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Extract from the Register of European Patents

EP About this file: EP3229771

EP3229771 - 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.02.2025
Database last updated on 16.04.2026
FormerThe patent has been granted
Status updated on  01.03.2024
FormerGrant of patent is intended
Status updated on  24.10.2023
FormerExamination is in progress
Status updated on  19.10.2018
FormerRequest for examination was made
Status updated on  15.09.2017
FormerThe international publication has been made
Status updated on  05.06.2017
Most recent event   Tooltip13.03.2026Lapse of the patent in a contracting state
New state(s): HU		published on 15.04.2026  [2026/16]
Applicant(s)For all designated states
Univerzita Palackého v Olomouci
Krízkovského 8
771 47 Olomouc / CZ
[2017/42]
Inventor(s)01 / DOLEZAL, Karel
Posluchov 31
78365 Hlubocky / CZ
02 / PLIHALOVA, Lucie
Za zahradami 393/19
783 01 Olomouc / CZ
03 / VYLICILOVA, Hana
Dukelska 11
779 00 Olomouc / CZ
04 / ZATLOUKAL, Marek
Revolucni 18a
78701 Sumperk / CZ
05 / PLIHAL, Ondrej
Za zahradami 393/19
783 01 Olomouc / CZ
06 / VOLLER, Jiri
Pristavni 1263/10B
635 00 Brno - Bystrc / CZ
07 / STRNAD, Miroslav
Zapadni 25
77900 Olomouc / CZ
08 / BRYKSOVA, Magdalena
Blazickova 20
779 00 Bystrovany / CZ
09 / VOSTALOVA, Jitka
Kozusany 67
783 75 Kozusany - Tazaly / CZ
10 / RAJNOCHOVA SVOBODOVA, Alena
Ksirova 1291/7
779 00 Olomouc / CZ
11 / ULRICHOVA, Jitka
Nova Ulice
Profesora Fuky 1279/16
779 00 Olomouc / CZ
12 / SPICHAL, Lukas
Bystrocice 43
77900 Olomouc / CZ
 [2023/47]
Former [2017/42]01 / DOLEZAL, Karel
Posluchov 31
78365 Hlubocky / CZ
02 / PLIHALOVA, Lucie
Za zahradami 393/19
783 01 Olomouc / CZ
03 / VYLICILOVA, Hana
Dukelska 11
779 00 Olomouc / CZ
04 / ZATLOUKAL, Marek
Revolucni 18a
78701 Sumperk / CZ
05 / PLIHAL, Ondrej
Handkeho 1a/757
779 00 Olomouc / CZ
06 / VOLLER, Jiri
Pristavni 1263/10B
635 00 Brno - Bystrc / CZ
07 / STRNAD, Miroslav
Zapadni 25
77900 Olomouc / CZ
08 / BRYKSOVA, Magdalena
Blazickova 20
779 00 Bystrovany / CZ
09 / VOSTALOVA, Jitka
Kozusany 67
783 75 Kozusany - Tazaly / CZ
10 / RAJNOCHOVA SVOBODOVA, Alena
Ksirova 1291/7
779 00 Olomouc / CZ
11 / ULRICHOVA, Jitka
Nova Ulice
Profesora Fuky 1279/16
779 00 Olomouc / CZ
12 / SPICHAL, Lukas
Bystrocice 43
77900 Olomouc / CZ
Representative(s)Hartvichova, Katerina, et al
HARBER IP s.r.o.
Dukelskych hrdinu 567/52
170 00 Praha 7 / CZ
[2024/14]
Former [2017/42]Hartvichova, Katerina
Inventia s.r.o.
Na Belidle 3
150 00 Praha 5 / CZ
Application number, filing date15774847.614.09.2015
[2017/42]
WO2015CZ50005
Priority number, dateCZ2014000087509.12.2014         Original published format: CZ 20140875
[2017/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016091235
Date:16.06.2016
Language:EN
[2016/24]
Type: A1 Application with search report 
No.:EP3229771
Date:18.10.2017
Language:EN
The application published by WIPO in one of the EPO official languages on 16.06.2016 takes the place of the publication of the European patent application.
[2017/42]
Type: B1 Patent specification 
No.:EP3229771
Date:03.04.2024
Language:EN
[2024/14]
Search report(s)International search report - published on:EP16.06.2016
ClassificationIPC:A61K8/60, A61Q17/04, A61Q19/08, A61K31/7076, C07H19/173, C07H19/19
[2017/42]
CPC:
C07H19/16 (EP,US); A61K31/7076 (EP,CZ,US); A61K8/606 (EP,CZ,US);
A61Q17/04 (EP,US); A61Q19/08 (EP,US); C07H19/173 (EP,CZ,US);
C07H19/19 (EP,CZ,US); A61K31/7052 (US); A61K31/7056 (US);
A61K31/706 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/42]
Extension statesBANot yet paid
MENot yet paid
Validation statesMANot yet paid
TitleGerman:6-ARYL-9-GLYCOSYLPURINE UND VERWENDUNGEN DAVON[2017/42]
English:6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF[2017/42]
French:6-ARYL-9-GLYCOSYLPURINES ET UTILISATION DE CELLES-CI[2017/42]
Entry into regional phase05.06.2017National basic fee paid 
05.06.2017Designation fee(s) paid 
05.06.2017Examination fee paid 
Examination procedure05.06.2017Examination requested  [2017/42]
05.06.2017Date on which the examining division has become responsible
04.01.2018Amendment by applicant (claims and/or description)
23.10.2018Despatch of a communication from the examining division (Time limit: M06)
