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Extract from the Register of European Patents

EP About this file: EP3056563

EP3056563 - METHOD OF PRODUCING RETINAL PIGMENT EPITHELIAL CELL [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.04.2021
Database last updated on 24.04.2024
FormerThe patent has been granted
Status updated on  22.05.2020
FormerGrant of patent is intended
Status updated on  09.01.2020
FormerRequest for examination was made
Status updated on  18.11.2019
FormerGrant of patent is intended
Status updated on  30.07.2019
FormerRequest for examination was made
Status updated on  17.07.2019
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
HEALIOS K.K.
4-1, Hamamatsu-cho 2-chome
Minato-ku
Tokyo 105-6115 / JP
For all designated states
RIKEN
2-1, Hirosawa
Wako-shi
Saitama 351-0198 / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
[2020/24]
Former [2019/04]For all designated states
HEALIOS K.K.
4-1, Hamamatsu-cho 2-chome
Minato-ku
Tokyo 105-6115 / JP
For all designated states
Riken
2-1 Hirosawa
Wako-shi, Saitama 351-0198 / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
Former [2016/33]For all designated states
Healios K.K.
4-1 Hamamatsu-cho 2-chome
Minato-ku
Tokyo 105-6115 / JP
For all designated states
Riken
2-1, Hirosawa
Wakou-shi, Saitama 351-0198 / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
Inventor(s)01 / SAWADA, Masanori
c/o Healios K.K.
4-1 Hamamatsu-cho 2-chome
Minato-ku
Tokyo 105-6115 / JP
02 / TAKAHASHI, Masayo
c/o RIKEN
2-1 Hirosawa
Wako-shi Saitama 351-0198 / JP
03 / SEKIGUCHI, Kiyotoshi
c/o OSAKA UNIVERSITY
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
 [2016/33]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2020/26]J A Kemp LLP
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2016/33]Tuxworth, Pamela M.
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date14851809.509.10.2014
[2016/33]
WO2014JP77111
Priority number, dateJP2013021234509.10.2013         Original published format: JP 2013212345
[2016/33]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015053375
Date:16.04.2015
Language:JA
[2015/15]
Type: A1 Application with search report 
No.:EP3056563
Date:17.08.2016
Language:EN
[2016/33]
Type: B1 Patent specification 
No.:EP3056563
Date:24.06.2020
Language:EN
[2020/26]
Search report(s)International search report - published on:JP16.04.2015
(Supplementary) European search report - dispatched on:EP09.05.2017
ClassificationIPC:C12N5/10, A61K35/12, A61K35/44, A61P27/02, C12N5/074, C12N5/0775, C12N15/09
[2016/33]
CPC:
C12N5/0621 (EP,KR,US); A61K35/30 (EP,KR,US); A61K9/0048 (US);
A61P27/02 (EP); C12N2501/727 (US); C12N2506/45 (EP,KR,US);
C12N2509/00 (US); C12N2533/52 (EP,KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/33]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG EINER RETINAPIGMENTEPITHELZELLE[2016/33]
English:METHOD OF PRODUCING RETINAL PIGMENT EPITHELIAL CELL[2016/33]
French:PROCÉDÉ DE PRODUCTION DE CELLULES ÉPITHÉLIALES DE PIGMENT RÉTINIEN[2016/33]
Entry into regional phase28.04.2016Translation filed 
28.04.2016National basic fee paid 
28.04.2016Search fee paid 
28.04.2016Designation fee(s) paid 
28.04.2016Examination fee paid 
Examination procedure28.04.2016Examination requested  [2016/33]
19.01.2018Amendment by applicant (claims and/or description)
31.07.2019Communication of intention to grant the patent
15.11.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
10.01.2020Communication of intention to grant the patent
14.05.2020Fee for grant paid
14.05.2020Fee for publishing/printing paid
14.05.2020Receipt of the translation of the claim(s)
