EP3578183 - RNA INTERFERENCE IN OCULAR INDICATIONS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 15.07.2022 Database last updated on 26.03.2025 | |
Former | The patent has been granted Status updated on 06.08.2021 | ||
Former | Grant of patent is intended Status updated on 28.03.2021 | ||
Former | Request for examination was made Status updated on 19.02.2021 | ||
Former | Grant of patent is intended Status updated on 25.10.2020 | ||
Former | Request for examination was made Status updated on 08.11.2019 | Most recent event Tooltip | 27.09.2024 | Lapse of the patent in a contracting state New state(s): MT | published on 30.10.2024 [2024/44] | Applicant(s) | For all designated states Phio Pharmaceuticals Corp. 257 Simarano Drive, Suite 101 Marlborough, MA 01752 / US | [2019/50] | Inventor(s) | 01 /
Libertine, Lyn 61 Nixon Road Framingham, MA Massachusetts 01701 / US | 02 /
Khvorova, Anastasia 10 Rocklawn Road Westborough, MA Massachusetts 01581 / US | 03 /
Salomon, William 2 Farrar Avenue, Apt. 2 Worcester, MA Massachusetts 01604 / US | 04 /
Kamens, Joanne 21 Wessex Road Newton, MA Massachusetts 02459 / US | 05 /
Samarsky, Dmitry 15 Wayside Road Westborough, MA Massachusetts 01581 / US | 06 /
Woolf, Tod, M. 14 Babe Ruth Drive Sudbury, MA Massachusetts 01176-1942 / US | 07 /
Cardia, James 11 Bacon Street Franklin, MA Massachusetts 02038 / US | [2019/50] | Representative(s) | Potter Clarkson Chapel Quarter Mount Street Nottingham NG1 6HQ / GB | [N/P] |
Former [2019/50] | Potter Clarkson The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB | Application number, filing date | 19168667.4 | 24.03.2011 | [2019/50] | Priority number, date | US201031725410P | 24.03.2010 Original published format: US 31725410 P | US201031762110P | 25.03.2010 Original published format: US 31762110 P | [2019/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP3578183 | Date: | 11.12.2019 | Language: | EN | [2019/50] | Type: | B1 Patent specification | No.: | EP3578183 | Date: | 08.09.2021 | Language: | EN | [2021/36] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 27.09.2019 | Classification | IPC: | A61K31/713, A61P27/00, A61P27/06, C12N15/113 | [2020/43] | CPC: |
A61K9/0051 (EP,CN,US);
A61K31/713 (EP,CN,US);
C12N15/1136 (US);
A61K45/06 (EP,US);
A61K47/554 (EP,US);
A61K9/0048 (US);
A61P27/00 (EP);
A61P27/02 (EP,US);
A61P27/06 (EP);
A61P7/10 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
C07H21/02 (CN);
C12N2310/14 (US);
C12N2310/313 (US);
C12N2310/321 (US);
C12N2310/322 (US);
C12N2310/3515 (US);
| C-Set: |
A61K31/713, A61K2300/00 (EP,US)
|
Former IPC [2019/50] | A61K31/713, A61P27/00, A61P27/06, A61P9/10 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2019/50] | Title | German: | RNA-INTERFERENZ BEI AUGENERKRANKUNGEN | [2019/50] | English: | RNA INTERFERENCE IN OCULAR INDICATIONS | [2019/50] | French: | INTERFÉRENCE D'ARN DANS DES INDICATIONS OCULAIRES | [2019/50] | Examination procedure | 12.04.2019 | Examination requested [2019/50] | 09.06.2020 | Amendment by applicant (claims and/or description) | 26.10.2020 | Communication of intention to grant the patent | 17.02.2021 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 29.03.2021 | Communication of intention to grant the patent | 29.07.2021 | Fee for grant paid | 29.07.2021 | Fee for publishing/printing paid | 29.07.2021 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP11760245.8 / EP2550001 | Opposition(s) | 09.06.2022 | No opposition filed within time limit [2022/33] | Fees paid | Renewal fee | 12.04.2019 | Renewal fee patent year 03 | 12.04.2019 | Renewal fee patent year 04 | 12.04.2019 | Renewal fee patent year 05 | 12.04.2019 | Renewal fee patent year 06 | 12.04.2019 | Renewal fee patent year 07 | 12.04.2019 | Renewal fee patent year 08 | 12.04.2019 | Renewal fee patent year 09 | 27.03.2020 | Renewal fee patent year 10 | 29.03.2021 | Renewal fee patent year 11 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 24.03.2011 | AL | 08.09.2021 | AT | 08.09.2021 | CY | 08.09.2021 | CZ | 08.09.2021 | DK | 08.09.2021 | EE | 08.09.2021 | ES | 08.09.2021 | FI | 08.09.2021 | HR | 08.09.2021 | IT | 08.09.2021 | LT | 08.09.2021 | LV | 08.09.2021 | MC | 08.09.2021 | MK | 08.09.2021 | MT | 08.09.2021 | NL | 08.09.2021 | PL | 08.09.2021 | RO | 08.09.2021 | RS | 08.09.2021 | SE | 08.09.2021 | SI | 08.09.2021 | SK | 08.09.2021 | SM | 08.09.2021 | BG | 08.12.2021 | NO | 08.12.2021 | GR | 09.12.2021 | IS | 08.01.2022 | PT | 10.01.2022 | IE | 24.03.2022 | LU | 24.03.2022 | BE | 31.03.2022 | CH | 31.03.2022 | LI | 31.03.2022 | [2024/44] |
Former [2024/25] | HU | 24.03.2011 | |
AL | 08.09.2021 | ||
AT | 08.09.2021 | ||
CY | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
IT | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
MK | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
BE | 31.03.2022 | ||
CH | 31.03.2022 | ||
LI | 31.03.2022 | ||
Former [2024/23] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CY | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
IT | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
MK | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
BE | 31.03.2022 | ||
CH | 31.03.2022 | ||
LI | 31.03.2022 | ||
Former [2024/20] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CY | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
IT | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
BE | 31.03.2022 | ||
CH | 31.03.2022 | ||
LI | 31.03.2022 | ||
Former [2023/10] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
IT | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
BE | 31.03.2022 | ||
CH | 31.03.2022 | ||
LI | 31.03.2022 | ||
Former [2023/09] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
CH | 31.03.2022 | ||
LI | 31.03.2022 | ||
Former [2023/08] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
IE | 24.03.2022 | ||
LU | 24.03.2022 | ||
Former [2022/47] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
MC | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
Former [2022/36] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
DK | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SI | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
Former [2022/29] | AL | 08.09.2021 | |
AT | 08.09.2021 | ||
CZ | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
Former [2022/25] | AT | 08.09.2021 | |
CZ | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SK | 08.09.2021 | ||
SM | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
Former [2022/24] | AT | 08.09.2021 | |
CZ | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
NL | 08.09.2021 | ||
PL | 08.09.2021 | ||
RO | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SK | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
IS | 08.01.2022 | ||
PT | 10.01.2022 | ||
Former [2022/23] | AT | 08.09.2021 | |
CZ | 08.09.2021 | ||
EE | 08.09.2021 | ||
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
PL | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
SK | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
PT | 10.01.2022 | ||
Former [2022/21] | AT | 08.09.2021 | |
ES | 08.09.2021 | ||
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
Former [2022/10] | ES | 08.09.2021 | |
FI | 08.09.2021 | ||
HR | 08.09.2021 | ||
LT | 08.09.2021 | ||
LV | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
GR | 09.12.2021 | ||
Former [2022/09] | ES | 08.09.2021 | |
FI | 08.09.2021 | ||
LT | 08.09.2021 | ||
RS | 08.09.2021 | ||
SE | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
Former [2022/08] | ES | 08.09.2021 | |
FI | 08.09.2021 | ||
LT | 08.09.2021 | ||
SE | 08.09.2021 | ||
BG | 08.12.2021 | ||
NO | 08.12.2021 | ||
Former [2022/07] | LT | 08.09.2021 | |
