blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3626832

EP3626832 - METHOD OF IDENTIFYING A PERSON HAVING A PREDISPOSITION TO OR AFFLICTED WITH A CARDIOMETABOLIC DISEASE [Right-click to bookmark this link]
Former [2020/13]METHOD OF IDENTIFYING AND TREATING A PERSON HAVING A PREDISPOSITION TO OR AFFLICTED WITH A CARDIOMETABOLIC DISEASE
[2023/38]
StatusGrant of patent is intended
Status updated on  29.01.2024
Database last updated on 24.04.2024
FormerExamination is in progress
Status updated on  10.01.2024
FormerGrant of patent is intended
Status updated on  04.09.2023
FormerExamination is in progress
Status updated on  25.02.2022
FormerRequest for examination was made
Status updated on  21.02.2020
Most recent event   Tooltip29.01.2024New entry: Communication of intention to grant a patent 
Applicant(s)For all designated states
The Brigham and Women's Hospital, Inc.
75 Francis Street
Boston, MA 02115 / US
For all designated states
The General Hospital Corporation
55 Fruit Street
Boston, MA 02114 / US
[2020/13]
Inventor(s)01 / EBERT, Benjamin, Levine
47 Greenough Street
Brookline, MA 02445 / US
02 / JAISWAL, Siddhartha
c/o The Brigham and Women's Hospital Inc.
75 Francis Street
Boston, MA 02115 / US
03 / KATHIRESAN, Sekar
c/o The Broad Institute Inc.
415 Main Street
Cambridge, MA 02145 / US
 [2020/13]
Representative(s)De Clercq & Partners
Edgard Gevaertdreef 10a
9830 Sint-Martens-Latem / BE
[2020/13]
Application number, filing date19195023.725.11.2015
[2020/13]
Priority number, dateUS201462084127P25.11.2014         Original published format: US 201462084127 P
[2020/13]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP3626832
Date:25.03.2020
Language:EN
[2020/13]
Type: A3 Search report 
No.:EP3626832
Date:13.05.2020
Language:EN
[2020/20]
Search report(s)(Supplementary) European search report - dispatched on:EP14.04.2020
ClassificationIPC:C12Q1/6883, C12Q1/6886
[2020/20]
CPC:
C12Q1/6883 (EP,US); C12Q1/6886 (EP,US); C12Q2600/156 (EP,US);
C12Q2600/158 (US); G01N2800/32 (US); G01N33/68 (US)
Former IPC [2020/13]C12Q1/68
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2020/13]
TitleGerman:VERFAHREN ZUR IDENTIFIZIERUNG EINER PERSON MIT EINER PRÄDISPOSITION FÜR EINE KARDIOMETABOLISCHE KRANKHEIT ODER EINE DAVON BETROFFENE PERSON[2023/38]
English:METHOD OF IDENTIFYING A PERSON HAVING A PREDISPOSITION TO OR AFFLICTED WITH A CARDIOMETABOLIC DISEASE[2023/38]
French:PROCÉDÉ D'IDENTIFICATION D'UNE PERSONNE PRÉSENTANT UNE PRÉDISPOSITION À OU SOUFFRANT D'UNE MALADIE CARDIO-MÉTABOLIQUE[2023/38]
Former [2020/13]VERFAHREN ZUR IDENTIFIZIERUNG UND BEHANDLUNG EINER PERSON MIT EINER PRÄDISPOSITION FÜR EINE KARDIOMETABOLISCHE KRANKHEIT ODER EINE DAVON BETROFFENE PERSON
Former [2020/13]METHOD OF IDENTIFYING AND TREATING A PERSON HAVING A PREDISPOSITION TO OR AFFLICTED WITH A CARDIOMETABOLIC DISEASE
Former [2020/13]PROCÉDÉ D'IDENTIFICATION ET DE TRAITEMENT D'UNE PERSONNE PRÉSENTANT UNE PRÉDISPOSITION À OU SOUFFRANT D'UNE MALADIE CARDIO-MÉTABOLIQUE
Examination procedure24.09.2019Examination requested  [2020/13]
12.11.2020Amendment by applicant (claims and/or description)
28.02.2022Despatch of a communication from the examining division (Time limit: M04)
14.06.2022Reply to a communication from the examining division
05.09.2023Communication of intention to grant the patent
05.01.2024Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
05.01.2024Fee for grant paid
05.01.2024Fee for publishing/printing paid
05.01.2024Receipt of the translation of the claim(s)
30.01.2024Communication of intention to grant the patent
Parent application(s)   TooltipEP15816941.7  / EP3224381
Fees paidRenewal fee
24.09.2019Renewal fee patent year 03
24.09.2019Renewal fee patent year 04
24.09.2019Renewal fee patent year 05
27.11.2020Renewal fee patent year 06
29.11.2021Renewal fee patent year 07
28.11.2022Renewal fee patent year 08
27.11.2023Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[I]WO2006026074  (UNIV DUKE [US], et al) [I] 1-12 * p. 3, l. 1-13; p. 5, 15-21; p. 5, l. 26-36; p. 6, l. 14-20; p. 119; para. bridging p. 259-260 *;
 [A]  - AXEL MUENDLEIN ET AL, "Occurrence of the JAK2 V617F mutation in patients with peripheral arterial disease", AMERICAN JOURNAL OF HEMATOLOGY, US, (20141026), vol. 90, no. 1, doi:10.1002/ajh.23874, ISSN 0361-8609, pages E17 - E21, XP055246813 [A] 1-12 * abstract; p. e17, para. "introduction"; p. e18, right-hand col., 4th para. *

