11 80538 München / DE
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Aeschenvorstadt 36 4051 Basel / CH Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Boxall, Sarah Jane Boxall IPM Ltd 9 King Street Sandwich Kent CT13 9BT / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2016/11]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazelles 75847 Paris Cedex 17 / FR Opponent's representative HGF Limited Saviour House 9 St. Saviourgate York YO1 8NQ / GB
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Aeschenvorstadt 36 4051 Basel / CH Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Boxall, Sarah Jane Boxall IPM Ltd 9 King Street Sandwich Kent CT13 9BT / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2016/01]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 20.11.2015 ADMISSIBLE Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Postfach 44 05 16 80754 München / DE
		03 10.11.2015 23.11.2015 ADMISSIBLE Regimbeau 20, Rue de Chazalles 75847 Paris Cedex 17 / FR Opponent's representative Regimbeau 20, rue de Chazelles 75847 Paris Cedex 17 / FR
		04 10.11.2015 24.11.2015 ADMISSIBLE CRISPR Therapeutics AG Aeschenvorstadt 36 4051 Basel / CH Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		05 11.11.2015 24.11.2015 ADMISSIBLE Storz, Dr. Ulrich Michalski Hüttermann & Partner Patentanwälte mbB Speditionstrasse 21 40221 Düsseldorf / DE
		06 11.11.2015 24.11.2015 ADMISSIBLE Novozymes A/S Krogshøjvej 36 2880 Bagsværd / DK Opponent's representative Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
		07 11.11.2015 24.11.2015 ADMISSIBLE Boxall Intellectual Property Management Limited Homefield 133 Woodnesborough Road Sandwich Kent CT13 0BA / GB Opponent's representative Boxall, Sarah Jane Boxall IPM Ltd 9 King Street Sandwich Kent CT13 9BT / GB
		08 11.11.2015 24.11.2015 ADMISSIBLE Sagittarius Intellectual Property LLP 19-21 Chapel Street Marlow Buckinghamshire SL7 3HN / GB Opponent's representative Teuten, Andrew John Sagittarius IP Three Globeside Fieldhouse Lane Marlow, Buckinghamshire SL7 1HZ / GB
		09 11.11.2015 24.11.2015 ADMISSIBLE Adams, Harvey Vaughan John Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB Opponent's representative Wilding, James Roger Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	Former [2015/51]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
		02 10.11.2015 Grund, Dr., Martin Nikolaistr. 15 80802 Munich / DE Opponent's representative Grund, Martin Grund Intellectual Property Group Postfach 44 05 16 80754 München / DE
	Former [2015/49]
	Opponent(s)	01 26.10.2015 29.10.2015 ADMISSIBLE Schlich, George 9 St Catherine's Road Littlehampton Sussex BN17 5HS / GB Opponent's representative Schlich, George, et al, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB
	22.12.2015	Invitation to proprietor to file observations on the notice of opposition
	30.06.2016	Reply of patent proprietor to notice(s) of opposition
	16.01.2018	Date of oral proceedings
	26.03.2018	Despatch of minutes of oral proceedings
	26.03.2018	Despatch of communication that the patent will be revoked
	16.01.2020	Legal effect of revocation of patent [2020/53]
Appeal following opposition	28.03.2018	Appeal received No. T0844/18
	01.08.2018	Statement of grounds filed
	30.07.2019	Invitation to file observations in an appeal (Time limit: M03) [2019/31]
