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Extract from the Register of European Patents

EP About this file: EP2970876

EP2970876 - SERUM-FREE CELL CULTURE MEDIUM [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  08.06.2018
Database last updated on 11.05.2024
FormerGrant of patent is intended
Status updated on  23.01.2018
FormerExamination is in progress
Status updated on  21.11.2016
Most recent event   Tooltip25.07.2023New entry: Date of oral proceedings 
Applicant(s)For all designated states
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown, NY 10591 / US
[2016/03]
Inventor(s)01 / OSHODI, Shadia
c/o Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Building 6, Room 63-134
Astoria, New York, NY 11102 / US
02 / JOHNSON, Amy
953 Long Hill Road
Briarcliff Manor, NY 10510 / US
03 / LAWRENCE, Shawn
371 Kings Highway
Valley Cottage, NY 10989 / US
 [2016/13]
Former [2016/03]01 / OSHODI, Shadia
204 West 108th Street
New York, NY 10025 / US
02 / JOHNSON, Amy
953 Long Hill Road
Briarcliff Manor, NY 10510 / US
03 / LAWRENCE, Shawn
371 Kings Highway
Valley Cottage, NY 10989 / US
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2018/28]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2016/03]Power, David
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date14723561.814.03.2014
[2016/03]
WO2014US28501
Priority number, dateUS201361790136P15.03.2013         Original published format: US 201361790136 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014144198
Date:18.09.2014
Language:EN
[2014/38]
Type: A1 Application with search report 
No.:EP2970876
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2970876
Date:11.07.2018
Language:EN
[2018/28]
Search report(s)International search report - published on:EP18.09.2014
ClassificationIPC:C12N5/00
[2016/03]
CPC:
C12N5/0031 (EP,IL,US); C12P21/00 (IL,KR,US); C12N5/0037 (EP,IL,KR,US);
C12N5/00 (EA); C07K16/00 (EP); C07K16/18 (IL,KR,US);
C12N5/0043 (EP,IL,US); C12N5/005 (EP,IL,US); C12N5/0682 (US);
C12N5/10 (EP); C12N2500/22 (US); C12N2500/24 (US);
C12N2500/32 (EP,IL,KR,US); C12N2500/34 (US); C12N2500/46 (EP,IL,KR,US);
C12N2510/02 (EP,IL,KR,US); C12N2510/04 (EP); C12N2511/00 (EP,IL,KR,US);
C12N2523/00 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA11.09.2015
ME11.09.2015
TitleGerman:SERUMFREIES ZELLKULTURMEDIUM[2016/03]
English:SERUM-FREE CELL CULTURE MEDIUM[2016/03]
French:MILIEU DE CULTURE CELLULAIRE SANS SÉRUM[2016/03]
Entry into regional phase11.09.2015National basic fee paid 
11.09.2015Designation fee(s) paid 
11.09.2015Examination fee paid 
Examination procedure11.09.2015Examination requested  [2016/03]
25.04.2016Amendment by applicant (claims and/or description)
14.07.2016Despatch of a communication from the examining division (Time limit: M04)
18.11.2016Reply to a communication from the examining division
24.01.2018Communication of intention to grant the patent
29.05.2018Fee for grant paid
29.05.2018Fee for publishing/printing paid
29.05.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18172141.6  / EP3378932
EP21184357.8  / EP3919611
EP22209628.1  / EP4159841
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.07.2016
Opposition(s)Opponent(s)01  09.04.2019  12.04.2019  ADMISSIBLE
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Opponent's representative
Tombling, Adrian George
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
 02  11.04.2019  16.04.2019  ADMISSIBLE
Maiwald GmbH
Elisenhof, Elisenstrasse 3
80335 München / DE
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
 [N/P]
Former [2021/16]
Opponent(s)01  09.04.2019  12.04.2019  ADMISSIBLE