DOI:   http://dx.doi.org/10.1002/ajh.23874
 [XI]  - H. YAGHOOTKAR ET AL, "Genetic Evidence for a Normal-Weight "Metabolically Obese" Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes", DIABETES, US, (20140721), vol. 63, no. 12, doi:10.2337/db14-0318, ISSN 0012-1797, pages 4369 - 4377, XP055533095 [X] 1,3-6,9 * abstract; p. 4372, para. bridging left- to right-hand col.; para. bridging p. 4372-4373; p. 4374, left-hand col., las para. * [I] 2,7,8,10-12

DOI:   http://dx.doi.org/10.2337/db14-0318
 [XP]  - SIDDHARTHA JAISWAL ET AL, "Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes", NEW ENGLAND JOURNAL OF MEDICINE, US, (20141126), vol. 371, no. 26, doi:10.1056/NEJMoa1408617, ISSN 0028-4793, pages 2488 - 2498, XP055246853 [XP] 1-12 * the whole document *

DOI:   http://dx.doi.org/10.1056/NEJMoa1408617
 [P]  - SIDDHARTHA JAISWAL ET AL, "Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes - Online supplementary appendix", NEW ENGLAND JOURNAL OF MEDICINE, US, (20141126), vol. 371, no. 26, doi:10.1056/NEJMoa1408617, ISSN 0028-4793, pages 2488 - 2498, XP055246869

DOI:   http://dx.doi.org/10.1056/NEJMoa1408617
 [AD]  - AMÉLIE BONNEFOND ET AL, "Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications", NATURE GENETICS., NEW YORK, US, (20130714), vol. 45, no. 9, doi:10.1038/ng.2700, ISSN 1061-4036, pages 1040 - 1043, XP055246874 [AD] 1-12 * the whole document *

DOI:   http://dx.doi.org/10.1038/ng.2700
 [A]  - MINGCHAO XIE ET AL, "Age-related mutations associated with clonal hematopoietic expansion and malignancies", NATURE MEDICINE., US, (20141019), vol. 20, no. 12, doi:10.1038/nm.3733, ISSN 1078-8956, pages 1472 - 1478, XP055246879 [A] 1-12 * the whole document *