	05.11.2019	Date of receipt of observations in an appeal [2019/45]
	16.01.2020	Result of appeal procedure: appeal of the proprietor was rejected
	13.01.2020	Date of oral proceedings
	28.01.2020	Minutes of the oral proceedings despatched
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Lapses during opposition Tooltip	HU	12.12.2013
	AL	11.02.2015
	BG	11.02.2015
	CY	11.02.2015
	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	MC	11.02.2015
	MK	11.02.2015
	MT	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	SI	11.02.2015
	SM	11.02.2015
	GR	12.05.2015
	[2018/46]
Former [2018/29]	HU	12.12.2013
	BG	11.02.2015
	CY	11.02.2015
	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	MC	11.02.2015
	MK	11.02.2015
	MT	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	SI	11.02.2015
	SM	11.02.2015
	GR	12.05.2015
Former [2017/39]	HU	12.12.2013
	BG	11.02.2015
	CY	11.02.2015
	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	MC	11.02.2015
	MT	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	SI	11.02.2015
	GR	12.05.2015
Former [2016/33]	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	MC	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	SI	11.02.2015
	GR	12.05.2015
Former [2016/12]	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	SI	11.02.2015
	GR	12.05.2015
Former [2015/50]	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	RO	11.02.2015
	RS	11.02.2015
	GR	12.05.2015
Former [2015/39]	HR	11.02.2015
	LT	11.02.2015
	LV	11.02.2015
	RS	11.02.2015
	GR	12.05.2015
Former [2015/37]	HR	11.02.2015
	LT	11.02.2015
	GR	12.05.2015
Former [2015/36]	HR	11.02.2015
	LT	11.02.2015
Former [2015/35]	LT	11.02.2015
Cited in	International search	[XPA] - L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055102030 [XP] 1-16,20-22,37-46,48-53 * abstract * * page 820, column l * [A] 17-19,23-36,47 DOI: http://dx.doi.org/10.1126/science.1231143
		[P] - L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [P] * figures S1, S8 * DOI: http://dx.doi.org/10.1126/science.1231143
		[XI] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067740 [X] 1 * the whole document * [I] 2-16,20-22,36-46,49,51-53 DOI: http://dx.doi.org/10.1126/science.1225829
		[ ] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067747 [ ] * figures S7, S8, S11; table S1 * DOI: http://dx.doi.org/10.1126/science.1225829
		[A] - G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [A] 1-53 * abstract * * page E2579 * * page E2583 * DOI: http://dx.doi.org/10.1073/pnas.1208507109
		[AP] - JIANG WENYAN ET AL, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY,, (20130129), vol. 31, no. 3, pages 233 - 239, XP002699849 [AP] 1-53 * abstract * DOI: http://dx.doi.org/10.1038/nbt.2508
		[A] - BLAKE WIEDENHEFT ET AL, "RNA-guided genetic silencing systems in bacteria and archaea", NATURE, (20120215), vol. 482, no. 7385, doi:10.1038/nature10886, ISSN 0028-0836, pages 331 - 338, XP055116249 [A] 1-53 * the whole document * DOI: http://dx.doi.org/10.1038/nature10886
		[A] - ELITZA DELTCHEVA ET AL, "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", NATURE, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, ISSN 0028-0836, pages 602 - 607, XP055068535 [A] 1-53 * abstract * DOI: http://dx.doi.org/10.1038/nature09886