NO | 08.12.2021 | Documents cited: | Search | [A]US2008107694 (TROGDEN JOHN T [US], et al) [A] 1-11,15 * the whole document *; | [A]WO2009102427 (RXI PHARMACEUTICALS CORP [US], et al) [A] 1-11,15* the whole document *; | [A]WO2010006973 (HOFFMANN LA ROCHE [CH], et al) [A] 1-11,15 * the whole document * | by applicant | US61310611 | WO2007 | US4201860 | US4235871 | US4501728 | US4737323 | US4810646 | US4837028 | US4853386 | US4897355 | WO9014074 | US4992540 | US5013830 | US5028703 | US5032401 | WO9116024 | WO9117424 | US5082936 | WO9203464 | WO9203568 | US5214135 | US5264423 | US5276019 | US5322841 | US5401727 | US5414077 | US5419966 | WO9523162 | US5504079 | US5512667 | US5525719 | US5580972 | US5587469 | US5591843 | US5607677 | US5646126 | US5652359 | WO9813526 | US5736392 | US5767099 | US5777153 | US5780053 | US5789416 | US5830653 | US5830430 | US5849902 | US5851548 | US5855910 | US5968811 | US6020483 | US6242594 | US6331313 | WO0212348 | US6355787 | US6432963 | US6444448 | US6476003 | US2003157030 | US2003216346 | US2004014715 | US2004063654 | US2004072785 | WO2004065601 | US2004162235 | US2005026286 | US2005037496 | US2005042227 | US2005064595 | US2005107325 | US2005265957 | US2005281781 | US2006008910 | WO2006007372 | US7041824 | US2006178327 | US2006240093 | US7205297 | US2007231392 | US2008038296 | WO2008021157 | WO2008036825 | US2008107694 | AU2004206255B | US2008112916 | US2008152661 | WO2009021157 | WO2009102427 | WO2009126933 | WO2009134487 | US2010010082 | US2010040656 | WO2010033247 | - ZUKER, M., Nucleic Acids Res., (20030000), vol. 31, no. 13, pages 3406 - 15 | - MATHEWS, D. H.; SABINA, J.; ZUKER, M.; TURNER, D. H., J. Mol. Biol., (19990000), vol. 288, pages 911 - 940 | - MATHEWS, D. H.; DISNEY, M. D.; CHILDS, J. L.; SCHROEDER, S. J.; ZUKER, M.; TURNER, D. H., Proc. Natl. Acad. Sci., (20040000), vol. 101, pages 7287 - 7292 | - DUAN, S.; MATHEWS, D. H.; TURNER, D. H., Biochemistry, (20060000), vol. 45, pages 9819 - 9832 | - WUCHTY, S.; FONTANA, W.; HOFACKER, I. L.; SCHUSTER, P., Biopolymers, (19990000), vol. 49, pages 145 - 165 | - AUGUSTYNS, K. et al., Nucl. Acids. Res., (19920000), vol. 18, page 4711 | - Handbook of Chemistry and Physics | - ORTIAGAO et al., Antisense Res. Dev., (19920000), vol. 2, page 129 | - BJERGARDE et al., Nucleic Acids Res., (19910000), vol. 19, page 5843 | - CARUTHERS et al., Nucleotides, (19910000), vol. 10, page 47 | - Antisense & Nucl. Acid Drug Dev., (19960000), vol. 6, page 267 | - Biochemica Biophysica Acta, (19990000), vol. 1489, page 141 | - Antisense & Nucl. Acid Drug Dev., (19970000), vol. 7, page 63 | - Antisense & Nucl. Acid Drug Dev., (19970000), vol. 7, page 151 | - Antisense & Nucl. Acid Drug Dev., (19970000), vol. 7, page 291 | - Antisense & Nucl. Acid Drug Dev., (19970000), vol. 7, page 187 | - STEC et al., J. Am. Chem. Soc., (19840000), vol. 106, page 6077 | - STEC et al., J. Org. Chem., (19850000), vol. 50, page 3908 | - STEC et al., J. Chromatog., (19850000), vol. 326, page 263 | - LAPLANCHE et al., Nucl. Acid. Res., (19860000), vol. 14, page 9081 | - LAMONE, Biochem. Soc. Trans., (19930000), vol. 21, page 1 | - KAWASAKI et al., J. Med. Chem., (19930000), vol. 36, page 831 | - UHLMANN et al., Chemical Reviews, (19900000), vol. 90, pages 543 - 584 | - AGRAWAL, Methods in Molecular Biology, vol. 26, page 1 | - MCNEAL et al., J. Am. Chem. Soc., (19820000), vol. 104, page 976 | - VIARI et al., Biomed. Environ. Mass Spectrom., (19870000), vol. 14, page 83 | - GROTJAHN et al., Nuc. Acid Res., (19820000), vol. 10, page 4671 | - BERGOT; EGAN, J. Chrom., (19920000), vol. 599, page 35 | - DNA Cloning, (19850000), vol. I, II | - Methods in Enzymology, Academic Press, Inc. | - BERGAN et al., Nucleic Acids Research, (19930000), vol. 21, page 3567 | - SHI, Y., Trends Genet, (20030119), vol. 9 | - REICHHART