| EP3243821 - PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.01.2021 Database last updated on 31.03.2026 | |
| Former | The patent has been granted Status updated on 24.01.2020 | ||
| Former | Grant of patent is intended Status updated on 17.01.2020 | ||
| Former | Examination is in progress Status updated on 03.01.2020 | ||
| Former | Grant of patent is intended Status updated on 19.08.2019 | ||
| Former | Examination is in progress Status updated on 07.09.2018 | ||
| Former | Request for examination was made Status updated on 13.10.2017 | Most recent event Tooltip | 15.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 17.08.2022 [2022/33] | Applicant(s) | For all designated states GB006, Inc. 3013 Science Park Road, Suite 200 San Diego, CA 92121 / US | [2020/14] |
| Former [2019/36] | For all designated states GB006, Inc. 251 Little Falls Drive Wilmington, New Castle 19808 / US | ||
| Former [2017/46] | For all designated states Adhaere Pharamaceuticals, Inc. 11950 S.W. 72nd Place Pinecrest, FL 33156 / US | Inventor(s) | 01 /
GUPTA, Vineet Adhaere Pharmaceuticals, Inc 11950 S.W. 72nd Place Pinecrest, FL 33156 / US | [2017/46] | Representative(s) | Murgitroyd & Company 165-169 Scotland Street Glasgow G5 8PL / GB | [N/P] |
| Former [2020/09] | Murgitroyd & Company Murgitroyd House 165-169 Scotland Street Glasgow G5 8PL / GB | ||
| Former [2017/46] | chapman + co 18 Staple Gardens Winchester, Hampshire SO23 8SR / GB | Application number, filing date | 17177006.8 | 02.05.2011 | [2017/46] | Priority number, date | US20100362363P | 08.07.2010 Original published format: US 362363 P | [2017/46] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3243821 | Date: | 15.11.2017 | Language: | EN | [2017/46] | Type: | B1 Patent specification | No.: | EP3243821 | Date: | 26.02.2020 | Language: | EN | [2020/09] | Type: | B8 Corrected title page of specification | No.: | EP3243821 | Date: | 15.04.2020 | [2020/16] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 11.08.2017 | Classification | IPC: | C07D417/06, A61K31/427, A61P29/00 | [2017/46] | CPC: |
C07D417/06 (EP,US);
A61K31/427 (CN);
A61K31/5377 (CN);
A61P1/04 (EP);
A61P11/06 (EP);
A61P13/12 (EP);
A61P17/00 (EP);
A61P17/02 (EP);
A61P17/06 (EP);
A61P19/02 (EP);
A61P19/04 (EP);
A61P25/00 (EP);
A61P25/28 (EP);
A61P29/00 (EP);
A61P3/04 (EP);
A61P3/06 (EP);
A61P3/10 (EP);
A61P31/18 (EP);
A61P33/06 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/00 (EP);
A61P37/02 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
A61P7/00 (EP);
A61P9/00 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2017/46] | Title | German: | PHARMAZEUTISCHE FORMULIERUNGEN ZUR REGULIERUNG VON INTEGRIN-CD11B/CD18 | [2017/46] | English: | PHARMACEUTICAL FORMULATIONS FOR REGULATING INTEGRIN CD11B/CD18 | [2017/46] | French: | FORMULATIONS PHARMACEUTIQUES POUR RÉGULER L'INTÉGRINE CD11B/CD18 | [2017/46] | Examination procedure | 20.06.2017 | Examination requested [2017/46] | 20.06.2017 | Date on which the examining division has become responsible | 11.05.2018 | Amendment by applicant (claims and/or description) | 07.09.2018 | Despatch of a communication from the examining division (Time limit: M04) | 18.12.2018 | Reply to a communication from the examining division | 26.03.2019 | Despatch of a communication from the examining division (Time limit: M04) | 17.05.2019 | Reply to a communication from the examining division | 20.08.2019 | Communication of intention to grant the patent | 20.12.2019 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 20.12.2019 | Fee for grant paid | 20.12.2019 | Fee for publishing/printing paid | 16.01.2020 | Information about intention to grant a patent | 16.01.2020 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP11803961.9 / EP2591092 | Divisional application(s) | EP20159424.9 / EP3682947 | Opposition(s) | 27.11.2020 | No opposition filed within time limit [2021/05] | Fees