24.04.2019Reply to a communication from the examining division
29.10.2019Despatch of a communication from the examining division (Time limit: M04)
02.12.2019Reply to a communication from the examining division
09.06.2020Despatch of a communication from the examining division (Time limit: M04)
26.09.2020Reply to a communication from the examining division
20.05.2021Despatch of a communication from the examining division (Time limit: M04)
13.09.2021Reply to a communication from the examining division
25.10.2023Communication of intention to grant the patent
23.02.2024Fee for grant paid
23.02.2024Fee for publishing/printing paid
23.02.2024Receipt of the translation of the claim(s)
Opposition(s)06.01.2025No opposition filed within time limit [2025/11]
Fees paidRenewal fee
28.08.2017Renewal fee patent year 03
06.08.2018Renewal fee patent year 04
19.09.2019Renewal fee patent year 05
30.09.2020Renewal fee patent year 06
15.09.2021Renewal fee patent year 07
29.09.2022Renewal fee patent year 08
29.09.2023Renewal fee patent year 09
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY14.09.2015
HU14.09.2015
AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
IT03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SE03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
IE14.09.2024
LU14.09.2024
BE30.09.2024
CH30.09.2024
FR30.09.2024
[2026/16]
Former [2026/10]CY14.09.2015
AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
IT03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SE03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
IE14.09.2024
LU14.09.2024
BE30.09.2024
CH30.09.2024
FR30.09.2024
Former [2025/42]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SE03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
IE14.09.2024
LU14.09.2024
BE30.09.2024
CH30.09.2024
FR30.09.2024
Former [2025/36]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
IE14.09.2024
LU14.09.2024
BE30.09.2024
CH30.09.2024
FR30.09.2024
Former [2025/35]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
LU14.09.2024
BE30.09.2024
CH30.09.2024
FR30.09.2024
Former [2025/34]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
LU14.09.2024
BE30.09.2024
Former [2025/33]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
GB14.09.2024
LU14.09.2024
Former [2025/26]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
LU14.09.2024
Former [2025/22]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
MC03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SI03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2025/10]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
NL03.04.2024
PL03.04.2024
RO03.04.2024
SK03.04.2024
SM03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2025/09]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
EE03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
NL03.04.2024
PL03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2025/08]AT03.04.2024
BG03.04.2024
CZ03.04.2024
DK03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
NL03.04.2024
PL03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2024/49]AT03.04.2024
BG03.04.2024
CZ03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
LV03.04.2024
NL03.04.2024
PL03.04.2024
NO03.07.2024
RS03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2024/48]AT03.04.2024
BG03.04.2024
CZ03.04.2024
ES03.04.2024
FI03.04.2024
HR03.04.2024
NL03.04.2024
NO03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2024/47]BG03.04.2024
FI03.04.2024
HR03.04.2024
NL03.04.2024
NO03.07.2024
GR04.07.2024
IS03.08.2024
PT05.08.2024
Former [2024/46]BG03.04.2024
FI03.04.2024
HR03.04.2024
NL03.04.2024
NO03.07.2024
IS03.08.2024
Former [2024/44]NL03.04.2024
Cited inInternational search[X] WO2012084173  (ROCHE DIAGNOSTICS GMBH et al.)
 [X] US2008131952  (WU WEIDONG et al.)
 [Y] WO2004058791  (USTAV EX BOTAN AKADEMIE VED CE et al.)
 [X] EP2657246  (PUBLIC UNIV CORP YOKOHAMA CITY et al.)
 [X] US6294522  (ZABLOCKI JEFF A et al.) [X] 5,6,8 * page 13, lines 12-16 *
 [X]   MICHAEL P. MCCRANE ET AL: "Oxidative Quenching of Quinone Methide Adducts Reveals Transient Products of Reversible Alkylation in Duplex DNA", CHEMICAL RESEARCH IN TOXICOLOGY, vol. 27, no. 7, 21 July 2014 (2014-07-21), US, pages 1282 - 1293, XP055224440, ISSN: 0893-228X, DOI: 10.1021/tx500152d

