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EP About this file: EP3421600

EP3421600 - LIVER-TYPE FATTY ACID-BINDING PROTEIN PREPARATION AND USE THEREOF [Right-click to bookmark this link]
Former [2019/01]	LIVER-TYPE FATTY ACID-BINDING PROTEIN PREPARATION, METHOD FOR EVALUATING PREPARATION, METHOD FOR REGULATING VARIATION RANGE OF MEASURED VALUE CAUSED BY LIVER-TYPE FATTY ACID-BINDING PROTEIN IN MEASUREMENT USING PREPARATION, LIVER-TYPE FATTY ACID-BINDING PROTEIN, DNA ENCODING PROTEIN, CELL TRANSFORMED BY DNA, METHOD FOR PRODUCING PROTEIN, METHOD FOR DRAWING CALIBRATION CURVE FOR LIVER-TYPE FATTY ACID-BINDING PROTEIN, AND METHOD FOR QUANTIFYING PROTEIN
	[2020/26]
Status	No opposition filed within time limit Status updated on 24.09.2021 Database last updated on 24.04.2024
Former	The patent has been granted Status updated on 16.10.2020
Former	Grant of patent is intended Status updated on 15.06.2020
Former	Examination is in progress Status updated on 16.12.2019
Former	Request for examination was made Status updated on 30.11.2018
Former	The international publication has been made Status updated on 28.12.2017
Most recent event Tooltip	14.07.2023	Lapse of the patent in a contracting state New state(s): HU	published on 16.08.2023 [2023/33]
Applicant(s)	For all designated states CMIC Holdings Co. Ltd. 1-1-1 Shibaura Minato-ku Tokyo 105-0023 / JP
	[2019/01]
Inventor(s)	01 / SUGAYA, Takeshi c/o CMIC Holdings Co., Ltd. 1-1-1, Shibaura Minato-ku Tokyo 105-0023 / JP
	02 / OKAZAKI, Masateru c/o CMIC Holdings Co., Ltd. 1-1-1, Shibaura Minato-ku Tokyo 105-0023 / JP
	03 / OIKAWA, Tsuyoshi c/o CMIC Holdings Co., Ltd. 1-1-1, Shibaura Minato-ku Tokyo 105-0023 / JP
	[2019/01]
Representative(s)	Appleyard Lees IP LLP 15 Clare Road Halifax HX1 2HY / GB
	[2019/01]
Application number, filing date	17813408.6	15.06.2017
	[2019/01]
	WO2017JP22209
Priority number, date	JP20160120073	16.06.2016 Original published format: JP 2016120073
	JP20160246001	19.12.2016 Original published format: JP 2016246001
	[2019/01]
Filing language	JA
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2017217514
	Date:	21.12.2017
	Language:	JA
	[2017/51]
	Type:	A1 Application with search report
	No.:	EP3421600
	Date:	02.01.2019
	Language:	EN
	[2019/01]
	Type:	B1 Patent specification
	No.:	EP3421600
	Date:	18.11.2020
	Language:	EN
	[2020/47]
Search report(s)	International search report - published on:	JP	21.12.2017
	(Supplementary) European search report - dispatched on:	EP	20.02.2019
Classification	IPC:	C12N15/09, C07K14/47, C12N1/15, C12N1/19, C12N1/21, C12N5/10, C12P21/02, G01N33/68	[2019/01]
	CPC:	C07K14/47 (EP,US); C12P21/02 (EP); G01N33/68 (EP,US); G01N2440/00 (EP); G01N2496/00 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/01]
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	MA	Not yet paid
	MD	Not yet paid
Title	German:	LEBERFETTSÄUREBINDENDES PROTEINSPRÄPARAT UND VERFAHREN	[2020/26]
	English:	LIVER-TYPE FATTY ACID-BINDING PROTEIN PREPARATION AND USE THEREOF	[2020/26]
	French:	PRÉPARATION DE PROTÉINE DE LIAISON AUX ACIDES GRAS DU TYPE HÉPATIQUE ET SON UTILISATION	[2020/26]
	Former [2019/01]	PRÄPARAT AUS LEBERFETTSÄUREBINDENDEM PROTEIN, VERFAHREN ZUR BEURTEILUNG DES PRÄPARATS, VERFAHREN ZUR REGELUNG DES VARIATIONSBEREICHS EINES GEMESSENEN WERTS EINES LEBERFETTSÄUREBINDENDEN PROTEINS BEI DER MESSUNG ANHAND DES PRÄPARATS, LEBERFETTSÄUREBINDENDES PROTEIN, DNA-CODIERENDES PROTEIN, DURCH DNA TRANSFORMIERTE ZELLE, VERFAHREN ZUR PROTEINHERSTELLUNG, VERFAHREN ZUR ZEICHNUNG DER KALIBRIERKURVE FÜR LEBERFETTSÄUREBINDENDES PROTEIN UND VERFAHREN ZUR PROTEINQUANTIFIZIERUNG