DOI:   http://dx.doi.org/10.1038/nm.3733
 [T]  - Anonymous, "ASXL1 Gene - GeneCards", (20200401), GeneCards, URL: https://www.genecards.org/cgi-bin/carddisp.pl?gene=ASXL1&keywords=asxl1, (20200401), XP055682097 [T] * p. 1 *
 [A]  - HANSSON G K ED - LONGO DAN L, "Inflammation, Atherosclerosis, and Coronary Artery Disease", THE NEW ENGLAND JOURNAL OF MEDICINE, - NEJM -, MASSACHUSETTS MEDICAL SOCIETY, US, (20050421), vol. 352, no. 16, doi:10.1056/NEJMRA043430, ISSN 0028-4793, pages 1685 - 1695, XP003014526 [A] 1-12 * abstract *

DOI:   http://dx.doi.org/10.1056/NEJMra043430
 [I]  - PARK UI-HYUN ET AL, "Reciprocal regulation of LXR[alpha] activity by ASXL1 and ASXL2 in lipogen", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, (20131207), vol. 443, no. 2, doi:10.1016/J.BBRC.2013.11.124, ISSN 0006-291X, pages 489 - 494, XP028808341 [I] 1-12 * abstract; para. bridging p. 489-490; p. 492, right-hand col., 1st para. *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2013.11.124
by applicantUS5446603
 US5545531
 US5569827
 US5574206
 US5620881
 US5631407
 US5688692
 US5720936
 US5723719
 US5807522
 US5811633
 US5814716
 US5824840
 US5824838
 US5837832
 US5837875
 US5847257
 US5850004
 US5850001
 US5874219
 US5894078
 US5907078
 US5917124
 US5936138
 US5981829
 US5989431
 US6002067
 US6025539
 US6037521
 US6114122
 US6127598
 US6137029
 US6156727
 US6175057
 US6184435
 US6187992
 US6201166
 US6211428
 US6215040
 US6238910
 US6245963
 WO0145843
 US6255555
 US6300540
 US6313373
 US6316693
 US6323391
 US6323390
 US6365418
 US6369295
 US6372958
 US6372957
 US6410229
 US6420114
 US6432696
 US6452065
 US6475808
 US6489159
 US6515197
 US6531645
 US6548256
 US6576812
 US6593512
 US6610905
 US6613958
 US6649811
 US6657104
 US6689937
 US6710226
 US6717031
 US6750375
 US7038105
 US7045678
 US7098376
 US7112715
 US7119249
 US7186882
 US7214850
 US7220892
 US7265259
 US7276644
 US7358416
 US7371920
 US7393994
 US7432414
 US7449615
 US7479579
 US7495147
 US7538258
 US7544855
 US7566812
 US7626076
 US7655700
 US7667090
 US7709695
 US8557746
 WO2014018423
 US8697359
 US2014170753
 WO2014093661
 WO2014093694
 WO2014093595
 WO2014093718
 WO2014093709
 WO2014093622
 WO2014093635
 WO2014093655
 WO2014093712
 WO2014093701
 US2014179770
 US2014179006
 US2014189896
 US2014186958
 US2014186919
 US2014186843
 US8771945
 US8795965
 EP2764103
 US2014227787
 US2014234972
 US2014242700
 US2014242699
 US2014242664
 EP2771468
 US2014248702
 US2014256046
 US2014273234
 US2014273232
 US2014273231
 US2014287938
 EP2784162
 US2014310830
 US8865406
 US8871445
 US8889356
 US8889418
 US8895308
 US8906616
 WO2014204723
 WO2014204724
 WO2014204725
 WO2014204726
 WO2014204727
 WO2014204728
 WO2014204729
 US8932814
 US8945839
 US8993233
 US8999641
 WO2015089351
 WO2015089354
 WO2015089364
 WO2015089427
 WO2015089462
 WO2015089419
 WO2015089465
 WO2015089486
 US2015184139
    - Nowell PC. Science, (19760000), vol. 194, pages 23 - 8
    - RIDKER PM et al., The New England journal of medicine, (20020000), vol. 347, pages 1557 - 65
    - RAWSTRON AC et al., The New England journal of medicine, (20080000), vol. 359, pages 575 - 83
    - BUSQUE L et al., Blood, (19960000), vol. 88, page 59 65
    - CHAMPION KM et al., British journal of haematology, (19970000), vol. 97, page 920 6
    - CHALLEN GA et al., Nature genetics, (20120000), vol. 44, pages 1179 - 31
    - JAN M et al., Science translational medicine, (20120000), vol. 4, page 149ra18
    - CONSORTIUM STD et al., Nature, (20140000), vol. 506, pages 495 - 101
    - ROULLAND S et al., Journal of clinical oncology: official journal of the American Society of Clinical Oncology, (20140000), vol. 32, pages 1347 - 55
    - MARDIS ER et al., The New England journal of medicine, (20090000), vol. 361, pages 1058 - 66
    - PAPAEMMANUIL E et al., The New England journal of medicine, (20110000), vol. 365, pages 1384 - 506
