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Extract from the Register of European Patents

EP About this file: EP3641819

EP3641819 - USE OF CANNABIDIOL IN THE TREATMENT OF TUBEROUS SCLEROSIS COMPLEX [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  08.09.2023
Database last updated on 01.04.2026
FormerGrant of patent is intended
Status updated on  22.06.2023
FormerExamination is in progress
Status updated on  11.02.2022
FormerRequest for examination was made
Status updated on  27.03.2020
FormerThe international publication has been made
Status updated on  31.12.2018
Formerunknown
Status updated on  17.07.2018
Most recent event   Tooltip19.03.2026New entry: Despatch of minutes of oral proceedings 
Applicant(s)For all designated states
GW Research Limited
Sovereign House Vision Park
Chivers Way
Histon
Cambridge, Cambridgeshire CB24 9BZ / GB
[2020/18]
Inventor(s)01 / WHALLEY, Benjamin
GW Pharma Limited
Soverign House
Vision Park
Chivers Way, Histon
Cambridge Cambridgeshire CB24 9BZ / GB
02 / HIND, William
GW Pharma Limited
Sovereign House
Vision Park
Chivers Way, Histon
Cambridge Cambridgeshire CB24 9BZ / GB
03 / GRAY, Royston
GW Pharma Limited
Sovereign House
Vision Park
Chivers Way, Histon
Cambridge Cambridgeshire CB24 9BZ / GB
04 / BAZELOT, Michael
GW Pharma Limited
Sovereign House
Vision Park
Chivers Way, Histon
Cambridge Cambridgeshire CB24 9BZ / GB
05 / DE SILVA SERRA, Ines
School of Psychology and Clinical Language Science
University of Reading
Reading Berkshire RG6 6AL / GB
06 / WILLIAMS, Claire
School of Psychology and Clinical Language Science
University of Reading
Reading Berkshire RG6 6AL / GB
07 / TEE, Andrew
Cancer&Genetics Building
Institute of Medical Genetics
Cardiff University
Heath Park
Cardiff South Glamorgan CF14 4XN / GB
 [2020/18]
Representative(s)HGF
HGF Limited
4th Floor, 1 City Square
Leeds LS1 2ES / GB
[N/P]
Former [2023/41]HGF
HGF Limited
1 City Walk
Leeds LS11 9DX / GB
Former [2020/18]HGF Limited
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Application number, filing date18737374.121.06.2018
[2020/18]
WO2018GB51733
Priority number, dateGB2017001004223.06.2017         Original published format: GB 201710042
[2020/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018234811
Date:27.12.2018
Language:EN
[2018/52]
Type: A1 Application with search report 
No.:EP3641819
Date:29.04.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 27.12.2018 takes the place of the publication of the European patent application.
[2020/18]
Type: B1 Patent specification 
No.:EP3641819
Date:11.10.2023
Language:EN
[2023/41]
Search report(s)International search report - published on:EP27.12.2018
ClassificationIPC:A61K31/436, A61K45/06, A61K31/352, A61P35/00
[2023/28]
CPC:
A61K31/352 (EP); A61K31/05 (GB); A61K31/658 (US);
A61K31/436 (EP); A61K45/06 (EP,US); A61P35/00 (EP,US);
A61P43/00 (GB); A61K2300/00 (GB) (-)
C-Set:
A61K31/352, A61K2300/00 (EP);
A61K31/436, A61K2300/00 (EP)
Former IPC [2020/18]A61K45/06, A61K31/436, A61K31/352, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/18]
Extension statesBANot yet paid
MENot yet paid
Validation statesKHNot yet paid
MANot yet paid
MDNot yet paid
TNNot yet paid
TitleGerman:VERWENDUNG VON CANNABIDIOL BEI DER BEHANDLUNG EINES TUBERÖSEN SKLEROSEKOMPLEXES[2020/18]
English:USE OF CANNABIDIOL IN THE TREATMENT OF TUBEROUS SCLEROSIS COMPLEX[2020/18]
French:UTILISATION DE CANNABIDIOL DANS LE TRAITEMENT DE LA SCLÉROSE TUBÉREUSE DE BOURNEVILLE[2020/18]
Entry into regional phase26.11.2019National basic fee paid 
26.11.2019Designation fee(s) paid 
26.11.2019Examination fee paid 
Examination procedure26.11.2019Examination requested  [2020/18]
26.11.2019Date on which the examining division has become responsible
24.07.2020Amendment by applicant (claims and/or description)
11.02.2022Despatch of a communication from the examining division (Time limit: M04)
07.06.2022Reply to a communication from the examining division
02.03.2023Despatch of a communication from the examining division (Time limit: M02)
10.05.2023Reply to a communication from the examining division
23.06.2023Communication of intention to grant the patent
30.08.2023Fee for grant paid
30.08.2023Fee for publishing/printing paid