	Former [2019/01]	LIVER-TYPE FATTY ACID-BINDING PROTEIN PREPARATION, METHOD FOR EVALUATING PREPARATION, METHOD FOR REGULATING VARIATION RANGE OF MEASURED VALUE CAUSED BY LIVER-TYPE FATTY ACID-BINDING PROTEIN IN MEASUREMENT USING PREPARATION, LIVER-TYPE FATTY ACID-BINDING PROTEIN, DNA ENCODING PROTEIN, CELL TRANSFORMED BY DNA, METHOD FOR PRODUCING PROTEIN, METHOD FOR DRAWING CALIBRATION CURVE FOR LIVER-TYPE FATTY ACID-BINDING PROTEIN, AND METHOD FOR QUANTIFYING PROTEIN
	Former [2019/01]	PRÉPARATION DE PROTÉINE DE LIAISON AUX ACIDES GRAS DU TYPE HÉPATIQUE, PROCÉDÉ D'ÉVALUATION DE LA PRÉPARATION, PROCÉDÉ DE RÉGULATION DE LA PLAGE DE VARIATION DE LA VALEUR MESURÉE PROVOQUÉE PAR LA PROTÉINE DE LIAISON AUX ACIDES GRAS DU TYPE HÉPATIQUE DANS LA MESURE À L'AIDE DE LA PRÉPARATION, PROTÉINE DE LIAISON AUX ACIDES GRAS DU TYPE HÉPATIQUE, ADN CODANT POUR LA PROTÉINE, CELLULE TRANSFORMÉE PAR L'ADN, PROCÉDÉ DE PRODUCTION DE PROTÉINE, PROCÉDÉ POUR TRACER UNE COURBE D'ÉTALONNAGE D'UNE PROTÉINE DE LIAISON AUX ACIDES GRAS DU TYPE HÉPATIQUE, ET PROCÉDÉ DE QUANTIFICATION DE LA PROTÉINE
Entry into regional phase	24.09.2018	Translation filed
	24.09.2018	National basic fee paid
	24.09.2018	Search fee paid
	24.09.2018	Designation fee(s) paid
	24.09.2018	Examination fee paid
Examination procedure	deleted	Date on which the examining division has become responsible
	24.09.2018	Examination requested [2019/01]
	05.09.2019	Amendment by applicant (claims and/or description)
	19.12.2019	Despatch of a communication from the examining division (Time limit: M04)
	29.04.2020	Reply to a communication from the examining division
	16.06.2020	Communication of intention to grant the patent
	12.10.2020	Fee for grant paid
	12.10.2020	Fee for publishing/printing paid
	12.10.2020	Receipt of the translation of the claim(s)
Opposition(s)	19.08.2021	No opposition filed within time limit [2021/43]
Fees paid	Renewal fee
	21.06.2019	Renewal fee patent year 03
	08.06.2020	Renewal fee patent year 04
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	15.06.2017
	AL	18.11.2020
	AT	18.11.2020
	CY	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
	IE	15.06.2021
	LU	15.06.2021
	BE	30.06.2021
	[2023/33]
Former [2023/30]	AL	18.11.2020
	AT	18.11.2020
	CY	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
	IE	15.06.2021
	LU	15.06.2021
	BE	30.06.2021
Former [2022/34]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
	IE	15.06.2021
	LU	15.06.2021
	BE	30.06.2021
Former [2022/23]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
	IE	15.06.2021
	LU	15.06.2021
Former [2022/21]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	PT	18.03.2021
	IE	15.06.2021
	LU	15.06.2021
Former [2022/18]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	PT	18.03.2021
	LU	15.06.2021
Former [2022/10]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	PT	18.03.2021
Former [2022/08]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	ES	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	MC	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/50]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SI	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/45]	AL	18.11.2020
	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/37]	AT	18.11.2020
	CZ	18.11.2020
	DK	18.11.2020
	EE	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/36]	AT	18.11.2020
	CZ	18.11.2020