paid | Renewal fee | 20.06.2017 | Renewal fee patent year 03 | 20.06.2017 | Renewal fee patent year 04 | 20.06.2017 | Renewal fee patent year 05 | 20.06.2017 | Renewal fee patent year 06 | 20.06.2017 | Renewal fee patent year 07 | 11.05.2018 | Renewal fee patent year 08 | 15.05.2019 | Renewal fee patent year 09 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 02.05.2011 | AL | 26.02.2020 | AT | 26.02.2020 | CY | 26.02.2020 | CZ | 26.02.2020 | DK | 26.02.2020 | EE | 26.02.2020 | ES | 26.02.2020 | FI | 26.02.2020 | HR | 26.02.2020 | IT | 26.02.2020 | LT | 26.02.2020 | LV | 26.02.2020 | MC | 26.02.2020 | MK | 26.02.2020 | MT | 26.02.2020 | NL | 26.02.2020 | PL | 26.02.2020 | RO | 26.02.2020 | RS | 26.02.2020 | SE | 26.02.2020 | SI | 26.02.2020 | SK | 26.02.2020 | SM | 26.02.2020 | TR | 26.02.2020 | LU | 02.05.2020 | BG | 26.05.2020 | NO | 26.05.2020 | GR | 27.05.2020 | BE | 31.05.2020 | IS | 26.06.2020 | PT | 19.07.2020 | [2022/31] |
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| NO | 26.05.2020 | Documents cited: | Search | [X] US2004002526 (KLEIN J PETER et al.) | [A] FARIDI MOHD H ET AL: "Identification of novel agonists of the integrin CD11b/CD18", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, vol. 19, no. 24, 15 December 2009 (2009-12-15), pages 6902 - 6906, XP026754144, ISSN: 0960-894X, [retrieved on 20091022], DOI: 10.1016/J.BMCL.2009.10.077 DOI: http://dx.doi.org/10.1016/j.bmcl.2009.10.077 | by applicant | "Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY | "Remington's Pharmaceutical Sciences", 1990 | "The United States Pharmacopeia", 1999, THE NATIONAL FORMULARY | MARCH: "Advanced Organic Chemistry", 1992, JOHN WILEY AND SONS | CAREY; SUNDBERG: "Advanced Organic Chemistry", vol. A, B, 1990, PLENUM PRESS, INC | GREEN; WUTS: "Protective groups in Organic Synthesis", 1991, JOHN WILEY AND SONS | LAROCK: "Comprehensive Organic Transformations", 1988, VCH PUBLISHERS, INC. | YANG, W.; C.V. CARMAN; M. KIM; A. SALAS; M. SHIMAOKA; T.A. SPRINGER: "A small molecule agonist of an integrin, alpha L beta 2.", J BIOL CHEM, 2006 | CANADAS, T.N.; X. CULLERE: "Neutrophil beta2 integrins: moderators of life or death decisions.", TRENDS IMMUNOL, vol. 26, no. 7, 2005, pages 388 - 95 | LEY, K. ET AL.: "Getting to the site of inflammation: the leukocyte adhesion cascade updated.", NAT REV IMMUNOL, vol. 7, no. 9, 2007, pages 678 - 89 | SIMON, D.I. ET AL.: "Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty", J CLIN INVEST, vol. 105, no. 3, 2000, pages 293 - 300 | CAO, C. ET AL.: "A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics.", BLOOD, vol. 106, no. 9, 2005, pages 3234 - 41 | TANG, T. ET AL.: "A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis.", J EXP MED, vol. 186, no. 11, 1997, pages 1853 - 63 | PLOW, E.F ET AL.: "Ligand binding to integrins.", J BIOL CHEM, vol. 275, no. 29, 2000, pages 21785 - 8 | SORIANO, S.G. ET AL.: "Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury.", STROKE, vol. 30, no. 1, 1999, pages 134 - 9, XP055093139, DOI: doi:10.1161/01.STR.30.1.134 DOI: http://dx.doi.org/10.1161/01.STR.30.1.134 | KUBOTA, Y ET AL.: "M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis.", J EXP MED, vol. 206, no. 5, 2009, pages 1089 - 102 | HYNES, R.O.: "Integrins: bidirectional, allosteric signaling machines", CELL, vol. 110, no. 6, 2002, pages 673 - 87 | ARNAOUT, M.A: "Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response", IMMUNOL REV, vol. 114, 1990, pages 145 - 80 | PHILLIPSON, M ET AL.: "Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade", J EXP MED, vol. 203, no. 12, 2006, pages 2569 - 75 | AHN, G.O. ET AL.: "Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment.", PROC NATL ACAD SCI USA., vol. 107, no. 18, pages 8363 - 8 | OPHASCHAROENSUK, V. ET AL.: "Role of intrinsic renal cells versus infiltrating cells in glomerular crescent formation", KIDNEY INT, vol. 54, no. 2, 