30.08.2023Receipt of the translation of the claim(s)
Opposition(s)Opponent(s)01  09.07.2024  10.07.2024  ADMISSIBLE
Kraus & Lederer PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
Opponent's representative
Kraus & Lederer PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
 [2024/33]
23.07.2024Invitation to proprietor to file observations on the notice of opposition
25.11.2024Reply of patent proprietor to notice(s) of opposition
04.06.2025Cancellation of oral proceeding that was planned for 25.11.2025
25.11.2025Date of oral proceedings
20.01.2026Date of oral proceedings
18.03.2026Despatch of minutes of oral proceedings
18.03.2026Despatch of communication that the patent will be revoked
Fees paidRenewal fee
12.06.2020Renewal fee patent year 03
11.06.2021Renewal fee patent year 04
31.03.2022Renewal fee patent year 05
31.03.2023Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY21.06.2018
HU21.06.2018
CZ11.10.2023
EE11.10.2023
HR11.10.2023
LT11.10.2023
LV11.10.2023
MC11.10.2023
PL11.10.2023
RO11.10.2023
RS11.10.2023
SI11.10.2023
SK11.10.2023
SM11.10.2023
BG11.01.2024
GR12.01.2024
IS11.02.2024
PT12.02.2024
AT21.06.2024
FI21.06.2024
IE21.06.2024
IT21.06.2024
LU21.06.2024
ES22.06.2024
SE22.06.2024
BE30.06.2024
DK30.06.2024
NO30.06.2024
[2026/16]
Former [2025/51]CY21.06.2018
CZ11.10.2023
EE11.10.2023
HR11.10.2023
LT11.10.2023
LV11.10.2023
MC11.10.2023
PL11.10.2023
RO11.10.2023
RS11.10.2023
SI11.10.2023
SK11.10.2023
SM11.10.2023
BG11.01.2024
GR12.01.2024
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PT12.02.2024
AT21.06.2024
FI21.06.2024
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SK11.10.2023
SM11.10.2023
BG11.01.2024
GR12.01.2024
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PT12.02.2024
AT21.06.2024
FI21.06.2024
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BG11.01.2024
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PT12.02.2024
FI21.06.2024
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Cited inInternational search[XY] WO2016191651  (INSYS DEV CO INC et al.) [X] 1-4,8-11,13,14 * paragraphs [0269] , [ 294]; claims 4, 5, 20 *[Y] 5-7,12
 [Y] CN104490873  (ZOU LIPING et al.) [Y] 5-7,12 * abstract *
 [Y] WO2013168131  (DOLCETTA DIEGO et al.) [Y] 5-7,12 * page 8, paragraph 3; claims 1, 7 *
 [XP] WO2018002637  (GW RES LTD et al.) [XP] 1-4,8-10,14 * paragraphs [0007] , [0 22] - [0023] - [0 31] , [0 56]; claims 8, 16 *
 [XP] WO2018002665  (GW RES LTD et al.) [XP] 1-4,8-11,13,14 * page 5, paragraph L; claims 15, 16, 27 *
 [XP] WO2017204986  (INSYS DEV CO INC et al.) [XP] 1-4,8-11,13,14 * paragraphs [0281] , [ 290] , [ 296]; claims 1-3, 11 *
ExaminationUS2016367496
OppositionWO2016191651
 US2016166515
   ANONYMOUS: "INNOVATING THROUGH PARTNERSHIPS", 2017 INTERNATIONAL RESEARCH CONFERENCE ON TSC AND LAM: INNOVATING THROUGH PARTNERSHIPS, 22 June 2017 (2017-06-22) - 24 June 2017 (2017-06-24), XP093195595
   HO CALVIN N., GABRIELLE RUSHING, JAMES E. VALENTINE, KARI LUTHER ROSBECK, STEVEN L. ROBERDS: "The Voice of the Patient A Report from the Tuberous Sclerosis Alliances Externally-Led Patient-Focused Drug Development Meeting", TUBEROUS SCLEROSIS ALLIANCE, 26 October 2017 (2017-10-26), XP093195598, Retrieved from the Internet
   FRANZ DAVID N., CAPAL JAMIE K.: "mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disorders", ORPHANET JOURNAL OF RARE DISEASES, BIOMED CENTRAL LTD, LO, vol. 12, no. 51, 1 December 2017 (2017-12-01), Lo , XP093195599, ISSN: 1750-1172, DOI: 10.1186/s13023-017-0596-2
   KRUEGER DARCY A., ET AL.: "Tuberous Sclerosis Complex Surveillance and Management: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference", PEDIATRIC NEUROLOGY, ELSEVIER SCIENCE., NL, vol. 49, no. 4, 1 October 2013 (2013-10-01), NL , pages 255 - 265, XP093195601, ISSN: 0887-8994, DOI: 10.1016/j.pediatrneurol.2013.08.002
   EVAN J. HESS; KIRSTEN A. MOODY; ALEXANDRA L. GEFFREY; SARAH F. POLLACK; LAUREN A. SKIRVIN; PATRICIA L. BRUNO; JAN L. PAOLINI; ELIZ: "Cannabidiol as a new treatment for drugresistant epilepsy in tuberous sclerosis complex", EPILEPSIA, RAVEN PRESS LTD, NEW YORK , US, vol. 57, no. 10, 3 October 2016 (2016-10-03), New York , US , pages 1617 - 1624, XP071213053, ISSN: 0013-9580, DOI: 10.1111/epi.13499