	EE	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/35]	AT	18.11.2020
	CZ	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RO	18.11.2020
	RS	18.11.2020
	SK	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/33]	AT	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LT	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RS	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/32]	AT	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RS	18.11.2020
	SM	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/28]	AT	18.11.2020
	FI	18.11.2020
	HR	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RS	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/25]	AT	18.11.2020
	FI	18.11.2020
	LV	18.11.2020
	PL	18.11.2020
	RS	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	IS	18.03.2021
	PT	18.03.2021
Former [2021/23]	AT	18.11.2020
	FI	18.11.2020
	LV	18.11.2020
	RS	18.11.2020
	BG	18.02.2021
	NO	18.02.2021
	GR	19.02.2021
	PT	18.03.2021
Former [2021/22]	FI	18.11.2020
	RS	18.11.2020
	NO	18.02.2021
	PT	18.03.2021
Former [2021/21]	FI	18.11.2020
	PT	18.03.2021
Former [2021/20]	FI	18.11.2020
Documents cited:	Search	[A] - THOMPSON JAMES ET AL, "The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates", JOURNAL OF BIOLOGICAL CHEMISTRY, (19970314), vol. 272, no. 11, ISSN 0021-9258, pages 7140 - 7150, XP002788455 [A] 7,8 * page 7143; figure 1 * * page 7146; figure 4 * DOI: http://dx.doi.org/10.1074/jbc.272.11.7140
		[A] - "RENISHEM L-FABP ELISA TMB Kit A kit for quantitative determination of human LFABP in urine", (201508), pages 1 - 4, CMIC HOLDING Co., TOKYO, URL: https://www.fabp.jp/eng/pdf/161114_tmb_inst.pdf, (20190128), XP002788456 [A] 1-15 * page 3, column r, paragraph "quality control" * * page 4, column l, paragraph "3. repeatability" *
	International search	[A]JPH08304395 (BETSUSERU RES LAB KK) [A] 1-15* , example 2 (Family: none) *;
		[A]WO2011007823 (UNIV TOKYO [JP], et al) [A] 1-15 * , example 1 & US 2012/0135433 A1 example 1 *;
		[A] - Ronald G.H.J. Maatman et al., "Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein", Biochim. Biophys. Acta ., (19940000), vol. 1214, no. 1, pages 1 - 10, XP 023366541 [A] 1-15 * , particularly, summary, page 3, left column, 3rd paragraph to right column, 3rd paragraph, table 1 *
		[A] - KIM YUN HO et al., "Comparing the effect on protein stability of methionine oxidation versus mutagenesis: Steps toward engineering oxidative resistance in proteins", Protein Engineering, (20010000), vol. 14, no. 5, pages 343 - 347, XP 002251172 [A] 1-15 * , particularly, 'Introduction', 2nd to 4th paragraphs *
		[A] - Mark Cornell Manning et al., "Stability of Protein Pharmaceuticals: An Update", Pharmaceutical Res ., (20100000), vol. 27, no. 4, pages 544 - 575, XP 019793935 [A] 1-15 * , particularly, page 551, 'Methionine Sanka' *
		[A] - Jing Yan, "Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity", J. Lipid Res., (20090000), vol. 50, no. 12, pages 2445 - 2454, XP 055465183 [A] 1-15 * , particularly, summary, page 2446, left column, 2nd paragraph, pages 2450 to 2451, 'Sanka Methionine Zanki no Dotei', page 2452, right column, 3rd paragraph to page 2453, left column, 1st paragraph *
		[A] - "Lenapro L-FABP test TMB", Data sheet, 3rd ed., (20150000), pages 1 - 4, URL: https://www.fabp.jp/pdf/MSDS_L-FABP.pdf, XP009508454 [A] 1-15 * , particularly, 'KeijoKozo To', 'Shiyo Mokuteki', 'Sokutei Genri', 'YohoYoryo' *
	Examination	US2012135433

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