		[A] - MICHAEL P TERNS ET AL, "CRISPR-based adaptive immune systems", CURRENT OPINION IN MICROBIOLOGY, (20110601), vol. 14, no. 3, doi:10.1016/j.mib.2011.03.005, ISSN 1369-5274, pages 321 - 327, XP055097823 [A] 1-53 * the whole document * DOI: http://dx.doi.org/10.1016/j.mib.2011.03.005
		[IP] - GAJ THOMAS ET AL, "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering", TRENDS IN BIOTECHNOLOGY, (20130701), vol. 31, no. 7, doi:10.1016/J.TIBTECH.2013.04.004, ISSN 0167-7799, pages 397 - 405, XP028571313 [IP] 1-53 * the whole document * DOI: http://dx.doi.org/10.1016/j.tibtech.2013.04.004
		[IP] - WANG HAOYI ET AL, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, (20130509), vol. 153, no. 4, doi:10.1016/J.CELL.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 [IP] 1-53 * abstract * DOI: http://dx.doi.org/10.1016/j.cell.2013.04.025
		[IP] - LUKE A. GILBERT ET AL, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", CELL, (20130701), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843 [IP] 1-53 * abstract * DOI: http://dx.doi.org/10.1016/j.cell.2013.06.044
		[IP] - KRZYSZTOF CHYLINSKI ET AL, "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA BIOLOGY, (20130501), vol. 10, no. 5, doi:10.4161/rna.24321, ISSN 1547-6286, pages 726 - 737, XP055116068 [IP] 1-53 * the whole document * DOI: http://dx.doi.org/10.4161/rna.24321
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		- GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185
		- BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530
		- MOL. CELL. BIOL., (1988), vol. 8, no. L, pages 466 - 472
		- PROC. NATL. ACAD. SCI. USA., (1981), vol. 78, no. 3, pages 1527 - 31
		- SMITH; JOHNSON, GENE, (1988), vol. 67, pages 31 - 40
		- AMRANN ET AL., GENE, (1988), vol. 69, pages 301 - 315
		- STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185, pages 60 - 89
		- BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234
		- KUIJAN; HERSKOWITZ, CELL, (1982), vol. 30, pages 933 - 943
		- SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123
		- SMITH ET AL., MOL. CELL. BIOL., (1983), vol. 3, pages 2156 - 2165
		- LUCKLOW; SUMMERS, VIROLOGY, (1989), vol. 170, pages 31 - 39
		- SEED, NATURE, (1987), vol. 329, page 840
		- KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195
		- PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277
		- CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275
		- WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733
		- BANEIJI ET AL., CELL, (1983), vol. 33, pages 729 - 740
		- QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748
		- BYRNE; RUDDLE, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477
		- EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916
		- KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379
		- CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546
		- ISHINO ET AL., J. BACTERIOL., (1987), vol. 169, pages 5429 - 5433
		- NAKATA ET AL., J. BACTERIOL., (1989), vol. 171, pages 3553 - 3556
		- GROENEN ET AL., MOL. MICROBIOL., (1993), vol. 10, pages 1057 - 1065
		- HOE ET AL., EMERG. INFECT. DIS., (1999), vol. 5, pages 254 - 263
		- MASEPOHL ET AL., BIOCHIM. BIOPHYS. ACTA, (1996), vol. 1307, pages 26 - 30
		- MOJICA ET AL., MOL. MICROBIOL., (1995), vol. 17, pages 85 - 93
		- JANSSEN ET AL., OMICS J. INTEG. BIOL., (2002), vol. 6, pages 23 - 33