1998, pages 416 - 25 | LE HIR, M. ET AL.: "Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis", J AM SOC NEPHROL, vol. 12, no. 10, 2001, pages 2060 - 71 | TANG, T. ET AL.: "A role for Mac-I (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor- dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis", J EXP MED, vol. 186, no. 11, 1997, pages 1853 - 63 | FAN, S.T.; T.S. EDGINGTON: "Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response", J CLIN INVEST, vol. 87, no. 1, 1991, pages 50 - 7 | WHITLOCK, B.B. ET AL.: "Differential roles for alpha(M)beta(2) integrin clustering or activation in the control of apoptosis via regulation of akt and ERK survival mechanisms", J CELL BIOL, vol. 151, no. 6, 2000, pages 1305 - 20 | REZZONICO. R. ET AL.: "Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-lbeta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB", BLOOD, vol. 97, no. 10, 2001, pages 2932 - 40 | GUHA, M.; N. MACKMAN: "The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells", J BIOL CHEM, vol. 277, no. 35, 2002, pages 32124 - 32 | RUBEL, C ET AL.: "Fibrinogen-CD11b/GD18 interaction activates the NF-kappa B pathway and delays apoptosis in human neutrophils", EUR J IMMUNOL, vol. 33, no. 5, 2003, pages 1429 - 38 | KETTRITZ, R. ET AL.: "Integrins and cytokines activate nuclear transcription factor-kappaB in human neutrophils", J BIOL CHEM, vol. 279, no. 4, 2004, pages 2657 - 65 | GIANCOTTI, F.G.; E, RUOSLAHTI: "Integrin signaling", SCIENCE, vol. 285, no. 5430, 1999, pages 1028 - 32 | SHEIKH, S.; G.B, NASH: "Continuous activation and deactivation of integrin CD11b/CD18 during de novo expression enables rolling neutrophils to immobilize on platelets", BLOOD, vol. 87, no. 12, 1996, pages 5040 - 50 | JAESCHKE, H. ET AL.: "Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver", HEPATOLOGY, vol. 17, no. 5, 1993, pages 915 - 23 | ROGERS, C.; E.R. EDELMAN; D.I. SIMON: "A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits", PROC NATL ACAD SCI U S A, vol. 95, no. 17, 1998, pages 10134 - 9 | WILSON, I. ET AL.: "Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart", CIRCULATION, vol. 88, 1993, pages II372 - 9 | PLOW, E.F.; L. ZHANG: "A MAC-1 attack: integrin functions directly challenged in knockout mice", J CLIN INVEST, vol. 99, no. 6, 1997, pages 1145 - 6 | YONEKAWA, K.; J.M. HARLAN: "Targeting leukocyte integrins in human diseases", J LEUKOC BIOL, vol. 77, no. 2, 2005, pages 129 - 40 | DOVE, A.: "CD18 trials disappoint again", NAT BIOTECHNOL, vol. 18, no. 8, 2000, pages 817 - 8 | SHIMIZU, K. ET AL.: "Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection", CIRCULATION, vol. 117, no. 15, 2008, pages 1997 - 2008 | RAMAMOORTHY, C. ET AL.: "CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus", J LEUKOC BIOL, vol. 61, no. 2, 1997, pages 167 - 72 | LUM, A.F. ET AL.: "Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow", J BIOL CHEM, vol. 277, no. 23, 2002, pages 20660 - 70 | ALLISON, M.: "PML problems loom for Rituxan", NAT BIOTECHNOL, vol. 28, no. 2, 2010, pages 105 - 6 | BANSAL, V.S. ET AL.: "Small molecule antagonists of complement receptor type 3 block adhesion and adhesion-dependent oxidative burst in human polymorphonuclear leukocytes", J PHARMACOL EXP THER, vol. 304, no. 3, 2003, pages 1016 - 24, XP055170322, DOI: doi:10.1124/jpet.102.045286 DOI: http://dx.doi.org/10.1124/jpet.102.045286 | BJORKLUND, M. ET AL.: "Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment", BIOCHEMISTRY, vol. 45, no. 9, 2006, pages 2862 - 71, XP055046653, DOI: doi:10.1021/bi052238b DOI: http://dx.doi.org/10.1021/bi052238b | FARIDI, M.H.: "Identification of novel agonists of the integrin CD11b/CD18", BIOORG MED CHEM LETT, 2009 | ARNAOUT, M.A. ET AL.: "Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol)", J CLIN INVEST, vol. 72, no. 1, 1983, pages 171 - 9 | WRIGHT, S.D. 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