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Extract from the Register of European Patents

EP About this file: EP3302572

EP3302572 - IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE [Right-click to bookmark this link]
StatusThe patent has been limited
Status updated on  20.06.2024
Database last updated on 31.03.2026
FormerNo opposition filed within time limit
Status updated on  12.11.2021
FormerThe patent has been granted
Status updated on  04.12.2020
FormerGrant of patent is intended
Status updated on  24.05.2020
FormerExamination is in progress
Status updated on  01.02.2020
FormerRequest for examination was made
Status updated on  09.03.2018
FormerThe international publication has been made
Status updated on  09.12.2016
Most recent event   Tooltip19.12.2025Lapse of the patent in a contracting state
New state(s): TR		published on 21.01.2026  [2026/04]
Applicant(s)For all designated states
Arvinas Operations, Inc.
5 Science Park
New Haven, CT 06511 / US
[2021/10]
Former [2018/15]For all designated states
Arvinas, Inc.
5 Science Park
New Haven, CT 06511 / US
Inventor(s)01 / CREWS, Craig, M.
286 Livingston Street
New Haven, CT 06511 / US
02 / CREW, Andrew, P.
2 Winterberry Road
Guilford, CT 06437 / US
03 / DONG, Hanqing
248 Opening Hill Road
Madison, CT 06443 / US
04 / WANG, Jing
25 Elm Street
Milford, CT 06460 / US
05 / QIAN, Yimin
5 Camas Court
Plainsboro, NJ 08536 / US
06 / SIU, Kam
42 Magnolia Road
Milford, CT 06461 / US
07 / JIN, Meizhong
34 Priscilla Circle
Wellesley, Massachusetts 02481 / US
 [2018/17]
Former [2018/15]01 / CREWS, Craig, M.
286 Livingston Street
New Haven, CT 06511 / US
02 / CREW, Andrew, P.
2 Winterberry Road
Guilford, CT 06437 / US
03 / DONG, Hanqing
248 Opening Hill Road
Madison, CT 06443 / US
04 / WANG, Jing
25 Elm Street
Milford, CT 06460 / US
05 / QIAN, Yimin
5 Camas Court
Plainsboro, NJ 08536 / US
06 / SIU, Kam
42 Magnolia Road
Milford, CT 06461 / US
07 / JIN, Meizhong
6 Diane Lane
East Northport, NY 11731 / US
Representative(s)Kasche, André
Kasche & Partner AG
c/o IPrime Rentsch Kaelin AG
Hirschengraben 1
8001 Zürich / CH
[N/P]
Former [2021/01]Kasche, André
Kasche & Partner AG
Bühlstrasse 1
8125 Zollikerberg / Zürich / CH
Former [2018/15]Kasche, André
Kasche & Partner AG
Resirain 1
8125 Zollikerberg / CH
Application number, filing date16804586.203.06.2016
[2018/15]
WO2016US35874
Priority number, dateUS201562171090P04.06.2015         Original published format: US 201562171090 P
US20151479241406.07.2015         Original published format: US201514792414
[2018/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2016197032
Date:08.12.2016
Language:EN
[2016/49]
Type: A1 Application with search report 
No.:EP3302572
Date:11.04.2018
Language:EN
The application published by WIPO in one of the EPO official languages on 08.12.2016 takes the place of the publication of the European patent application.
[2018/15]
Type: B1 Patent specification 
No.:EP3302572
Date:06.01.2021
Language:EN
[2021/01]
Type: B8 Corrected title page of specification 
No.:EP3302572
Date:24.03.2021
[2021/12]
Type: B3 Limited patent 
No.:EP3302572
Date:24.07.2024
Language:EN
[2024/30]
Search report(s)International search report - published on:US08.12.2016
(Supplementary) European search report - dispatched on:EP04.10.2018
ClassificationIPC:C07D401/14, C07D495/14, A61P35/00
[2018/44]
CPC:
C07D401/14 (EP,AU,KR,RU); A61K47/66 (RU); C07D401/04 (EP,AU,RU);
A61K31/436 (AU); A61K31/454 (AU); A61K31/551 (KR);
A61K45/06 (AU); A61K47/545 (EP,AU,KR); A61K47/55 (KR);
A61P35/00 (EP,AU,KR,RU); C07D405/14 (KR); C07D417/14 (KR);
C07D495/14 (EP,AU,KR,RU) (-)
Former IPC [2018/15]A61K47/48, C07D401/14
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/15]
TitleGerman:IMID-BASIERTE MODULATOREN VON PROTEOLYSE UND ASSOZIIERTE VERFAHREN ZUR VERWENDUNG[2018/15]
English:IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE[2018/15]
French:MODULATEURS À BASE D'IMIDE DE PROTÉOLYSE ET PROCÉDÉS D'UTILISATION ASSOCIÉS[2018/15]
Entry into regional phase21.12.2017National basic fee paid 
21.12.2017Search fee paid 
21.12.2017Designation fee(s) paid 
21.12.2017Examination fee paid 
Examination procedure21.12.2017Examination requested  [2018/15]