Opposition(s)25.03.2021No opposition filed within time limit [2021/22]
Fees paidRenewal fee
11.10.2016Renewal fee patent year 03
11.10.2017Renewal fee patent year 04
11.10.2018Renewal fee patent year 05
15.10.2019Renewal fee patent year 06
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.10.2014
AL24.06.2020
AT24.06.2020
CY24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
MK24.06.2020
MT24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SI24.06.2020
SK24.06.2020
SM24.06.2020
TR24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
IE09.10.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
CH31.10.2020
LI31.10.2020
[2022/32]
Former [2022/27]HU09.10.2014
AL24.06.2020
AT24.06.2020
CY24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
MT24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SI24.06.2020
SK24.06.2020
SM24.06.2020
TR24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
IE09.10.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
CH31.10.2020
LI31.10.2020
Former [2021/46]AL24.06.2020
AT24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SI24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
IE09.10.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
CH31.10.2020
LI31.10.2020
Former [2021/37]AL24.06.2020
AT24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SI24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
CH31.10.2020
LI31.10.2020
Former [2021/36]AL24.06.2020
AT24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SI24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
Former [2021/31]AL24.06.2020
AT24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
MC24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
LU09.10.2020
IS24.10.2020
PT26.10.2020
Former [2021/20]AL24.06.2020
AT24.06.2020
CZ24.06.2020
DK24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
IS24.10.2020
PT26.10.2020
Former [2021/10]AL24.06.2020
AT24.06.2020
CZ24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
NL24.06.2020
PL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SK24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
IS24.10.2020
PT26.10.2020
Former [2021/09]AL24.06.2020
AT24.06.2020
CZ24.06.2020
EE24.06.2020
ES24.06.2020
FI24.06.2020
HR24.06.2020
IT24.06.2020
LT24.06.2020
LV24.06.2020
NL24.06.2020
RO24.06.2020
RS24.06.2020
SE24.06.2020
SM24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
PT26.10.2020
Former [2021/04]AL24.06.2020
FI24.06.2020
HR24.06.2020
LT24.06.2020
LV24.06.2020
NL24.06.2020
RS24.06.2020
SE24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
Former [2021/01]FI24.06.2020
HR24.06.2020
LT24.06.2020
LV24.06.2020
RS24.06.2020
SE24.06.2020
BG24.09.2020
NO24.09.2020
GR25.09.2020
Former [2020/51]FI24.06.2020
HR24.06.2020
LT24.06.2020
LV24.06.2020
RS24.06.2020
SE24.06.2020
NO24.09.2020
GR25.09.2020
Former [2020/50]FI24.06.2020
HR24.06.2020
LT24.06.2020
LV24.06.2020
SE24.06.2020
NO24.09.2020
GR25.09.2020
Former [2020/48]FI24.06.2020
LT24.06.2020
SE24.06.2020
NO24.09.2020
Former [2020/47]LT24.06.2020
NO24.09.2020
Documents cited:Search[XA]WO2008129554  (HADASIT MED RES SERVICE [IL], et al) [X] 5,6,9 * page 41 - page 42 * * page 48; claims 16, 17, 22, 33 * [A] 1-4,7,8;
 [XAY]US2013196369  (HIKITA SHERRY [US], et al) [X] 5,6 * paragraph [0025] - paragraph [0027] * [A] 9 [Y] 1-4,7,8;
 [XA]SG192878  (RIKEN [JP]) [X] 5,6,9 * page 7 - page 8 * * page 34 - page 35; claims 1-3, 6, 7 * [A] 1-4,7,8;
 [XA]  - YU ZHU ET AL, "Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium", PLOS ONE, (20130124), vol. 8, no. 1, doi:10.1371/journal.pone.0054552, page e54552, XP055332448 [X] 5,6,9 * page 10 * [A] 1-4,7,8