    - WALTER MJ et al., Leukemia, (20110000), vol. 25, pages 1153 - 8
    - J. S. WELCH et al., Cell, (20120000), vol. 150, pages 264 - 278
    - "Cancer Genome Atlas Research N. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia", The New England journal of medicine, (20130000), vol. 368, pages 2059 - 74
    - E. PAPAEMMANUIL et al., Blood, (20130000), vol. 122, pages 3616 - 3627
    - WALTER MJ et al., Leukemia, (20130000), vol. 27, pages 1275 - 82
    - ZHANG et al., Proceedings of the National Academy of Sciences of the United States of America, (20130000), vol. 110, pages 1398 - 403
    - MORIN RD et al., Nature, (20110000), vol. 476, pages 298 - 303
    - LENZ G et al., Science, (20080000), vol. 319, pages 1676 - 9
    - LOHR JG et al., Proceedings of the National Academy of Sciences of the United States of America, (20120000), vol. 109, pages 3879 - 84
    - M. TONELLI et al., Circulation, (20080000), vol. 117, pages 163 - 168
    - JEONG M et al., Nature genetics, (20140000), vol. 46, pages 17 - 23
    - KOH KP et al., Cell stem cell, (20110000), vol. 8, pages 200 - 13
    - K. MORAN-CRUSIO et al., Cancer cell, (20110000), vol. 20, pages 11 - 24
    - ODEJIDE O et al., Blood, (20140000), vol. 123, pages 1293 - 6
    - ASMAR F et al., Haematologica, (20130000), vol. 98, pages 1912 - 20
    - COURONNE L et al., The New England journal of medicine, (20120000), vol. 366, pages 95 - 6
    - P. C. NOWELL, Science, (19760000), vol. 194, pages 23 - 28
    - R. BEJAR et al., N Engl J Med, (20110000), vol. 364, pages 2496 - 2506
    - "N. Cancer Genome Atlas Research, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia", N Engl J Med, (20130000), vol. 368, pages 2059 - 2074
    - T. HAFERLACH et al., Leukemia, (20140000), vol. 28, pages 241 - 247
    - G. GENOVESE et al., N Engl J Med, (20140000), vol. 371, pages 2477 - 2487
    - M. XIE et al., Nat Med, (20140000), vol. 20, pages 1472 - 1478
    - D. P. STEENSMA et al., Blood, (20150000), vol. 126, pages 9 - 16
    - K. J. MOORE et al., Nat Rev Immunol, (20130000), vol. 13, pages 709 - 721
    - M. CUCHEL et al., Circulation, (20060000), vol. 113, pages 2548 - 2555
    - R. ROSS, N Engl J Med, (19990000), vol. 340, pages 115 - 126
    - P. LIBBY, Nature, (20020000), vol. 420, pages 868 - 874
    - P. LIBBY et al., Am J Med, (20040000), vol. 116, no. 6A, pages 9S - 16S
    - P. M. RIDKER et al., N Engl J Med, (20020000), vol. 347, pages 1557 - 1565
    - M. MADJID et al., J Am Coll Cardiol, (20040000), vol. 44, pages 1945 - 1956
    - G. D. BARISH et al., Cell Metab, (20120000), vol. 15, pages 554 - 562
    - R. K. TANGIRALA et al., Proceedings of the National Academy of Sciences of the United States of America, (20020000), vol. 99, pages 11896 - 11901
    - A. E. MULLICK et al., J Clin Invest, (20050000), vol. 115, pages 3149 - 3156
    - K. S. MICHELSEN et al., Proceedings of the National Academy of Sciences of the United States of America, (20040000), vol. 101, pages 10679 - 10684
    - P. DUEWELL et al., Nature, (20100000), vol. 464, pages 1357 - 1361
    - A. CASTRILLO et al., Mol Cell, (20030000), vol. 12, pages 805 - 816
    - A. CHAWLA et al., Mol Cell, (20010000), vol. 7, pages 161 - 171
    - G. PASCUAL et al., Nature, (20050000), vol. 437, pages 759 - 763
    - A. CHAWLA, Circ Res, (20100000), vol. 106, pages 1559 - 1569
    - S. NGUYEN et al., Dev Dyn, (20070000), vol. 236, pages 1663 - 1676
    - A. MULLALLY et al., Cancer cell, (20100000), vol. 17, pages 584 - 596
    - J. HETTINGER et al., Nat Immunol, (20130000), vol. 14, pages 821 - 830
    - A. BASU et al., Cell, (20130000), vol. 154, pages 1151 - 1161
    - CONG, L.RAN, F.A.COX, D.LIN, S.BARRETTO, R.HABIB, N.HSU, P.D.WU, X.JIANG, W.MARRAFFINI, L.A, "Multiplex genome engineering using CRISPR/Cas systems", Science, (20150215), vol. 339, no. 6121, doi:doi:10.1126/science.1231143, pages 819 - 23, XP055400719