DOI:   http://dx.doi.org/10.1021/tx500152d
 [X]   WILLEM F. VELDHUYZEN ET AL: "Thermodynamic versus Kinetic Products of DNA Alkylation as Modeled by Reaction of Deoxyadenosine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, no. 45, 1 November 2001 (2001-11-01), US, pages 11126 - 11132, XP055224505, ISSN: 0002-7863, DOI: 10.1021/ja011686d

DOI:   http://dx.doi.org/10.1021/ja011686d
 [X]   SAKO M. ; ISHIKURA H. ; HIROTA K. ; MAKI Y.: "A newly devised method for the debenzylation of N6-benzyladenosines. A convenient synthesis of [6-15N]-labeled adenosines", NUCLEOSIDES AND NUCLEOTIDES, vol. 13, no. 6&7, 1994, pages 1239 - 1246, XP009186954, ISSN: 0732-8311, DOI: 10.1080/15257779408012148

DOI:   http://dx.doi.org/10.1080/15257779408012148
Examination  KAREL DOLEŽAL ET AL: "Preparation, biological activity and endogenous occurrence of N6-benzyladenosines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 11, 1 June 2007 (2007-06-01), pages 3737 - 3747, XP055103745, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2007.03.038 [X] 5-8 * page 3739; table 1 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2007.03.038
   GONZALEZ M P ET AL: "A radial distribution function approach to predict A"2"B agonist effect of adenosine analogues", BIOORGANIC & MEDICINAL CHEMI, PERGAMON, GB, vol. 13, no. 3, 1 February 2005 (2005-02-01), pages 601 - 608, XP004710824, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2004.10.063 [X] 5-8 * page 604; table 6 *

DOI:   http://dx.doi.org/10.1016/j.bmc.2004.10.063
   NOBUO SAKAIRI ET AL: "Chemical Conversion of Some Ribonucleosides into the Corresponding a-d-Arabinofuranosyl Derivatives", NUCLEOSIDES AND NUCLEOTIDES, vol. 2, no. 3, 19 January 1983 (1983-01-19), US, pages 221 - 229, XP055575873, ISSN: 0732-8311, DOI: 10.1080/07328318308078856

DOI:   http://dx.doi.org/10.1080/07328318308078856
by applicant  BARAI ET AL., VESTSI AKADEMII NAUK BELARUSI, vol. 1, 1992, pages 18 - 22
   MARUYAMA ET AL., CHEM. PHARM. BULL., vol. 44, 1996, pages 2331 - 2334
   MASAKATSU ET AL., CHEM. PHARM. BULL., vol. 25, 1977, pages 2482 - 2489
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   SPIELMANN H; BALLS M; DUPUIS J; PAPE WJ; PECHOVITCH G; DE SILVA 0; HOLZHIITTER HG; CLOTHIER R; DESOLLE P; GERBERICK F, TOXICOL IN VITRO, vol. 12, no. 3, 1 June 1998 (1998-06-01), pages 305 - 27
   SPIELMANN H; BALLS M; DUPUIS J; PAPE J; PECHOVITCH G; DE SILVA 0; HOLZHTTER HG; CLOTHIER R; DESOLLE P; ERBERICK F, TOXICOL IN VITRO., vol. 12, no. 3, 1 June 1998 (1998-06-01), pages 305 - 27
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.