		- MOJICA ET AL., MOL. MICROBIOL., (2000), vol. 36, pages 244 - 246
		- VAN EMBDEN ET AL., J. BACTERIOL., (2000), vol. 182, pages 2393 - 2401
		- JANSEN ET AL., MOL. MICROBIOL., (2002), vol. 43, pages 1565 - 1575
		- NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES., (2000), vol. 28, doi:doi:10.1093/nar/28.1.292, page 292, XP002941557 DOI: http://dx.doi.org/10.1093/nar/28.1.292
		- ZUKER; STIEGLER, NUCLEIC ACIDS RES., (1981), vol. 9, pages 133 - 148
		- A.R. GRUBER ET AL., CELL, (2008), vol. 106, no. 1, pages 23 - 24
		- PA CARR; GM CHURCH, NATURE BIOTECHNOLOGY, (2009), vol. 27, no. 12, pages 1151 - 62
		- ANDERSON, SCIENCE, (1992), vol. 256, pages 808 - 813
		- NABEL; FELGNER, TIBTECH, (1993), vol. 11, pages 211 - 217
		- MITANI; CASKEY, TIBTECH, (1993), vol. 11, pages 162 - 166
		- DILLON, TIBTECH, (1993), vol. 11, pages 167 - 175
	- MILLER, NATURE, (1992), vol. 357, pages 455 - 460
	- VAN BRUNT, BIOTECHNOLOGY, (1988), vol. 6, no. 10, pages 1 149 - 1154
	- VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, (1995), vol. 8, pages 35 - 36
	- KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, (1995), vol. 51, no. 1, pages 31 - 44
	- YU ET AL., GENE THERAPY, (1994), vol. 1, pages 13 - 26
	- CRYSTAL, SCIENCE, (1995), vol. 270, pages 404 - 410
	- BLAESE, CANCER GENE THER, (1995), vol. 2, pages 291 - 297
	- BEHR ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 382 - 389
	- REMY ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 647 - 654
	- GAO ET AL., GENE THERAPY, (1995), vol. 2, pages 710 - 722
	- AHMAD ET AL., CANCER RES., (1992), vol. 52, pages 4817 - 4820
	- BUCHSCHER ET AL., J. VIROL., (1992), vol. 66, pages 2731 - 2739
	- JOHANN ET AL., J. VIROL., (1992), vol. 66, pages 1635 - 1640
	- SOMMNERFELT ET AL., VIROL, (1990), vol. 176, pages 58 - 59
	- WILSON ET AL., J. VIROL., (1989), vol. 63, pages 2374 - 2378
	- MILLER ET AL., J. VIROL., (1991), vol. 65, pages 2220 - 2224
	- WEST ET AL., VIROLOGY, (1987), vol. 160, pages 38 - 47
	- KOTIN, HUMAN GENE THERAPY, (1994), vol. 5, pages 793 - 801
	- MUZYCZKA, J. CLIN. INVEST., (1994), vol. 94, page 1351
	- TRATSCHIN ET AL., MOL. CELL. BIOL, (1985), vol. 5, pages 3251 - 3260
	- TRATSCHIN ET AL., MOL. CELL. BIOL., (1984), vol. 4, pages 2072 - 2081
	- HERMONAT; MUZYCZKA, PNAS, (1984), vol. 81, pages 6466 - 6470
	- SAMULSKI ET AL., J. VIROL., (1989), vol. 63, pages 03822 - 3828
	- MORRELL ET AL., "Crop genomics:advances and applications", NAT REV GENET, (20111229), vol. 13, no. 2, pages 85 - 96
	- MCLVOR EL; POLAK U; NAPIERALA M., "New insights into repeat instability: role of RNA?DNA hybrids", RNA BIOL., (201009), vol. 7, no. 5, pages 551 - 8
	- TANGRI S ET AL., "Rationally engineered therapeutic proteins with reduced immunogenicity", J IMMUNOL., (20050315), vol. 174, no. 6, pages 3187 - 96
	- GRUBER ET AL., NUCLEIC ACIDS RESEARCH, (2008), vol. 36, page W70
	- SAPRANAUSAKS, CUCLEIC ACIS RESEARCH, (2011), vol. 39, page 9275
	- GASIUNAS, PROC. NATL. ACAD. SCI. USA, (2012), vol. 109, page E2579
	- JINEK ET AL., SCIENCE, (2012), vol. 337, page 816
	- MAKAROVA ET AL., NAT REV MICROBIOL, (2011), vol. 9, page 467
	- URNOV, F.D.; REBAR, E.J.; HOLMES, M.C.; ZHANG, H.S.; GREGORY, P.D., "Genome editing with engineered zinc finger nucleases", NAT. REV. GENET, (2010), vol. 11, doi:doi:10.1038/nrg2842, pages 636 - 646, XP008150557 DOI: http://dx.doi.org/10.1038/nrg2842
