blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3266463

EP3266463 - HEMOGLOBIN COMPOSITIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  18.10.2024
Database last updated on 01.04.2026
FormerThe patent has been granted
Status updated on  10.11.2023
FormerGrant of patent is intended
Status updated on  11.07.2023
FormerExamination is in progress
Status updated on  24.04.2020
FormerRequest for examination was made
Status updated on  13.07.2018
FormerThe application has been published
Status updated on  08.12.2017
Most recent event   Tooltip13.03.2026Lapse of the patent in a contracting state
New state(s): HU		published on 15.04.2026 [2026/16]
Applicant(s)For all designated states
Prolong Pharmaceuticals, LLC
300 Corporate Court Suite B
South Plainfield, NJ 07080 / US
[2018/02]
Inventor(s)01 / ABUCHOWSKI, Abraham
62 Bunnvale Road
California, NJ 07830 / US
02 / SLOSHBERG, Steven
2255 Balmoral Avenue
Union, NJ 07083 / US
03 / O'HARE, Keith
76 Cypress Drive
East Windsor, NJ 08520 / US
 [2018/02]
Representative(s)Harrison IP Limited
3 Ebor House
Millfield Lane
Nether Poppleton
York YO26 6QY / GB
[N/P]
Former [2018/02]Harrison IP Limited
3 Ebor House
Millfield Lane
Nether Poppleton, York YO26 6QY / GB
Application number, filing date17188857.109.06.2010
[2018/02]
Priority number, dateUS20090185547P09.06.2009         Original published format: US 185547 P
[2018/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3266463
Date:10.01.2018
Language:EN
[2018/02]
Type: B1 Patent specification 
No.:EP3266463
Date:13.12.2023
Language:EN
[2023/50]
Search report(s)(Supplementary) European search report - dispatched on:EP17.11.2017
ClassificationIPC:A61K38/42, A61K9/00, A61K9/08, A61K47/02, A61K47/60, A61P9/10, A61P7/00, A61P7/06, A61P7/08, A61P9/00, A61P17/02, A61P35/00, A61P39/06
[2023/27]
CPC:
A61K38/42 (EP,KR,US); A61K38/17 (KR); A61K41/10 (US);
A61K47/02 (EP,KR,US); A61K47/18 (KR); A61K47/50 (KR);
A61K47/60 (EP,KR,US); A61K9/0019 (EP,KR,US); A61K9/08 (EP,KR,US);
A61P17/02 (EP); A61P35/00 (EP); A61P39/06 (EP);
A61P7/00 (EP); A61P7/06 (EP); A61P7/08 (EP);
A61P9/00 (EP); A61P9/10 (EP) (-)
Former IPC [2018/02]A61K38/42, A61K9/00, A61P9/10
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2018/33]
Former [2018/02]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  SM,  TR 
TitleGerman:HÄMOGLOBINZUSAMMENSETZUNGEN[2018/02]
English:HEMOGLOBIN COMPOSITIONS[2018/02]
French:COMPOSITIONS D'HÉMOGLOBINE[2018/02]
Examination procedure31.08.2017Date on which the examining division has become responsible
09.07.2018Amendment by applicant (claims and/or description)
09.07.2018Examination requested  [2018/33]
29.04.2020Despatch of a communication from the examining division (Time limit: M06)
04.11.2020Reply to a communication from the examining division
09.11.2021Despatch of a communication from the examining division (Time limit: M03)
03.02.2022Reply to a communication from the examining division
12.07.2023Communication of intention to grant the patent
07.11.2023Fee for grant paid
07.11.2023Fee for publishing/printing paid
07.11.2023Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10727289.0  / EP2440239
Opposition(s)16.09.2024No opposition filed within time limit [2024/47]
Fees paidRenewal fee
31.08.2017Renewal fee patent year 03
31.08.2017Renewal fee patent year 04
31.08.2017Renewal fee patent year 05
31.08.2017Renewal fee patent year 06
31.08.2017Renewal fee patent year 07
31.08.2017Renewal fee patent year 08
27.06.2018Renewal fee patent year 09
27.06.2019Renewal fee patent year 10
29.06.2020Renewal fee patent year 11
28.06.2021Renewal fee patent year 12
27.06.2022Renewal fee patent year 13
23.06.2023Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY09.06.2010
HU09.06.2010
AT13.12.2023
CZ13.12.2023
EE13.12.2023
FI13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
MC13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
LU09.06.2024
[2026/16]
Former [2025/51]CY09.06.2010
AT13.12.2023
CZ13.12.2023
EE13.12.2023
FI13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
MC13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
LU09.06.2024
Former [2025/45]AT13.12.2023
CZ13.12.2023
EE13.12.2023
FI13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
MC13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
LU09.06.2024
Former [2025/13]AT13.12.2023
CZ13.12.2023
EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
MC13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
LU09.06.2024
Former [2025/11]AT13.12.2023
CZ13.12.2023
EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
MC13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
Former [2024/49]AT13.12.2023
CZ13.12.2023
EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
RO13.12.2023
SI13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
Former [2024/36]AT13.12.2023
CZ13.12.2023
EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
RO13.12.2023
SK13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
PT15.04.2024
Former [2024/35]AT13.12.2023
CZ13.12.2023
EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
RO13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
Former [2024/34]EE13.12.2023
HR13.12.2023
LT13.12.2023
LV13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
Former [2024/33]HR13.12.2023
LT13.12.2023
LV13.12.2023
SM13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
Former [2024/32]HR13.12.2023
LT13.12.2023
LV13.12.2023
BG13.03.2024
GR14.03.2024
IS13.04.2024
Former [2024/26]HR13.12.2023
LT13.12.2023
LV13.12.2023
BG13.03.2024
GR14.03.2024
Former [2024/24]HR13.12.2023
LT13.12.2023
BG13.03.2024
GR14.03.2024
Former [2024/21]LT13.12.2023
BG13.03.2024
GR14.03.2024
Former [2024/20]GR14.03.2024
Documents cited:Search[X] WO2006096774  (SANGART INC et al.)
 [A] US2004072729  (KWANG NHO et al.)
 [A] US2006135753  (ACHARYA SEETHARAMA A et al.)
 [AD] US5234903  (NHO KWANG et al.)
 [I]   CHARLES D CONOVER ET AL: "The Ability of Polyethylene Glycol Conjugated Bovine Hemoglobin (PEG-Hb) To Adequately Deliver Oxygen in Both Exchange Transfusion and Top-Loaded Rat Models", ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOL, MARCEL DEKKER INC, US, vol. 27, no. 2, 1 March 1999 (1999-03-01), pages 93 - 107, XP008169461, ISSN: 1073-1199, DOI: 10.3109/10731199909117685