J M et al., Genesis, (20020000), vol. 34, no. 1-2, page 1604 | - YU et al., Proc. Natl. Acad Sci. USA, (20020000), vol. 99, page 6047 | - SUI et al., Proc. Natl. Acad Sci. USA, (20020000), vol. 99, page 5515 | - BARTZATT, R. et al., Biotechnol. Appl. Biochem., (19890000), vol. 11, page 133 | - WAGNER E. et al., Proc. Natl. Acad. Sci., (19920000), vol. 88, page 4255 | - SOTO; OSTROFF, "Characterization of multilayered nanoparticles encapsulated in yeast cell wall particles for DNA delivery", Bioconjug Chem, (20080000), vol. 19, no. 4, doi:doi:10.1021/bc700329p, pages 840 - 8, XP055011701 DOI: http://dx.doi.org/10.1021/bc700329p | - "Oral Macrophage Mediated Gene Delivery System", SOTO; OSTROFF, Nanotech, (20070000), vol. 2, pages 378 - 381 | - LI et al., "Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88-and Syk kinase-dependent pathways", Clinical Immunology, (20070000), vol. 124, no. 2, doi:doi:10.1016/j.clim.2007.05.002, pages 170 - 181, XP022156792 DOI: http://dx.doi.org/10.1016/j.clim.2007.05.002 | - SOTO; OSTROFF, Bioconjug Chem, (20080000), vol. 19, page 840 | - VLASSOV et al., Biochimica et Biophysica Acta, (19940000), vol. 1197, pages 95 - 108 | - LEWIS et al., Proc. Natl. Acad. Sci. USA, (19960000), vol. 93, page 3176 | - HOPE et al., Molecular Membrane Biology, (19980000), vol. 15, page 1 | - KAMATA et al., Nucl. Acids. Res., (19940000), vol. 22, page 536 | - LEWIS et al., Proc. Natl. Acad. Sci., (19960000), vol. 93, page 3176 | - MURPHY et al., Proc. Natl. Acad. Sci., (19980000), vol. 95, page 1517 | - ZUCKERMANN, R. N. et al., J. Am. Chem. Soc., (19920000), vol. 114, page 10646 | - ZUCKERMANN, R. N. et al., Int. J. Peptide Protein Res., (19920000), vol. 40, page 497 | - HUNAG et al., Chemistry and Biology, (19980000), vol. . 5, page 345 | - HUNAG et al., Chemistry and Biology, (19980900), vol. 5, page 345 | - LEWIS et al., Proc. Natl. Acad. Sci. US.A., (19960000), vol. 93, page 3176 | - POOGA et al., Nature Biotechnology, (19980000), vol. 16, page 857 | - DEROSSI et al., Trends in Cell Biology, (19980000), vol. 8, page 84 | - ELLIOTT; O'HARE, Cell, (19970000), vol. 88, page 223 | - PROCHIANTZ, A., Curr. Opin. Neurobiol., (19960000), vol. 6, page 629 | - DEROSSI et al., Trends Cell Biol., (19980000), vol. 8, page 84 | - TROY et al., J. Neurosci., (19960000), vol. 16, page 253 | - VIVES et al., J. Biol. Chem., (19970000), vol. 272, page 16010 | - PROCHIANTZ, Current Opinion in Neurobiol., (19960000), vol. 6, page 629 | - ALLINQUANT et al., J Cell Biol., (19950000), vol. 128, page 919 | - SMITH et al., Biochem J, (19910000), vol. 276, pages 417 - 2 | - BUNNELL et al., Somatic Cell and Molecular Genetics, (19920000), vol. 18, page 559 | - LIANG et al., Pharmazie, (19990000), vol. 54, pages 559 - 566 | - GINOBBI et al., Anticancer Res., (19970000), vol. 17, page 29 | - CONSTANTINIDES et al., Pharmaceutical Research, (19940000), vol. 11, page 1385 | - HO et al., J. Pharm. Sci., (19960000), vol. 85, pages 138 - 143 | - M. Y. CHIANG et al., J Biol Chem., (19910000), vol. 266, pages 18162 - 71 | - T. FISHER et al., Nucleic Acids Research, (19930000), vol. 21, page 3857 | - CHEN et al., J. Biol. Chem., vol. 271, page 28259 | - GOULD, S. J.; SUBRAMANI, S., Anal. Biochem., (19880000), vol. 7, pages 404 - 408 | - GORMAN C. M.; MOFFAT, L. F.; HOWARD, B. H., Mol. Cell. Biol., (19820000), vol. 2, pages 1044 - 1051 | - SELDEN, R.; BURKE-HOWIE, K.; ROWE, M. E.; GOODMAN, H. M.; MOORE, D. D., Mol. Cell, Biol., (19860000), vol. 6, pages 3173 - 3179 | - ALTSCHUL, Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, pages 2264 - 68 | - ALTSCHUL, Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 5873 - 77 | - ALTSCHUL et al., J. Mol. Biol., (19900000), vol. 215, pages 403 - 10 | US20080199661 | WO2009US00852 | WO2009US05247 | WO2009US05251 | WO2009US06211 |