Extract from the Register of European Patents

EP About this file: EP3601239

EP3601239 - NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.06.2025
Database last updated on 31.03.2026
FormerThe patent has been granted
Status updated on  27.06.2024
FormerGrant of patent is intended
Status updated on  19.02.2024
FormerExamination is in progress
Status updated on  31.03.2023
FormerGrant of patent is intended
Status updated on  29.11.2022
FormerExamination is in progress
Status updated on  28.10.2022
FormerGrant of patent is intended
Status updated on  21.06.2022
FormerExamination is in progress
Status updated on  27.05.2022
FormerGrant of patent is intended
Status updated on  25.01.2022
FormerExamination is in progress
Status updated on  03.04.2021
FormerRequest for examination was made
Status updated on  03.01.2020
FormerThe international publication has been made
Status updated on  29.09.2018
Most recent event   Tooltip06.06.2025No opposition filed within time limitpublished on 09.07.2025  [2025/28]
Applicant(s)For all designated states
Jacobio Pharmaceuticals Co., Ltd.
Unit 2, Building 5, BYBP
No.88 Kechuang Street 6th
Business Development Area
Daxing
Beijing 101111 / CN
[2024/31]
Former [2020/06]For all designated states
Jacobio Pharmaceuticals Co., Ltd.
Unit 2, Building 5, BYBP
No.88 Kechuang Street 6th
Business Development Area
Daxing
Beijing 101111 / CN
Inventor(s)01 / MA, Cunbo
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
02 / GAO, Panliang
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
03 / HU, Shaojing
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
04 / XU, Zilong
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
05 / HAN, Huifeng
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
06 / WU, Xinping
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
07 / KANG, Di
Unit 2 Building 5
BYBP
No.88 Kechuang Street 6th
Business Development Area, Daxing
Beijing 101111 / CN
 [2020/06]
Representative(s)Mathys & Squire
32 London Bridge Street The Shard
London SE1 9SG / GB
[N/P]
Former [2024/31]Arch, Peter Jonathan Sanders, et al
Mathys & Squire The Shard
32 London Bridge Street
London SE1 9SG / GB
Former [2020/06]Sun, Yiming
HUASUN Patent- und Rechtsanwälte
Friedrichstraße 33
80801 München / DE
Application number, filing date18770877.123.03.2018
[2020/06]
WO2018IB51973
Priority number, dateWO2017IB5169023.03.2017         Original published format: PCT/IB2017/051690
[2020/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2018172984
Date:27.09.2018
Language:EN
[2018/39]
Type: A1 Application with search report 
No.:EP3601239
Date:05.02.2020
Language:EN
The application published by WIPO in one of the EPO official languages on 27.09.2018 takes the place of the publication of the European patent application.