21.12.2017Date on which the examining division has become responsible
30.04.2019Amendment by applicant (claims and/or description)
05.02.2020Despatch of a communication from the examining division (Time limit: M04)
12.02.2020Reply to a communication from the examining division
25.05.2020Communication of intention to grant the patent
08.07.2020Fee for grant paid
08.07.2020Fee for publishing/printing paid
08.07.2020Receipt of the translation of the claim(s)
Opposition(s)07.10.2021No opposition filed within time limit [2021/50]
Limitations:07.10.2021Date of receipt of request for limitation
 admissible
15.04.2024Communication of intention to limit the patent
Fees paidRenewal fee
27.06.2018Renewal fee patent year 03
13.06.2019Renewal fee patent year 04
27.11.2020Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
30.06.202005   M06   Fee paid on   27.11.2020
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
MT06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
TR06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
[2026/04]
Former [2025/04]AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
MT06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
Former [2024/41]AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
MT06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
Former [2024/22]AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
Former [2023/30]AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
Former [2022/34]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
BE30.06.2021
Former [2022/23]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
Former [2022/21]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
IE03.06.2021
LU03.06.2021
Former [2022/18]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
LU03.06.2021
Former [2022/13]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2022/10]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2022/07]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/50]AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/49]AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/48]AT06.01.2021
CZ06.01.2021
EE06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/46]AT06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
SM06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/42]AT06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/39]AT06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/38]AT06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
RS06.01.2021
SE06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/37]AT06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
RS06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/36]FI06.01.2021
HR06.01.2021
LT06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/35]FI06.01.2021
HR06.01.2021
LT06.01.2021
NO06.04.2021
PT06.05.2021
Former [2021/33]FI06.01.2021
LT06.01.2021
NO06.04.2021
PT06.05.2021
Documents cited:Search[XP] WO2015160845  (ARVINAS INC et al.) [XP] 1-15 * claims 2, 6, 13, 14, 15, 22; compounds 14, 15, 15 *
International search[Y] US2014356322  (CREWS CRAIG M et al.) [Y] 3, 6 * (para [0039];[0042];[0065]; [0109];[0110); Claim 148 *
 [XY]   WINTER ET AL.: "Phthalimide conjugation as a strategy for in vivo target protein degradation", SCIENCE, vol. 348, no. 6241, 21 May 2015 (2015-05-21), pages 1376 - 1381, XP055328122 [X] 1, 2, 15 * abstract; pg 1376, Col 3, para 3 to pg 1377, Col 1, para 1, Figure 1a; pg 1379, Col 1, para 2 *[Y] 3, 6

DOI:   http://dx.doi.org/10.1126/science.aab1433
 [A]   ZENGERLE ET AL.: "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4", ACS CHEMICAL BIOLOGY, vol. 10, 2 June 2015 (2015-06-02), pages 1770 - 1777, XP055333869 [A] 1-3, 6, 15 * . pg 1777, Col 2, para 2 *

DOI:   http://dx.doi.org/10.1021/acschembio.5b00216
by applicantUS2012063401
 WO2012078559
   VALLEE ET AL.: "Tricyclic Series of Heat Shock Protein 90 (HSP90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-C]Pyridines as Potent Inhibitors of the HSP90 Molecular Chaperone", J.MED.CHEM., vol. 54, 2011, pages 7206, XP055240728, DOI: 10.1021/jm200784m [A] 1-3, 6, 15 * . pg 1777, Col 2, para 2 *

DOI:   http://dx.doi.org/10.1021/jm200784m
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.