DOI:   http://dx.doi.org/10.3109/10731199909117685
Examination  VANDEGRIFF K D ET AL: "MP4, a new nonvasoactive PEG-Hb conjugate", TRANSFUSION, AMERICAN ASSOCIATION OF BLOOD BANKS, BETHESDA, MD, US, vol. 43, 1 April 2003 (2003-04-01), pages 509 - 516, XP002977872, ISSN: 0041-1132, DOI: 10.1046/J.1537-2995.2003.00341.X

DOI:   http://dx.doi.org/10.1046/j.1537-2995.2003.00341.x
   FRONTICELLI C ET AL: "Allosteric modulation by tertiary structure in mammalian hemoglobins /INTRODUCTION OF THE FUNCTIONAL CHARACTERISTICS OF BOVINE HEMOGLOBIN INTO HUMAN HEMOGLOBIN BY FIVE AMINO ACID SUBSTITUTIONS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 270, no. 51, 22 December 1995 (1995-12-22), pages 30588 - 30592, XP002996147, ISSN: 0021-9258, DOI: 10.1074/JBC.270.51.30588

DOI:   http://dx.doi.org/10.1074/jbc.270.51.30588
   VANDEGRIFF KIMD. ET AL: "Kinetics of NO and O2 binding to a maleimide poly(ethylene glycol)-conjugated human haemoglobin", BIOCHEMICAL JOURNAL, vol. 382, no. 1, 15 August 2004 (2004-08-15), GB, pages 183 - 189, XP055855029, ISSN: 0264-6021, Retrieved from the Internet DOI: 10.1042/BJ20040156