DOI:   http://dx.doi.org/10.1371/journal.pone.0054552
 [XA]  - PENG SHAOMIN; QIU CAIHONG; LI LINA; ADELMAN RON A; RIZZOLO LAWRENCE J, "Tight Junctions of RPE Derived from Human Embryonic Stem Cells", ARVO ANNUAL MEETING ABSTRACT SEARCH AND PROGRAM PLANNER, (20110502), XP055197442 [X] 5,6 * abstract * [A] 1-4,7-9
 [XA]  - TAKUYA KURODA ET AL, "Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells", PLOS ONE, (20120517), vol. 7, no. 5, doi:10.1371/journal.pone.0037342, page e37342, XP055382467 [X] 5,6 * page 2 * * page 8; table 1 * [A] 1-4,7-9

DOI:   http://dx.doi.org/10.1371/journal.pone.0037342
 [XDA]  - TEISHA J. ROWLAND ET AL, "Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, (20130818), vol. 7, no. 8, doi:10.1002/term.1458, ISSN 1932-6254, pages 642 - 653, XP055121216 [XD] 5,6 * page 643, column l, paragraph 4 - page 644, column l, paragraph 1 * * page 645; table 1 * * page 646, column l * * page 651 * [A] 1-4,7-9

DOI:   http://dx.doi.org/10.1002/term.1458
 [YA]  - TAKAMICHI MIYAZAKI ET AL, "Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells", NATURE COMMUNICATIONS, (20121204), vol. 3, doi:10.1038/ncomms2231, page 1236, XP055055638 [Y] 1-4,7,8 * page 2, column r * * page 8, column r - page 9, column l * [A] 9

DOI:   http://dx.doi.org/10.1038/ncomms2231
 [A]  - RODIN SERGEY ET AL, "Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511", NATURE BIOTECHNOLOGY, GALE GROUP INC, US, (20100601), vol. 28, no. 6, ISSN 1087-0156, pages 611 - 615, XP009135150 [A] 1-9 * page 611 - page 612 * * page 614 *
International search[X]WO2008129554  (HADASIT MED RES SERVICE [IL], et al);
 [Y]WO2011043405  (UNIV OSAKA [JP], et al);
 [X]WO2012115244  (RIKEN [JP], et al);
 [X]  - PENG SHAOMIN ET AL., "Tight Junctions of RPE Derived from Human Embryonic Stem Cells", VISIONARY GENOMICS, (2011), XP055197442
 [X]  - ZHU YU ET AL., "Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium", PLOS ONE, (201301), vol. 8, no. 1, page E54552, XP055332448

DOI:   http://dx.doi.org/10.1371/journal.pone.0054552
 [X]  - KURODA TAKUYA ET AL., "Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells", PLOS ONE, (2012), vol. 7, no. 5, page E37342, XP055332450

DOI:   http://dx.doi.org/10.1371/journal.pone.0037342
 [Y]  - KIYOTOSHI SEKIGUCHI, "Tanosei Kansaibo Feeder Free Baiyo Kizai no Kaihatsu", CLINICAL EVALUATION, (201307), vol. 41, no. 1, pages 124 - 127, XP008183598
 [Y]  - MIYAZAKI TAKAMICHI ET AL., "Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells", NATURE COMMUNICATIONS, (2012), vol. 3, pages 1 - 10, XP055055638

DOI:   http://dx.doi.org/10.1038/ncomms2231
 [A]  - RODIN SERGEY ET AL., "Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511", NATURE BIOTECHNOLOGY, (2010), vol. 28, no. 6, pages 611 - 615, XP009135150
Examination   - TAKUYA KURODA ET AL, "Highly Sensitive In Vitro Methods for Detection of Residual Undifferentiated Cells in Retinal Pigment Epithelial Cells Derived from Human iPS Cells", PLOS ONE, (20120517), vol. 7, no. 5, doi:10.1371/journal.pone.0037342, page e37342, XP055382467

DOI:   http://dx.doi.org/10.1371/journal.pone.0037342
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.