	- BOGDANOVE, A.J.; VOYTAS, D.F. TAL EFFECTORS: CUSTOMIZABLE PROTEINS FOR DNA TARGETING, SCIENCE, (2011), vol. 333, pages 1843 - 1846
	- STODDARD, B.L., "Homing endonuclease structure and function.", Q. REV. BIOPHYS, (2005), vol. 38, doi:doi:10.1017/S0033583505004063, pages 49 - 95, XP008065807 DOI: http://dx.doi.org/10.1017/S0033583505004063
	- BAE, T.; SCHNEEWIND, O., "Allelic replacement in Staphylococcus aureus with inducible counter-selection.", PLASMID, (2006), vol. 55, doi:doi:10.1016/j.plasmid.2005.05.005, pages 58 - 63, XP024939950 DOI: http://dx.doi.org/10.1016/j.plasmid.2005.05.005
	- SUNG, C.K.; LI, H.; CLAVERYS, J.P.; MONISON, D.A., "An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae", APPL. ENVIRON. MICROBIOL., (2001), vol. 67, pages 5190 - 5196
	- SHARAN, S.K.; THOMASON, L.C.; KUZNETSOV, S.G.; COURT, D.L., "Recombineering: a homologous recombination-based method of genetic engineering", NAT. PROTOC., (2009), vol. 4, doi:doi:10.1038/nprot.2008.227, pages 206 - 223, XP001525689 DOI: http://dx.doi.org/10.1038/nprot.2008.227
	- JINEK, M. ET AL., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.", SCIENCE, (2012), vol. 337, doi:doi:10.1126/science.1225829, pages 816 - 821, XP055229606 DOI: http://dx.doi.org/10.1126/science.1225829
	- DEVEAU. H.; GARNEAU, J.E.; MOINEAU, S., "CRISPR-Cas system and its role in phage- bacteria interactions", ANNU. REV. MICROBIOL, (2010), vol. 64, doi:doi:10.1146/annurev.micro.112408.134123, pages 475 - 493, XP055067789 DOI: http://dx.doi.org/10.1146/annurev.micro.112408.134123
	- HORVATH, P.; BARRANGOU, R., "CRISPR-Cas, the immune system of bacteria and archaea", SCIENCE, (2010), vol. 327, doi:doi:10.1126/science.1179555, pages 167 - 170, XP055016971 DOI: http://dx.doi.org/10.1126/science.1179555
	- TERNS, M.P.; TERNS, R.M., "CRISPR-based adaptive immune systems.", CURR. OPIN. MICROBIOL., (2011), vol. 14, doi:doi:10.1016/j.mib.2011.03.005, pages 321 - 327, XP055097823 DOI: http://dx.doi.org/10.1016/j.mib.2011.03.005
	- VAN DER OOST, J.; JORE, M.M.; WESTRA, E.R.; LUNDGREN, M.; BROUNS, S.J., "CRISPR-based adaptive and heritable immunity in prokaryotes", TRENDS. BIOCHEM. SCI, (2009), vol. 34, doi:doi:10.1016/j.tibs.2009.05.002, pages 401 - 407, XP002559963 DOI: http://dx.doi.org/10.1016/j.tibs.2009.05.002
	- BROUNS, S.J. ET AL., "Small C'RISPR RNAs guide antiviral defense in prokaryotes", SCIENCE, (2008), vol. 321, doi:doi:10.1126/science.1159689, pages 960 - 964, XP002559962 DOI: http://dx.doi.org/10.1126/science.1159689
	- CARTE, J.; WANG, R.; LI, H.; TERNS, R.M.; TERNS, M.P., "Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes", GENES DEV., (2008), vol. 22, doi:doi:10.1101/gad.1742908, pages 3489 - 3496, XP055054069 DOI: http://dx.doi.org/10.1101/gad.1742908
	- DELTCHEVA, E. ET AL., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III.", NATURE, (2011), vol. 471, doi:doi:10.1038/nature09886, pages 602 - 607, XP055068535 DOI: http://dx.doi.org/10.1038/nature09886
	- HATOUM-ASLAN, A.; MANIV, I.; MARRAFFINI, L.A., "Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site", PROC. NATL. ACAD. SCI. U.S.A., (2011), vol. 108, doi:doi:10.1073/pnas.1112832108, pages 21218 - 21222, XP055250498 DOI: http://dx.doi.org/10.1073/pnas.1112832108