DOI:   http://dx.doi.org/10.1042/BJ20040156
by applicantUS5386014
 US5234903
 US5932462
 US5629384
 WO9417039
 US5324844
 WO9418247
 WO9404193
 US5219564
 US5122614
 WO9013540
 US5281698
 WO9315189
 WO9415625
 WO9409027
 US4412989
 US5672662
 US6376604
 WO9945964
 WO9621469
 US5446090
 WO9934833
 WO9914259
 US6348558
 US5342940
 US5643575
 US5919455
 US6113906
 US5183660
 WO0209766
 US5084558
 US5296465
 US7241282
 US5466573
 US6649072
 US4650858
 US5399670
 WO9109122
 WO0168109
 US5565427
 US5605884
 US5763401
 US5874408
 US5962650
 US5972885
 WO8909784
 WO9407510
 US6329176
 WO9920767
 WO0011416
 WO0222776
 WO0238162
 WO0183725
 WO0158935
 US5580560
 WO9215686
 WO9111514
 WO8810295
 WO0028065
 US6232336
 US5910316
 US5650447
 US5380758
 US5703073
 WO9727749
 WO9819672
 WO9309806
 US5284872
 US5428061
 US5661129
 US5807847
 US5883122
 WO9746521
 WO0054756
 WO03013432
 US6656452
   "Red Blood Cell Substitutes", 1998, DEKKER
   SPATOLA, A. F.: "CHEMISTRY AND BIOCHEMISTRY OF AMINO ACIDS, PEPTIDES AND PROTEINS", 1983, MARCEL DEKKER, pages: 267
   "Pharmaceutical Biotechnology", 1997, HARWOOD PUBLISHERS, article "Further explanation of ''half-life'' is found", pages: 101 - 120
   VERONESE, APP. BIOCHEM. BIOTECH., vol. 11, 1985, pages 141 - 45
   HARRIS, MACRONOL. CHEM. PHYS., vol. C25, 1985, pages 325 - 373
   SCOUTEN, METHODS IN ENZYMOLOGY, vol. 135, 1987, pages 30 - 65
   WONG ET AL., ENZYME MICROB. TECHNOL., vol. 14, 1992, pages 866 - 874
   DELGADO ET AL., CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 9, 1992, pages 249 - 304
   ZALIPSKY, BIOCONJUGATE CHEM., vol. 6, 1995, pages 150 - 165
   BHADRA ET AL., PHARMAZIE, vol. 57, 2002, pages 5 - 29
   KODERA Y., BIOCONJUGATE CHEMISTRY, vol. 5, 1994, pages 283 - 288
   YAMASAKI ET AL., AGRIC. BIOL. CHEM., vol. 52, 1998, pages 2125 - 2127
   BIO/TECHNOLOGY, vol. 12, 1994, pages 55 - 59
   PHARMACEUTICAL ENGINEERING, vol. 11, 1991, pages 15 - 23
   NATURE, vol. 356, 1992, pages 258 - 260
   MARCH: "ADVANCED ORGANIC CHEMISTRY", 1985, JOHN WILEY & SONS
   HERMANSON: "BIOCONJUGATE TECHNIQUES", 1996, ACADEMIC PRESS
   FEENEY ET AL.: "MODIFICATION OF PROTEINS; Advances in Chemistry Series", vol. 198, 1982, AMERICAN CHEMICAL SOCIETY
   GREENE ET AL.: "PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", 1991, JOHN WILEY & SONS
   SIMS ET AL., ANAL. BIOCHEM, vol. 107, 1980, pages 60 - 63
   MURPHY ET AL., BLOOD, vol. 60, no. 1, 1982, pages 194 - 200
   MURPHY: "The Preparation and Storage of Platelets for Transfusion", 1980, PJD PUBLICATIONS, LTD.
   MURPHY: "Platelet Transfusion", vol. III, 1976, GRUNE AND STRATTON, INC., article "Progress in Hemostasis and Thrombosis"
   MURPHY ET AL., BLOOD, vol. 46, no. 2, 1975, pages 209 - 218
   KILKSON ET AL., BLOOD, vol. 64, no. 2, 1984, pages 406 - 414
   MURPHY: "Platelet Storage for Transfusion", SEMINARS IN HEMATOLOGY, vol. 22, no. 3, 1985, pages 165 - 177
   SIMON ET AL., TRANSFUSION, vol. 23, 1983, pages 207 - 212
   CESAR ET AL., TRANSFUSION, vol. 27, no. 5, 1987, pages 434 - 437
   DICKINSON ET AL., J. BIO. CHEM., vol. 272, 1997, pages 19875 - 19879
   KEMBALL-COOK ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 8516 - 8521
   BHARADWAJ ET AL., J. BIOL. CHEM., vol. 271, 1996, pages 30685 - 30691
   RUF ET AL., BIOCHEMISTRY, vol. 38, 1999, pages 1957 - 1966
   OAE ET AL., ORG. PREP. PROC. INT., vol. 15, no. 3, 1983, pages 165 - 198
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.