DOI:   http://dx.doi.org/10.1126/science.1231143
    - JIANG W.BIKARD D.COX D.ZHANG FMARRAFFINI LA, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", Nat Biotechnol, (20130300), vol. 31, no. 3, doi:doi:10.1038/nbt.2508, pages 233 - 9, XP055249123

DOI:   http://dx.doi.org/10.1038/nbt.2508
    - WANG H.YANG H.SHIVALILA CS.DAWLATY MM.CHENG AW.ZHANG F.JAENISCH R., "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, (20130509), vol. 153, no. 4, doi:doi:10.1016/j.cell.2013.04.025, pages 910 - 8, XP028538358

DOI:   http://dx.doi.org/10.1016/j.cell.2013.04.025
    - KONERMANN SBRIGHAM MDTREVINO AEHSU PDHEIDENREICH MCONG LPLATT RJSCOTT DACHURCH GMZHANG F, "Optical control of mammalian endogenous transcription and epigenetic states", Nature, (20130822), vol. 500, no. 7463, pages 472 - 6
    - RAN, FA.HSU, PD.WRIGHT, JAGARWALA, V.SCOTT, DA.ZHANG, F., "Genome engineering using the CRISPR-Cas9 system", Nature Protocols, (20131100), vol. 8, no. 11, doi:doi:10.1038/nprot.2013.143, pages 2281 - 308, XP009174668

DOI:   http://dx.doi.org/10.1038/nprot.2013.143
    - NISHIMASU, H.RAN, FA.HSU, PD.KONERMANN, S.SHEHATA, SI.DOHMAE, N.ISHITANI, R.ZHANG, F.NUREKI, O., "Crystal structure of cas9 in complex with guide RNA and target DNA", Cell, (20140227), vol. 156, no. 5, doi:doi:10.1016/j.cell.2014.02.001, pages 935 - 49, XP028667665

DOI:   http://dx.doi.org/10.1016/j.cell.2014.02.001
    - PLATT et al., "CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling", Cell, (20140000), vol. 159, no. 2, doi:doi:10.1016/j.cell.2014.09.014, pages 440 - 455, XP055523070

DOI:   http://dx.doi.org/10.1016/j.cell.2014.09.014
    - HSU et al., "Development and Applications of CRISPR-Cas9 for Genome Engineering", Cell, (20140605), vol. 157, doi:doi:10.1016/j.cell.2014.05.010, pages 1262 - 1278, XP055529223

DOI:   http://dx.doi.org/10.1016/j.cell.2014.05.010
    - WANG et al., "Genetic screens in human cells using the CRISPR/Cas9 system", Science, (20140103), vol. 343, no. 6166, doi:doi:10.1126/science.1246981, pages 80 - 84, XP055294787