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Opponent's representative
Tombling, Adrian George
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
 02  11.04.2019  16.04.2019  ADMISSIBLE
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof, Elisenstrasse 3
80335 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2019/21]
Opponent(s)01  09.04.2019  12.04.2019  ADMISSIBLE
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Opponent's representative
Tombling, Adrian George
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
 02  11.04.2019  16.04.2019  ADMISSIBLE
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstrasse 3
80335 München / DE
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2019/20]
Opponent(s)01  09.04.2019    ADMISSIBLE
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Opponent's representative
Tombling, Adrian George
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
26.04.2019Invitation to proprietor to file observations on the notice of opposition
06.09.2019Reply of patent proprietor to notice(s) of opposition
11.08.2020Cancellation of oral proceeding that was planned for 16.09.2020
16.09.2020Date of oral proceedings
Appeal following opposition03.11.2021Appeal received No.  T1978/21
03.11.2021Payment of appeal fee
04.01.2022Statement of grounds filed
13.09.2024Date of oral proceedings
Fees paidRenewal fee
23.03.2016Renewal fee patent year 03
23.03.2017Renewal fee patent year 04
23.03.2018Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL11.07.2018
CY11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
MK11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
LU14.03.2019
MT14.03.2019
[2022/31]
Former [2021/26]AL11.07.2018
CY11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
LU14.03.2019
MT14.03.2019
Former [2020/29]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
LU14.03.2019
MT14.03.2019
Former [2020/01]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
LU14.03.2019
Former [2019/46]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
Former [2019/37]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
RS11.07.2018
SI11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
Former [2019/26]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
RS11.07.2018
SK11.07.2018
SM11.07.2018
BG11.10.2018
Former [2019/24]AL11.07.2018
EE11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
RS11.07.2018
SK11.07.2018
BG11.10.2018
Former [2019/12]AL11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
RS11.07.2018
BG11.10.2018
Former [2019/11]HR11.07.2018
LT11.07.2018
RS11.07.2018
BG11.10.2018
Former [2019/07]LT11.07.2018
Cited inInternational search[X]EP1321515  (INGENIUM PHARMACEUTICALS AG [DE]) [X] 1,7-9,19-22,35,36 * paragraph [0052]; claim 1 *;
 [XDY]WO2007077217  (BAXTER INT [US], et al) [XD] 1,2,7-11,13,16-24,28,29,35,36,38-40,48 * page 1; figure 3 * * page 6, paragraph 019 * * page 8 * * page 10 * [Y] 1-48;
 [XY]US2010285533  (KRUEGER OLAF [DE], et al) [X] 1,7-11,13,16-22,35,36,38-40 * page 1, paragraph 0010 * * paragraph [0015] - paragraph [0019] * * paragraph [0030] - paragraph [0031] * * paragraph [0037] * * paragraph [0066]; claims 1-2 * [Y] 1-48;
 [X]US2011229933  (KRISHNAN RAJESH [US], et al) [X] 1,2,9-11,16-24,28,29,38-40,48 * claims 1-2 *;
 [X]US2012034674  (GRILLBERGER LEOPOLD [AT], et al) [X] 1 * page 12 *;
 [X]  - HOLTTA E ET AL, "Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 721, no. 4, doi:10.1016/0167-4889(82)90085-4, ISSN 0167-4889, (19821230), pages 321 - 327, (19821230), XP025221778 [X] 1,3,4,7-9,19-21 * page 321 - page 323; table 2 *

