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Extract from the Register of European Patents

EP About this file: EP3252037

EP3252037 - PROCESS FOR THE PREPARATION OF (3Z,5S)-5-(HYDROXYMETHYL)-1-[(2 ́-METHYL-1,1 ́-BIPHENYL-4-YL)CARBONYL)PYRROLIDIN-3-ONE O-METHYLOXIME [Right-click to bookmark this link]
Former [2017/49]PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1A RECEPTORS ANTAGONISTS
[2020/33]
StatusNo opposition filed within time limit
Status updated on  13.01.2023
Database last updated on 01.04.2026
FormerThe patent has been granted
Status updated on  04.02.2022
FormerGrant of patent is intended
Status updated on  18.03.2021
FormerExamination is in progress
Status updated on  15.02.2021
FormerGrant of patent is intended
Status updated on  14.02.2021
FormerExamination is in progress
Status updated on  15.12.2020
FormerGrant of patent is intended
Status updated on  03.09.2020
FormerExamination is in progress
Status updated on  02.11.2018
FormerRequest for examination was made
Status updated on  08.06.2018
FormerThe application has been published
Status updated on  03.11.2017
Most recent event   Tooltip13.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 16.10.2024  [2024/42]
Applicant(s)For all designated states
ObsEva S.A.
12, Chemin des Aulx
1228 Plan-les-Ouates/Geneve / CH
[2017/49]
Inventor(s)01 / CHOLLET, André
c/o ObsEva S.A.
12, chemin des Aulx
1228 Plan-les-Ouates / CH
 [2017/49]
Representative(s)KATZAROV S.A.
Geneva Business Center
12 Avenue des Morgines
1213 Petit-Lancy / CH
[2022/10]
Former [2017/49]KATZAROV S.A.
European Patent Attorneys 19, rue des Epinettes
1227 Genève / CH
Application number, filing date17177956.425.07.2014
[2017/49]
Priority number, dateEP2013018372310.09.2013         Original published format: EP 13183723
[2017/49]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3252037
Date:06.12.2017
Language:EN
[2017/49]
Type: B1 Patent specification 
No.:EP3252037
Date:09.03.2022
Language:EN
[2022/10]
Search report(s)(Supplementary) European search report - dispatched on:EP29.09.2017
ClassificationIPC:C07D207/22, A61K31/4025, A61P5/10
[2017/49]
CPC:
C07D207/22 (EP,CN,EA,KR,US); A61K31/40 (EP,KR,US); A61K31/401 (KR);
A61K31/4025 (EA); A61K31/573 (KR); A61K45/06 (KR);
A61K9/0019 (KR,US); A61K9/0034 (KR); A61K9/0053 (US);
A61P13/08 (EP); A61P15/00 (EP); A61P15/04 (EP);
A61P15/06 (EP); A61P15/08 (EP); A61P15/10 (EP);
A61P25/00 (EP); A61P25/02 (EP); A61P25/14 (EP);
A61P25/18 (EP); A61P25/22 (EP); A61P25/24 (EP);
A61P3/14 (EP); A61P43/00 (EP); A61P5/00 (EP);
A61P5/10 (EP,EA); A61P5/38 (EP); A61P5/40 (EP);
A61P9/00 (EP); A61P9/08 (EP); C07D207/09 (EP,US);
A61K2300/00 (KR) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2018/28]
Former [2017/49]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBA26.06.2017
ME26.06.2017
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON (3Z,5S)-5-(HYDROXYMETHYL)-1-[(2 ́-METHYL-1,1 ́-BIPHENYL-4-YL)CARBONYL)PYRROLIDIN-3-ON O-METHYLOXIM[2020/33]
English:PROCESS FOR THE PREPARATION OF (3Z,5S)-5-(HYDROXYMETHYL)-1-[(2 ́-METHYL-1,1 ́-BIPHENYL-4-YL)CARBONYL)PYRROLIDIN-3-ONE O-METHYLOXIME[2020/33]
French:PROCÉDÉ POUR LA PRÉPARATION DE (3Z,5S)-5-(HYDROXYMETHYL)-1-[(2 ́-METHYL-1,1 ́-BIPHENYL-4-YL)CARBONYL)PYRROLIDIN-3-ONE O-METHYLOXIME[2020/33]
Former [2017/49]PYRROLIDINDERIVATE ALS OXYTOCIN-/VASOPRESSIN-V1A-REZEPTORANTAGONISTEN
Former [2017/49]PYRROLIDINE DERIVATIVES AS OXYTOCIN / VASOPRESSIN V1A RECEPTORS ANTAGONISTS
Former [2017/49]DÉRIVÉS DE PYRROLIDINE COMME ANTAGONISTES DES RÉCEPTEURS V1A DE VASOPRESSINE/OXYTOCINE
Examination procedure26.06.2017Date on which the examining division has become responsible
01.06.2018Amendment by applicant (claims and/or description)
01.06.2018Examination requested  [2018/28]
30.10.2018Despatch of a communication from the examining division (Time limit: M04)
18.02.2019Reply to a communication from the examining division
17.06.2019Despatch of a communication from the examining division (Time limit: M06)
23.03.2020Reply to a communication from the examining division
04.09.2020Communication of intention to grant the patent
15.12.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
19.03.2021Communication of intention to grant the patent
19.08.2021Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
07.10.2021Fee for grant paid
07.10.2021Fee for publishing/printing paid