[2020/06]
Type: B1 Patent specification 
No.:EP3601239
Date:31.07.2024
Language:EN
[2024/31]
Search report(s)International search report - published on:CN27.09.2018
(Supplementary) European search report - dispatched on:EP17.04.2020
ClassificationIPC:C07D401/14, C07D491/107, C07D495/10, C07D471/20, A61K31/497, A61P35/00, C07D405/14, C07D491/113, C07D491/20, C07D513/10, C07F9/6558, C07D471/10
[2020/20]
CPC:
A61P35/00 (EP,EA,KR); C07D401/14 (EP,EA,KR,US); C07D413/14 (US);
A61K31/497 (KR); A61K31/5377 (KR); A61P27/02 (KR);
A61P35/04 (KR); A61P37/00 (KR); A61P43/00 (KR);
A61P9/00 (KR); C07D401/04 (KR,US); C07D405/14 (EP,EA);
C07D471/10 (EP,EA,KR,US); C07D471/20 (EP,EA,KR,US); C07D491/107 (EP,EA,KR,US);
C07D491/113 (EP,EA); C07D491/20 (EP,EA); C07D495/10 (EP,EA,KR,US);
C07D513/10 (EP,EA,KR,US); C07F9/65583 (EP,EA) (-)
Former IPC [2020/06]C07D241/18, C07D241/20, C07D401/14, C07D401/04, C07D491/107, C07D498/10, C07D471/10, A61K31/497, A61P35/00, A61P35/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/06]
Extension statesBA23.10.2019
ME23.10.2019
Validation statesMA23.10.2019
MD23.10.2019
TN23.10.2019
TitleGerman:NEUARTIGE, ALS SHP2-INHIBITOREN NÜTZLICHE HETEROCYCLISCHE DERIVATE[2020/06]
English:NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS[2020/06]
French:NOUVEAUX DÉRIVÉS HÉTÉROCYCLIQUES UTILES EN TANT QU'INHIBITEURS DE SHP2[2020/06]
Entry into regional phase23.10.2019National basic fee paid 
23.10.2019Search fee paid 
23.10.2019Designation fee(s) paid 
23.10.2019Examination fee paid 
Examination procedure23.10.2019Examination requested  [2020/06]
17.11.2020Amendment by applicant (claims and/or description)
08.04.2021Despatch of a communication from the examining division (Time limit: M04)
18.08.2021Reply to a communication from the examining division
26.01.2022Communication of intention to grant the patent
26.05.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
22.06.2022Communication of intention to grant the patent
27.10.2022Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
30.11.2022Communication of intention to grant the patent
29.03.2023Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
24.04.2023Despatch of a communication from the examining division (Time limit: M06)
03.11.2023Reply to a communication from the examining division
20.02.2024Communication of intention to grant the patent
19.06.2024Fee for grant paid
19.06.2024Fee for publishing/printing paid
19.06.2024Receipt of the translation of the claim(s)
Divisional application(s)EP24191584.2   Application deemed to be withdrawn  : 30.01.2025
Opposition(s)01.05.2025No opposition filed within time limit [2025/28]
Fees paidRenewal fee
24.03.2020Renewal fee patent year 03
09.03.2021Renewal fee patent year 04
16.03.2022Renewal fee patent year 05
13.03.2023Renewal fee patent year 06
01.03.2024Renewal fee patent year 07
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Documents cited:Search[XP] WO2016203406  (NOVARTIS AG et al.) [XP] 1-3,6,8,11,12,15-18,20,21,26,38-43
 [XA] WO2015107495  (NOVARTIS AG et al.) [X] 1-4,9,15-17,22,23,26,38-43 * formula Ia with p = q =1;; claims 1-10,12-14 *[A] 6-8,10-14,18-21,24,25,27-37
 [XA] WO2017211303  (JACOBIO PHARMACEUTICALS CO LTD et al.) [X] 1-4,9,15-17,22,23,26,38-43 * paragraphs [0029] , [0033]; claims 2-9, 22-23 *[A] 6-8,10-14,18-21,24,25,27-37
 [XP] WO2007057775  (PFIZER LTD et al.) [XP] 1-3,6,8,11,12,15-18,20,21,26,38-43 * claims 1,29,35 *
International search[PX] WO2018013597  (REVOLUTION MEDICINES INC et al.) [PX] 1-130 * claims, examples *
 [X] WO2016203406  (NOVARTIS AG et al.) [X] 1-130 * claims 1, 4-14, examples *
 [X] WO2015107495  (NOVARTIS AG et al.) [X] 1-130 * examples, claims *
 [A] WO2015107494  (NOVARTIS AG et al.) [A] 1-130 * claims, examples *
ExaminationWO2017211303
by applicantWO2017211303
   "Design of Prodrugs", 1985, ELSEVIER
   Y. UTO ET AL., BIOORG. MED. CHEM. LETT., vol. 20, 2010, pages 746 - 754
   J. ORG. CHEM., vol. 64, 1999, pages 5504 - 5510
   "REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY", 1995, MACK PUBLISHING CO.
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