DOI:   http://dx.doi.org/10.1126/science.1246981
    - KONERMANN SBRIGHAM MDTREVINO AEJOUNG JABUDAYYEH 00BARCENA CHSU PDHABIB NGOOTENBERG JSNISHIMASU H, "Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex", Nature, (20150129), vol. 517, no. 7536, doi:doi:10.1038/nature14136, pages 583 - 8, XP055585957

DOI:   http://dx.doi.org/10.1038/nature14136
    - ZETSCHE BVOLZ SEZHANG F., "A split-Cas9 architecture for inducible genome editing and transcription modulation", Nat Biotechnol., (20150202), vol. 33, no. 2, doi:doi:10.1038/nbt.3149, pages 139 - 42, XP055227889

DOI:   http://dx.doi.org/10.1038/nbt.3149
    - CHEN SSANJANA NEZHENG KSHALEM OLEE KSHI XSCOTT DASONG JPAN JQWEISSLEDER R, "Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis,", Cell, (20150312), vol. 160, doi:doi:10.1016/j.cell.2015.02.038, pages 1246 - 1260, XP029203797

DOI:   http://dx.doi.org/10.1016/j.cell.2015.02.038
    - RAN FACONG LYAN WXSCOTT DAGOOTENBERG JSKRIZ AJZETSCHE BSHALEM OWU XMAKAROVA KS, "n vivo genome editing using Staphylococcus aureus Cas9", Nature, (20150401), vol. 520, no. 7546, doi:doi:10.1038/nature14299, pages 186 - 91, XP055484527

DOI:   http://dx.doi.org/10.1038/nature14299
    - SHALEM et al., "High-throughput functional genomics using CRISPR-Cas9", Nature Reviews Genetics, (20150500), vol. 16, doi:doi:10.1038/nrg3899, pages 299 - 311, XP055207968

DOI:   http://dx.doi.org/10.1038/nrg3899
    - XU et al., "Sequence determinants of improved CRISPR sgRNA design", Genome Research, (20150800), vol. 25, doi:doi:10.1101/gr.191452.115, pages 1147 - 1157, XP055321186

DOI:   http://dx.doi.org/10.1101/gr.191452.115
    - PARNAS et al., "A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks", Cell, (20150730), vol. 162, doi:doi:10.1016/j.cell.2015.06.059, pages 675 - 686, XP029248090

DOI:   http://dx.doi.org/10.1016/j.cell.2015.06.059
    - RAMANAN et al., "CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus", Scientific Reports, (20150602), vol. 5, doi:doi:10.1038/srep10833, page 10833, XP055305966

DOI:   http://dx.doi.org/10.1038/srep10833
    - NISHIMASU et al., "Crystal Structure of Staphylococcus aureus Cas9", Cell, (20150827), vol. 162, doi:doi:10.1016/j.cell.2015.08.007, pages 1113 - 1126, XP055304450

DOI:   http://dx.doi.org/10.1016/j.cell.2015.08.007
    - CANVER et al., "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis", Nature, (20151112), vol. 527, no. 7577, doi:doi:10.1038/nature15521, pages 192 - 7, XP055274680

DOI:   http://dx.doi.org/10.1038/nature15521
    - ZETSCHE et al., "Cpfl Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System", Cell, (20150925), vol. 163, pages 759 - 71
    - SHMAKOV et al., "Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems", Molecular Cell, (20151022), vol. 60, no. 3, doi:doi:10.1016/j.molcel.2015.10.008, pages 385 - 397, XP055482679

