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EP About this file: WO2023241799

WO2023241799 - FLAVANOLS FOR USE IN THE TREATMENT OF RETROVIRAL INFECTIONS [Right-click to bookmark this link]
Status	The international publication has been made Status updated on 22.12.2023 Database last updated on 12.12.2024
Former	unknown Status updated on 11.07.2022
Most recent event Tooltip	22.12.2023	PCT data prior to European publication
	22.12.2023	New entry: applicant or inventor
Applicant(s)	For: UNIVERSITÉ LIBRE DE BRUXELLES 50 avenue F.D. Roosevelt 1050 Bruxelles / BE
	For: NIEBES, Paul Rue du Lambais 64 1390 Grez-Doiceau / BE
	[N/P]
Inventor(s)	01 / NIEBES, Paul 1390 Grez-Doiceau / BE
	02 / VAN LINT, Carine 1150 Bruxelles / BE
	03 / BENDOUMOU, Maryam 6180 Courcelles / BE
	[N/P]
Application number, filing date	22734922.2	15.06.2022
	WO2022EP66424
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2023241799
	Date:	21.12.2023
	Language:	EN
	[2023/51]
Search report(s)	International search report - published on:	EP	21.12.2023
Classification	IPC:	A61K31/353, A61P31/14, A61P31/18, A61K45/06
	CPC:	A61K31/353 (EP); A61K45/06 (EP); A61P31/14 (EP); A61P31/18 (EP)
	C-Set:	A61K31/353, A61K2300/00 (EP)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Extension states	BA	Not yet paid
	ME	Not yet paid
Validation states	KH	Not yet paid
	MA	Not yet paid
	MD	Not yet paid
	TN	Not yet paid
Title	English:	FLAVANOLS FOR USE IN THE TREATMENT OF RETROVIRAL INFECTIONS
	French:	FLAVANOLS DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'INFECTIONS RÉTROVIRALES
Cited in	International search	[XYI]EP2179722 (HEINRICH PETTE INST FUER EXPER [DE]) [X] 1-7,14,15,18-22 * catechin (C), catechin-gallate (CG), gallocatechin (GC), gallocatechin-gallate (GCG), epicatechin (EC), epicatechin-gallate (ECG), epigallocatechin (EGC), epigallocatechin-gallate (EGCG);; claims 1-14 * [Y] 23 [I] 8-13,16,17,23;
		[XYI]WO2010108410 (ZHAO YALI [CN], et al) [X] 1-8,14,15,18-22 * claims 1-10; compounds ECGC, ECG, CG, GCG * * paragraphs [0066] - [0069] - [0 93] - [0096] - [ 110] - [0156] * [Y] 23 [I] 9-13,16,17,23;
		[XYI]CN103193752 (UNIV BEIJING TECHNOLOGY, et al) [X] 1-7,14,15,18-22 * claims 1, 3, 5; compounds (-)Epicatechin * [Y] 23 [I] 8-13,16,17,23;
		[XYI] - TILLEKERATNE L.M.V ET AL, "Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Amsterdam NL, vol. 11, no. 20, doi:10.1016/S0960-894X(01)00577-7, ISSN 0960-894X, (20011001), pages 2763 - 2767, URL: https://www.sciencedirect.com/science/article/pii/S0960894X01005777?via%3Dihub, XP093014005 [X] 1-7,14,15,18-22 * (-) epicatechin gallate (-) epigallocatechin gallate (-) epicatechin;; table 1 * [Y] 23 [I] 9-13,16,17,23 DOI: http://dx.doi.org/10.1016/S0960-894X(01)00577-7
		[XYI] - Wu Pei-Lin ET AL, "Cytotoxic and Anti-HIV Principles from the Rhizomes of Begonia nantoensis", Chem. Pharm. Bull., (20040101), pages 345 - 349, URL: https://www.jstage.jst.go.jp/article/cpb/52/3/52_3_345/_article, (20230113), XP093014019 [X] 1-7,14,15,18-22 * table 3; compounds (-) catechin * * page 346, column right, paragraph last * * abstract * [Y] 23 [I] 9-13,16,17,23