	- HAURWITZ, R.E.; JINEK, M.; WIEDENHEFT, B.; ZHOU, K.; DOUDNA, J.A., "Sequence- and structure-specific RNA processing by a CRISPR endonuclease", SCIENCE, (2010), vol. 329, doi:doi:10.1126/science.1192272, pages 1355 - 1358, XP055244668 DOI: http://dx.doi.org/10.1126/science.1192272
	- DEVEAU, H. ET AL., "Phage response to CRISPR-encoded resistance in Streptococcus thermophilus", J. BACTERIOL, (2008), vol. 190, doi:doi:10.1128/JB.01412-07, pages 1390 - 1400, XP002679468 DOI: http://dx.doi.org/10.1128/JB.01412-07
	- MAKAROVA, K.S.; ARAVIND, L.; WOLF, Y.I.; KOONIN, E.V., "Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems", BIOL. DIRECT., (2011), vol. 6, page 38
	- BARRANGOU, R., "RNA-mediated programmable DNA cleavage", NAT. BIOTECHNOL., (2012), vol. 30, doi:doi:10.1038/nbt.2357, pages 836 - 838, XP055118675 DOI: http://dx.doi.org/10.1038/nbt.2357
	- BROUNS, S.J., "MoLecular biology. A Swiss army knife of immunity", SCIENCE, (2012), vol. 337, pages 808 - 809
	- CARROLL, D., "A CRISPR Approach to Gene Targeting", MOL. THER., (2012), vol. 20, doi:doi:10.1038/mt.2012.171, pages 1658 - 1660, XP055106489 DOI: http://dx.doi.org/10.1038/mt.2012.171
	- BIKARD, D.; HATOUM-ASLAN, A.; MUCIDA, D.; MARRAFFINI, L.A., "CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection", CELL HOST MICROBE, (2012), vol. 12, doi:doi:10.1016/j.chom.2012.06.003, pages 177 - 186, XP028934538 DOI: http://dx.doi.org/10.1016/j.chom.2012.06.003
	- ZAHNER, D.; HAKENBECK, R., "The Streptococcus pneumoniae beta-galactosidase is a surface protein.", J. BACTERIOL., (2000), vol. 182, doi:doi:10.1128/JB.182.20.5919-5921.2000, pages 5919 - 5921, XP002529681 DOI: http://dx.doi.org/10.1128/JB.182.20.5919-5921.2000
	- MARRAFFINI, L.A.; DEDENT, A.C.; SCHNEEWIND, O., "Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria.", MICROBIOL. MOL. BIOL. REV., (2006), vol. 70, doi:doi:10.1128/MMBR.70.1.192-221.2006, pages 192 - 221, XP002459580 DOI: http://dx.doi.org/10.1128/MMBR.70.1.192-221.2006
	- MOTAMEDI, M.R.; SZIGETY, S.K.; ROSENBERG, S.M., "Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivo", GENES DEV., (1999), vol. 13, pages 2889 - 2903
	- HOSAKA, T. ET AL., "The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli.", MOL. GENET. GENOMICS, (2004), vol. 271, pages 317 - 324
	- COSTANTINO, N.; COURT, D.L., "Enhanced levels of lambda Red-mediated recombinants in mismatch repair mutants", PROC. NATL. ACAD. SCI. U.S.A., (2003), vol. 100, pages 15748 - 15753
	- EDGAR, R.; QIMRON, U., "The Escherichia coli CRISPR system protects from lambda lysogenization, lysogens, and prophage induction", J. BACTERIOL., (2010), vol. 192, pages 6291 - 6294
	- MARRAFFINI, L.A.; SONTHEIMER, E.J., "Self versus non-self discrimination during CRISPR RNA-directed immunity", NATURE, (2010), vol. 463, doi:doi:10.1038/nature08703, pages 568 - 571, XP055118462 DOI: http://dx.doi.org/10.1038/nature08703
	- FISCHER, S. ET AL., "An archaeal immune system can detect multiple Protospacer Adjacent Motifs (PAMs) to target invader DNA..I.", BIOL. CHEM., (2012), vol. 287, pages 33351 - 33363
	- GUDBERGSDOTTIR, S. ET AL., "Dynamic properties of the Sulfolobus CRISPR-Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers.", MOL. MICROBIOL., (2011), vol. 79, pages 35 - 49