07.10.2021Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP14744104.2  / EP3044206
Divisional application(s)EP22160832.6  / EP4129979
Opposition(s)12.12.2022No opposition filed within time limit [2023/07]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
07.10.2021Request for further processing filed
07.10.2021Full payment received (date of receipt of payment)
Request granted
19.10.2021Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
23.03.2020Request for further processing filed
23.03.2020Full payment received (date of receipt of payment)
Request granted
31.03.2020Decision despatched
Fees paidRenewal fee
26.06.2017Renewal fee patent year 03
26.06.2017Renewal fee patent year 04
27.07.2018Renewal fee patent year 05
29.07.2019Renewal fee patent year 06
27.07.2020Renewal fee patent year 07
27.07.2021Renewal fee patent year 08
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.07.2014
AL09.03.2022
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
MK09.03.2022
MT09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
TR09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
[2024/42]
Former [2024/29]HU25.07.2014
AL09.03.2022
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
MK09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
TR09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
Former [2024/22]HU25.07.2014
AL09.03.2022
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
MK09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
Former [2024/20]HU25.07.2014
AL09.03.2022
AT09.03.2022
CY09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
Former [2024/18]HU25.07.2014
AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
Former [2023/33]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
IE25.07.2022
LU25.07.2022
BE31.07.2022
Former [2023/25]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
LU25.07.2022
BE31.07.2022
Former [2023/21]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
LU25.07.2022
Former [2023/11]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
MC09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2023/10]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SI09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2023/07]AL09.03.2022
AT09.03.2022
CZ09.03.2022
DK09.03.2022
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LT09.03.2022
LV09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
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SE09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2023/01]AL09.03.2022
AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2022/51]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
IS09.07.2022
PT11.07.2022
Former [2022/50]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
PL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/49]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SK09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/48]AT09.03.2022
CZ09.03.2022
EE09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/47]AT09.03.2022
FI09.03.2022
HR09.03.2022
LT09.03.2022
LV09.03.2022
NL09.03.2022
RO09.03.2022
RS09.03.2022
SE09.03.2022
SM09.03.2022
BG09.06.2022
NO09.06.2022
GR10.06.2022
PT11.07.2022
Former [2022/44]FI09.03.2022
HR09.03.2022
LT09.03.2022
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BG09.06.2022
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Former [2022/39]FI09.03.2022
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Former [2022/36]HR09.03.2022
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Former [2022/35]HR09.03.2022
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NO09.06.2022
Former [2022/33]LT09.03.2022
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Documents cited:Search[I] WO2004005249  (APPLIED RESEARCH SYSTEMS et al.)
 [A] WO2005082848  (APPLIED RESEARCH SYSTEMS et al.)
by applicantWO0172705
 WO02102799
 WO02074741
 WO2004005249
 WO2005082848
   T. HIGUCHI; V. STELLA: "A. C. S. Symposium Series", vol. 14, 1976, article "Prodrugs as Novel Delivery Systems"
   "Design of Prodrugs", 1985, ELSEVIER
   "Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
   "Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING COMPANY, pages: 1289 - 1329
   GENNARO, A. R. ET AL.: "Remington's Pharmaceutical Sciences", 1995, EASTON: THE MACK PUBLISHING COMPANY
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.