DOI:   http://dx.doi.org/10.1111/epi.13499
   A. SHRIVASTAVA, P. M. KUZONTKOSKI, J. E. GROOPMAN, A. PRASAD: "Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 7, 1 July 2011 (2011-07-01), US , pages 1161 - 1172, XP055418898, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-10-1100

DOI:   http://dx.doi.org/10.1158/1535-7163.MCT-10-1100
   KALENDEROGLOU NIKOLETTA, MACPHERSON TARA, WRIGHT KAREN L.: "Cannabidiol Reduces Leukemic Cell Size But Is It Important?", FRONTIERS IN PHARMACOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 8, CH , XP093195605, ISSN: 1663-9812, DOI: 10.3389/fphar.2017.00144
   DA SILVA SERRA INS : "The Effect of Cannabidiol in Tuberous Sclerosis Complex", THESIS, 1 April 2019 (2019-04-01), pages 1 - 182, XP093241933
   LEUNG, A.K.C. ROBSON, W.L.M.: "Tuberous Sclerosis Complex: A Review", JOURNAL OF PEDIATRIC HEALTH CARE, vol. 21, no. 2, 23 February 2007 (2007-02-23), AMSTERDAM, NL , pages 108 - 114, XP005898717, ISSN: 0891-5245, DOI: 10.1016/j.pedhc.2006.05.004

DOI:   http://dx.doi.org/10.1016/j.pedhc.2006.05.004
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