	- WANG, H.H. ET AL., "Genome-scale promoter engineering by coselection MAGE", NAT METHODS, (2012), vol. 9, pages 591 - 593
	- HOSKINS, J. ET AL., "Genome of the bacterium Streptococcus pneumoniae strain R6", J. BACTERIOL, (2001), vol. 183, doi:doi:10.1128/JB.183.19.5709-5717.2001, pages 5709 - 5717, XP002231307 DOI: http://dx.doi.org/10.1128/JB.183.19.5709-5717.2001
	- HAVARSTEIN, L.S.; COOMARASWAMY, G.; MORRISON, D.A., "An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae.", PROC. NATL. ACAD. SCI. U.S.A., (1995), vol. 92, doi:doi:10.1073/pnas.92.24.11140, pages 11140 - 11144, XP000892151 DOI: http://dx.doi.org/10.1073/pnas.92.24.11140
	- HORINOUCHI, S.; WEISBLUM, B., "Nucleotide sequence and functional map of pC194, a plasmid that specifies inducible chloramphenicol resistance", J. BACTERIOL., (1982), vol. 150, pages 815 - 825
	- HORTON, R.M., "In Vitro Recombination and Mutagenesis of DNA : SOEing Together Tailor-Made Genes.", METHODS MOL. BIOL, (1993), vol. 15, pages 251 - 261
	- PODBIELSKI, A.; SPELLERBERG, B.; WOISCHNIK, M.; POHL, B.; LUTTICKEN, R., "Novel series of plasmid vectors for gene inactivation and expression analysis in group A streptococci (GAS", GENE, (1996), vol. 177, doi:doi:10.1016/0378-1119(96)84178-3, pages 137 - 147, XP004043388 DOI: http://dx.doi.org/10.1016/0378-1119(96)84178-3
	- HUSMANN, L.K.; SCOTT, J.R.; LINDAHL, G.; STENBERG, L., "Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.", INFECTION AND IMMUNITY, (1995), vol. 63, pages 345 - 348
	- GIBSON. D.G. ET AL., "Enzymatic assembly of DNA molecules up to several hundred kilobases", NAT METHODS, (2009), vol. 6, doi:doi:10.1038/nmeth.1318, pages 343 - 345, XP055224105 DOI: http://dx.doi.org/10.1038/nmeth.1318
	WO1994US05700
	other	WO2014093661
		- JINEK M. ET AL, "A PROGRAMMABLE DUAL-RNA-GUIDED DNA ENDONUCLEASE IN ADAPTIVE BACTERIAL IMMUNITY (SUPPLEMENTARY MATERIAL)", SCIENCE, vol. 337, no. 6096, doi:10.1126/SCIENCE.1225829, pages 816 - 821, XP055067740 DOI: http://dx.doi.org/10.1126/science.1225829
		- CONG L. ET AL, "MULTIPLEX GENOME ENGINEERING USING CRISPR/CAS SYSTEMS", SCIENCE, (20130215), vol. 339, no. 6121, pages 819 - 823, XP055102030 DOI: http://dx.doi.org/10.1126/science.1231143
		- MALI P. ET AL, "RNA-GUIDED HUMAN GENOME ENGINEERING VIA CAS9", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/SCIENCE.1232033, pages 823 - 826, XP055111247 DOI: http://dx.doi.org/10.1126/science.1232033
		- WOONG Y HWANG ET AL, "EFFICIENT GENOME EDITING IN ZEBRAFISH USING A CRISPR-CAS SYSTEM", NATURE BIOTECHNOLOGY, (201303), vol. 31, no. 3, doi:10.1038/NBT.2501, pages 227 - 229, XP055086625 DOI: http://dx.doi.org/10.1038/nbt.2501
	Opposition	WO2014093694
		- Rainer Schulte, "Applicant deemed to be entitled", Rainer Schulte, Rainer Schulte, Patentgesetz mit Europäischem Patentübereinkommen, 9. Auflage, (20140000), page 376, XP055340142
		- "Voraussetzungen für die Inanspruchnahme der Unionspriorität", WIECZOREK. et al., Die Unionspriorität im Patentrecht Patentrecht - Grundfragen des Artikels 4 der Pariser Verbandsübereinkunft, (19750000), pages 128 - 149, ISBN 978-3-452-17822-0, XP055340146
		- SAUER, "Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.", PNAS, (19880000), vol. 85, no. 14, pages 5166 - 70, XP000615552 DOI: http://dx.doi.org/10.1073/pnas.85.14.5166