DOI:   http://dx.doi.org/10.1016/j.molcel.2015.10.008
    - TSAI et al., "Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing", Nature Biotechnology, (20140000), vol. 32, no. 6, pages 569 - 77, XP055378307
    - KONERMANN et al., Genome-scale transcription activation by an engineered CRISPR-Cas9 complex
    - ZUKERSTIEGLER, Nucleic Acids Res., (19810000), vol. 9, pages 133 - 148
    - A.R. GRUBER et al., Cell, (20080000), vol. 106, no. 1, pages 23 - 24
    - PA CARRGM CHURCH, Nature Biotechnology, (20090000), vol. 27, no. 12, pages 1151 - 62
    - KARGINOVHANNON, "The CRISPR system: small RNA-guided defence in bacteria and archaea", Mole Cell, (20100115), vol. 37, no. 1, doi:doi:10.1016/j.molcel.2009.12.033, page 7, XP055016972

DOI:   http://dx.doi.org/10.1016/j.molcel.2009.12.033
    - BAILEY et al., J Mol Med (Berl, (19990100), vol. 77, no. 1, pages 244 - 9
    - SATO et al., Nature Biotechnology, (20080400), vol. 26, no. 4, pages 431 - 442
    - ROZEMA et al., PNAS, (20070807), vol. 104, no. 32
    - INGLESE et al., Nature Chemical Biology, (20070000), vol. 3, pages 438 - 441
    - MYERSMILLER, CABIOS, (19880000), vol. 4, pages 11 - 17
    - HIROTA et al., Jinrui Idengaku Zasshi, (19890900), vol. 34, no. 3, pages 217 - 23
    - JOHN et al., Nucleic Acids Res., (19910125), vol. 19, no. 2, page 408
    - KARLINALTSCHUL, Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, pages 2264 - 2268
    - KARLINALTSCHUL, Proc. Natl. Acad. Sci. USA, (19930000), vol. 90, pages 5873 - 5877
    - PEARSONLIPMAN, Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, pages 2444 - 2448
    - ALTSCHULGISH, "Local alignment statistics", Methods in Enzymology, (19960000), vol. 266, pages 460 - 480
    - ALTSCHUL et al., Journal of Molecular Biology, (19900000), vol. 215, pages 403 - 410
    - GISHSTATES, Nature Genetics, (19930000), vol. 3, pages 266 - 272
    - WILBURLIPMAN, Proc Natl Acad Sci USA, (19830000), vol. 80, page 726
    - CIBULSKIS K et al., Nature biotechnology, (20130000), vol. 31, pages 213 - 9
    - COSTELLO M et al., Nucleic acids research, (20130000), vol. 41, page e67
    - ALEXANDROV LB et al., Nature, (20130000), vol. 500, pages 415 - 21
    - ROLLISON DE et al., Blood, (20080000), vol. 112, pages 45 - 52
    - PERLSTEIN TS et al., Archives of internal medicine, (20090000), vol. 169, pages 588 - 94
    - BAZICK HS et al., Critical care medicine, (20110000), vol. 39, pages 1913 - 21
    - BONNEFOND A et al., Nature genetics, (20130000), vol. 45, pages 1380 - 5
    - OLEFSKY JMGLASS CK, Annual review of physiology, (20100000), vol. 72, pages 219 - 46
    - SEMPOS CT et al., The American journal of the medical sciences, (19990000), vol. 317, pages 142 - 6
    - LI HDURBIN R., Bioinformatics, (20090000), vol. 25, pages 1754 - 60
    - DEPRISTO MA et al., Nature genetics, (20110000), vol. 43, pages 491 - 8
    - NG PC et al., PLoS genetics, (20080000), vol. 4, page e1000160
    - FINE JPGRAY, RJ, Journal of the American Statistical Association, (19990000), vol. 94, pages 496 - 509
 WO2013US51418
 EP20130818570
 EP20130824232
 EP20140170383
 WO2013US74743
 WO2013US74790
 WO2013US74611
 WO2013US74825
 WO2013US74812
 WO2013US74667
 WO2013US74691
 WO2013US74736
 WO2013US74819
 WO2013US74800
 WO2014US41790
 WO2014US41800
 WO2014US41803
 WO2014US41804
 WO2014US41806
 WO2014US41808
 WO2014US41809
 WO2014US69897
 WO2014US69902
 WO2014US69925
 WO2014US70068
 WO2014US70127
 WO2014US70057
 WO2014US70135
 WO2014US70175
 WO2015US51691
 WO2015US51830
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.