		[XYI] - LI SHENWEI ET AL, "Epigallocatechin Gallate Inhibits the HIV Reverse Transcription Step", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, England, vol. 21, no. 6, doi:10.3851/IMP1774, ISSN 2040-2066, (20110801), pages 239 - 243, URL: http://journals.sagepub.com/doi/full-xml/10.3851/IMP1774, XP093014411 [X] 1-7,14,15,18-22 * (-) epigallocatechin and (-) epigallocatechin gallate;; figure 1 * * Results; page 241 * [Y] 23 [I] 9-13,16,17,23 DOI: http://dx.doi.org/10.3851/IMP1774
		[XYI] - XU HONG-XI ET AL, "INHIBITORY ACTIVITY OF FLAVONOIDS AND TANNINS AGAINST HIV-1 PROTEASE", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, (20000901), vol. 23, no. 9, ISSN 0918-6158, pages 1072 - 1076, XP001247378 [X] 1-8,14,15,18-22 * (+) catechin and (-) epicatechin;; table 2 * [Y] 23 [I] 9-13,16,17,23
		[XYI] - KASHIWADA Y ET AL, "Evaluation of tea polyphenols as anti-hiv agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, (19960319), vol. 6, no. 6, doi:10.1016/0960-894X(96)00095-9, ISSN 0960-894X, pages 695 - 700, XP004135008 [X] 1-8,14,15,18-22 * figure 1; compounds 1-4, 7-8, 11 * * table 1 * [Y] 23 [I] 9-13,16,17,23 DOI: http://dx.doi.org/10.1016/0960-894X(96)00095-9
		[XYI] - YANG, JIE ET AL, "HIV fusion-inhibiting activity of peracetate ester of (-)-epigallocatechin gallate and the mechanism", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2011:23715, URL: STN, XP002808481 [X] 1-3,14,15,18-22 * abstract * [Y] 23 [I] 7,9-13,16,17
		[XYI] - KO YEON-JU ET AL, "Flavonoids as Potential Inhibitors of Retroviral Enzymes", HAN'GUG EUNG'YONG SAENGMYEONG HWA HAGHOEJI - JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, Seoul, Korea, vol. 52, no. 4, doi:10.3839/jksabc.2009.057, ISSN 1738-2203, (20090831), pages 321 - 326, URL: https://applbiolchem.springeropen.com/articles/10.3839/jksabc.2009.057, XP093014440 [X] 1-6,14,15,18-22 * table 1 * [Y] 23 [I] 7-13,16,17,23 DOI: http://dx.doi.org/10.3839/jksabc.2009.057
		[XYI] - Andrae-Marobela Kerstin ET AL, "Polyphenols: A Diverse Class of Multi-Target Anti-HIV-1 Agents", Current Drug Metabolism, (20130101), pages 392 - 413, URL: https://www.eurekaselect.com/article/51240, (20230113), XP093013995 [X] 1-6,14,15,18-22 * catechin gallate, epicatechin gallate, gallocatechin gallate, epigallocatechin gallate;; table 1 * [Y] 23 [I] 7-13,16,17,23
		[XYI] - HARAKEH S. ET AL, "Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells", MEDICAL ONCOLOGY, GB, vol. 25, no. 1, doi:10.1007/s12032-007-0036-6, ISSN 1357-0560, (20070814), pages 30 - 39, URL: http://link.springer.com/article/10.1007/s12032-007-0036-6/fulltext.html, XP093015457 [X] 1-5,7,14,15,18-22 * abstract * * the whole document * [Y] 23 [I] 6,8-13,16,17 DOI: http://dx.doi.org/10.1007/s12032-007-0036-6
		[A] - MAREGESI S M ET AL, "Phytochemical and biological investigations of Elaeodendron schlechteranum", JOURNAL OF ETHNOPHARMACOLOGY, ELSEVIER IRELAND LTD, IE, vol. 129, no. 3, doi:10.1016/J.JEP.2010.03.034, ISSN 0378-8741, (20100616), pages 319 - 326, (20100529), XP027065404 [A] 1-23 * compounds 4-5 * * last sentence before point 4 (discussion); page 324, column right * DOI: http://dx.doi.org/10.1016/j.jep.2010.03.034
	by applicant	EP0370498
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		EP0721331
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		WO9933793
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		WO2013050422
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