		- REISS, "RecA protein stimulates homologous recombination in plants", PNAS, (19960000), vol. 93, pages 3094 - 98, XP002113813 DOI: http://dx.doi.org/10.1073/pnas.93.7.3094
		- RAYMOND, "High-Efficiency FLP and ΦC31 Site-Specific Recombination in Mammalian Cells", Plos One, (20070000), vol. 2, no. 1, page e162, XP055069998 DOI: http://dx.doi.org/10.1371/journal.pone.0000162
		- CARNEY, "Induction of DNA Double-Strand Breaks by Electroporation of Restriction Enzymes into Mammalian Cells", CARNEY, Henderson Daryl S., DNA Repair Protocols, (19990000), vol. 113, pages 465 - 71, ISBN 978-1-59259-675-1, XP055340155 DOI: http://dx.doi.org/10.1385/1-59259-675-4:465
		- MORGAN, "INDUCIBLE EXPRESSION AND CYTOGENETIC EFFECTS OF THE ECORI RESTRICTION ENDONUCLEASE IN CHINESE HAMSTER OVARY CELLS", Cell Biol, (19880000), vol. 8, no. 10, pages 4204 - 11, XP008014767
		- HARCK et al., Unionsprioritat, (20020700), pages 1 - 44, XP055340157
		- BREMI., "Traps when transferring priority rights, or When in Rome do as the Romans do: A discussion of some recent European and national case law and its practical implications", Institute of Professional Representatives before the European Patent Office, (20100100), pages 17 - 24, XP055340164
		- LIEBER, "The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.", Annu Rev Biochem, (20100000), vol. 79, no. 1, pages 181 - 211, XP055340167 DOI: http://dx.doi.org/10.1146/annurev.biochem.052308.093131
		- JENSEN, "An update on targeted gene repair in mammalian cells: methods and mechanisms", Journal of Biomedical Science, (20110000), vol. 18, no. 1, pages 1 - 14, XP021085735 DOI: http://dx.doi.org/10.1186/1423-0127-18-10
		- DAVIS, "Zinc Finger Nucleases for Genome Editing", Genetic Engineering and Biotechnology News, (20100000), vol. 30, no. 13, XP055340181
		- MUSSOLINO., "A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity", Nucleic Acid Res, (20110000), vol. 39, no. 21, pages 9283 - 9293, XP055021128 DOI: http://dx.doi.org/10.1093/nar/gkr597
		- YARRIS, "Programmable DNA Scissors Found for Bacterial Immune System", Berkeley Lab, (20120628), URL: http://newscenter.lbl.gov/2012/06/28/programmable-dna.scissors/, XP055340187
		- GOLIC, "RNA-Guided Nucleases: A New Era for Engineering the Genomes of Model and Nonmodel Organisms", Genetics, (20130000), vol. 195, no. 2, pages 303 - 308, XP055340188 DOI: http://dx.doi.org/10.1534/genetics.113.155093
		- XU, "The Next Generation Biotechnology for Apple Improvement and Beyond: The CRISPR/Cas9 Story", New York Fruit Quarterly, (20130000), vol. 21, no. 4, pages 19 - 22, XP055340191
		- CHO, "Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9-sgRNA Ribonucleoproteins", Genetics, (20131100), vol. 195, no. 3, pages 1177 - 1180, XP055102693 DOI: http://dx.doi.org/10.1534/genetics.113.155853
		- CARROLL, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Therapy, (20081101), vol. 15, no. 22, pages 1463 - 1468, XP055041104 DOI: http://dx.doi.org/10.1038/gt.2008.145
		- REYON et al., "FLASH assembly of TALENs for high-throughput genome editing", Nature Biotech, (20120408), vol. 30, no. 5, pages 460 - 465, XP055171169 DOI: http://dx.doi.org/10.1002/0471142727.mb1216s103

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