DOI:   http://dx.doi.org/10.1016/0167-4889(82)90085-4
 [X]  - HAWEL L ET AL, "Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 1222, no. 1, doi:10.1016/0167-4889(94)90020-5, ISSN 0167-4889, (19940526), pages 15 - 26, (19940526), XP023788723 [X] 1 * page 15; table 1 *

DOI:   http://dx.doi.org/10.1016/0167-4889(94)90020-5
 [A]  - IGARASHI K ET AL, "Modulation of cellular function by polyamines", INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY, PERGAMON, GB, vol. 42, no. 1, doi:10.1016/J.BIOCEL.2009.07.009, ISSN 1357-2725, (20100101), pages 39 - 51, (20090728), XP026909603 [A] 1-48 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.biocel.2009.07.009
by applicantUS4072565
 USRE30985E
 US4560655
 US4615977
 US4786599
 US5063157
 US5122469
 US5426699
 US5705364
 US5811299
 US5856179
 US5976833
 US6048728
 US6180401
 US6528286
 WO2005028626
 US6924124
 US6927004
 US7087411
 US7105348
 US2007212770
 US7279159
 US7294484
 US7429491
 US7435553
 US7455988
 WO2008154014
 US2009137416
 US2009162901
 US7666416
 US2010304436
 US2010331527
    - WARD ET AL., NATURE, (1989), vol. 241, pages 544 - 546
    - HOLLIGER ET AL., PNAS USA, (1993), vol. 90, pages 6444 - 6448
    - POLJAK ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123
    - KIPRIYANOV ET AL., HUMAN ANTIBODIES AND HYBRIDOMAS, (1995), vol. 6, pages 93 - 101
    - KIPRIYANOV ET AL., MOL. IMMUNOL., (1994), vol. 31, pages 1047 - 1058
    - TAYLOR ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 6287 - 6295
    - ASHKENAZI ET AL., PROC. NATL. ACAD. SCL USA, (1991), vol. 88, page 10535
    - BYRN ET AL., NATURE, (1990), vol. 344, page 677
    - HOLLENBAUGH ET AL., "Construction of Immunoglobulin Fusion Proteins", CURRENT PROTOCOLS IN IMMUNOLOGY, (1992), pages 10.19.1 - 10.19.11
    - EAGLE, SCIENCE, (1955), vol. 112, no. 3168, pages 501 - 504
    - HAM, PROC. NAT'L. ACAD. SCI. USA, (1965), vol. 53, pages 288 - 293
    - PROC. NATL. ACAD. SCI. USA., (195208), vol. 38, no. 8, pages 747 - 752
    - HOLMES; WOLF, BIOPHYS. BIOCHEM. CYTOL., (1961), vol. 10, pages 389 - 401
    - DAVIDSON; WAYMOUTH, BIOCHEM. J., (1945), vol. 39, no. 2, pages 188 - 199
    - WILLIAM'S ET AL., EXP. CELL RES., (1971), vol. 69, page 105
    - MOORE ET AL., J. AMER. MED. ASSOC., (1967), vol. 199, pages 519 - 524
    - BETTGER ET AL., PROC. NAT'L. ACAD. SCI. USA, (1981), vol. 78, no. 9, pages 5588 - 5592
    - ORR ET AL., APPL. MICROBIOL., (1973), vol. 25, no. 1, pages 49 - 54
    - Y.M. HUANG ET AL., BIOTECHNOL PROG., (201009), vol. 26, no. 5, pages 1400 - 10
    - C. ALTAMIRANO ET AL., BIOTECHNOL PROG., (200111), vol. 17, no. 6, pages 1032 - 41
    - KAUFMAN, R. J., LARGE SCALE MAMMALIAN CELL CULTURE, (1990), pages 15 - 69
    - BRASEL ET AL., BLOOD, (1996), vol. 88, pages 2004 - 2012
    - KAUFMAN ET AL., J.BIOL CHEM, (1988), vol. 263, pages 6352 - 6362
    - MCKINNON ET AL., J MOL ENDOCRINOL, (1991), vol. 6, pages 231 - 239
    - WOOD ET AL., J IMMUNOL., (1990), vol. 145, pages 3011 - 3016
    - URLAUB ET AL., PROC NATL ACAD SCI USA, (1980), vol. 77, pages 4216 - 4220
    - KAUFMAN RJ., METH ENZYMOL, (1990), vol. 185, pages 537 - 566
OppositionEP1321515
 WO2007077217
 US2010285533
 US2011229933
    - FROUD et al., "Polyamine enhanced product expression from transformed and recombinant cell lines", Production of Biologicals from Animal Cells in Culture, (19910000), pages 107 - 109, XP055454149
    - FUSI et al., "Effects of putrescine, cadaverine, spermine, spermidine and b-phenylethylamine on cultured bovine mammary epithelial cells", Ital. J. Anim. Sci, (20080000), vol. 7, no. 2, pages 131 - 140, XP055314462

DOI:   http://dx.doi.org/10.4081/ijas.2008.131
    - PASTORIAN, K.E. et al., "Tolerance to Putrescine Toxicity in Chinese Hamster Ovary Cells Is Associated with Altered Uptake and Export", Experimental Cell Research, (19970000), vol. 231, no. 2, pages 284 - 295, XP009163335

DOI:   http://dx.doi.org/10.1006/excr.1996.3467
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.