Extract from the Register of European Patents

EP About this file: EP3520811

EP3520811 - METHODS FOR INCREASING FORCED EXPIRATORY VOLUME IN ASTHMATICS USING BENRALIZUMAB [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  05.11.2021
Database last updated on 09.04.2026
FormerThe patent has been granted
Status updated on  27.11.2020
FormerGrant of patent is intended
Status updated on  08.07.2020
FormerRequest for examination was made
Status updated on  14.02.2020
FormerThe application has been published
Status updated on  05.07.2019
Most recent event   Tooltip05.11.2021No opposition filed within time limitpublished on 08.12.2021  [2021/49]
Applicant(s)For all designated states
Astrazeneca AB
151 85 Södertälje / SE
[2019/32]
Inventor(s)01 / WARD, Christine
c/o MedImmune LLC
One Medimmune Way
Gaithersburg, Maryland 20878 / US
02 / ROSKOS, Lorin
c/o MedImmune LLC
One Medimmune Way
Gaithersburg, Maryland 20878 / US
03 / WANG, Bing
c/o Medimmune LLC
One Medimmune Way
Gaithersburg, Maryland 20878 / US
04 / RAIBLE, Donald
317 Lenape Drive
Berwyn, Pennsylvania 19312 / US
 [2019/32]
Representative(s)AstraZeneca Intellectual Property
Eastbrook House
Shaftesbury Road
Cambridge CB2 8BF / GB
[N/P]
Former [2019/32]AstraZeneca
Milstein Building
Granta Park
Cambridge CB21 6GH / GB
Application number, filing date19158446.507.08.2014
[2019/32]
Priority number, dateUS201361864948P12.08.2013         Original published format: US 201361864948 P
[2019/32]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP3520811
Date:07.08.2019
Language:EN
[2019/32]
Type: B1 Patent specification 
No.:EP3520811
Date:30.12.2020
Language:EN
[2020/53]
Search report(s)(Supplementary) European search report - dispatched on:EP13.05.2019
ClassificationIPC:A61K39/00, A61K39/395, G01N33/48, A61P11/06
[2019/32]
CPC:
C07K16/2866 (EP,CN,US); A61K39/39541 (CN); A61K39/395 (RU);
A61K45/06 (EP,US); A61P11/06 (EP,RU); A61P43/00 (EP);
A61K2039/505 (EP,CN,US); C07K2317/24 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/12]
Former [2019/32]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
Extension statesBA07.02.2020
ME07.02.2020
TitleGerman:VERFAHREN ZUR ERHÖHUNG DES FORCIERTEN EXSPIRATORISCHEN VOLUMENS BEI ASTHMATIKERN MIT BENRALIZUMAB[2019/32]
English:METHODS FOR INCREASING FORCED EXPIRATORY VOLUME IN ASTHMATICS USING BENRALIZUMAB[2019/32]
French:PROCÉDÉ POUR AUGMENTER LE VOLUME D'EXPIRATION FORCÉE CHEZ DES ASTHMATIQUES À L'AIDE DE BENRALIZUMAB[2019/32]
Examination procedure05.02.2020Amendment by applicant (claims and/or description)
07.02.2020Examination requested  [2020/12]
07.02.2020Date on which the examining division has become responsible
09.07.2020Communication of intention to grant the patent
18.11.2020Fee for grant paid
18.11.2020Fee for publishing/printing paid
18.11.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP14836725.3  / EP3033104
Divisional application(s)EP20208316.8  / EP3875487
EP25150773.7  / EP4579236
EP25191983.3
Opposition(s)01.10.2021No opposition filed within time limit [2021/49]
Fees paidRenewal fee
21.06.2019Renewal fee patent year 03
21.06.2019Renewal fee patent year 04
21.06.2019Renewal fee patent year 05
02.09.2019Renewal fee patent year 06
31.08.2020Renewal fee patent year 07
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Documents cited:Search[A] WO2013066780  (MEDIMMUNE LLC et al.)
 [A] WO2008143878  (MEDIMMUNE LLC et al.)
 [A]   MICHEL LAVIOLETTE ET AL: "Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 132, no. 5, 16 July 2013 (2013-07-16), AMSTERDAM, NL, pages 1086 - 1096.e5, XP055277773, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2013.05.020

DOI:   http://dx.doi.org/10.1016/j.jaci.2013.05.020
 [A]   MERCK: "Asthma Severity and Control Monitoring Guide", 1 January 2007 (2007-01-01), XP055341967, Retrieved from the Internet [retrieved on 20170203]
 [A]   GHAZI AASIA ET AL: "Benralizumab--a humanized mAb to IL-5R[alpha] with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma", EXPERT OPINION ON BIOLOGICAL THERAPY, INFORMA HEALTHCARE, UK, vol. 12, no. 1, 1 January 2012 (2012-01-01), pages 113 - 118, XP009159038, ISSN: 1744-7682, DOI: 10.1517/14712598.2012.642359

DOI:   http://dx.doi.org/10.1517/14712598.2012.642359
 [A]   N. A. MOLFINO ET AL: "Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor", CLINICAL & EXPERIMENTAL ALLERGY, vol. 42, no. 5, 1 May 2012 (2012-05-01), pages 712 - 737, XP055026155, ISSN: 0954-7894, DOI: 10.1111/j.1365-2222.2011.03854.x

DOI:   http://dx.doi.org/10.1111/j.1365-2222.2011.03854.x
 [T]   EUGENE R BLEECKER ET AL: "Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting &bgr;2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial", LANCET, vol. 388, no. 10056, 1 October 2016 (2016-10-01), AMSTERDAM, NL, pages 2115 - 2127, XP055342068, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(16)31324-1

DOI:   http://dx.doi.org/10.1016/S0140-6736(16)31324-1
by applicantWO2013066780
 US2010291073
 US6018032
   MASOLI M ET AL., ALLERGY, vol. 59, 2004, pages 469 - 78
   LEDERLE F ET AL., ARCH INT MED, vol. 147, 1987, pages 2201 - 03
   KRISHNAN J ET AL., AJRCCM, vol. 170, 2004, pages 1281 - 85
   JAMES A., CURR OPIN PULM MED, vol. 77, no. 1, 2005, pages 1 - 6
   JANSON C; HERALA M., RESP MED, vol. 86, no. 2, 1992, pages 101 - 104
   ULRIK C; FREDERICKSEN J., CHEST, vol. 108, 1995, pages 10 - 15
   RESTREPO R; PETERS J., CURR OPIN PULM MED, vol. 14, 2008, pages 13 - 23
   BELLIDO-CASADO J ET AL., ARCH BRONCONEUMOL, vol. 46, no. 11, 2010, pages 587 - 93
   GREEN R ET AL., LANCET, vol. 360, 2002, pages 1715 - 21
   HALDAR P ET AL., NEJM, vol. 360, 2009, pages 973 - 84
   BUSSE W ET AL., JACI, vol. 125, 2010, pages 1237 - 1244
   HANKINSON ET AL., AM J RESPIR CRIT CARE MED, vol. 159, 1999, pages 179 - 87
   SORKNESS ET AL., JAPPL PHYSIOL, vol. 104, 2008, pages 394 - 403
   SORKNESS ET AL., J APPL PHYSIOL, vol. 104, 2008, pages 394 - 403
   "Am JRespir Crit Care Med.", vol. 161, 2000, AMERICAN THORACIC SOCIETY, pages: 309 - 329
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